scholarly journals Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis

2021 ◽  
Vol 2 ◽  
Author(s):  
Hady Haririan ◽  
Oleh Andrukhov ◽  
Markus Laky ◽  
Xiaohui Rausch-Fan
Keyword(s):  
Sensitivity And Specificity ◽  
Combined Model ◽  
Global Consensus ◽  
Inflammatory Protein ◽  
Study Protocols ◽  
Biomarker Analysis ◽  
Turnover Markers ◽  
Meta Analyses ◽  
Periodontal Diagnostics

Saliva has the potential to be used as a diagnostic and monitoring tool for various diseases if biomarkers of an adequate sensitivity and specificity could be identified. Several reviews and even meta-analyses have been performed in recent years, which have found some candidate biomarkers for periodontitis, like macrophage inflammatory protein-1 alpha, interleukin-1ß, interleukin-6, matrix metalloproteinase-8, or hemoglobin. However, none of those are currently in use to replace conventional periodontal diagnostics with a periodontal probe. For periimplantitis, to date, heterogeneity of different study protocols and implant types did not permit to discover clear biomarkers, which were able to distinguish between healthy and diseased implants. Few proinflammatory cytokines, similar to periodontitis, have been characterized as adjunct tools to clinical diagnosis. The additional determination of antimicrobial peptides, bone turnover markers, and bacteria could help to enhance sensitivity and specificity in a combined model for periodontitis and periimplantitis. Furthermore, proteomic approaches might be preferred over single biomarker determinations. A global consensus is also needed to harmonize salivary sampling methods as well as procedures of biomarker analysis to ensure future comparability.

scholarly journals Differentiating PSP from MSA using MR planimetric measurements: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Beatrice Heim ◽  
Florian Krismer ◽  
Klaus Seppi
Keyword(s):  
Sensitivity And Specificity ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Index Test ◽  
Study Quality ◽  
Parkinsonian Syndromes ◽  
Quantitative Mr ◽  
Meta Analyses ◽  
Planimetric Measurements

AbstractDifferential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology. Quantitative MR planimetric measurements were reported to discriminate between progressive supranuclear palsy (PSP) and non-PSP-parkinsonism. Several studies have used midbrain to pons ratio (M/P) and the Magnetic Resonance Parkinsonism Index (MRPI) in distinguishing PSP patients from those with Parkinson's disease. The current meta-analysis aimed to compare the performance of these measures in discriminating PSP from multiple system atrophy (MSA). A systematic MEDLINE review identified 59 out of 2984 studies allowing a calculation of sensitivity and specificity using the MRPI or M/P. Meta-analyses of results were carried out using random effects modelling. To assess study quality and risk of bias, the QUADAS-2 tool was used. Eight studies were suitable for analysis. The meta‐analysis showed a pooled sensitivity and specificity for the MRPI of PSP versus MSA of 79.2% (95% CI 72.7–84.4%) and 91.2% (95% CI 79.5–96.5%), and 84.1% (95% CI 77.2–89.2%) and 89.2% (95% CI 81.8–93.8%), respectively, for the M/P. The QUADAS-2 toolbox revealed a high risk of bias regarding the methodological quality of patient selection and index test, as all patients were seen in a specialized outpatient department without avoiding case control design and no predefined threshold was given regarding MRPI or M/P cut-offs. Planimetric brainstem measurements, in special the MRPI and M/P, yield high diagnostic accuracy for the discrimination of PSP from MSA. However, there is an urgent need for well-designed, prospective validation studies to ameliorate the concerns regarding the risk of bias.

Biomarkers of Stress in Music Interventions: A Systematic Review

2021 ◽  
Author(s):  
Melanie Mitsui Wong ◽  
Talha Tahir ◽  
Michael Mitsui Wong ◽  
Annilee Baron ◽  
Rachael Finnerty
Keyword(s):  
Psychological Stress ◽  
Acute Stress ◽  
Well Being ◽  
Health Concern ◽  
Music Intervention ◽  
P Values ◽  
Stress Biomarkers ◽  
Study Protocols ◽  
Significant Public Health ◽  
Meta Analyses

Abstract Psychological stress is a significant public health concern as it is associated with various comorbidities and long-term health implications. Music interventions are emerging therapies for alleviating psychological stress and improving one’s physical and mental well-being. We conducted a systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines for reporting to identify all neuroendocrine biomarkers used to evaluate psychological stress in randomized control trials involving music interventions. We identified 18 unique biomarkers of stress from 14 full-text randomized controlled trials studies. Only one of the 14 music studies included a music therapy intervention. The most frequently used biomarkers across the studies were plasma cortisol, salivary cortisol, and salivary α-amylase. Of the 14 studies, 12 included in this review assessed at least one of these three biomarkers. Of these 12 studies, five papers reported p-values for changes in both stress biomarkers and psychological stress outcome measures. Four of the five studies found significant p-values for the reduction of both stress biomarkers and psychological stress in music intervention groups. The variety of stress biomarkers used and the variance in study protocols makes it difficult to assess the magnitude of effect of music interventions on psychological stress. However, our findings suggest that music interventions have the potential for reducing both stress biomarker levels and psychological stress in acute stress situations.

Direct determination of the concentration dependence of diffusivities using combined model-based Raman and NMR experiments

2009 ◽  
Vol 277 (2) ◽  
pp. 96-106 ◽  
Author(s):  
E. Kriesten ◽  
M.A. Voda ◽  
A. Bardow ◽  
V. Göke ◽  
F. Casanova ◽  
...  
Keyword(s):  
Concentration Dependence ◽  
Direct Determination ◽  
Combined Model ◽  
Model Based

Child Abuse

PEDIATRICS ◽  
1990 ◽  
Vol 86 (5) ◽  
pp. 805-806
Author(s):  
ALLAN R. DE JONG ◽  
MIMI ROSE
Keyword(s):  
Sexual Abuse ◽  
Child Abuse ◽  
Sensitivity And Specificity ◽  
Gold Standard ◽  
Child Protective Services ◽  
Iron Pyrite ◽  
Protective Services ◽  
Physical Evidence

In Reply.— We thank Dr Smith for his interesting perspective regarding screening for child abuse. We had hoped our article would help physicians focus on the verbal evidence of abuse and show how insensitive the physical evidence is in predicting which child had been abused sexually. To apply the principles of sensitivity and specificity to the assessment of child abuse or sexual abuse, we must have a gold standard which characterizes these problems. Neither a child protective services decision nor a legal determination of "no proven abuse" can be used as a gold standard, unless we can accept a "gold standard" made of iron pyrite.

scholarly journals Use of Research Biopsies in Clinical Trials: Are Risks and Benefits Adequately Discussed?

2013 ◽  
Vol 31 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Michael J. Overman ◽  
Janhavi Modak ◽  
Scott Kopetz ◽  
Ravi Murthy ◽  
James C. Yao ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Tumor Tissue ◽  
Eligibility Criterion ◽  
Solid Organ ◽  
Complication Rates ◽  
Limited Information ◽  
Risks And Benefits ◽  
Study Protocols ◽  
Primary Indication ◽  
Biomarker Analysis

Purpose Although the incorporation of research biopsies into clinical trials is increasing, limited information is available about how study protocols and informed consents integrate and describe their use. Methods All therapeutic clinical trials in which image-guided research biopsies were performed from January 1, 2005, to October 1, 2010, were identified from an interventional radiology database. Data from study protocols and informed consents were extracted and analyzed. Procedural complications were recorded. Results A total of 57 clinical trials were identified, of which 38 (67%) contained at least one mandatory biopsy. The analysis of the research biopsy tumor tissue was a study end point in 95% of trials. The primary indication for a research biopsy was for integral biomarker analysis in 32% and for correlative science in 68% of trials. A statistical analytic plan for the correlative science research biopsy tumor tissue was mentioned in 26%, described as exploratory in 51%, and not mentioned in 23% of trials. For studies with mandatory biopsies, biopsy was an eligibility criterion in 71% of trials, and a statistical justification for the research biopsy sample size was present in 50% of trials. A total of 745 research biopsies were performed on 576 patients. Overall and major complication rates were 5.2% (39 of 745 biopsies) and 0.8% (six of 745 biopsies), respectively. Complication rates for intrathoracic and abdominal/pelvic solid organ biopsies were 17.1% (36 of 211 biopsies) and 1.6% (three of 189 biopsies), respectively. Site-stratified research biopsy–related risks were discussed in five consents. Conclusion A better representation of the risks and benefits of research biopsies in study protocols and informed consents is needed.

scholarly journals Red-lesion extraction in retinal fundus images by directional intensity changes’ analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maryam Monemian ◽  
Hossein Rabbani
Keyword(s):  
Sensitivity And Specificity ◽  
Retinal Disease ◽  
Extraction Process ◽  
Efficient Performance ◽  
Intensity Changes ◽  
Significant Intensity ◽  
Almost All ◽  
Retinal Fundus ◽  
Distinguishing Features

AbstractDiabetic retinopathy (DR) is an important retinal disease threatening people with the long diabetic history. Blood leakage in retina leads to the formation of red lesions in retina the analysis of which is helpful in the determination of severity of disease. In this paper, a novel red-lesion extraction method is proposed. The new method firstly determines the boundary pixels of blood vessel and red lesions. Then, it determines the distinguishing features of boundary pixels of red-lesions to discriminate them from other boundary pixels. The main point utilized here is that a red lesion can be observed as significant intensity changes in almost all directions in the fundus image. This can be feasible through considering special neighborhood windows around the extracted boundary pixels. The performance of the proposed method has been evaluated for three different datasets including Diaretdb0, Diaretdb1 and Kaggle datasets. It is shown that the method is capable of providing the values of 0.87 and 0.88 for sensitivity and specificity of Diaretdb1, 0.89 and 0.9 for sensitivity and specificity of Diaretdb0, 0.82 and 0.9 for sensitivity and specificity of Kaggle. Also, the proposed method has a time-efficient performance in the red-lesion extraction process.

scholarly journals A meta-analysis of channel switching approaches for reducing zapping delay in internet protocol television

2021 ◽  
Vol 22 (3) ◽  
pp. 1476
Author(s):  
Timothy T. Adeliyi ◽  
Ropo E. Ogunsakin ◽  
Marion O. Adebiyi ◽  
Oludayo O. Olugbara
Keyword(s):  
Meta Analysis ◽  
Internet Protocol ◽  
Experimental Studies ◽  
Channel Switching ◽  
Major Bottleneck ◽  
Internet Protocol Television ◽  
Delay Component ◽  
Meta Analyses

Channel zapping delays are inconveniences that are often experienced by the subscribers of Internet protocol television (IPTV). It is a major bottleneck in the IPTV channels switching system that affect the quality of experience of users. Consequently, numerous channels switching approaches to minimize zapping delay in IPTV have been suggested. However, there is little knowledge reported in the literature on the determination of the strength of the evidence presented on the approaches of reducing zapping delay in IPTV, which is the prime purpose of this study. The extraction of the relevant articles was designed following the technique of preferred reporting items for systematic reviews and meta-analyses (PRISMA). All the included research articles were searched from the widely used databases of Google Scholar, and Web of Science. All statistical analyses were performed with the aid of the random-effects model implementation in Stata version 15. The overall pooled estimated delay component was presented in forest plots. Overall, thirteen studies were included in the meta-analysis and the overall pooled estimate was 10% (95% CI: 7%, 30%)). Experimental studies have shown that virtual elimination of IPTV zapping delay is possible for a relevant chunk of channel switching requests.

Determination of sensitivity and specificity of a novel gene dosage assay for prenatal screening of trisomy 21 syndrome

2012 ◽  
Vol 45 (3) ◽  
pp. 267-271 ◽  
Author(s):  
Ahmad Reza Kamyab ◽  
Fahimeh Shahrokhi ◽  
Elmira Shamsian ◽  
Mina Hayat Nosaied ◽  
Parvin Dibajnia ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Trisomy 21 ◽  
Prenatal Screening ◽  
Gene Dosage ◽  
Novel Gene

Odontogenic Sinusitis Index (OSI)

2021 ◽  
Vol 20 (5) ◽  
pp. 58-62
Author(s):  
S. Yu. Naumov ◽  
◽  
S. A. Artyushkin ◽  
O. A. Drozdova ◽  
M. A. Aflitonov ◽  
...  
Keyword(s):  
Data Analysis ◽  
Sensitivity And Specificity ◽  
Specificity And Sensitivity ◽  
Odontogenic Sinusitis ◽  
Simple Summation

The criteria for «odontogenic sinusitis» (OS) with the highest values of specificity and sensitivity were identified. An integral odontogenicity sinusitis index (OSI) was developed based on the identified criteria. To measure the sensitivity and specificity of the criteria, a group of 261 patients was selected (113 women (43.29%), 148 men (56.70%), the average age of the patients was 36 years), consisting of 150 known to have OS and 111 patients who were known to be without OS. As a result of data analysis, the values of sensitivity and specificity were obtained for all 13 criteria. Based on the sensitivity and specificity values, all criteria were combined into an odontogenicity sinusitis index (OSI) and divided into «minor» and «major». The “large” criteria were assigned a significance point of 2, and for the “small” criteria, a significance point of 1. The determination of the odontogenic nature of sinusitis was carried out by a simple summation of the points assigned to patients during the survey, examination, and analysis of CT criteria. An odontogenic cause of sinusitis is recognized if there is a minimum of 4 points of significance, for example, one “large” (2 points) and two “small” (1 point each) criteria. The general sensitivity of the integral OSI index was 93%, the general specificity was 94%. These rates are high enough that OSI can be used to determine the «odontogenic» nature of sinusitis.

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