scholarly journals Increased Blood Retinol Levels Are Associated With a Reduced Risk of TIA or Stroke in an Adult Population: Lifestyle Factors- and CVDs-Stratified Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Linjuan Guo ◽  
Ying Huang ◽  
Rong Wan ◽  
Yang Shen ◽  
Kui Hong

Background: Data on the existing evidence for the association between blood retinol and transient ischemic attack (TIA)/stroke risk are limited, and the results are inconclusive. This study aimed to further assess the associations between the blood retinol levels and the risk of TIA/stroke after controlling the lifestyle factors and age-related confounders.Methods: The cross-sectional data from 1,113 individuals (aged 34–84 years old) were obtained from the Midlife in the United States (MIDUS) study. The multivariable analyses were performed to investigate the association of blood retinol levels with ever and currently TIA/stroke.Results: There was an inverse association between the blood retinol levels and the risk of ever TIA or stroke (for per 1 μmol/L adjusted odds ration [OR]: 0.93; 95% CI: 0.89–0.97; for per 1-SD adjusted OR: 0.89; 95% CI: 0.83–0.96) and currently diagnosed TIA or stroke (for per 1 μmol/L adjusted OR: 0.91; 95% CI: 0.87–0.96; for per 1-SD adjusted OR: 0.84; 95% CI: 0.80–0.91) after controlling the lifestyle factors and age-related confounders. The significance of these associations was maintained after a sensitivity analysis and involving “ever chronic respiratory diseases” as a covariate. Moreover, the stratified analyses suggested that the inverse associations could be affected by overweight [body mass index (BMI) ≥ 28, kg/m2], hypertension, and diabetes.Conclusions: A significant inverse association between blood retinol and the risk of TIA or stroke was found. This inverse association did not change even after adjustment for many potential confounders. Moreover, the potential protective effect of retinol on TIA/stroke could be blunted by overweight [BMI ≥ 28, kg/m2], hypertension, and diabetes.

Obesity ◽  
2014 ◽  
Vol 22 (9) ◽  
pp. 2080-2090 ◽  
Author(s):  
Orison O. Woolcott ◽  
Oscar A. Castillo ◽  
Cesar Gutierrez ◽  
Robert M. Elashoff ◽  
Darko Stefanovski ◽  
...  

Rheumatology ◽  
2020 ◽  
Vol 59 (9) ◽  
pp. 2556-2562 ◽  
Author(s):  
Raúl Cortés Verdú ◽  
José M Pego-Reigosa ◽  
Daniel Seoane-Mato ◽  
Mercedes Morcillo Valle ◽  
Deseada Palma Sánchez ◽  
...  

Abstract Objectives Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.


Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Xiao Zhang ◽  
Akira Fujiyoshi ◽  
Aya Kadota ◽  
Vasudha Ahuja ◽  
Abhishek Vishnu ◽  
...  

Background: Soy isoflavones (ISFs) are regularly consumed in Japan and other Asian countries where some studies showed a significant inverse association of ISFs intake with incident coronary heart disease (CHD). However, a US randomized clinical trial did not find ISFs as anti-atherogenic. This discrepancy may be due to the higher capacity of people in Japan than in the US to produce equol, a metabolite of ISF by the gut microbiome. Equol may have greater anti-atherogenic properties than ISFs. It is unknown whether equol producers (EP), people who produce equol after consuming ISF, have lower aortic calcification (AC), a biomarker of atherosclerosis, as compared to non-EP. Aim: To determine the association between equol producing status and AC in Japanese men. Method: This cross-sectional, population-based study included 302 Japanese men aged 40-49, free of CHD. EP was defined as participants with serum levels of equol ≥20 nM. AC was measured in the entire aorta and quantified by the Agatston method. The presence of AC was defined as AC score ≥10. We analyzed the association between equol producing status and AC using the Tobit and the logistic regressions. Result: We observed 125 participants as EP. In multivariable analyses, EP had non-significantly lower AC score by 147 (95% confidence interval (CI): -386, 92) units and an odds ratio of 0.71 (95% CI: 0.40, 1.26) for the AC presence as compared to non-EP. As significant interaction of equol producing status with age was present, we stratified the analyses by the median age. In men aged 45-49 years, EP had non-significantly lower AC score by 246 units and a non-significant 0.62 times the odds of AC presence as compared to non-EP; the corresponding values in men aged 40-44 were 12 units and 0.91 times (Table). Such an association was not observed with serum ISFs (data not shown). Conclusion: Japanese middle-aged men who were EP had non-significantly lower AC than non-EP and such association was stronger in men aged 45-49 than 40-44 years. Further study with much larger sample size is warranted.


Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1877 ◽  
Author(s):  
Yangbo Sun ◽  
Buyun Liu ◽  
Yang Du ◽  
Linda Snetselaar ◽  
Qi Sun ◽  
...  

Background: The organic food market has grown rapidly worldwide in the past 15 years. However, evidence concerning the health effects of organic foods is scarce. We evaluated the cross-sectional association of organic food purchase, as a proxy of organic food consumption, with diabetes in a nationally representative population. Methods: We included 8199 participants aged ≥20 years from the National Health and Nutrition Examination Survey 2007–2008 and 2009–2010. Organic food purchase and frequency were ascertained by questionnaires. Diabetes was defined as a self-reported physician diagnosis or a hemoglobin A1c level ≥6.5% or both. We used logistic regression with sample weights to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Results: Individuals who reported purchasing organic foods were less likely to have diabetes compared to those who did not report organic food purchase. After adjustment for age, gender, race/ethnicity, family history of diabetes, socioeconomic status, and dietary and lifestyle factors, the OR of diabetes associated with organic food purchase was 0.80 (95% CI 0.68–0.93). The association remained significant after additional adjustment for BMI with OR of 0.80 (0.69–0.94). Conclusions: In a nationally representative population, frequent organic food purchase was inversely associated with diabetes prevalence in adults in the United States.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S884-S884
Author(s):  
Fadi Youkhana ◽  
Yanyan Wu ◽  
Catherine M Pirkle ◽  
Eric Hurwitz ◽  
Andrew Grandinetti ◽  
...  

Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease in the United States with more than 50,000 new cases annually. Studies have reported an inverse relationship between smoking status and the risk for PD. Current smoking status, the number of pack-years smoked, and the lifetime duration of smoking have all been shown to have a lower risk for PD compared to non-smokers. However, studies exploring smoking behaviors in a multiethnic cohort with an ample sample size of PD cases to analyze smoking differences between men and women are rare. Using the Multiethnic Cohort (MEC), our study included 680 self-reported cases of PD from total sample of 98,191 Blacks, Latinos, Japanese, Native Hawaiians, and Whites from Hawaii and Los Angeles surveyed in 2003-2007. Stratified by sex, we conducted a cross-sectional logistic regression analysis to examine the odds of developing PD by various smoking indicators. Overall, current smokers had the lowest risk for PD (OR=0.46, 95%CI 0.27-0.76) compared to non-smokers. The odds of developing PD gradually decreased as the number of years of smoking increased with participants that smoked for 50 years or more having the lowest odds of developing PD (OR= 0.41, 95%CI 0.22-0.78) compared to non-smokers. Using a multiethnic cohort, our analyses further supported the inverse association between PD and smoking status, as well as the number of years of smoking. Future studies are necessary to investigate the possible genetic modulation on the relationship between tobacco and PD.


2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Karima Mohtadi ◽  
Rajaa Msaad ◽  
Najwa Benalioua ◽  
Ali Jafri ◽  
Hasnaa Meftah ◽  
...  

Several studies had revealed that following the Mediterranean diet (MD) contributes to beneficial health status and a decreased risk of many chronic diseases. The aim of our study was to assess adherence to MD in Casablanca City and to identify the relationship between MD adherence and sociodemographic and lifestyle parameters. This cross-sectional study concerned 719 subjects with complete dietary data. Data collection was performed using a questionnaire including sociodemographic and lifestyle factors. The dietary intake was assessed with the use of a food-frequency questionnaire. The compliance with MD was evaluated with a simplified MD score. Our study showed that high adherence to the MD was characterized by high intakes of vegetables, fruits, pulses, fish, cereals, olive oil, and low meat and dairy consumption according to the Simplified MD score. As regard to the multivariate logistic, being a man, being married, persons with a level of education >6 years, luxurious housing, and consumption of alcohol were associated with a higher adherence to MD, while, the overweight was negatively associated with a higher adherence to MD. Maintaining the traditional MD pattern is crucial for public health; in this way, more research is needed in this area in order to precisely measure these associations.


1980 ◽  
Vol 3 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Willy Lens ◽  
Antoine Gailly

Age related differences in extension of future time perspective in motivational goals are studied at three socio-economic levels in a representative sample of the French speaking adult population in Belgium. The hypothesis of an inverted U-shaped relationship between age and extension of future time perspective is tested statistically. It cannot be maintained when using two indices of future extension that are borrowed from earlier studies in this field: (a) the proportion of number of references to the near future to the number of references to the distant future, and (b) the mean future extension score in number of years. The proportion of the mean future extension score to the statistically calculated expected life time is proposed as a new and better index of future extension for comparing different age groups. With this new index the hypothesis is confirmed at the three socioeconomic levels. The limits of the cross-sectional method that is used and the relative value of the new index of extension of future time perspective are discussed.


2014 ◽  
Vol 38 (4) ◽  
pp. 350-358 ◽  
Author(s):  
Gisela Jia ◽  
Jennifer Chen ◽  
HyeYoung Kim ◽  
Phoenix-Shan Chan ◽  
Changmo Jeung

This cross-sectional study investigated the bilingual lexical skills of 175 US school-age children (5 to18 years old) with Cantonese, Mandarin, or Korean as their heritage language (HL), and English as their dominant language. Primary study goals were to identify potential patterns of development in bilingual lexical skills over the elementary to high school time span and to examine the relation of environmental factors to lexical skills. HL and English productive lexical skills were assessed with a Picture Naming and a Verbal Fluency task. English receptive lexical skills were assessed with Peabody Picture Vocabulary Test. A survey obtained information about participants’ language use in six environmental contexts. There were age-related significant increases in both HL and English skills. However, English proficiency already had a significant lead over HL proficiency at the youngest age. English receptive lexical skills reached monolingual expectations from age 8, whereas for HL, high school age participants on average only reached the level of early elementary school monolinguals. Although more English use at home at younger ages was associated with stronger English skills, the relation did not exist for older participants. Instead, among older participants, more English use at home was associated with weaker HL skills. Children’s attendance at HL programs and visits to home countries bore little relation to HL proficiency.


2020 ◽  
Vol 19 (3) ◽  
pp. 2497
Author(s):  
V. G. Vilkov ◽  
S. A. Shalnova ◽  
Yu. A. Balanova ◽  
S. E. Evstifeeva ◽  
A. E. Imaeva ◽  
...  

Aim. To study the prevalence of hypotension according to several criteria in the Russia and the USA.Material and methods. We used data of Russian population studies performed in 1975-1982 and ESSE-RF study performed in 2012-2014 at the National Medical Research Center for Therapy and Preventive Medicine. A comparison was made with the data of cross-sectional stu - dies of the US population — National Health and Nutrition Examination Survey (NHANES): NHANES II (1976-1980) and Continuous NHANES (2007-2012). We analyzed age, sex, and systolic and diastolic blood pressure. The prevalence of individuals with hypotension was calculated in men and women of five age groups using four different criteria for hypertension.Results. The prevalence of hypotension in studies of different years according to different criteria was as follows: in the Russia — 0,3-9,0% in men and 2-15% in women; in the USA — 5-30% in men and 8-45% in women. In age group >30 years, the prevalence of hypotension in Russia, by most criteria, decreased approximately by 50% in men and did not change in women. In the United States, according to all criteria, the prevalence in men and women has increased 2-3 times.Conclusion. The prevalence of hypotension in the adult population ranges from decimal percentages to 45% and varies many times depending on the selected criterion.


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