scholarly journals Dermoscopic Features Summarization and Comparison of Four Types of Cutaneous Vascular Anomalies

2021 ◽  
Vol 8 ◽  
Author(s):  
Jing Gao ◽  
Wenmin Fei ◽  
Changbing Shen ◽  
Xue Shen ◽  
Minghui Sun ◽  
...  
Keyword(s):  
Age Groups ◽  
Pyogenic Granuloma ◽  
Vascular Anomalies ◽  
White Background ◽  
Chinese Han ◽  
Vascular Morphology ◽  
Vessel Morphology ◽  
Homogeneous Area ◽  
Black Area ◽  
Curved Vessels

Objective: Dermoscopic features of cutaneous vascular anomalies have been reported, but the described features currently known are limited and not well-understood. The aim of this study is to comprehensively summarize and compare the dermoscopic features of the four different types of cutaneous vascular anomalies [infantile hemangiomas (IH), cherry angioma (CA), angiokeratomas (AK), and pyogenic granuloma (PG)] in the Chinese Han population.Materials and Methods: Dermoscopic features of 31 IH, 172 CA, 31 AK, and 45 PG were collected based on the contact non-polarized mode of dermoscopy at 20-fold magnification. Dermoscopic features including background, lacunae, vessel morphology and distribution were collected and summarized. Additionally, we compared these features by age stage, gender, and anatomical locations in CA.Results: The dermoscopic features of IH included the red lacunae, red/red-blue/red-white backgrounds, and vessel morphology such as linear curved vessels, serpiginous vessels, coiled vessels. For CA, the lacunae appeared reddish brown to reddish blue or only red. In terms of vascular morphology, serpentine vessels, coiled vessels, looped vessels, and curved vessels could be seen in the lesions. A few lesions were black or presented with a superficial white veil. There were statistical differences in red background (P = 0.021), unspecific vessel distribution (P = 0.030), black area (P = 0.029), and white surface (P = 0.042) among different age groups. Red-brown lacunae (P = 0.039), red-blue (P = 0.013), red-white background (P = 0.015), black area (P = 0.016), and white surface (P = 0.046) were of statistical difference in terms of the locations of lesions. Lacunae were also observed in AK, which presented with red, dark purple, dark blue, black. Global dermoscopic patterns that were characterized by a homogeneous area were obvious in all PG lesions, among which 30 (66.7%) were red-white and 15 (33.3%) were red. As for local features, “white rail” lines were detected in 19 (42.2%) lesions and white collarette was seen in 34 (75.6%) lesions.Conclusions: Dermoscopy is an applicable diagnostic tool for the diagnosis of cutaneous vascular anomalies. It is necessary to take into account the age stage and lesion location when we diagnose CA using dermoscopy.

scholarly journals Establishment of the reference interval for serum pro-gastrin-releasing peptide in healthy adults of Chinese Han ethnicity

2018 ◽  
Vol 33 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Bing Zhao ◽  
Miaomiao Zhang ◽  
Feng Lin ◽  
Jing Xie ◽  
Yan Liang ◽  
...  
Keyword(s):  
Age Groups ◽  
Reference Interval ◽  
Reference Intervals ◽  
Chinese Han ◽  
Gastrin Releasing Peptide ◽  
Han Ethnicity ◽  
Significant Difference ◽  
Healthy Chinese ◽  
Han Adults ◽  
Non Parametric

Objective: The aim of this study is to establish the reference interval for serum pro-gastrin-releasing peptide (proGRP) determined by electrochemiluminescence immunoassay (ECLIA) in healthy Chinese Han ethnic adults. Methods: After screening, 9932 healthy Chinese Han adults (age range 18–95 years) were enrolled in this study, including 6220 men and 3712 women. Serum proGRP levels were measured by ECLIA. The reference interval was defined by non-parametric 95th percentile interval. Results: Serum proGRP levels conformed to a non-Gussian distribution. The reference interval for healthy Chinese Han adults calculated by the non-parametric method was 0–73.90 ng/mL in this study. Since serum proGRP levels were significantly correlated with age (r=0.226, P<0.001), the participants were divided into six age groups: 18–39, 40–49, 50–59, 60–69, 70–79, and ⩾80 years. No significant difference for serum proGRP levels was found between the sexes at each of six age groups. The reference intervals were gradually increased with age (65.35 ng/mL, 68.65 ng/mL, 74.10 ng/mL, 77.65 ng/mL, 84.57 ng/mL, and 98.03 ng/mL in 18–39, 40–49, 50–59, 60–69, 70–79, and ⩾80 years, respectively). Conclusions: We established the reference interval for serum proGRP, which was determined by ECLIA in the healthy Chinese Han population. Furthermore, our study suggests that it is necessary to establish the age-specific reference intervals for serum proGRP.

scholarly journals Impact of vascular morphology and plaque characteristics on computed tomography derived fractional flow reserve in early stage coronary artery disease

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
T Tsugu ◽  
K Tanaka ◽  
D Belsack ◽  
H Devos ◽  
Y Nagatomo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Stage ◽  
Fractional Flow ◽  
Vascular Morphology ◽  
Flow Reserve ◽  
Vessel Morphology ◽  
Calcified Plaque ◽  
Artery Disease ◽  
Distal Vessel

Abstract Background FFRCT gradually decreases from the proximal to the distal part of a vessel and reach the pathological threshold for significant ischemia even in the absence of obstructive coronary artery disease (CAD). The exact mechanisms of such gradual FFRCT decline remain unknown. Purpose The aims of this study are (1) to clarify the mechanisms of the gradual decline of computed tomography (CT) derived fractional flow reserve (FFRCT); and (2) to identify the predictive factors of an FFRCT decline below the pathological value of 0.80 in no apparent CAD vessels. Methods A total of 1058 outpatients with suspected CAD and who underwent CT angiography (CTA) with FFRCT analysis between January 2017 and December 2019 were evaluated. Among them, 150 consecutive patients who had both a CTA coupled to an FFRCT analysis and an invasive angiogram showing &lt;25% coronary stenosis were included for analysis. Vessels were divided into two groups according to FFRCT at the distal vessel: FFRCT &gt;0.80 (n=317) and FFRCT ≤0.80 (n=114). ΔFFRCT was defined as the magnitude of the change in FFRCT from the proximal to the distal vessel. Plaque characterization and vessel morphology measurements were performed semi-automatically. Vessel constituents were characterized based on Hounsfield units (HU) into lumen volume (&lt;−50 HU), non-calcified plaque (NCP) (−50–150 HU), and calcified plaque (&gt;150 HU). Results FFRCT decreased continuously from the proximal to distal across the three major vessels in both FFRCT&gt;0.80 and FFRCT ≤0.80 groups (Figure 1). Compared to FFRCT&gt;0.80 group, NCP volume was significantly higher in all three major vessels in FFRCT ≤0.80 group (210.2±83.6 mm3 vs. 140.9±139.3 mm3 for the RCA, p=0.01; 177.5±150.2 mm3 vs. 133.2±112.2 mm3 for the LAD, p=0.04; 127.6±91.5 mm3 vs. 58.7±57.7 mm3 for the LCX, p&lt;0.01). Next, we investigated the vessel parameters that correlated with ΔFFRCT. ΔFFRCT was correlated with lumen volume in FFRCT&gt;0.80 group (r=−0.24, p&lt;0.0001), whereas ΔFFRCT was correlated with NCP volume in FFRCT ≤0.80 group (r=0.42, p&lt;0.001) (Figure 2). An NCP volume above 44.8 mm3 was the strongest predictor of distal FFRCT of ≤0.80 (area under the curve 0.69, p&lt;0.0001, sensitivity 95%, specificity 39%). Conclusions FFRCT is affected by vascular morphology and plaque characteristics even in the early stage of coronary artery disease. Our study highlights that subclinical coronary artery disease strongly influences FFRCT by effects unrelated to coronary stenosis. The presence of NCP is a major predictor of the gradual decrease of FFRCT toward pathological values. Anatomical findings as vessel morphology and plaque characteristics should be taken into consideration when interpreting numerical values of FFRCT to avoid unnecessary referrals for invasive coronary angiography or percutaneous coronary intervention. FUNDunding Acknowledgement Type of funding sources: None. Figure 1 Figure 2

scholarly journals Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged

ISRN Oncology ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Elise Langenkamp ◽  
Franziska M. vom Hagen ◽  
Peter J. Zwiers ◽  
Henk E. Moorlag ◽  
Jan P. Schouten ◽  
...  
Keyword(s):  
Gene Expression ◽  
Major Change ◽  
Drug Regimen ◽  
Growth Stages ◽  
Separate Analysis ◽  
Small Vessels ◽  
Vascular Morphology ◽  
Vessel Morphology ◽  
Significant Difference ◽  
Different Growth Stages

In established tumors, angiogenic endothelial cells (ECs) coexist next to “quiescent” EC in matured vessels. We hypothesized that angio-gene expression of B16.F10 melanoma would differ depending on the growth stage. Unraveling the spatiotemporal nature thereof is essential for drug regimen design aimed to affect multiple neovascularization stages. We determined the angiogenic phenotype—represented by 52 angio-genes—and vascular morphology of small, intermediate, and large s.c. growing mouse B16.F10 tumors and demonstrated that expression of these genes did not differ between the different growth stages. Yet vascular morphology changed dramatically from small vessels without lumen in small to larger vessels with increased lumen size in intermediate/large tumors. Separate analysis of these vascular morphologies revealed a significant difference in αSMA expression in relation to vessel morphology, while no relation with VEGF, HIF-1α, nor Dll4 expression levels was observed. We conclude that the tumor vasculature remains actively engaged in angiogenesis during B16.F10 melanoma outgrowth and that the major change in tumor vascular morphology does not follow molecular concepts generated in other angiogenesis models.

Burn Hemangioma: A New Variant of Hemangioma

Dermatology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Khalifa E. Sharquie ◽  
Muhsin A. Al-Dhalimi ◽  
Ahmed Abdulhussein Kawen ◽  
Samer A. Dhaher
Keyword(s):  
Age Groups ◽  
Case Series ◽  
Infantile Hemangioma ◽  
Pyogenic Granuloma ◽  
Infants And Children ◽  
Rapid Progression ◽  
New Variant ◽  
History Of ◽  
Age Range ◽  
Second Degree

<b><i>Background:</i></b> Burn hemangioma, also known as scalded pyogenic granuloma, is considered a variant of pyogenic granuloma, but unlike the classic type it presents with rapid progression. Most patients are infants and young children with a history of burns caused by liquids. <b><i>Objective:</i></b> The present study aims to present all patients with burn hemangiomas treated at our institutions with a full clinical and histopathological assessment. <b><i>Patients and Methods:</i></b> This case series includes 34 cases that were treated during the period from 2016 to 2021. <b><i>Results:</i></b> A total of 34 patients (16 female/18 male, mean age of 17.6 years) were included. Two age groups presented: infants and children (<i>n</i> = 22, age range 0.5–8 years, 10 female/12 male), and adults (<i>n</i> = 11, age range 25–44 years, 6 female/6 male). Lesions appeared 1–2 weeks following predominantly second-degree burns, and multiple lesions predominated in infants and children. The lesions evolved to large lesions within weeks, and these appeared to be either static or involute. The histopathology was compatible with hemangioma, rather than pyogenic granuloma. <b><i>Conclusion:</i></b> Burn hemangioma should be considered a new variant of hemangioma rather than a type of pyogenic granuloma that follows second-degree burns. They have many similarities with infantile hemangioma, both clinically and histopathologically.

scholarly journals The Histopathological Spectrum of Pyogenic Granuloma: A Case Series

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Vinay Marla ◽  
Ashish Shrestha ◽  
Khushboo Goel ◽  
Sajeev Shrestha
Keyword(s):  
Endothelial Cells ◽  
Clinical Course ◽  
Age Groups ◽  
Case Series ◽  
Pyogenic Granuloma ◽  
Capillary Hemangioma ◽  
Lobular Capillary Hemangioma ◽  
Case Presentation ◽  
Solitary Nodule ◽  
Slow Growing

Background.Pyogenic granuloma is a reactive tumor-like lesion commonly affecting the oral cavity. These lesions usually appear as localized solitary nodule with a sessile or pedunculated base and colour varying from red, purplish, or pink, depending on the vascularity of the lesion. Pyogenic granuloma shows predilection for gingiva and is usually slow growing, but at times it shows rapid growth. The natural course of this lesion can be categorized into three distinct phases, namely, (i) cellular phase, (ii) capillary phase/vascular phase, and (iii) involutionary phase. Histopathologically, pyogenic granuloma is classified into lobular capillary hemangioma (LCH) and non-lobular capillary hemangioma (non-LCH).Case Presentation. In this series, four cases (varied age groups and both genders) of pyogenic granuloma showing varying histopathological presentation in relation to its clinical course have been described. The lesion in its early phase reveals diffuse endothelial cells, with few budding into capillaries. Among the capillary phase, the LCH type shows numerous blood vessels organized into lobular aggregates whereas the non-LCH type does not show any such organization and resembles granulation tissue. The involutionary phase shows healing of the lesion and is characterized by extensive fibrosis in the connective tissue.Conclusion.In conclusion, knowledge of the various histopathological presentation of this lesion is necessary for proper identification.

Patterns of Bone Marrow Micro Vessel Morphology in AML and High Risk MDS Predict Treatment Outcome Following Intensive Chemotherapy and Bevacizumab

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1555-1555 ◽  
Author(s):  
Alida C. Weidenaar ◽  
Arja ter Elst ◽  
Cees AGM van Montfort ◽  
Tiny G.J. Meeuwsen-de Boer ◽  
Stefano Rosati ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Reference Line ◽  
Bone Marrow Biopsies ◽  
Group Iii ◽  
Vascular Morphology ◽  
Thin Walls ◽  
Vessel Morphology ◽  
Group I ◽  
Bevacizumab Treatment ◽  
Vessel Count

Abstract Abstract 1555 An increase in micro vessel density has been shown in Acute Myeloid Leukemia (AML) bone marrow biopsies at diagnosis, correlating with increased expression of Vascular Endothelial Growth Factor (VEGFA) (de Bont et al, 2001, 2002; Padro et al, 2000; Aguayo et al, 1999). Previously we reported heterogeneity in AML bone marrow vessel patterns, and three subgroups can be distinguished: (a) low vessel count', (b) angiogenic sprouting' (biopsies exhibiting high vessel count with mainly a network of small vessels with thin walls, narrow lumen and branching) and (c) ‘vessel hyperplasia’ (biopsies displaying high number of vessels with predominantly a large lumen and thin walls) (Weidenaar et al, abstract ASH 2010; 2011). In this study we set out to confirm the previously defined morphology groups in a larger group of patients, and investigated the relationship between vascular morphology and clinical outcome in the HOVON81 study which is a multicenter phase II trial evaluating the additional value of Bevacizumab (Roche, Basel, Switzerland) (5 mg/kg to a maximum of 10 mg/kg) at day 1 and 15 of cycle I and II to standard intensive chemotherapy in elderly AML patients (>60 years). AML bone marrow biopsies at diagnosis (n=93) were immunohistochemical stained for FVIII (endothelial cell marker) and SMA (pericytes marker). The three previously reported AML vessel morphology patterns could be confirmed in this cohort (Fig 1A-B). The median percentage of vessels covered by pericytes was 50.1% (range 2.1–100.0, n=66), and was not significantly (P=.27) different between the three groups. In addition it was shown that patients with ‘angiogenic sprouting’ and ‘low vessel count’ (EFS 2 yr: 10%) have a decreased EFS as compared to patients with 'vessel hyperplasia' (EFS 2 yr 30%) (P=.017). For OS, a trend for unfavorable outcome was observed for the ‘angiogenic sprouting’ subgroup (P=.055). Interestingly, treatment with Bevacizumab significantly increased EFS and tended to be associated with a beneficial OS for patients displaying ‘low vessel count’ profile (P=.023 and P=.099 respectively). EFS and OS were not increased in patients with ‘angiogenic sprouting’ or ‘vessel hyperplasia’ upon Bevacizumab treatment. Multivariate analysis established vessel morphology (HR: 2.2 (95% CI 1.1–4.0)) as a prognostic indicator independent of other statistical significant risk factors (for EFS (P=.015)). In conclusion, our results demonstrate that different vasculature patterns in AML bone marrow biopsies are related to treatment outcome in AML patients. Patients displaying an ‘angiogenic sprouting’ profile seem to constitute an unfavorable subset of patients. In addition, AML patients with ‘low vessel count’ might be good candidates for Bevacizumab treatment. Our results show that AML vascular morphology provides prognostic information; therefore, it might be useful to study vessel patterns at diagnosis. Fig. 1. AML biopsies prior to treatment divided into three morphology groups. (A) Scatterplot representing the AML biopsies at diagnosis. Biopsies with a ‘low vessel count’ are displayed below the Y-axis reference line (13 microvessels/hpf, group I). The X-axis reference line divides AML biopsies at diagnosis with a ‘high vessel count’ into two subgroups according to the median Chalkley count of 5.4 in AML at diagnosis. Cut-off points are based on previously described results. Samples with a Chalkley count ≤5.4 were defined as ‘angiogenic sprouting’ (group II) and samples with a Chalkley count >5.4 as ‘vessel hyperplasia’ (group III). (B) A representative picture of the three groups is shown. Fig. 1. AML biopsies prior to treatment divided into three morphology groups. (A) Scatterplot representing the AML biopsies at diagnosis. Biopsies with a ‘low vessel count’ are displayed below the Y-axis reference line (13 microvessels/hpf, group I). The X-axis reference line divides AML biopsies at diagnosis with a ‘high vessel count’ into two subgroups according to the median Chalkley count of 5.4 in AML at diagnosis. Cut-off points are based on previously described results. Samples with a Chalkley count ≤5.4 were defined as ‘angiogenic sprouting’ (group II) and samples with a Chalkley count >5.4 as ‘vessel hyperplasia’ (group III). (B) A representative picture of the three groups is shown. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Association between self-reported snoring and hypertension among Chinese Han population aged 30–79 in Chongqing, China

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Meng Xiao ◽  
Xiaojun Tang ◽  
Fan Zhang ◽  
Li Zhou ◽  
Xiaoqing Bu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Age Groups ◽  
Pressure Control ◽  
Chinese Han ◽  
Face To Face ◽  
Final Sample ◽  
Increased Risk ◽  
Physical Examinations ◽  
And Gender ◽  
Prevention Of Hypertension

Abstract Background We aim to explore the association between self-reported snoring and hypertension among adults aged 30–79 in Chongqing, China. Methods A total of 23,342 individuals aged 30–79 were included at baseline from August 2018 to January 2019, and the final sample size for the analysis was 22,423. Face-to-face interviews and physical examinations were conducted by trained investigators. Logistic regression was performed to study age-specific and gender-specific associations between snoring and hypertension. Results Frequent snoring was associated with the risk of hypertension for each age and gender group, and the frequency of snoring was positively correlated with the risk for hypertension. For the three age groups (< 45, 45–59, ≥ 60), compared with the non-snoring group, those who snore often had a 64.5%, 53.3%, and 24.5% increased risk of hypertension (< 45: OR = 1.65, 95%CI 1.34–2.02; 45–59: OR = 1.53, 95%CI 1.37–1.72; ≥ 60: OR = 1.25, 95%CI 1.09–1.42), respectively. For men and women, those who snore often had a 46.8% and 97.2% increased risk of hypertension, respectively, than the non-snoring group (men: OR = 1.47, 95%CI 1.33–1.63; women: OR = 1.97, 95%CI 1.75–2.23). Conclusions People who snore frequently should pay close attention to their blood pressure levels in order to achieve early prevention of hypertension, particularly for snorers who are female and aged under 45; importance should be attached to their blood pressure control.

scholarly journals Intravital microscopy of tumor vessel morphology and function using a standard fluorescence microscope

2021 ◽  
Author(s):  
Jon-Vidar Gaustad ◽  
Trude G. Simonsen ◽  
Lise Mari K. Hansem ◽  
Einar K. Rofstad
Keyword(s):  
Blood Supply ◽  
Intravital Microscopy ◽  
Small Diameter ◽  
Fluorescence Microscope ◽  
Tumor Vessel ◽  
Antiangiogenic Treatment ◽  
Fluorescent Marker ◽  
Vascular Morphology ◽  
Vessel Morphology ◽  
And Function

Abstract Purpose The purpose of the study was to demonstrate the performance and possible applications of an intravital microscopy assay using a standard fluorescence microscope. Methods Melanoma and pancreatic ductal adenocarcinoma xenografts were initiated in dorsal window chambers and subjected to repeated intravital microscopy. The entire tumor vasculature as well as the normal tissue surrounding the tumor was imaged simultaneously with high spatial and temporal resolution. Vascular morphology images were recorded by using transillumination, and vascular masks were produced to quantify vessel density, vessel diameter, vessel segment length, and vessel tortuosity. First-pass imaging movies were recorded after an intravenous injection of a fluorescent marker and were used to investigate vascular function. Lymphatics were visualized by intradermal injections of a fluorescent marker. Results The intravital microscopy assay was used to study tumor growth and vascularization, tumor vessel morphology and function, tumor-associated lymphatics, and vascular effects of acute cyclic hypoxia and antiangiogenic treatment. The assay was sensitive to tumor-line differences in vascular morphology and function and detected tumor-induced lymphatic dilation. Acute cyclic hypoxia induced angiogenesis and increased the density of small diameter vessels and blood supply times, whereas antiangiogenic treatment selectively removed small-diameter vessels, reduced blood supply times, and induced hypoxia. Moreover, the window chamber was compatible with magnetic resonance imaging (MRI), and parametric images derived by dynamic contrast-enhanced MRI were shown to reflect vascular morphology and function. Conclusions The presented assay represents a useful and affordable alternative to intravital microscopy assays using confocal and multi-photon microscopes.

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