Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to Tumorigenesis

Abstract. Background: Peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala polymorphism (rs1801282) has been associated with metabolic syndrome components in some studies. Moreover, the PPARγ gene may mediate the physiological response to dietary fat intake in a ligand-dependent manner. Methods: Metabolic syndrome components (body mass index, waist circumference, and lipid profile) were determined in 290 type 2 diabetes mellitus patients in a cross-sectional study. DNA genotyping for determining PPARγ Pro12Ala polymorphism was conducted using the polymerase chain reaction-restriction length polymorphism method. A semi-quantitative food frequency questionnaire was used to assess the participants’ dietary intakes in the previous year. Results: There were significant differences between the two genotype groups of PPARγ Pro12Ala polymorphism, Ala carriers (Pro/Ala + Ala/Ala) versus non-Ala carriers (Pro/Pro), in terms of mean body mass index (p = 0.04) and waist circumference (p = 0.02). Below the median percentage of energy from monounsaturated and polyunsaturated fatty acids, Ala carriers had a higher body mass index (p = 0.01) compared to non-Ala carriers. Furthermore, a significant interaction between this single-nucleotide polymorphism and polyunsaturated fatty acids intake on serum triglyceride levels (p = 0.01) was seen, and in higher polyunsaturated fatty acids intake (≥ median) Ala carriers had lower triglyceride levels than non-Ala carriers (p = 0.007). Conclusions: The findings of the current study support a significant association between PPARγ Pro12Ala polymorphism and metabolic syndrome components, and they suggest that this polymorphism can modulate the biological response of dietary fat intake on body mass index and triglyceride levels.

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Food frequency questionnaire as an indicator of serum essential n‐3 and n‐6 polyunsaturated fatty acids concentrations in early pregnancy, according to body mass index (1022.3)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.1022.3 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Jaqueline Lepsch ◽

Juliana Vaz ◽

Thatiana Pinto ◽

Fernanda Rebelo ◽

Dayana Farias ◽

...

Keyword(s):

Body Mass Index ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Body Mass ◽

Early Pregnancy ◽

Food Frequency Questionnaire ◽

Food Frequency

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Serum Polyunsaturated Fatty Acids in Middle Childhood and Body Mass Index Change Through Adolescence

Annals of Nutrition and Metabolism ◽

10.1159/000502077 ◽

2019 ◽

Vol 75 (1) ◽

pp. 77-85

Author(s):

Kerry S. Flannagan ◽

Sheila Gahagan ◽

Arun K. Das ◽

Raquel A. Burrows ◽

Betsy Lozoff ◽

...

Keyword(s):

Body Mass Index ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Body Mass ◽

Middle Childhood ◽

Activity Index ◽

Growth Curves ◽

Δ5 Desaturase ◽

Z Scores ◽

Development Objective

Background: Polyunsaturated fatty acids (PUFA) status in childhood may be associated with adiposity development. Objective: To assess associations of serum PUFA biomarkers in childhood with change in body mass index (BMI)-for-age Z scores (BMIZ) through adolescence. Methods: We quantified serum PUFA at ages 5 and 10 years among 418 children from Santiago, Chile. BMI was measured at 5, 10, and 16 years. We compared BMIZ change through age 16 years between quartiles of PUFA at 5 and 10 years and PUFA change 5–10 years by fitting growth curves from mixed effects models. Results: At age 5 years, serum docosahexaenoic acid was inversely associated with BMIZ change from ages 5 to 16 years. At age 10 years, arachidonic acid (AA) was nonlinearly positively related to BMIZ change from ages 10 to 16 years. Change in AA and the Δ5-desaturase (D5D) activity index between 5 and 10 years were each positively associated with BMIZ change from ages 10 to 16 years. Change in eicosapentaenoic acid was inversely associated with change in BMIZ. Conclusions: Serum long-chain n-3 PUFA in middle childhood were associated with less BMI gain through adolescence, whereas AA and D5D activity was related to greater BMI gain.

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Overweight and erythrocyte polyunsaturated fatty acid changes in menopause

The EuroBiotech Journal ◽

10.2478/ebtj-2020-0016 ◽

2020 ◽

Vol 4 (3) ◽

pp. 144-149

Author(s):

Giulia D’Alberti ◽

Carla Ferreri ◽

Anna Vita Larocca ◽

Pierangelo Torquato ◽

Antonio Boccuto ◽

...

Keyword(s):

Body Mass Index ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Body Mass ◽

Saturated Fatty Acids ◽

Monounsaturated Fatty Acids ◽

The Body ◽

Control Group ◽

Menopausal Women ◽

And Control

AbstractLipid disorders have been implicated in overweight and menopause. However, evidence on lipidomic analysis of fatty acids in erythrocytes of menopausal women is scarce. The aim of this study was to investigate the relationship between the body mass index within or beyond 5 years of menopause and erythrocyte fatty acid profile. This case-control study was conducted on out of 37 menopausal women total patients, 22 with body mass index ≥ 25 and 12 matched controls (body mass index <25). Experimental procedures were performed on the blood through robotic equipment for isolation of erythrocyte and cell membrane fatty acids were analyzed by using gas-liquid chromatography. Results showed that erythrocyte membranes did not change significantly in lipid composition between case and control group. However, the percentage of women who had a physiological content of saturated fatty acids was lower in case than in control group, and the percentage of women who had a physiological content of monounsaturated fatty acids and polyunsaturated fatty acids was lower in control than in case group. Woman with BMI>25 and non-physiological content of fatty acids, were richer in percentage of saturated fatty acids and poorer of monounsaturated fatty acids and polyunsaturated fatty acids than women with BMI<25. The percentage of physiological n-6/n-3 polyunsaturated ratio was lower in women with BMI>25 than in women with BMI<25. Interestingly, the percentage of patients that had physiological values of lipids beyond 5 years of menopause increased in comparison patients within 5 years of menopause. Notably, n-6/n-3 polyunsaturated fatty acids physiological ratio beyond 5 years of menopause increased in both case and control patients, indicating normalization over time. In conclusion erythrocytes fatty acids composition may be related to the body mass index and to the time from menopause.

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The Relationship between Sex, Body Mass Index, and Postoperative Outcomes in Patients Undergoing Surgery for Colorectal cancer

10.26226/morressier.5a9844c4d462b80296ca4754 ◽

2018 ◽

Author(s):

Arwa Almasaudi

Keyword(s):

Colorectal Cancer ◽

Body Mass Index ◽

Body Mass ◽

Postoperative Outcomes ◽

The Relationship

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Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽

10.3390/cancers13143592 ◽

2021 ◽

Vol 13 (14) ◽

pp. 3592

Author(s):

Chong-Chi Chiu ◽

Chung-Han Ho ◽

Chao-Ming Hung ◽

Chien-Ming Chao ◽

Chih-Cheng Lai ◽

...

Keyword(s):

Colorectal Cancer ◽

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Survival Rates ◽

Normal Weight ◽

P Value ◽

Administrative Claims ◽

The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

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