scholarly journals Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage

2021 ◽  
Vol 12 ◽  
Author(s):  
Xinyu Wang ◽  
Heng Liu ◽  
Xiaoli Liao ◽  
Lixing Qiao ◽  
Lihua Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Animal Studies ◽  
Neurological Diseases ◽  
Treatment Strategies ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Brain Functions ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Prematurely Born Infants

Long non-coding RNA (LncRNA) has high expression in the brain. Animal studies have shown that lncRNA plays an important role in brain functions and mediates the development of many neurological diseases. However, data on the expression of lncRNAs and the clinical significance in prematurely born infants with diseases such as periventricular white matter damage (PWMD) remains scant. Here, we compared the expression of the lncRNAs in whole blood samples obtained from prematurely born infants with PWMD with samples from prematurely born infants without PWMD. Our data demonstrated differential expression of the lncRNAs between the two groups. Further, we showed that the lncRNAs play important roles in the development of PWMD. Our findings give insights into the functions of the lncRNAs in PWMD and provide evidence for the improvement of diagnostic and treatment strategies in infants with PWMD.

scholarly journals Role of Long Non-Coding RNA Polymorphisms in Cancer Chemotherapeutic Response

2021 ◽  
Vol 11 (6) ◽  
pp. 513
Author(s):  
Zheng Zhang ◽  
Meng Gu ◽  
Zhongze Gu ◽  
Yan-Ru Lou
Keyword(s):  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Cellular Processes ◽  
Dna And Rna ◽  
Chemotherapeutic Response ◽  
Non Coding Rna ◽  
Response To Chemotherapy ◽  
Personalized Oncology ◽  
Long Non Coding Rna

Genetic polymorphisms are defined as the presence of two or more different alleles in the same locus, with a frequency higher than 1% in the population. Since the discovery of long non-coding RNAs (lncRNAs), which refer to a non-coding RNA with a length of more than 200 nucleotides, their biological roles have been increasingly revealed in recent years. They regulate many cellular processes, from pluripotency to cancer. Interestingly, abnormal expression or dysfunction of lncRNAs is closely related to the occurrence of human diseases, including cancer and degenerative neurological diseases. Particularly, their polymorphisms have been found to be associated with altered drug response and/or drug toxicity in cancer treatment. However, molecular mechanisms are not yet fully elucidated, which are expected to be discovered by detailed studies of RNA–protein, RNA–DNA, and RNA–lipid interactions. In conclusion, lncRNAs polymorphisms may become biomarkers for predicting the response to chemotherapy in cancer patients. Here we review and discuss how gene polymorphisms of lncRNAs affect cancer chemotherapeutic response. This knowledge may pave the way to personalized oncology treatments.

scholarly journals Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage

Genomics ◽  
2020 ◽  
Vol 112 (4) ◽  
pp. 2875-2885
Author(s):  
Lixing Qiao ◽  
Sisi Mo ◽  
Yan Zhou ◽  
Yi Zhang ◽  
Bangbang Li ◽  
...  
Keyword(s):  
White Matter ◽  
Premature Infants ◽  
Whole Blood ◽  
Circular Rna ◽  
Periventricular White Matter ◽  
Rna Expression ◽  
White Matter Damage

Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage

Neonatology ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 339-346 ◽  
Author(s):  
Xiangyun Yin ◽  
Jixiu Zhao ◽  
Hong Jiang ◽  
Liangliang Li ◽  
Jian Jiang ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

scholarly journals Inferences from dysregulated long non-coding RNA-mediated competing endogenous RNAs in various chemotherapy drugs and evaluation of drug response in breast cancer

2020 ◽  
Author(s):  
Ziwen Zhang ◽  
Dongbo Li ◽  
Han Zhang ◽  
Qi Qin ◽  
Qingyuan Zhang
Keyword(s):  
Breast Cancer ◽  
Drug Response ◽  
Treatment Strategies ◽  
Molecular Characteristics ◽  
Cancer Hallmarks ◽  
Chemotherapy Drugs ◽  
Non Coding Rna ◽  
Competing Endogenous Rnas ◽  
Novel Treatment Strategies ◽  
Long Non Coding Rna

Abstract Backgroud: Differences in individual drug response, especially drug resistance, present an obstacle to the treatment of breast cancer (BRCA). Thus, the ability to predict drug response would contribute to developing novel treatment strategies. Accumulating evidence have suggested that tumor molecular profiles and drug response data provide opportunities and challenges for the discovery of new molecular characteristics and mechanisms of drug response in BRCA. Methods: In the present study, an integrated pipeline was developed to explore drug response-related long non-coding RNA (lncRNA)-mediated competing endogenous RNAs (ceRNAs) motifs in BRCA. Results: Drug response-specific ceRNAs indicated that lncRNAs play an essential role in various drug treatments for BRCA. Several key drug-resistant and -sensitive dysregulated ceRNAs were identified in Adriamycin, Cytoxan, and Tamoxifen. The interactions in these ceRNAs showed strong correlations in BRCA. Most drug response-related dysregulated ceRNAs were only present in one kind of drug. A number of drug response-related ceRNAs presented diverse dysregulation patterns. We also extracted some key drug response-related lncRNAs, such as HCP5 and FAM182A. These lncRNAs were associated with certain cancer hallmarks and survival in BRCA. Conclusions: Ultimately, understanding the underlying lncRNA-mediated ceRNAs in drug responses will facilitate improved individual reactions to chemotherapy and overall outcomes of BRCA treatment.

scholarly journals Defective motion processing in children with cerebral visual impairment due to periventricular white matter damage

2011 ◽  
Vol 54 (7) ◽  
pp. e1-e8 ◽  
Author(s):  
JOEL M WEINSTEIN ◽  
RICK O GILMORE ◽  
SUMERA M SHAIKH ◽  
ALLEN R KUNSELMAN ◽  
WILLIAM V TRESCHER ◽  
...  
Keyword(s):  
White Matter ◽  
Visual Impairment ◽  
Motion Processing ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Cerebral Visual Impairment

scholarly journals Characterization of Cerebral White Matter Damage in Preterm Infants Using 1H and 31P Magnetic Resonance Spectroscopy

2000 ◽  
Vol 20 (10) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nicola J. Robertson ◽  
Jacob Kuint ◽  
Serena J. Counsell ◽  
Mary A. Rutherford ◽  
Glyn A. Coutts ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Preterm Infants ◽  
Term Infant ◽  
Cerebral White Matter ◽  
Resonance Spectroscopy ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Term Infants

The biochemical characteristics of white matter damage (WMD) in preterm infants were assessed using magnetic resonance spectroscopy (MRS). The authors hypothesized that preterm infants with WMD at term had a persisting cerebral lactic alkalosis and reduced N-acetyl aspartate (NAA)/creatine plus phosphocreatine (Cr), similar to that previously documented in term infants weeks after perinatal hypoxia–ischemia (HI). Thirty infants (gestational age 27.9 ± 3.1 weeks, birth weight 1122 ± 445 g) were studied at postnatal age of 9.8 ± 4.1 weeks (corrected age 40.3 ± 3.9 weeks). Infants were grouped according to the presence or absence of WMD on magnetic resonance (MR) images. The peak area ratios of lactate/Cr, NAA/Cr, myo-inositol/Cr, and choline (Cho)/Cr were measured from an 8-cm3 voxel in the posterior periventricular white matter (WM) using proton MRS. Intracellular pH (pHi) was calculated using phosphorus MRS. Eighteen infants had normal WM on MR imaging; 12 had WMD. For infants with WMD, lactate/Cr and myo-inositol/Cr were related ( P < 0.01); lactate/Cr and pHi were not ( P = 0.8). In the WMD group, mean lactate/Cr and myo-inositol/Cr were higher ( P < 0.001, P < 0.05, respectively) than the normal WM group. There was no difference in the NAA/Cr, Cho/Cr, or pHi between the two groups, although pHi was not measured in all infants. These findings suggest that WMD in the preterm infant at term has a different biochemical profile compared with the term infant after perinatal HI.

scholarly journals Inferences from dysregulated long non-coding RNA-mediated competing endogenous RNAs in various chemotherapy drugs and evaluation of drug response in breast cancer

2020 ◽  
Author(s):  
Ziwen Zhang ◽  
Dongbo Li ◽  
Han Zhang ◽  
Qi Qin ◽  
Qingyuan Zhang
Keyword(s):  
Breast Cancer ◽  
Drug Response ◽  
Treatment Strategies ◽  
Molecular Characteristics ◽  
Cancer Hallmarks ◽  
Chemotherapy Drugs ◽  
Non Coding Rna ◽  
Competing Endogenous Rnas ◽  
Novel Treatment Strategies ◽  
Long Non Coding Rna

Abstract Backgroud: Differences in individual drug response, especially drug resistance, present an obstacle to the treatment of breast cancer (BRCA). Thus, the ability to predict drug response would contribute to developing novel treatment strategies. Accumulating evidence have suggested that tumor molecular profiles and drug response data provide opportunities and challenges for the discovery of new molecular characteristics and mechanisms of drug response in BRCA. Methods: In the present study, an integrated pipeline was developed to explore drug response-related long non-coding RNA (lncRNA)-mediated competing endogenous RNAs (ceRNAs) motifs in BRCA. Results: Drug response-specific ceRNAs indicated that lncRNAs play an essential role in various drug treatments for BRCA. Several key drug-resistant and -sensitive dysregulated ceRNAs were identified in Adriamycin, Cytoxan, and Tamoxifen. The interactions in these ceRNAs showed strong correlations in BRCA. Most drug response-related dysregulated ceRNAs were only present in one kind of drug. A number of drug response-related ceRNAs presented diverse dysregulation patterns. We also extracted some key drug response-related lncRNAs, such as HCP5 and FAM182A. These lncRNAs were associated with certain cancer hallmarks and survival in BRCA. Conclusions: Ultimately, understanding the underlying lncRNA-mediated ceRNAs in drug responses will facilitate improved individual reactions to chemotherapy and overall outcomes of BRCA treatment.

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