scholarly journals Clinical Features of Spontaneous Regression of Retinopathy of Prematurity in China: A 5-Year Retrospective Case Series

2021 ◽  
Vol 8 ◽  
Author(s):  
Liang Wang ◽  
Manhong Li ◽  
Jun Zhu ◽  
Hongxiang Yan ◽  
Lei Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Analysis ◽  
Clinical Features ◽  
Retinopathy Of Prematurity ◽  
Time Course ◽  
Spontaneous Regression ◽  
Pediatric Patients ◽  
Retinal Vessels ◽  
Appearance Time ◽  
Independent Risk Factors

Purpose: The aim of this study is to explore the clinical features of spontaneous regression of retinopathy of prematurity (ROP) in China, including fundus appearance, time course, and affecting factors.Methods: Data of pediatric patients in whom ROP spontaneously regressed without treatment were collected, including general demographics, medical history, zones and stages of ROP, and changes of fundus appearance. The fundus manifestations of spontaneous regression in ROP were systematically summarized. Meanwhile, the time course of spontaneous regression in ROP was further analyzed, including the onset time, completion time, and duration of regression, which were all compared across different ROP zones and stages. The associated factors were analyzed by survival analysis for their correlation with delayed regression for the first time.Results: Two hundred thirty-seven eyes of 237 pediatric patients were included. The fundus manifestations of regression differed across stages. Lesions gradually subsided, and the retinal vessels gradually vascularized completely. However, despite ROP regression, some abnormalities remained. We observed avascular retina in the temporal periphery (19.0%), increased vascular branching (6.8%), retinal pigmentary changes (6.8%), and smaller angle between the upper and lower temporal retinal vessel trunks (3.0%). Acute ROP started to regress at a median 40 weeks of postmenstrual age (PMA) and completely regressed by median 49.0 weeks of PMA. The median duration for regression was 8.5 weeks. The zone II ROP and stage 3 ROP had a later time for onset and completion of regression, and longer duration. Anemia and retinal hemorrhage (RH) were identified as independent risk factors for delayed regression by survival analysis.Conclusions: During spontaneous regression, the fundus appearance is diverse, and the retinal vessels gradually vascularized completely. The time course of regression differs depending on the ROP zone and stage. Anemia and RH are independent risk factors for delayed regression. Further research of the natural course of the regression of ROP is needed to help design effective screening and follow-up plans.

scholarly journals Incidence and Risk Factors of Inferior Rectus Muscle Palsy in Pediatric Orbital Blowout Fractures

2018 ◽  
Vol 11 (1) ◽  
pp. 028-034 ◽  
Author(s):  
Stephanie M. Young ◽  
Yan Tong Koh ◽  
Errol W. Chan ◽  
Shantha Amrith
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Pediatric Patients ◽  
Rectus Muscle ◽  
Orbital Floor ◽  
Case Review ◽  
Inferior Rectus ◽  
Retrospective Case ◽  
Orbital Blowout Fractures ◽  
Inferior Rectus Muscle

The aim of this study was to evaluate the incidence, clinical features, and risk factors of sustaining inferior rectus (IR) palsy in a group of pediatric patients with orbital floor blowout fractures. We performed a retrospective case review of sequential cases of pediatric orbital floor blowout fractures (<18 years old) from 2000 to 2013 in a tertiary ophthalmic center in Singapore. A total of 48 patients were included in our study, of whom 5 had IR palsy (10.4%). Patients with IR palsy had a higher mean age (16.4 ± 1.5 years) compared with patients without IR palsy (12.4 ± 3.3 years), had significantly ( p < 0.05) worse preoperative motility, and had significantly greater proportion developing postoperative hypertropia (100%) compared with patients without IR palsy (4.7%). Our series of pediatric blowout fractures demonstrated IR palsy prevalence and clinical features for IR palsy which may be distinct to the pediatric group.

scholarly journals A Causally Naïve and Rigid Population Model of Disease Occurrence Given Two Non-Independent Risk Factors

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Olaf Dammann ◽  
Kenneth Chui ◽  
Anselm Blumer
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Population Model ◽  
Outcome Variable ◽  
Risk Factor Prevalence ◽  
Disease Occurrence ◽  
Independent Risk Factors ◽  
Simulation Results ◽  
Changes In Risk

We describe a computational population model with two risk factors and one outcome variable in which the prevalence (%) of all three variables, the association between each risk factor and the disease, as well as the association between the two risk factors is the input. We briefly describe three examples: retinopathy of prematurity, diabetes in Panama, and  smoking and obesity as risk factors for diabetes. We describe and discuss the simulation results in these three scenarios including how the published information is used as input and how changes in risk factor prevalence changes outcome prevalence.

scholarly journals A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jiayi Chen ◽  
Xiaobei Shi ◽  
Mengyuan Diao ◽  
Guangyong Jin ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Clinical Features ◽  
Sofa Score ◽  
Adverse Outcomes ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Gastrointestinal Infections ◽  
Independent Risk Factors ◽  
Poor Outcomes

Abstract Background Sepsis-associated encephalopathy (SAE) is a common complication of sepsis that may result in worse outcomes. This study was designed to determine the epidemiology, clinical features, and risk factors of SAE. Methods This was a retrospective study of all patients with sepsis who were admitted to the Critical Care Medicine Department of Hangzhou First People’s Hospital Affiliated with Zhejiang University School of Medicine from January 2015 to December 2019. Results A total of 291 sepsis patients were screened, and 127 (43.6%) were diagnosed with SAE. There were significant differences in median age, proportion of underlying diseases such as hypertension, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, gastrointestinal infections, detection rate of Enterococcus, and 28-day mortality between the SAE and non-SAE groups. Both the SOFA score and APACHE II score were independent risk factors for SAE in patients with sepsis. All 127 SAE patients were divided into survival and non-survival groups. The age, SOFA score, and APACHE II score were independently associated with 28-day mortality in SAE patients. Conclusion In the present retrospective study, nearly half of patients with sepsis developed SAE, which was closely related to poor outcomes. Both the SOFA score and APACHE II score were independent risk factors for predicting the occurrence and adverse outcome of SAE.

Dopamine and Indomethacin: Independent Risk Factors for Threshold Retinopathy of Prematurity?

2003 ◽  
Vol 5 (3) ◽  
pp. 111-115
Author(s):  
K Allegaert ◽  
C Vanhole ◽  
G Naulaers ◽  
V de Halleux ◽  
I Casteels ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinopathy Of Prematurity ◽  
Independent Risk Factors

scholarly journals Retinopathy of prematurity and its association with neonatal factors

2017 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Mohammod Shahidullah ◽  
Arjun Chandra Dey ◽  
Firoz Ahmed ◽  
Ismat Jahan ◽  
Sanjoy Kumer Dey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Associated Factors ◽  
Preterm Newborn ◽  
Oxygen Administration ◽  
Eye Examination ◽  
Independent Risk Factors ◽  
The Mean

<p>Retinopathy of prematurity is considered as an important cause of blindness. This prospective study was undertaken to document the frequency and the associated factors of retinopathy of prematurity among 97 preterm newborn weighing &lt;2000 g and/or with a gestation of &lt;35 weeks. The first eye examination was performed by an ophthalmologist at 4 weeks of postnatal age for the infants born at ≥30 weeks of gestation or birth weight ≥1200 g and at 3 weeks of postnatal age for the infants &lt;30 weeks of gestation or birth weight &lt;1200 g. The overall incidence of retinopathy of prematurity was 23.7%. Premature newborn with retinopathy was having significant low mean birth weight (p=0.001) and the mean gestational age (p=&lt;0.001) when compared with newborns without retinopathy of prematurity. Newborns with retinopathy of prematurity were requiring a longer duration of oxygen (p=0.005) than that of non-retinopathy of prematurity newborns. Logistic regression shows the duration of oxygen in the hospital and lower gestational age were independent risk factors of retinopathy of prematurity. Prematurity and longer duration of oxygen administration were the risk factors for the development of retinopathy of prematurity.</p>

scholarly journals Clinical features and risk factors for mortality in patients with open pelvic fracture: A retrospective study of 46 cases

2020 ◽  
Vol 28 (2) ◽  
pp. 230949902093983
Author(s):  
Qingshan Guo ◽  
Letian Zhang ◽  
Siru Zhou ◽  
Zhiyang Zhang ◽  
Huayu Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Clinical Features ◽  
Pelvic Fracture ◽  
Injury Severity ◽  
Univariate Analysis ◽  
Pelvic Fractures ◽  
Average Hospital ◽  
Transfusion Requirements ◽  
Independent Risk Factors

Background: This study aimed to investigate the clinical features, current management strategies, and outcomes of open pelvic fracture patients. Methods: We performed a retrospective review of data on patients with blunt trauma and open pelvic fractures admitted to our trauma center over a 5-year period (January 2013 to December 2017). Demographic as well as clinical data including injury mechanism, injury severity score (ISS), fracture classifications, transfusion requirements, interventions, length of hospital and intensive care unit (ICU) stay, and prognosis were investigated. Univariate analysis and binary logistic regression were used to identify the risk variables of death. Finally, a brief literature review was performed to understand the current capacity of treatment and prognosis of this type of injury. Results: Forty-six patients (36 male and 10 female) were included in this study, mean age 43.2 ± 14.2 years. The overall mortality rate was 17.4%; 43.5% of the patients were hypotensive (systolic blood pressure (SBP) <90 mmHg) on arrival. The average ISS was 31.7 ± 6.7, and the average packed red blood cell (PRBC) transfusion during the first 24 h was 9.6 ± 7.4 units. Five patients (10.9%) underwent transcatheter arterial embolization in the early stage of management. The average hospital and ICU length of stay were 53.0 ± 37.6 days and 14.3 ± 15.3 days, respectively. Statistically significant differences were found in ISS, PRBC units received with the first 24 h, SBP, lactate and base excess on admission, and mechanism of injury when comparing between the death and the survival groups ( p < 0.05). ISS and lactate on admission were found to be the independent risk factors for mortality. Conclusion: The mortality rate of open pelvic fractures remains high. ISS and lactate on admission were the independent risk factors for mortality. Optimization of the trauma care algorithms for early identification and treatment of this injury could be the key to decreasing mortality.

scholarly journals Clinical features and risk factors associated with bacteremia of nontyphoidal salmonellosis in pediatric patients, 2010–2018

2021 ◽  
Vol 120 (1) ◽  
pp. 196-203
Author(s):  
Chieh-Ming Lee ◽  
Min-Sheng Lee ◽  
Te-Liang Yang ◽  
Kuan-Lin Lee ◽  
Ting-Yu Yen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Pediatric Patients ◽  
Factors Associated

scholarly journals Prognostic death factors in SHLH children with MODS receiving CRRT: a multicenter prospective nested case-control study

2020 ◽  
Author(s):  
Yun Cui ◽  
Jingyi Shi ◽  
Yijun Shan ◽  
Chunxia Wang ◽  
Yuqian Ren ◽  
...  
Keyword(s):  
Risk Factors ◽  
Organ Dysfunction ◽  
Pediatric Patients ◽  
Case Control Study ◽  
Case Control ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Independent Risk Factors ◽  
Nested Case Control ◽  
Control Study

Abstract Background: Multiple organ dysfunction syndrome (MODS) with secondary hemophagocytic lymphohistiocytosis (SHLH) causes significant mortality, while continuous renal replacement therapy (CRRT) is commonly conducted. The objective is to identify the predictor factors associated with poor outcomes in pediatric patients with SHLH -associated MODS who received CRRT. Methods: A multicenter prospective nested case-control study in four PICUs of tertiary university children’s hospital in Shanghai from September 2013 to August 2018.We prospectively studied 52 SHLH-associated MODS pediatric patients receiving CRRT. Results: Overall PICU mortality rate was 46.15%(24/52). Less respiratory (28.6% vs. 87.5%, P <0.001) or cardiovascular dysfunction (25% vs. 83.3%, P <0.001) caused in survivors at CRRT initiation, as well as reduced demands of mechanical ventilation and vasoactive agents (28.6% vs. 87.5%,17.9 % vs. 66.7 %, both P <0.001). Non-survivors had higher levels of serum lactate dehydrogenase (1404.5 (713.25, 2793) vs. 982.7 (692, 1461) (U/L), P = 0.037), lactic acid (1.9 (1.3, 4.53) (mmol/L) vs. 1.65 (0.8, 2.45) , P=0.034), triglyceride (2.88 (1.94, 5.08) (mmol/L) vs. 2.41 (1.63, 3.32), P=0.032) and IL-6 (28.66 (17.77, 113.63) (pg/ml) vs.0.98 (0.1, 4.63) P=0.000). More than 3 organ dysfunction (Odd ratio [ OR ] : 3.464; 95% confidence interval [ CI ] [1.018-11.788], P = 0.047), and the serum IL-6 level higher than 13.12 pg/mL ( OR :1.388; 95% CI [1.058-1.821], P = 0.018 ) were two independent risk factors for mortality. Conclusions: The number of organ dysfunction and IL-6 levels at CRRT initiation are the independent risk factors for mortality in SHLH-associated MODS patients.

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