scholarly journals Multiple Country and Breed Genomic Prediction of Tick Resistance in Beef Cattle

2021 ◽  
Vol 12 ◽  
Author(s):  
Fernando Flores Cardoso ◽  
Oswald Matika ◽  
Appolinaire Djikeng ◽  
Ntanganedzeni Mapholi ◽  
Heather M. Burrow ◽  
...  
Keyword(s):  
Beef Cattle ◽  
Genetic Correlation ◽  
Predictive Ability ◽  
Tick Control ◽  
Factors Affecting ◽  
Partial Data ◽  
Wide Range ◽  
Tick Counts ◽  
Over Dispersion ◽  
Tick Resistance

Ticks cause substantial production losses for beef and dairy cattle. Cattle resistance to ticks is one of the most important factors affecting tick control, but largely neglected due to the challenge of phenotyping. In this study, we evaluate the pooling of tick resistance phenotyped reference populations from multi-country beef cattle breeds to assess the possibility of improving host resistance through multi-trait genomic selection. Data consisted of tick counts or scores assessing the number of female ticks at least 4.5 mm length and derived from seven populations, with breed, country, number of records and genotyped/phenotyped animals being respectively: Angus (AN), Brazil, 2,263, 921/1,156, Hereford (HH), Brazil, 6,615, 1,910/2,802, Brangus (BN), Brazil, 2,441, 851/851, Braford (BO), Brazil, 9,523, 3,062/4,095, Tropical Composite (TC), Australia, 229, 229/229, Brahman (BR), Australia, 675, 675/675, and Nguni (NG), South Africa, 490, 490/490. All populations were genotyped using medium density Illumina SNP BeadChips and imputed to a common high-density panel of 332,468 markers. The mean linkage disequilibrium (LD) between adjacent SNPs varied from 0.24 to 0.37 across populations and so was sufficient to allow genomic breeding values (GEBV) prediction. Correlations of LD phase between breeds were higher between composites and their founder breeds (0.81 to 0.95) and lower between NG and the other breeds (0.27 and 0.35). There was wide range of estimated heritability (0.05 and 0.42) and genetic correlation (-0.01 and 0.87) for tick resistance across the studied populations, with the largest genetic correlation observed between BN and BO. Predictive ability was improved under the old-young validation for three of the seven populations using a multi-trait approach compared to a single trait within-population prediction, while whole and partial data GEBV correlations increased in all cases, with relative improvements ranging from 3% for BO to 64% for TC. Moreover, the multi-trait analysis was useful to correct typical over-dispersion of the GEBV. Results from this study indicate that a joint genomic evaluation of AN, HH, BN, BO and BR can be readily implemented to improve tick resistance of these populations using selection on GEBV. For NG and TC additional phenotyping will be required to obtain accurate GEBV.

Selection of cattle for tick resistance, and the effect of herds of different susceptibility on Boophilus populations

1962 ◽  
Vol 13 (5) ◽  
pp. 974 ◽  
Author(s):  
PR Wilkinson
Keyword(s):  
Tick Infestation ◽  
Tick Control ◽  
Boophilus Microplus ◽  
Skin Thickness ◽  
Adult Females ◽  
Cattle Ticks ◽  
In Parenthesis ◽  
Tick Counts ◽  
Tick Resistance ◽  
Selection Of

Weekly counts of Boophilus microplus (Canestrini) on 30 Australian Illawarra Shorthorn heifers enabled the cattle to be ranked in order of tick infestation, with highly significant correlations between counts of two observers and between counts of one observer on different occasions. In May 1960, when the heifers were 1½–2 years old, 12 were selected as relatively tick-resistant and 12 as relatively tick-susceptible. Each of these groups was divided at random into herds of six, and the four herds were then allotted randomly to separate paddocks, each onequarter of the area previously grazed. A herd was sprayed with 0.5% DDT emulsion when its average count of ticks (adult females over 5 mm in length) on one side of the animals exceeded 40. During the ensuing tick season, from October 5, 1960, to June 7, 1961, the sums of average weekly tick counts, and the numbers of sprayings (in parenthesis) were: susceptible herds 4853 (5) and 5962 (6): resistant herds 718 (0) and 1073 (1). Counts of tick larvae on defined body areas showed that, in the summer after segregation, resistant herds carried fewer larvae than the susceptible herds, apparently because fewer mature ticks fell from the resistant cattle in the preceding spring and winter. As a consequence of this, counts of adult ticks were comparatively lower after than before segregation. There was little or no 'spring rise' of tick infestation on the resistant herds. There was no significant correlation between tick resistance and coat score, sweat gland dimensions, or total skin thickness, but a correlation of -0.53 with follicle depth was significant at the 1% level. There was no evidence of adaptation of cattle ticks to the resistant animals, either in the field experiment or in observations on stalled cattle. The experiment draws attention to the appreciable proportion of tick-resistant animals within the Australian Illawarra Shorthorn breed, which has largely been overlooked in past discussions on tick-resistant breeds of cattle. It also suggests a technique for estimating the improvement in tick control that may be obtained by a given degree of selection within any breed, for any given environment.

scholarly journals Towards a new phenotype for tick resistance in beef and dairy cattle: a review

2019 ◽  
Vol 59 (8) ◽  
pp. 1401 ◽  
Author(s):  
Heather M. Burrow ◽  
Ben J. Mans ◽  
Fernando F. Cardoso ◽  
Michael A. Birkett ◽  
Andrew C. Kotze ◽  
...  
Keyword(s):  
Genetic Selection ◽  
Cost Effective ◽  
Tick Control ◽  
Cattle Tick ◽  
Factors Affecting ◽  
Control Programs ◽  
Cattle Management ◽  
Genetically Improved ◽  
Cattle Herds ◽  
Tick Resistance

About 80% of the world’s cattle are affected by ticks and tick-borne diseases, both of which cause significant production losses. Cattle host resistance to ticks is the most important factor affecting the economics of tick control, but it is largely neglected in tick-control programs due to technical difficulties and costs associated with identifying individual-animal variation in resistance. The present paper reviews the scientific literature to identify factors affecting resistance of cattle to ticks and the biological mechanisms of host tick resistance, to develop alternative phenotype(s) for tick resistance. If new cost-effective phenotype(s) can be developed and validated, then tick resistance of cattle could be genetically improved using genomic selection, and incorporated into breeding objectives to simultaneously improve cattle productive attributes and tick resistance. The phenotype(s) could also be used to improve tick control by using cattle management. On the basis of the present review, it is recommended that three possible phenotypes (haemolytic analysis; measures of skin hypersensitivity reactions; simplified artificial tick infestations) be further developed to determine their practical feasibility for consistently, cost-effectively and reliably measuring cattle tick resistance in thousands of individual animals in commercial and smallholder farmer herds in tropical and subtropical areas globally. During evaluation of these potential new phenotypes, additional measurements should be included to determine the possibility of developing a volatile-based resistance phenotype, to simultaneously improve cattle resistance to both ticks and biting flies. Because the current measurements of volatile chemistry do not satisfy the requirements of a simple, cost-effective phenotype for use in commercial cattle herds, consideration should also be given to inclusion of potentially simpler measures to enable indirect genetic selection for volatile-based resistance to ticks.

scholarly journals PSVIII-38 Genomic prediction for tick resistance in Angus cattle

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 263-263
Author(s):  
Gabriel Campos ◽  
Fernando F Cardoso ◽  
Claudia Cristina Gulias-Gomes ◽  
Robert Domingues ◽  
Luciana Regitano ◽  
...  
Keyword(s):  
Fixed Effects ◽  
Predictive Ability ◽  
Relative Increase ◽  
Single Step ◽  
Angus Cattle ◽  
Increase In Accuracy ◽  
Estimate Variance ◽  
Tick Counts ◽  
Reduced Data ◽  
Tick Resistance

Abstract The main objective of this study was to evaluate the feasibility of single-step genomic BLUP (ssGBLUP) for genetic evaluation of tick resistance in Angus cattle in Brazil. Additionally, we investigated population parameters, namely effect population size (Ne) and inbreeding (F) based on pedigree (PED) and genomic (GEN) information. Half-body tick counts were recorded up to three times in the same animal, totaling 2291 records. To normalize the distribution, records were log-transformed prior to the analysis. From 7073 animals in the pedigree, 1299 were genotyped with 3 different SNP chips of density 50k, 77k, and 150k. After imputation and quality control, 61,066 SNP remained. A repeatability animal model was used to estimate variance components, traditional EBV, and genomic EBV (GEBV). Validation was carried out for young genotyped animals, with no phenotypes in the reduced data but at least one record in the complete data, using two different approaches: 1) predictive ability as the correlation between phenotypes adjusted for fixed effects and (G)EBV; 2) a method based on linear regressions that is called LR, which uses correlations between (G)EBV in the complete and reduced data as a measure of consistency between subsequent evaluations. Heritability for tick counts was 0.18 ± 0.03. Based on PED and GEN, Ne was 254 and 199, whereas F was 0.016 and 0.003, respectively. Predictive ability for tick counts was 0.11 for EBV and 0.14 for GEBV, which is considered low. Conversely, when LR validation was used, the relative increase in accuracy by adding extra phenotypic information was 0.49 for EBV and 0.61 for GEBV. Even though tick counts has low heritability, our study indicates that genomic selection can help to improve prediction accuracy and, therefore, to increase tick resistance in this Angus population.

scholarly journals Comparison of Tick Control and Antibiotic Use Practices at Farm Level in Regions of High and Low Acaricide Resistance in Uganda

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Joseph Byaruhanga ◽  
Fred Odua ◽  
Yvette Ssebunya ◽  
Olivia Aketch ◽  
Dickson Stuart Tayebwa ◽  
...  
Keyword(s):  
Raw Milk ◽  
Antibiotic Use ◽  
Tick Control ◽  
Antibiotic Residues ◽  
Acaricide Resistance ◽  
Farm Level ◽  
Livestock Sector ◽  
Test Kit ◽  
Tick Counts ◽  
Tick Resistance

Uganda has experienced tick acaricide resistance in the livestock sector. With increase in incidence of tick-borne diseases (TBDs), use of antibiotics for control of TBDs and other opportunistic diseases has raisedserious concerns. The purpose of this study was to compare the farmers’ tick control and antibiotic use practices on farms in regions of low (LARA) and high (HARA) tick acaricide resistance in Uganda, determine the prevalence of antibiotic residues in milk from both regions, and identify factors associated with antibiotic residues in milk. One representative district was selected from each region from which 10 farms were randomly selected. Delvotest SP-NT® test kit was used to detect antibiotic residues in milk. Half-body tick counts and acaricide efficacy tests were performed. Majority (70%) of HARA’s respondents reported a corresponding increase in a monthly incidence of TBDs with an average of 3.2 cases of TBDs treated per farm compared to 0.2 cases in LARA. East Coast fever (ECF) was identified as the most common TBD in both regions, though cases of coinfection were more common in HARA. Half of HARA’s respondents reported a corresponding increase in the use of antibiotics on their farms due to tick resistance compared to LARA. Antibiotics were the most used drugs on farms in both regions with oxytetracycline being the commonly used antibiotic. Ticks from HARA were resistant to deltamethrin, amitraz, and coformulation (chlorpyriphos and cypermethrin) while resistance against deltamethrin was confirmed in LARA. HARA farms had a significantly higher prevalence of antibiotic residues (21.25%) in raw milk than in LARA (4%) farms (p <  0.05). Acaricide resistance and practice of reading drug use instructions were significantly associated with antibiotic residues in milk at farm level. Overall, the study provides vital information linking acaricide resistance to antibiotic use practices, consequently leading to antibiotic residues in milk.

Factors Affecting Molecular Self-Assembly and Its Mechanism

2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Molecular Structures ◽  
Polymer Science ◽  
New Approach ◽  
Factors Affecting ◽  
Dna Structures ◽  
Self Assembling ◽  
Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

Uphoff Norman, Priti Ramamurthy, and Roy Steiner. Managing Irrigation: Analysing and Improving the Performance of Bureaucracies. New Delhi/Newbury Park/London: Sage Publications. 1991. Hardbound. Price not given.

1993 ◽  
Vol 32 (2) ◽  
pp. 226-228
Author(s):  
Zakir Hussain
Keyword(s):  
Water Distribution ◽  
Irrigation System ◽  
Irrigation Management ◽  
Performance Criterion ◽  
New Delhi ◽  
Irrigation Performance ◽  
Factors Affecting ◽  
Wide Range ◽  
Resource Mobilisation ◽  
Management Issues

The book; under review provides a valuable account of the issues and factors in managing the irrigation system, and presents a lucid and thorough discussion on the performance of the irrigation bureaucracies. It comprises two parts: the first outlines the factors affecting irrigation performance under a wide range of topics in the first five chapters. In Chapter One, the authors have attempted to assess the performance of the irrigation bureaucracies, conceptualise irrigation management issues, and build an empirical base for analysis while drawing upon the experience of ten country cases in Asia, Africa, and Latin America. The Second Chapter focuses on the variations in the management structures identified and the types of irrigation systems; and it defines the variables of the management structures. The activities and objectives of irrigation management are discussed in Chapter Three. The objectives include: greater production and productivity of irrigation projects; improved water distribution; reduction in conflicts; greater resource mobilisation and a sustained system performance. The authors also highlight the performance criterion in this chapter. They identify about six contextual factors which affect the objectives and the performance of irrigation, which are discussed in detail in Chapter Four. In Chapter Five, some organisational variables, which would lead to improvements in irrigation, are examined.

Business Aviation in Russia: Specific Features and Prospects of Development

2020 ◽  
Vol 26 (1) ◽  
pp. 86-93
Author(s):  
D. V. Slivinsky ◽  
I. A. Fomina ◽  
D. G. Menshikh
Keyword(s):  
Systems Approach ◽  
National Policy ◽  
Civil Aviation ◽  
Economic Growth Rate ◽  
Factors Affecting ◽  
Organization And Management ◽  
Transport Services ◽  
Business Aviation ◽  
Wide Range

The presented study determines the role of business aviation in the modern economy and examines the specific features of its development in Russia.Aim. The study aims to analyze the development of business aviation in Russia and its correlation with economic development in general.Tasks. The authors determine the benefits of business aviation as a business tool, examine the specific features of the Russian business aviation market and problems of its development, and identify factors that affect the development of business aviation in Russia.Methods. This study uses the methods of comparative and retrospective analysis, cross-country comparison, systems approach, and expert analytics.Results. Business aviation is a new segment of civil aviation for Russia. Therefore, it is advisable to rely on foreign practices in the management of its development. In many countries, business aviation is a separate industry that specializes in providing transport services to a wide range of corporate clients and/or individuals. The development of this industry is associated with the economic growth rate and the development level of the national economy, and also depends on the national institutional specifics. This study describes the specific features of development of business aviation in Russia and problems arising in the organization and management of this type of business.Conclusions. The authors develop a system of factors affecting the development of business aviation in Russia, describe the major problems of this industry, and propose solutions. The results of this study can be used in the development (adjustment) of business aviation development strategies in Russia both at the industrial and corporate level, and in the implementation of the national policy in this field.

Qualitative Analysis of Underlying Factors Affecting Vaccine Hesitancy in Iran- A Study Protocol (Preprint)

2020 ◽  
Author(s):  
Salime Goharinezhad
Keyword(s):  
Vaccine Coverage ◽  
Deep Understanding ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Slight Reduction ◽  
Cultural Variation ◽  
Global Public Health ◽  
Factors Affecting ◽  
Wide Range ◽  
Context Specific

BACKGROUND World Health Organization declared the vaccine hesitancy as a global public health threat in 2019. Since even a slight reduction in vaccine coverage rates can lead to a decrease in herd immunity, it is imperative to explore the underlying factors affecting vaccine hesitancy. in specific contexts, considering socioeconomic and cultural variation, to ensure interventions targeting hesitancy are well formulated and intervened. OBJECTIVE The main objective of this study is to identify underlying factors affecting vaccine hesitancy in Iran. METHODS A framework qualitative study will be conducted in the west of Tehran province in 2020. Participants in the study will be recruited hesitance-parents who extracted from the SIB system (an electronic health record in Iran) to maximize diversity. Interviews will be analyzed based on ''Determinants of Vaccine Hesitancy Matrix'' which developed by the WHO-SAGE Working Group. RESULTS deep understanding from the context-specific reasons for vaccine hesitancy cause to formulate better strategies to address them. The ultimate goal of this study is to inform future policies to increase the uptake of the vaccine in Iran. CONCLUSIONS This result of study will show variety opinions about vaccination among different types of socioeconomic and demographic households. The wide range of reasons related to vaccine hesitancy imply to more comprehensive, context-specific interventions. Today, the most important intervention issues focus on improving information about effectiveness and safety of vaccines, while other interventions for promoting vaccination is need to addressed.

scholarly journals Developing Equations for Converting Digestible Energy to Metabolizable Energy for Korean Hanwoo Beef Cattle

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1696
Author(s):  
Ridha Ibidhi ◽  
Rajaraman Bharanidharan ◽  
Jong-Geun Kim ◽  
Woo-Hyeong Hong ◽  
In-Sik Nam ◽  
...  
Keyword(s):  
Linear Regression ◽  
Beef Cattle ◽  
Strong Relationship ◽  
Dietary Factors ◽  
Metabolizable Energy ◽  
Coefficient Of Determination ◽  
Simple Linear Regression ◽  
Male And Female ◽  
Digestible Energy ◽  
Wide Range

This study was performed to update and generate prediction equations for converting digestible energy (DE) to metabolizable energy (ME) for Korean Hanwoo beef cattle, taking into consideration the gender (male and female) and body weights (BW above and below 350 kg) of the animals. The data consisted of 141 measurements from respiratory chambers with a wide range of diets and energy intake levels. A simple linear regression of the overall unadjusted data suggested a strong relationship between the DE and ME (Mcal/kg DM): ME = 0.8722 × DE + 0.0016 (coefficient of determination (R2) = 0.946, root mean square error (RMSE) = 0.107, p < 0.001 for intercept and slope). Mixed-model regression analyses to adjust for the effects of the experiment from which the data were obtained similarly showed a strong linear relationship between the DE and ME (Mcal/kg of DM): ME = 0.9215 × DE − 0.1434 (R2 = 0.999, RMSE = 0.004, p < 0.001 for the intercept and slope). The DE was strongly related to the ME for both genders: ME = 0.8621 × DE + 0.0808 (R2 = 0.9600, RMSE = 0.083, p < 0.001 for the intercept and slope) and ME = 0.7785 × DE + 0.1546 (R2 = 0.971, RMSE = 0.070, p < 0.001 for the intercept and slope) for male and female Hanwoo cattle, respectively. By BW, the simple linear regression similarly showed a strong relationship between the DE and ME for Hanwoo above and below 350 kg BW: ME = 0.9833 × DE − 0.2760 (R2 = 0.991, RMSE = 0.055, p < 0.001 for the intercept and slope) and ME = 0.72975 × DE + 0.38744 (R2 = 0.913, RMSE = 0.100, p < 0.001 for the intercept and slope), respectively. A multiple regression using the DE and dietary factors as independent variables did not improve the accuracy of the ME prediction (ME = 1.149 × DE − 0.045 × crude protein + 0.011 × neutral detergent fibre − 0.027 × acid detergent fibre + 0.683).

scholarly journals Factors Affecting Acoustic Properties of Natural-Fiber-Based Materials and Composites: A Review

Textiles ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 55-85
Author(s):  
Tufail Hassan ◽  
Hafsa Jamshaid ◽  
Rajesh Mishra ◽  
Muhammad Qamar Khan ◽  
Michal Petru ◽  
...  
Keyword(s):  
Sound Absorption ◽  
Natural Fiber ◽  
Volume Fraction ◽  
Fiber Type ◽  
Alkali Treatment ◽  
Acoustic Properties ◽  
Synthetic Fiber ◽  
Sound Insulation ◽  
Factors Affecting ◽  
Wide Range

Recently, very rapid growth has been observed in the innovations and use of natural-fiber-based materials and composites for acoustic applications due to their environmentally friendly nature, low cost, and good acoustic absorption capability. However, there are still challenges for researchers to improve the mechanical and acoustic properties of natural fiber composites. In contrast, synthetic fiber-based composites have good mechanical properties and can be used in a wide range of structural and automotive applications. This review aims to provide a short overview of the different factors that affect the acoustic properties of natural-fiber-based materials and composites. The various factors that influence acoustic performance are fiber type, fineness, length, orientation, density, volume fraction in the composite, thickness, level of compression, and design. The details of various factors affecting the acoustic behavior of the fiber-based composites are described. Natural-fiber-based composites exhibit relatively good sound absorption capability due to their porous structure. Surface modification by alkali treatment can enhance the sound absorption performance. These materials can be used in buildings and interiors for efficient sound insulation.

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