scholarly journals Targeting the NLRP3 Inflammasome via BTK

2021 ◽  
Vol 9 ◽  
Author(s):  
Alexander N. R. Weber
Keyword(s):  
Nlrp3 Inflammasome ◽  
Therapeutic Potential ◽  
Future Research ◽  
Research Directions ◽  
Open Questions ◽  
Human Disorders ◽  
Future Research Directions ◽  
Mechanistic Basis ◽  
Btk Inhibitors

The NLRP3 inflammasome represents a critical inflammatory machinery driving pathology in many acute (e. g., myocardial infarction or stroke) and chronic (Alzheimer's disease, atherosclerosis) human disorders linked to the activity of IL-1 cytokines. Although the therapeutic potential of NLRP3 is undisputed, currently no clinically approved therapies exist to target the NLRP3 inflammasome directly. The recent discovery of BTK as a direct and positive regulator of the NLRP3 inflammasome has, however, raised the intriguing possibility of targeting the NLRP3 inflammasome via existing or future BTK inhibitors. Here, I review the mechanistic basis for this notion and discuss the molecular and cellular role of BTK in the inflammasome process. Specific attention will be given to cell-type dependent characteristics and differences that may be relevant for targeting approaches. Furthermore, I review recent (pre-)clinical evidence for effects of BTK inhibitors on NLRP3 activity and highlight and discuss open questions and future research directions. Collectively, the concept of targeting BTK to target NLRP3-dependent inflammation will be explored comprehensively at the molecular, cellular and therapeutic levels.

scholarly journals Antiangiogenics: The Potential Role of Integrating This Novel Treatment Modality With Chemoradiation for Solid Cancers

2007 ◽  
Vol 25 (26) ◽  
pp. 4033-4042 ◽  
Author(s):  
Dan G. Duda ◽  
Rakesh K. Jain ◽  
Christopher G. Willett
Keyword(s):  
Treatment Modality ◽  
Therapeutic Approach ◽  
Potential Role ◽  
Therapeutic Potential ◽  
Clinical Development ◽  
Future Research ◽  
Research Directions ◽  
Novel Treatment ◽  
Future Research Directions

Although still in very early stages of clinical development, the combination of antiangiogenics with contemporary chemoradiotherapy regimens has emerged as a feasible and promising approach to many cancers. We review the rationale and the current understanding of antiangiogenics and their therapeutic potential in combination with chemoradiotherapy. Finally, we offer a perspective on future research directions aimed at making this complex therapeutic approach successful in the clinic.

Interpersonal Psychotherapy for the Treatment of Eating Disorders

2010 ◽  
pp. 347-372 ◽  
Author(s):  
Marian Tanofsky-Kraff ◽  
Denise E. Wilfley
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Care ◽  
Interpersonal Psychotherapy ◽  
Future Research ◽  
Cognitive Behavior ◽  
Research Directions ◽  
Routine Clinical Care ◽  
Interpersonal Factors ◽  
Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of EDs. IPT is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of EDs. IPT is a viable alternative to cognitive behavior therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is currently being explored. Future research directions include enhancing the delivery of IPT for EDs, increasing the availability of IPT in routine clinical care settings, exploring IPT adolescent and parent–child adaptations, and developing IPT for the prevention of eating and weight-related problems that may promote full-syndrome EDs or obesity.

The Effectiveness of Family-Supportive Supervisors: The Moderating Role of Employees’ Collectivistic Self-Construal

2020 ◽  
Vol 51 (6) ◽  
pp. 442-455
Author(s):  
Peng Wang ◽  
Zhengxue Luo ◽  
Zhen Wang
Keyword(s):  
Self Determination Theory ◽  
Employee Perceptions ◽  
Future Research ◽  
Research Directions ◽  
Self Construal ◽  
Member Exchange ◽  
Future Research Directions ◽  
Work Family ◽  
Work Family Enrichment

Built upon conservation of resource theory and self-determination theory, this study explores boundary conditions under which family-supportive supervisors (FSSs) influence employee-perceived leader–member exchange (LMX) and work–family enrichment (WFE). Findings from this research reveal that FSSs positively relate to employee perceptions of LMX and WFE. Employees’ collectivistic self-construals moderate the effect of FSSs on LMX but not on WFE. Implications and future research directions are discussed.

Cardiovascular Comorbidities of Psoriasis and Psoriatic Arthritis: A Report from the GRAPPA 2012 Annual Meeting

2013 ◽  
Vol 40 (8) ◽  
pp. 1434-1437 ◽  
Author(s):  
April W. Armstrong ◽  
Joel M. Gelfand ◽  
Wolf-Henning Boehncke ◽  
Ehrin J. Armstrong
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Tumor Necrosis ◽  
Panel Discussion ◽  
Future Research ◽  
Research Directions ◽  
Cardiovascular Comorbidities ◽  
Future Research Directions ◽  
Necrosis Factor

At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Stockholm, Sweden, several GRAPPA members led a panel discussion on cardiovascular (CV) comorbidities of psoriasis and psoriatic arthritis (PsA). The panelists discussed the role of insulin resistance in the pathophysiology of psoriasis, the possible effect of tumor necrosis factor inhibitors on CV comorbidities, and the effect of 12/23 monoclonal antibodies on CV outcomes. The panelists also addressed how lessons from CV comorbidity research could be applied to other areas of comorbidity research in psoriasis and PsA and identified future research directions in this area.

scholarly journals Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA

ExRNA ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Fangfang Jin ◽  
Zhigang Guo
Keyword(s):  
Small Rna ◽  
Current Knowledge ◽  
Future Research ◽  
Regulatory Rna ◽  
Biological Functions ◽  
Research Directions ◽  
Non Coding Rna ◽  
Future Research Directions ◽  
Non Coding Rnas

Abstract The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-derived small RNA (tsRNA), serves as a new regulator of gene expression. tsRNA has been determined participate in regulating some specific physiological and pathological processes. Although knowledge regarding the biological roles of miRNA and piRNA is expanding, whether tsRNAs play similar roles remains poorly understood. Here, we review the current knowledge regarding the mechanisms of action and biological functions of tsRNAs in intracellular, extracellular and intergenerational inheritance, and highlight the potential application of tsRNAs in human diseases, and present the current problems and future research directions.

scholarly journals Reducibility and Solvability of Some Classes of Kryuchkov Binary Tree Pairs

10.37236/2028 ◽  
2012 ◽  
Vol 18 (2) ◽  
Author(s):  
Maria Madonia ◽  
Giuseppe Scollo
Keyword(s):  
Induction Hypothesis ◽  
Binary Tree ◽  
Binary Trees ◽  
Equal Size ◽  
Future Research ◽  
Theoretic Approach ◽  
Research Directions ◽  
Open Questions ◽  
Future Research Directions

This paper addresses the problem of characterizing classes of pairs of binary trees of equal size for which a signed reassociation sequence, in the Eliahou-Kryuchkov sense, can be shown to exist, either with a size induction hypothesis (reducible pairs), or without it (solvable pairs). A few concepts proposed by Cooper, Rowland and Zeilberger, in the context of a language-theoretic approach to the problem, are here reformulated in terms of signed reassociation sequences, and some of their results are recasted and proven in this framework. A few strategies, tactics and combinations thereof for signed reassociation are introduced, which prove useful to extend the results obtained by the aforementioned authors to new classes of binary tree pairs. In particular, with reference to path trees, i.e. binary trees that have a leaf at every level, we show the reducibility of pairs where (at least) one of the two path trees has a triplication at the first turn below the top level, and we characterize a class of weakly mutually crooked path tree pairs that are neither reducible nor solvable by any previously known result, but prove solvable by appropriate reassociation strategies. This class also includes a subclass of mutually crooked path tree pairs. A summary evaluation of the achieved results, followed by an outline of open questions and future research directions conclude the paper.

scholarly journals 3D quantum Hall effects and nonlinear Hall effect

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Shuai Li ◽  
C. M. Wang ◽  
Z. Z. Du ◽  
Fang Qin ◽  
Hai-Zhou Lu ◽  
...  
Keyword(s):  
Hall Effect ◽  
Condensed Matter ◽  
Quantum Hall ◽  
Future Research ◽  
Research Directions ◽  
New Members ◽  
Quantum Hall Effects ◽  
Open Questions ◽  
Hall Effects ◽  
Future Research Directions

AbstractThe classical and quantum Hall effects are important subjects in condensed matter physics. The emergent 3D quantum Hall effects and nonlinear Hall effect have attracted considerable interest recently, with the former elevating the quantum Hall effect to a higher dimension and the latter extending the Hall effect to higher-order responses. In this perspective, we briefly introduce these two new members of the Hall family and discuss the open questions and future research directions.

Value Co-Creation in Cloud Services

2013 ◽  
pp. 74-91 ◽  
Author(s):  
Ammar Rashid ◽  
William Yu Chung Wang ◽  
Felix B. Tan
Keyword(s):  
Service Providers ◽  
Practical Experience ◽  
Cloud Services ◽  
Future Research ◽  
Research Directions ◽  
Technical Aspects ◽  
Creation Process ◽  
Managerial Implications ◽  
Future Research Directions

In recent years, there has been considerable interest in cloud services in academic literature. Most research in this area has focused on the technical aspects of designing and implementing cloud services, with few studies focusing on understanding the value of cloud services and the processes by which consumer and service providers engage each other to co-create these services. This chapter explains the co-creation processes, and, the role of consumer in the value co-creation process of cloud services. It incorporates extant marketing and information systems literature, industry reports, and practical experience reflections to highlight the significance of cloud services. The drivers of co-creation are explored with the description of co-creation processes and the underlying factors involved in value co-creation of cloud services. The chapter concludes by outlining the opportunities associated with the development of cloud services, noting future research directions and discussing academic and managerial implications.

The Role of Human Resources in Hotels in China

2015 ◽  
pp. 164-181
Author(s):  
Jenny Chen
Keyword(s):  
Human Resources ◽  
Hotel Industry ◽  
Future Research ◽  
Great Contribution ◽  
Research Directions ◽  
Good Person ◽  
Future Research Directions ◽  
Points Of View

There was a famous saying from the celebrated hotelier, “king of hoteliers and hotelier to kings,” Mr. Cesar Ritz, that a good person is priceless (Leng, 2013). Human resources has always played a very important role in hotels. This is because the hotel industry is a labor-intensive industry that requires great contribution and support from human resources to identify and recruit the required staff, train and manage the manpower to fill the various jobs, and retain and develop the talented employees for greater responsibilities or higher positions. This chapter displays the changes of the role of human resources in hotels in China and its significant impact of the changes to the industry. In addition, this chapter also provides its unique points of view in the part of Solutions and Recommendations and in the part of Future Research Directions.

Business Models and Organizational Processes Changes

2011 ◽  
pp. 192-205
Author(s):  
Helena Halas ◽  
Tomaž Klobucar
Keyword(s):  
Pervasive Computing ◽  
Business Models ◽  
Business Processes ◽  
Future Research ◽  
Organizational Processes ◽  
Research Directions ◽  
Main Stress ◽  
Future Research Directions ◽  
Future Business

This chapter explores the influence of pervasive computing on companies and their businesses, with the main stress on business models. The role of business models for companies is presented. Introduction to pervasive computing and a survey of existing e-business models classifications are used as a base for our research. The main characteristics of today’s business models are discussed and a method for evaluating business models characteristics is proposed. We concentrate on characteristics of pervasive computing and their influence on companies’ business processes and business models. The present and future business characteristics and business models are briefly compared, and future research directions on pervasive computing and business models are presented.

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