scholarly journals C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights

2020 ◽  
Vol 11 ◽  
Author(s):  
Peter C. Hart ◽  
Ibraheem M. Rajab ◽  
May Alebraheem ◽  
Lawrence A. Potempa
Keyword(s):  
Inflammatory Response ◽  
Acute Phase ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Defense Responses ◽  
The Body ◽  
Blood Levels ◽  
C Reactive Protein ◽  
Diagnostic Significance ◽  
Reactive Protein

Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in a metastatic process affecting multiple tissues and organs. As tumors grow and metastasize, they affect normal tissue integrity and homeostasis which signals the body to trigger the acute phase inflammatory response. C-reactive protein (CRP) is a predominant protein of the acute phase response; its blood levels have long been used as a minimally invasive index of any ongoing inflammatory response, including that occurring in cancer. Its diagnostic significance in assessing disease progression or remission, however, remains undefined. By considering the recent understanding that CRP exists in multiple isoforms with distinct biological activities, a unified model is advanced that describes the relevance of CRP as a mediator of host defense responses in cancer. CRP in its monomeric, modified isoform (mCRP) modulates inflammatory responses by inserting into activated cell membranes and stimulating platelet and leukocyte responses associated with acute phase responses to tumor growth. It also binds components of the extracellular matrix in involved tissues. Conversely, CRP in its pentameric isoform (pCRP), which is the form quantified in diagnostic measurements of CRP, is notably less bioactive with weak anti-inflammatory bioactivity. Its accumulation in blood is associated with a continuous, low-level inflammatory response and is indicative of unresolved and advancing disease, as occurs in cancer. Herein, a novel interpretation of the diagnostic utility of CRP is presented accounting for the unique properties of the CRP isoforms in the context of the developing pro-metastatic tumor microenvironment.

scholarly journals PSV-35 Correlation of acute-phase blood proteins level and quality and cryostability of sperm in horses

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 337-338
Author(s):  
Mikhail Atroshchenko ◽  
Mariya Engalycheva ◽  
Anna Kudlaeva ◽  
Elena Borodkina ◽  
Mariya Fomina ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Acute Phase ◽  
Total Protein ◽  
Development Program ◽  
The Body ◽  
Blood Proteins ◽  
C Reactive Protein ◽  
Russian Science ◽  
Reactive Protein ◽  
Hypothermic Storage

Abstract The aim of this work was to study the relationship between acute phase indicators of a biochemical blood test with the quality and cryostability sperm in stallions. Semen from 59 stallions (aged from 5 to 15 years) were collected during the breeding season (February–May). Blood plasma samples were studied using a Vegasys automatic biochemical analyzer (Analyzer Medical System, Italy). The following parameters were determined in blood plasma: total protein, level of albumin, globulin, albumin/globulin ratio, C-reactive protein, fibrinogen. Each sperm sample was evaluated by volume, concentration, total sperm, as well as progressive motility and survival of sperm in chilled and thawed sperm during hypothermic storage at +40С. The normality of the distribution of quantitative traits was determined using the Shapiro-Wilk test. For each of the indicators, the Spearman coefficient was calculated. Significance of differences was assessed using the Mann-Whitney test, the results were statistically significant at P ≤0.05. The concentration of biochemical parameters in blood serum averaged: total protein - 67.4 ± 0.7 g/l, albumin - 39.4±0.6 g/l, globulins - 28.4±0.8 g/l, C reactive protein - 0.3±0.1 mg/l, fibrinogen - 3.1±0.1 g/l. A significant negative correlation between the plasma fibrinogen and sperm survival during hypothermic storage (at +4ºС) of chilled (r=0.48; P < 0.001) sperm and progressive sperm motility after thawing (r =-0.29; < 0.05) was found. We suggest that an increase in the level of fibrinogen in the blood may indicate the presence of latent inflammatory, immuno-mediated processes in the body, including those affecting the quality and cryostability of sperm in stallions. Authors acknowledge financial support from Russian Science Foundation, Grant No: 20-16-00101, development program of Bioresource collections “Cryobank of genetic recourses the All-Russian Research Institute for Horse Breeding.”

scholarly journals EFFECT OF RED MULBERRY JUICE (MORUS RUBRA) ON THE INFLAMMATORY RESPONSE IN MALE WISTAR RATS DUE TO EXPOSURE TO CIGARETTE SMOKE

2021 ◽  
Vol 16 (3) ◽  
pp. 233
Author(s):  
Rivan Virlando Suryadinata ◽  
Merryana Adriani ◽  
Stefani Cornelia Sardjono
Keyword(s):  
Inflammatory Response ◽  
Cigarette Smoke ◽  
Wistar Rats ◽  
Positive Control ◽  
The Body ◽  
Positive Control Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Mulberry Juice

The increasing number of tobacco users will directly impact to an increase in the number of passive smokers. Various harmful substances that enter the respiratory tract can cause health problems. The airway will recognize these substances as pathogen and activate immune response accordingly. Inflammatory response becomes one of the effects of body compensation due to an increased pathogen. This effect is indicated by the elevation of C-Reactive Protein as one systemic inflammatory response parameters in the body. This study aimed to determine the efficacy of red mulberry juice to reduce levels of C-Reactive Protein in Wistar rats because exposure to cigarette smoke. This is an experimental study with a post-test control group design. Animals were divided into negative control group, positive control group, and 3 treatment groups with different red mulberry doses. The positive control group showed the highest increase   in C-Reactive Protein levels compared with the red mulberry intake group (p<0,001). In conclusion, the administration of red mulberry juice can reduce inflammatory response in rats because of exposure to cigarette smoke.

scholarly journals Hubungan Antara Kadar Laju Endap Darah (LED) Dengan Kadar C-Reaktiv Protein (CRP) Pada Penderita Tuberkulosis (TBC) Di Wilayah Kerja Puskesmas Alas Barat

2020 ◽  
Vol 7 (1) ◽  
pp. 34
Author(s):  
Aini Aini Aini ◽  
Nurmawan Nurmawan ◽  
Jumari Ustiawaty
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Acute Phase ◽  
Sedimentation Rate ◽  
The Body ◽  
Bacterial Invasion ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Positive Smear ◽  
Smear Negative

Tuberculosis is a disease caused by rod-shaped bacteria (basil) with another name Mycrobacterium tuberculosis. Mycrobacterium tuberculosis enters the body then causes inflammation, inflammation and bacterial invasion which then induces liver cells to synthesize acute phase C-reactive protein protein (CRP). CRP will increase sharply after inflammation, as well as the formation of aggregates derived from the acute phase protein hormone which causes an increase in the Erythrocyte sedimentation rate (ESR)). The purpose of this study was to determine the relationship Erytrocyte sedimentation rate (ESR) and levels of C-Reactiv protein (CRP) in tuberculosis (TBC) patients. This research is an analytical descriptive study using cross sectional. Data collectors are done using the Non Random Accidental Sampling technique. The number of respondents in this study were 11 people with tuberculosis. Based on the results of this study it is known that TBC patients with smear negative as much as 7 people (63.6%) and TB patients with positive smear as much as 4 people (36.4%), both in TB patients with negative smear and positive smear both have levels of ESR not normal with an average ESR level in positive smear of 101.3 mm / hour and the average ESR level in smear negative is 20.8 mm / hour. All TBC patients with smear positive CRP levels (not normal) with an average mean value of CRP of 36 mg / L or an average CRP level in TBC smear negative patients of 0.9 mg / L. Based on the Pearson test results between levels of erythrocyte sedimentation rate (ESR) with C-Reactive protein (CRP) in tuberculosis (TBC) patients obtained a value of p <0.01 (0.000 <0.01). This shows a strong relationship between LED and CRP levels in TB patients

Hereditary Cerebral Hemorrhage with Amyloidosis -Dutch Type: A Study of Fibrinolysis

1992 ◽  
Vol 67 (01) ◽  
pp. 016-018 ◽  
Author(s):  
J Haan ◽  
C Kluft ◽  
F W G Leebeek ◽  
A C W de Bart ◽  
O J S Buruma ◽  
...  
Keyword(s):  
Factor Viii ◽  
Acute Phase ◽  
Cerebral Hemorrhage ◽  
Blood Levels ◽  
Bleeding Tendency ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Quiescent Phase ◽  
Hemostasis Factors

SummaryIn view of reported associations between increased bleeding tendency and systemically decreased α2-antiplasmin in patients with systemic amyloid deposition we studied α2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D).None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII: Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII: Ag level in the acute phase is unclear.

P1451MONOCYTE/NEUTROPHIL: LYMPHOCYTE RATIO, C-REACTIVE PROTEIN IN THE LAST YEAR BEFORE DEATH IN DIFFERENT VINTAGE GROUPS - RESULTS FROM THE MONDO INITIATIVE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Xiaoling Ye ◽  
Rupert Bright ◽  
Kevin Woollard ◽  
Charles Dickson Pusey ◽  
Neill Duncan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Phase Analysis ◽  
Acute Phase ◽  
Lymphocyte Count ◽  
Inflammatory Markers ◽  
Stable Phase ◽  
C Reactive Protein ◽  
Dialysis Patients ◽  
Reactive Protein ◽  
Dialysis Vintage

Abstract Background and Aims Both experimental and clinical evidence have indicated the relationship between chronic inflammation and adverse outcomes in dialysis patients. It is also well know that higher white blood cell counts and their subtypes including monocyte and neutrophil counts, as well as higher neutrophil to lymphocyte ration (NLR) and monocyte to lymphocyte ration (MLR), and C-reactive protein (CRP) are related to inflammation, and higher risk of access failure, hospitalizations and death in dialysis patients. However, little has been done to explore the characteristics for each of these markers for patients with different dialysis vintage in a large sample of cohorts. Method Four time periods were identified: a) acute phase - patients who died within the 1 years on dialysis, b) early-stable phase - patients who died within the 2nd year on dialysis, c) mid-stable phase – died on the 3rd year on dialysis, and 4) late-stable phase – died on the 4th year on dialysis. All-cause mortality was recorded during the 4 studied periods. Patients with at least one monocyte count, neutrophil count, and lymphocyte count during each of the study period were included. Cubic spline functions were applied to plot the trends of neutrophil counts, monocyte counts, lymphocyte counts, MLR, NLR and CRP with month 0 being the month of the event death and counting backward until the 12 months preceding to death for the 4 studied phases. Rate of change functions were also built to study the accelerating and decelerating changes of the trends within the 12 months preceding death for each of the inflammatory markers. Results A total of 2,504 patients were included in acute phase analysis; 1,696 in the early-stable phase analysis, 1,462 patients in the mid-stable analysis, and 1,305 patients in the late-stable phase analysis (Figure 1). The rising trends in NLR and MLR started to happen around 6 months before patient death with a dramatic acceleration approximately 3 months before death. This is accompanied by a rise in CRP. There is an apparent ordered inflammatory response with dialysis vintage with trends being more marked in acute phase patients versus late-stable phase patients (Figure 2). Patients who died within the 1st year on dialysis had the highest neutrophil and monocyte counts, lower levels of lymphocyte count, and consequently higher levels of NLR and MLR in all months preceding to death. Conclusion The consistent observation of this large observational study that all the inflammatory markers show a similar trajectories in the 6 months anticipating death is remarkable. There is an apparent ordered inflammatory response by era across 4 dialysis vintage groups (acute, early-stable, mid-stable and late-stable phases) which might indicate a pathogenic role for these cell types or be an observed epiphenomena related to survivor advantage for example. This is the first detailed description of increased neutrophil and monocyte counts and notably decreased lymphocyte counts several months before death and possible mechanisms are under investigation.

Inflammatory interactions in fish exposed to pollutants and parasites: a role for apoptosis and C reactive protein

Parasitology ◽  
2003 ◽  
Vol 126 (7) ◽  
pp. S71-S85 ◽  
Author(s):  
D. HOOLE ◽  
J. W. LEWIS ◽  
P. M. M. SCHUWERACK ◽  
C. CHAKRAVARTHY ◽  
A. K. SHRIVE ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Inflammatory Responses ◽  
Endocrine System ◽  
Original Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ultrastructural Appearance ◽  
Two Parameters ◽  
Established Infection

Although previous studies have highlighted the inflammatory responses of fish infected with parasites and exposed to pollutants, very little is known about how these two stressors interact within the fish. In this review, which also contains original data, the effect of these two parameters on the fish inflammatory response is assessed and, in particular, the role of apoptosis and the acute phase protein, C reactive protein, is evaluated. InCyprinus carpioexposed to 0·5 mg NH4+l−1or 0·1 mg Cd2+l−1and experimentally infected with the blood fluke,Sanguinicola inermis, the pollutant type and the order in which the fish experiences the parasite and toxicant, significantly affects the ultrastructural appearance and cellular content of the pronephros and thymus. This is reflected in the intensity of infection where the pollutant appears to have less effect on an established infection. Both stressors, pollutant and infection, may mediate their effects via the endocrine system. Studies have revealed that cortisol at 100 ng ml−1is able to induce apoptosis in pronephric cells of carp and that an increase in apoptosis is associated with an increase in phagocytosis in this immune organ. In addition, C reactive protein, which is used as a biomarker of the inflammatory response in humans and other mammals, is evaluated as a possible indicator of physiological states in fish exposed to pathogens and pollutants.

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