Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?

Abstract Objectives Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.

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The prevalence of rheumatoid arthritis in Spain

Scientific Reports ◽

10.1038/s41598-020-76511-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Lucía Silva-Fernández ◽

Cristina Macía-Villa ◽

Daniel Seoane-Mato ◽

Raúl Cortés-Verdú ◽

Antonio Romero-Pérez ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Urban Areas ◽

Adult Population ◽

Geographic Origin ◽

High Body Mass Index ◽

Population Based ◽

Cross Sectional Study ◽

Computer Assisted ◽

Cross Sectional ◽

General Adult Population

AbstractRheumatoid arthritis (RA) prevalence is believed to be around 1% worldwide, although it varies considerably among different populations. The aim of EPISER2016 study was to estimate the prevalence of RA in the general adult population in Spain. We designed a population-based cross-sectional study. A national survey was conducted between November 2016 and October 2017 involving a probabilistic sample from the general population aged 20 years or older. Subjects were randomly selected for phone screening using a computer-assisted telephone interviewer system. Positive RA screening results were evaluated by a rheumatologist. Cases fulfilled the 1987 ACR and/or the 2010 ACR/EULAR criteria; previous diagnosis established by a rheumatologist and clearly identified in medical records were also accepted regardless of the criteria used. Prevalence estimates with 95% CI were calculated taking into account the design of the sample (weighting based on age, sex, and geographic origin using as a reference the distribution of the population in Spain). 4916 subjects participated in the study and 39 RA cases were confirmed. RA estimated prevalence was 0.82% (95% CI 0.59–1.15). Mean age of RA cases was 60.48 (14.85) years, they were more frequently women (61.5%), from urban areas (74.4%), non-smokers (43.6%), and with a high body mass index (53.8% with overweight). Extrapolating to the population in Spain (approximately 37 million are ≥ 20 years old), it was estimated that there were between 220,000 and 430,000 people aged 20 years or older with RA. No undiagnosed cases were detected, which could be related to the establishment of early arthritis clinics around the country, increasing the rates of diagnosis during early phases of RA.

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Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults

Frontiers in Nutrition ◽

10.3389/fnut.2021.735174 ◽

2021 ◽

Vol 8 ◽

Author(s):

Fatemeh Dehghani Firouzabadi ◽

Ahmad Jayedi ◽

Elaheh Asgari ◽

Zahra Akbarzadeh ◽

Nasim Janbozorgi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Adult Population ◽

Positive Association ◽

Population Based ◽

Cross Sectional Study ◽

Significant Positive Association ◽

Cross Sectional ◽

General Adult Population ◽

Education Status ◽

Inflammation Score

Objective: We aimed to evaluate the association between the dietary and lifestyle inflammation score (DLIS) and metabolic syndrome (MetS) and its components in a sample of Iranian adults.Design: Population-based cross-sectional study.Setting: General adult population living in Tehran, Iran.Subjects: We included 827 adult men and women with an age range of 18–59 years who were referred to health centers in different districts of Tehran, Iran. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The DLIS was calculated based on four components, including dietary inflammation score, physical activity, cigarette smoking, and general obesity. Higher DLIS represents a more proinflammatory diet and lifestyle. The odds ratio (OR) and 95% confidence interval (CI) of the MetS across quartiles of the DLIS was calculated by using logistic regression analysis, controlling for age, sex, energy intake, marital status, education status, and occupation.Results: A total of 827 participants (31% men) were included, with a mean age of 44.7 ± 10.7 years. The prevalence of the MetS was 30.5%. The DLIS ranged between −2.35 and +3.19 (mean ± SD: 0.54 ± 1.09). There was a significant positive association between the DLIS and odds of MetS (OR fourthvs.thefirstquartile: 1.57, 95% CI: 1.01–2.45) in the fully adjusted model.Conclusion: Our results showed a significant positive association between the DLIS and odds of MetS. The results of the present crosssectional study suggested that having a more proinflammatory lifestyle can be associated with MetS. More prospective studies are needed to confirm the findings.

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PREVALENCE OF HYPERTENSION IN ADULT POPULATION OF HAYATABAD PESHAWAR

Journal of Saidu Medical College, Swat ◽

10.52206/jsmc.2015.5.1.644-647 ◽

1969 ◽

Vol 5 (1) ◽

pp. 644-647

Author(s):

SARA GUL ◽

ATIF HUSSAIN ◽

KASHIF UR REHMAN KHALIL ◽

IMRANULLAH ◽

MUHAMMAD ISHTIAQ ◽

...

Keyword(s):

Communicable Disease ◽

Adult Population ◽

Positive Association ◽

Developed Countries ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Study Results ◽

History Of ◽

Study Population

BACKGROUND: Hypertension is one of the common non communicable disease and is reported to beprevalent in 20% to 50% of the adult population, hypertension is one of the major contributor ofmortality and morbidity in developing and developed countries. The cross-sectional descriptive studywas formulated to find the prevalence and to assess different etiological factors of hypertension.MATERIAL & METHODS: This cross-sectional study among 400 adults of age 25-75 years wasconducted in months of June to December 2014 in Phase 5, Hayatabad Peshawar. A detailed structuredproforma having important questions was used to collect important data regarding various variables.RESULTS: Our study results showed that 22.75% of the study people were hypertensive i.e. 10.25% ofmales and 12.5% of females; and the prevalence of hypertension showed positive association withadvancing age. Out of all respondents; 60.25% were males while 39.75% were females; 28.5% weresmokers; 5.25% consume predominantly meat; 32.5% were obese & overweight; 36.75% checked theirB.P regularly; and 19.75% had positive history of hypertension in family.CONCLUSION: We conclude that hypertension prevalence was high among our study population andwas associated with various modifiable and non modifiable risk factors thus population based preventivestrategies are needed to control and prevent hypertension.KEY WORDS: Hypertension, Age, Diet, Smokers, Hayatabad, Peshawar.

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SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: adult population-based cross-sectional study

PeerJ ◽

10.7717/peerj.12149 ◽

2021 ◽

Vol 9 ◽

pp. e12149

Author(s):

Charles Huamaní ◽

Lucio Velásquez ◽

Sonia Montes ◽

Ana Mayanga-Herrera ◽

Antonio Bernabé-Ortiz

Keyword(s):

High Altitude ◽

Adult Population ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Ecological Studies ◽

Cross Sectional ◽

Factors Associated ◽

San Sebastian ◽

Population Based Survey

Background There are several ecological studies, but few studies of the prevalence of SARS-COV-2 at high altitude. We aimed to estimate the population-based seroprevalence of SARS-COV-2 in three settings of Cusco at the end of the first wave among adults. Methods A population-based survey was conducted in September 2020, in three settings in the region of Cusco: (1) Cusco city at 3,300 meters above the sea level (m.a.s.l.), (2) the periphery of Cusco (Santiago, San Jerónimo, San Sebastián, and Wanchaq) at 3,300 m.a.s.l., and (3) Quillabamba city, located at 1,050 m.a.s.l. People aged ≥ 18 years within a family unit were included. The diagnosis of SARS-CoV-2 infection was based on identifying anti- SARS-CoV-2 total antibodies (IgM and IgG) in serum using the Elecsys Anti-SARS-CoV-2 chemiluminescence test. Results We enrolled 1924 participants from 712 families. Of the total, 637 participants were anti-SARS-CoV-2 seropositive. Seroprevalence was 38.8% (95% CI [33.4%–44.9%]) in Cusco city, 34.9% (95% CI [30.4%–40.1%]) in the periphery of Cusco, and 20.3% (95% CI [16.2%–25.6%]) in Quillabamba. In 141 families (19.8%; 95% CI [17.0%–22.8%]) the whole members were positive to the test. Living with more than three persons in the same house, a positive COVID-19 case at home, and a member who died in the last five months were factors associated with SARS-COV-2 seropositivity. Dysgeusia/dysosmia was the symptom most associated with seropositivity (aPR = 2.74, 95% CI [2.41–3.12]); whereas always wearing a face shield (aPR = 0. 73; 95% CI [0.60–0.89]) or a facial mask (aPR = 0.76, 95% CI [0.63–0. 92) reduced that probability. Conclusions A great proportion of Cusco’s city inhabitants presented anti-SARS-CoV-2 antibodies at the end of the first wave, with significant differences between settings. Wearing masks and face shields were associated with lower rate of seropositivity; however, efforts must be made to sustain them over time since there is still a high proportion of susceptible people.

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Higher prevalence of psoriatic arthritis in the adult population in Spain? A population-based cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0234556 ◽

2020 ◽

Vol 15 (6) ◽

pp. e0234556

Author(s):

Antonio Romero Pérez ◽

Rubén Queiro ◽

Daniel Seoane-Mato ◽

Eduard Graell ◽

Eugenio Chamizo ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Adult Population ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Prevalence of Major Cardiovascular Risk Factors and Coronary Heart Disease in a Sample of Greek Adults: The Saronikos Study

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192401610010069 ◽

2016 ◽

Vol 10 (1) ◽

pp. 69-80 ◽

Cited By ~ 9

Author(s):

Aristofanis Gikas ◽

Vaia Lambadiari ◽

Alexios Sotiropoulos ◽

Demosthenes Panagiotakos ◽

Stavros Pappas

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Adult Population ◽

Target Population ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

Geographical Regions ◽

Region Data

Background: Comprehensive data regarding prevalence of coronary heart disease (CHD) and associated factors in different geographical regions are very important to our understanding of global distribution and evolution of CHD. The aim of this study was to assess the current prevalence of self-reported risk factors and CHD in Greek adult population. Methods: A community-based cross-sectional study was conducted in May 2014, during an election day, among residents of Saronikos municipality (Attica region). Data were collected from face-to-face interviews. The study sample included 2636 subjects (men, 49.5%; mean age, 50.5; range 20-95 years), with similar age and sex distribution to the target population. Results: The age-standardized prevalence rates of five major risk factors were as follows: type 2 diabetes 11.1%, hypercholesterolemia (cholesterol>240 mg/dl or using cholesterol-lowering medication) 23.8%, hypertension 27.2%, current smoking 38.9% and physical inactivity 43%. Of the participants, only 21% were free of any of these factors. Clustering of two to five risk factors was more frequent among persons aged 50 years and older as compared with younger ones (60% vs 27%, P=0.000). The age-adjusted prevalence of CHD was 6.3% (in men, 8.9%; in women, 3.8%) and that of myocardial infarction was 3.6% (in men, 5.2%; in women, 2.1%). According to multivariate analysis age, gender, education level, obesity, diabetes, hypercholesterolemia, hypertension and ever smoking were strongly associated with CHD. Conclusion: Classic risk factors are highly prevalent and frequently clustered, especially in adults aged 50 years and older. These findings raise concerns about future trends of already increased rates of CHD. Multifactorial and integrated population-based interventions need to be applied to reduce the burden of cardiovascular conditions.

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Seroprevalence, prevalence, and genomic surveillance: monitoring the initial phases of the SARS-CoV-2 pandemic in Betim, Brazil

10.1101/2021.10.21.21265140 ◽

2021 ◽

Author(s):

Ana Valesca Fernandes Gilson Silva ◽

Diego Menezes ◽

Filipe Romero Rebello Moreira ◽

Octavio Alcantara Torres ◽

Paula Luize Camargos Fonseca ◽

...

Keyword(s):

Local Government ◽

Geographical Area ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

The Third ◽

Molecular Tests ◽

Epidemiological Monitoring ◽

The City

The Covid-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial pandemic stages in Betim City, Brazil. We collected 3239 subjects in a population-based age-, sex- and neighborhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling the same geographical area. In the first survey, overall prevalence (participants positive in serological or molecular tests) reached 0.46% (90% CI 0.12% - 0.80%), followed by 2.69% (90% CI 1.88% - 3.49%) in the second survey and 6.67% (90% CI 5.42% - 7.92%) in the third. The underreporting reached 11, 19.6, and 20.4 times in each survey, respectively. We observed increased odds to test positive in females compared to males (OR 1.88 95% CI 1.25 - 2.82), while the single best predictor for positivity was ageusia/ anosmia (OR 8.12, 95% CI 4.72 - 13.98). Thirty-five SARS-CoV-2 genomes were sequenced, of which 18 were classified as lineage B.1.1.28, while 17 were B.1.1.33. Multiple independent viral introductions were observed. Integration of multiple epidemiological strategies was able to describe Covid-19 dispersion in the city adequately. Presented results have helped local government authorities to guide pandemic management.

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Impact of Two Different Recruitment Procedures (Random versus Volunteer Selection) on the Results of Seroepidemiological Study (SARS-CoV-2)

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18189928 ◽

2021 ◽

Vol 18 (18) ◽

pp. 9928

Author(s):

Maksymilian Gajda ◽

Małgorzata Kowalska ◽

Jan Eugeniusz Zejda

Keyword(s):

Selection Bias ◽

Epidemiological Studies ◽

Population Based ◽

Cross Sectional Study ◽

National Registry ◽

Effective Control ◽

Nasopharyngeal Swab ◽

Willingness To Participate ◽

Cross Sectional ◽

Small Component

The proper recruitment of subjects for population-based epidemiological studies is critical to the external validity of the studies and, above all, to the sound and correct interpretation of the findings. Since 2020, the novel coronavirus SARS-CoV-2 pandemic has been a new factor that has been, additionally, hindering studies. Therefore, the aim of our study is to compare demographic, socio-economic, health-related characteristics and the frequency of SARS-CoV-2 infection occurrence among the randomly selected group and the group composed of volunteers. We compare two groups of participants from the cross-sectional study assessing the seroprevalence of SARS-CoV-2 coronavirus, which was conducted in autumn 2020, in three cities of the Silesian Voivodeship in Poland. The first group consisted of a randomly selected, nationally representative, age-stratified sample of subjects (1167 participants, “RG” group) and was recruited using personal invitation letters and postal addresses obtained from a national registry. The second group (4321 volunteers, “VG” group) included those who expressed their willingness to participate in response to an advertisement published in the media. Compared with RG subjects, volunteers were more often females, younger and professionally active, more often had a history of contact with a COVID-19 patient, post-contact nasopharyngeal swab, fewer comorbidities, as well as declared the occurrence of symptoms that might suggest infection with SARS-CoV-2. Additionally, in the VG group the percentage of positive IgG results and tuberculosis vaccination were higher. The findings of the study confirm that surveys limited to volunteers are biased. The presence of the bias may seriously affect and distort inference and make the generalizability of the results more than questionable. Although effective control over selection bias in surveys, including volunteers, is virtually impossible, its impact on the survey results is impossible to predict. However, whenever possible, such surveys could include a small component of a random sample to assess the presence and potential effects of selection bias.

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Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17124242 ◽

2020 ◽

Vol 17 (12) ◽

pp. 4242

Author(s):

Ignatios Ioakeim-Skoufa ◽

Beatriz Poblador-Plou ◽

Jonás Carmona-Pírez ◽

Jesús Díez-Manglano ◽

Rokas Navickas ◽

...

Keyword(s):

General Population ◽

Large Scale ◽

Musculoskeletal Diseases ◽

Epidemiological Studies ◽

Population Based ◽

Cross Sectional Study ◽

Real World Data ◽

Cross Sectional ◽

Complex Interactions ◽

And Gender

The correct management of patients with multimorbidity remains one of the main challenges for healthcare systems worldwide. In this study, we analyze the existence of multimorbidity patterns in the general population based on gender and age. We conducted a cross-sectional study of individuals of all ages from the EpiChron Cohort, Spain (1,253,292 subjects), and analyzed the presence of systematic associations among chronic disease diagnoses using exploratory factor analysis. We identified and clinically described a total of 14 different multimorbidity patterns (12 in women and 12 in men), with some relevant differences in the functions of age and gender. The number and complexity of the patterns was shown to increase with age in both genders. We identified associations of circulatory diseases with respiratory disorders, chronic musculoskeletal diseases with depression and anxiety, and a very consistent pattern of conditions whose co-occurrence is known as metabolic syndrome (hypertension, diabetes, obesity, and dyslipidaemia), among others. Our results demonstrate the potential of using real-world data to conduct large-scale epidemiological studies to assess the complex interactions among chronic conditions. This could be useful in designing clinical interventions for patients with multimorbidity, as well as recommendations for healthcare professionals on how to handle these types of patients in clinical practice.

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Prevalence and risk factors of strongyloidiasis in patients with systemic lupus erythematosus in Southern Thailand

Lupus ◽

10.1177/0961203320911091 ◽

2020 ◽

Vol 29 (6) ◽

pp. 539-546

Author(s):

Siriporn Juthong ◽

Alan F. Geater ◽

Paron Dekumyoy ◽

Thanaporn Hortiwakul ◽

Boonjing Siripaitoon ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Agar Plate ◽

Strongyloides Stercoralis ◽

Epidemiological Studies ◽

Cross Sectional Study ◽

Culture Technique ◽

Systemic Lupus ◽

Cross Sectional ◽

Southern Thailand

Background Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Thailand. Methods A cross-sectional study was conducted on 180 SLE patients attending the Rheumatology Clinic at Songklanagarind Hospital. Stool specimens were collected and examined using the direct smear technique and agar plate culture technique. Serum anti- Strongyloides stercoralis IgG was measured by IgG-ELISA. Results The overall prevalence of strongyloidiasis by combined parasitologyl and/or serology was 15.6%. The prevalence of strongyloidiasis by parasitological methods was 2.2%. Positive parasitology and/or serology was associated with male sex and a SLE disease duration of less than two years. Conclusion Strongyloidiasis is highly prevalent among the SLE population. A combination of serological and parasitological methods increases the rate of diagnosis of strongyloidiasis in SLE patients.

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