scholarly journals Integrated Analysis Identifies a Nine-microRNA Signature Biomarker for Diagnosis and Prognosis in Colorectal Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Ziyang Di ◽  
Maojun Di ◽  
Weihua Fu ◽  
Qiang Tang ◽  
Yanwei Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Integrated Analysis ◽  
Diagnosis And Prognosis

scholarly journals Circulating Biomarkers of Colorectal Cancer (CRC)—Their Utility in Diagnosis and Prognosis

2021 ◽  
Vol 10 (11) ◽  
pp. 2391
Author(s):  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Mediators ◽  
Colorectal Adenomas ◽  
Global Burden ◽  
Circulating Biomarkers ◽  
Specific Nature ◽  
Diagnosis And Prognosis ◽  
Specific Proteins ◽  
Novel Biomarkers ◽  
Number Of Publications

The global burden of colorectal cancer (CRC) is expected to increase, with 2.2 million new cases and 1.1 million annual deaths by 2030. Therefore, the establishment of novel biomarkers useful in the early diagnosis of CRC is of utmost importance. A number of publications have documented the significance of the overexpression of several specific proteins, such as inflammatory mediators, in CRC progression. However, little is known about the potential utility of these proteins as circulating blood tumor biomarkers of CRC. Therefore, in the present review we report the results of our previous original studies as well as the findings of other authors who investigated whether inflammatory mediators might be used as novel biomarkers in the diagnosis and prognosis of CRC. Our study revealed that among all of the tested proteins, serum M-CSF, CXCL-8, IL-6 and TIMP-1 have the greatest value in the diagnosis and progression of CRC. Serum TIMP-1 is useful in differentiating between CRC and colorectal adenomas, whereas M-CSF and CRP are independent prognostic factors for the survival of patients with CRC. This review confirms the promising significance of these proteins as circulating biomarkers for CRC. However, due to their non-specific nature, further validation of their sensitivity and specificity is required.

scholarly journals Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Youenn Drouet ◽  
Isabelle Treilleux ◽  
Alain Viari ◽  
Sophie Léon ◽  
Mojgan Devouassoux-Shisheboran ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Protein Expression ◽  
Predictive Marker ◽  
Integrated Analysis

Integrated analysis of coexpression and competitive endogenous RNA networks identified survival-related genes in gastrointestinal tumors

2021 ◽  
Author(s):  
Dan Bai ◽  
Huhu Feng ◽  
Jiajun Yang ◽  
Haitao Shi ◽  
Fanpu Ji ◽  
...  
Keyword(s):  
Cox Regression ◽  
Expression Patterns ◽  
Curve Analysis ◽  
Guanosine Monophosphate ◽  
Gastrointestinal Tumors ◽  
Integrated Analysis ◽  
Cox Regression Analysis ◽  
Cerna Network ◽  
Diagnosis And Prognosis ◽  
Competitive Endogenous Rna

Abstract Early diagnosis and prognosis rely on the successful identification of biomarkers and understanding the mechanisms. Through pan-cancer analysis amongst three types of gastrointestinal tumors, we constructed competitive endogenous RNA (ceRNA) networks, differentially expressed set of genes were distinguished, validated, and analyzed, their relevance to survival elucidated with immune infiltration profiles. Shared genes in esophageal, gastric and colon cancers were found significantly enriched in the processes of cell cycle, cell differentiation, DNA replication, synaptic transmission, the cyclic guanosine monophosphate protein-dependent protein kinase (cGMP-PKG) signaling pathway, and the glutamate receptor and other functions. Principal component analysis of the ceRNA network suggested the expression patterns of identified genes. Using Cox regression analysis of mRNAs, miRNAs and lncRNAs in the ceRNA network, genes including hsa-mir-196b, hsa-mir-584, PPP1R12B, SYNM, PDE2A, ALDH6A1 and MIR22HG were found significantly survival-related. Receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA) showed that the identified genes were not related to the survival in thyroid nor breast cancers, but effective for the prognosis of gastrointestinal tumors. These results could provide new theoretical and experimental clues, unravel the mechanisms, assisting molecular diagnosis and prognosis of gastrointestinal tumors.

scholarly journals Chemokines—What Is Their Role in Colorectal Cancer?

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482090338 ◽  
Author(s):  
Sara Pączek ◽  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko
Keyword(s):  
Colorectal Cancer ◽  
Current Knowledge ◽  
Early Stage ◽  
Distant Metastases ◽  
Cell Types ◽  
Diagnosis And Prognosis ◽  
Novel Biomarkers ◽  
Specific Receptors ◽  
Common Malignancy

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. It is the second most frequently diagnosed malignancy in Europe and third worldwide. Colorectal malignancies diagnosed at an early stage offer a promising survival rate. However, advanced tumors often present distant metastases even after the complete resection of a primary tumor. Therefore, novel biomarkers of CRC are sorely needed in the diagnosis and prognosis of this common malignancy. A family of chemokines are composed of small, secreted proteins. They are best known for their ability to stimulate the migration of several cell types. Some investigations have indicated that chemokines are involved in cancer development, including CRC. This article presents current knowledge regarding chemokines and their specific receptors in CRC progression. Moreover, the prime aim of this review is to summarize the potential role of these proteins as biomarkers in the diagnosis and prognosis of CRC.

Identification of the circRNA-miRNA-mRNA regulatory network of Hsp90 inhibitor-induced cell death in colorectal cancer by integrated analysis

Gene ◽  
2020 ◽  
Vol 727 ◽  
pp. 144232
Author(s):  
Kaisheng Liu ◽  
Yaomin Guo ◽  
Kai Zheng ◽  
Chang Zou ◽  
Haixiong Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Regulatory Network ◽  
Hsp90 Inhibitor ◽  
Integrated Analysis

scholarly journals Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship

mSystems ◽  
2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Ce Yuan ◽  
Melanie Graham ◽  
Christopher Staley ◽  
Subbaya Subramanian
Keyword(s):  
Colorectal Cancer ◽  
Cardiovascular Disease ◽  
Nonhuman Primates ◽  
Current Knowledge ◽  
Distal Colon ◽  
Food Sources ◽  
Integrated Analysis ◽  
Strongly Correlated ◽  
Dietary Component ◽  
Metabolic Interactions

ABSTRACT The intestinal microbiota is highly metabolically active and plays an important role in many metabolic processes absent from the human host. Altered microbiota metabolism has been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. However, there is a gap in the current knowledge on how the microbiota interact with its host in terms of metabolic interactions. Here, we performed an integrated analysis between the mucosa-associated microbiota and the mucosa metabolome in healthy, nonhuman primates to investigate these relationships. The microbiota composition was distinct at each tissue location, with variation by host individual also observed. Microbiota-metabolome dynamics were primarily driven by interactions in the distal colon. These interactions were strongly correlated with dietary component, indicating a possibility to modulate microbiota-metabolomic interactions using prebiotic strategies. IMPORTANCE In a healthy colon, the microbiota produces a vast amount of metabolites that are essential to maintaining homeostasis in the colon microenvironment. In fact, these metabolites produced by the microbiota have been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. In this study, we used healthy nonhuman primate models to investigate the relationship between microbiota and tissue metabolites. We found that both microbiota and metabolites have location-specific signatures along the intestine. Most importantly, we found that metabolites from food sources correlate with multiple bacteria in different intestinal locations. Overall, this work presents a systems-level map of the association between the microbiota and the metabolites in healthy nonhuman primates, provides candidates for experimental validation, and suggests a possibility to regulate the gut microbiota through specific prebiotic combinations.

scholarly journals Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Open Biology ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 180212 ◽  
Author(s):  
Bing Chen ◽  
Zijing Xia ◽  
Ya-Nan Deng ◽  
Yanfang Yang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Target Genes ◽  
Research Use ◽  
Biological Processes ◽  
Functional Roles ◽  
Analytical Technique ◽  
Diagnosis And Prognosis ◽  
Recurrence Prediction ◽  
Extracellular Mirnas ◽  
Non Coding Rnas

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

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