scholarly journals Assessing the Fungal Simultaneous Removal Efficiency of Carbamazepine, Diclofenac and Ibuprofen in Aquatic Environment

2021 ◽  
Vol 12 ◽  
Author(s):  
Teddy K. Kasonga ◽  
Martie A. A. Coetzee ◽  
Ilunga Kamika ◽  
Maggy N. B. Momba
Keyword(s):  
Removal Efficiency ◽  
Drug Concentration ◽  
Manganese Peroxidase ◽  
Aquatic Environment ◽  
Emerging Pollutants ◽  
Enzymatic Activities ◽  
Fungal Mycelium ◽  
Simultaneous Removal ◽  
Rhizopus Microsporus ◽  
Drug Concentrations

Unused pharmaceutical compounds (PhCs) discharged into the aquatic environment have been regarded as emerging pollutants due to potential harmful effects on humans and the environment. Microbial bioremediation is considered as a viable option for their removal from wastewater. The aim of this study was to assess the simultaneous removal of carbamazepine (CBZ), diclofenac (DCF) and ibuprofen (IBP) by previously isolated fungi (Aspergillus niger, Mucor circinelloides, Trichoderma longibrachiatum, Trametes polyzona, and Rhizopus microsporus). The tolerance to PhCs was conducted by tracking the fungal mycelium mat diameters in solid media and its dry biomass in liquid media, at the drug concentration range of 0.1 to 15 mg/L. The fungal enzymatic activities were determined for lignin peroxidase (LiP), manganese peroxidase (MnP) and laccase (Lac), respectively. The PhC removal efficiency of the fungi was assessed in aerated batch flasks and the drug concentrations and intermediate compounds formation were determined by using SPE-UPLC/MS. A tolerance over 70% was recorded for all the fungi at drug concentration of 0.1 mg/L. Manganese peroxidase was produced by all the fungi with very low amount of LiP, while all the enzymes were produced by T. polyzona. The pH of 4.3, temperature 37 ± 1.5°C and incubation time of 6 days were the optimum parameters for the fungal enzymatic activities. The best removal of CBZ (87%) was achieved by R. microsporus after 10 days. Between 78 and 100% removal of DCF was observed by all the fungi after 24 h, while 98% of IBP was removed after 2 days by M. circinelloides. Only a few intermediate compounds were identified after 3 days and disappeared after 10 days of incubation. This study demonstrated that apart from the basidiomycetes, the ascomycetes and zygomycetes are also producers of ligninolytic enzymes and have the ability to biodegrade emerging pollutants such as PhCs.

Removal Mechanisms for Pharmaceuticals and Personal Care Products (PPCPs) in Water by NF/RO Membranes

2013 ◽  
Vol 726-731 ◽  
pp. 2502-2505
Author(s):  
Zhong Hua Huang ◽  
Zheng Li Liu ◽  
Li Jun Zhu ◽  
Guli Mira Akbar
Keyword(s):  
Human Health ◽  
Removal Efficiency ◽  
Aquatic Environment ◽  
Membrane Filtration ◽  
Personal Care Products ◽  
Separation Method ◽  
Ecological Environment ◽  
Personal Care ◽  
Removal Mechanisms ◽  
Micro Pollutants

Pharmaceuticals and personal care products (PPCPs) have been widely detected in aquatic environment in recent years; as emerging micro-pollutants, their influence on human health and ecological environment safety are of increasing concern. Membrane filtration is considered as the suitable separation method for PPCPs removal due to different removal mechanisms. This paper reviews the removal efficiency and removal mechanisms for PPCPs by NF/RO membranes.

scholarly journals Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection

2009 ◽  
Vol 53 (12) ◽  
pp. 5022-5025 ◽  
Author(s):  
M. Mar Rodríguez ◽  
F. Javier Pastor ◽  
Enrique Calvo ◽  
Valentina Salas ◽  
Deanna A. Sutton ◽  
...  
Keyword(s):  
Serum Levels ◽  
Rhizopus Microsporus ◽  
In Vitro Susceptibility ◽  
In Vivo Efficacy ◽  
Susceptibility Data ◽  
Microdilution Method ◽  
Drug Concentrations ◽  
Broth Microdilution Method

ABSTRACT A broth microdilution method was used to evaluate the in vitro activities of seven antifungal agents against 15 clinical strains of Rhizopus microsporus. Amphotericin B (AMB) and posaconazole (POS) were the most active drugs. In a model of disseminated R. microsporus infection in immunosuppressed mice, we studied the efficacy of POS administered once or twice daily against four of the strains previously tested in vitro and compared it with that of liposomal AMB (LAMB). LAMB was the most effective treatment for the two strains with intermediate susceptibility to POS. For the two POS-susceptible strains, LAMB and POS at 20 mg/kg of body weight twice a day orally showed similar efficacies. The in vivo efficacy of POS administered twice a day orally correlated with the in vitro susceptibility data and the serum drug concentrations.

Postmortem Drug Redistribution: A Compilation of Postmortem/Antemortem Drug Concentration Ratios

2020 ◽  
Author(s):  
Dylan Mantinieks ◽  
Dimitri Gerostamoulos ◽  
Linda Glowacki ◽  
Matthew Di Rago ◽  
Jennifer Schumann ◽  
...  
Keyword(s):  
Drug Concentration ◽  
Forensic Toxicology ◽  
Mixed Effects ◽  
Cardiovascular Drugs ◽  
Drug Concentrations ◽  
Femoral Blood ◽  
Drug Dependent ◽  
Drugs And Metabolites ◽  
Concentration Ratios

Abstract Postmortem drug redistribution (PMR) is a well-known phenomenon in forensic toxicology with implications for medico-legal death investigations. Paired antemortem (AM) specimen and postmortem (PM) mortuary admission femoral blood drug concentrations from 811 coronial cases were used to construct a retrospective compilation of PM/AM drug concentration ratios for 42 parent drugs and metabolites. The median PM/AM ratios for all antidepressants were > 1 and consistent with PMR In contrast, the median PM/AM ratios of most benzodiazepines were < 1. The antipsychotics were varied (0.63–3.3) and suggest the mixed effects of PMR and drug instability. Amphetamines exhibited no trends (0.90–0.95) and are likely confounded by many factors. The PM/AM ratios of cardiovascular drugs, opioids and other drugs are also reported. This research represents an expansive retrospective compilation of paired AM and PM drug concentrations for many toxicologically relevant drugs. While the median PM/AM ratios demonstrate some drug-dependent trends, there was no obvious relationship between AM specimens and PM femoral blood taken at mortuary admission.

Ranitidine Fails to Suppress the Growth in vitro of Haemopoietic Progenitors from Human Peripheral Blood or Bone Marrow

1989 ◽  
Vol 8 (1) ◽  
pp. 19-22
Author(s):  
C.D.L. Reid ◽  
A. Kirk
Keyword(s):  
Bone Marrow ◽  
Drug Concentration ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Erythroid Progenitors ◽  
Drug Concentrations ◽  
Normal Human ◽  
Normal Human Peripheral Blood ◽  
Clonal Assays

Ranitidine was added in various concentrations (25-1600 ng/ml) to clonal assays of haemopoietic progenitors of normal human peripheral blood or bone marrow. Although a significant reduction in colonies forming from granulocyte-macrophage progenitors (CFU-GM) was demonstrated at the lowest drug concentration, no significant growth suppression was seen at higher concentrations. There was no evidence for growth inhibition of either erythroid progenitors (BFU-E) or pluripotent progenitors (CFU-mix) at any of the drug concentrations studied. A direct toxic effect of ranitidine on normal haemopoietic progenitors thus appears an unlikely cause of cytopenias observed during treatment.

Transport and metabolism of 6-thioguanine and 6-mercaptopurine in mouse small intestine

1988 ◽  
Vol 74 (6) ◽  
pp. 629-638 ◽  
Author(s):  
J. R. Bronk ◽  
Norma Lister ◽  
M. I. Shaw
Keyword(s):  
Small Intestine ◽  
Xanthine Oxidase ◽  
Drug Concentration ◽  
Time Course ◽  
Oxidase Inhibitor ◽  
Unknown Compound ◽  
Xanthine Oxidase Inhibitor ◽  
Drug Concentrations ◽  
Xanthine Oxidase Inhibitors ◽  
Mouse Small Intestine

1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen of the intestinal loops contained either 6-thioguanine or 6-mercaptopurine at a concentration of 1 mmol/l, the concentration of unmetabolized drug in the serosal secretions reached a maximum of 0.13 ± 0.02 mmol/l (mean ± sem). 3. Analysis of the serosal secretions from the perfusions with either of the drugs revealed the appearance of an unknown compound which had the characteristics of a thiopurine and the same time course of appearance as the unmetabolized drug. Thus 6-thioguanine and 6-mercaptopurine are significantly metabolized during absorption in mouse intestine. 4. The unknown compound was identified as 6-thiouric acid, and with 1 mmol/l 6-thioguanine or 6-mercaptopurine in the lumen the concentration of this metabolite in the serosal secretions rose to a maximum of 0.13 ± 0.01 and 0.18 ± 0.03 mmol/l, respectively. At luminal drug concentrations of 0.1 mmol/l, the metabolite accounted for approximately 90% of the serosal thiopurine. 5. After an initial lag period of 20 min, linear rates of appearance in the serosal secretions were obtained for both the unmetabolized drugs and 6-thiouric acid. 6. Addition of the xanthine oxidase inhibitor oxypurinol at a luminal concentration of 0.3 mmol/l prevented the formation of 6-thiouric acid from 6-thioguanine. However, the inhibitor reduced the rate of 6-thioguanine appearance in the serosal secretions by 50%. 7. The conversion of 6-mercaptopurine to 6-thiouric acid was prevented when allopurinol or oxypurinol were added to the lumen. At a luminal drug concentration of 1 mmol/l, allopurinol increased the rate at which 6-mercaptopurine appeared in the serosal secretions by 90% compared with an increase of only 50% with oxypurinol. 8. The transport of water and glucose by the mouse intestinal loops was unaffected by 6-thioguanine or the xanthine oxidase inhibitors. However, 6-mercaptopurine caused significant reductions in the rate of water transport (30%) and glucose transport (39%). These effects were observed at a luminal drug concentration of 0.1 mmol/l and there was no further increase at a drug concentration of 1 mmol/l.

Further studies on the use of chicken embryo infections for the study of drug resistance in Eimeria tenella

Parasitology ◽  
1976 ◽  
Vol 73 (3) ◽  
pp. 275-282 ◽  
Author(s):  
H. D. Chapman
Keyword(s):  
Drug Resistance ◽  
Drug Concentration ◽  
Chicken Embryo ◽  
The Other ◽  
Cross Resistance ◽  
Drug Resistant ◽  
Mutagenic Agent ◽  
Development Of Resistance ◽  
Drug Concentrations ◽  
Resistant Lines

Infections in the chicken embryo have been used to study the development of drug resistance in an embryo adapted strain of E. tenella. Resistance was developed to decoquinate, clopidol and robenidine by serially passaging this strain, but evidence for the development of resistance to amprolium was inconclusive. Resistance to decoquinate developed more readily than to the other drugs. Attempts to increase resistance to clopidol, robenidine and amprolium by increasing the sporozoite inoculum and by the use of a mutagenic agent were unsuccesful. No cross-resistance was found between the 4 drugs.Drug resistant lines of the Houghton strain (H) of E. tenella, made resistant to the 4 anticoccidial drugs by passage in chickens, were found to be resistant when evaluated using chicken embryo infections. Lines made resistant to decoquinate were not controlled by any concentration of this drug, suggesting that resistance, once developed, was absolute and not dependent on drug concentration. Lines made resistant to robenidine, clopidol and amprolium, however, were controlled by higher drug concentrations suggesting that in this case resistance was dependent on drug concentration.

scholarly journals Analysis of Microplastics Released from Plain Woven Classified by Yarn Types during Washing and Drying

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2988
Author(s):  
Sola Choi ◽  
Miyeon Kwon ◽  
Myung-Ja Park ◽  
Juhea Kim
Keyword(s):  
Removal Efficiency ◽  
Aquatic Environment ◽  
Sewage Treatment ◽  
Woven Fabric ◽  
Minimum Length ◽  
Sewage Treatment Plants ◽  
Strict Control ◽  
Filtration System ◽  
Washing Process ◽  
Different Types

Microplastics reach the aquatic environment through wastewater. Larger debris is removed in sewage treatment plants, but filters are not explicitly designed to retain sewage sludge’s microplastic or terrestrial soils. Therefore, the effective quantification of filtration system to mitigate microplastics is needed. To mitigate microplastics, various devices have been designed, and the removal efficiency of devices was compared. However, this study focused on identifying different fabrics that shed fewer microplastics. Therefore, in this study, fabric-specific analyses of microplastics of three different fabrics during washing and drying processes were studied. Also, the change in the generation of microplastics for each washing process of standard washing was investigated. The amount of microplastics released according to the washing process was analyzed, and the collected microplastics’ weight, length, and diameter were measured and recorded. According to the different types of yarn, the amount of microplastic fibers produced during washing and drying varied. As the washing processes proceed, the amount of microplastics gradually decreased. The minimum length (>40 µm) of micro-plastics generated were in plain-woven fabric. These results will be helpful to mitigate microplastics in the production of textiles and in selecting built-in filters, and focusing on the strict control of other parameters will be useful for the development of textile-based filters, such as washing bags.

scholarly journals Photocatalytic abatement of emerging pollutants in pure water and wastewater effluent by TiO2 and Ce-ZnO: degradation kinetics and assessment of transformation products

2019 ◽  
Vol 18 (4) ◽  
pp. 845-852 ◽  
Author(s):  
Debora Fabbri ◽  
María José López-Muñoz ◽  
Alessandro Daniele ◽  
Claudio Medana ◽  
Paola Calza
Keyword(s):  
Removal Efficiency ◽  
Emerging Contaminants ◽  
Degradation Kinetics ◽  
Pure Water ◽  
Transformation Products ◽  
Emerging Pollutants ◽  
Wastewater Effluent ◽  
Transient Transformation ◽  
Water And Wastewater

A good removal efficiency was obtained for a mixture of seven emerging contaminants in wastewater effluent using two catalysts, Ce-ZnO and TiO2-SG, as evidenced by the formation of several transient transformation products.

scholarly journals Practical study on the electrochemical simultaneous removal of copper and cadmium from simulated wastewater using rotating tubular packed bed cathode

2019 ◽  
Vol 7 (2) ◽  
pp. 90-100
Author(s):  
Jenan Hemeidan ◽  
Ali Abbar
Keyword(s):  
Current Efficiency ◽  
Removal Efficiency ◽  
Rotation Speed ◽  
Total Concentration ◽  
Packed Bed ◽  
Weight Percent ◽  
Simultaneous Removal ◽  
Electrolysis Time ◽  
Initial Stage ◽  
Simulated Wastewater

The simultaneous removal of copper and cadmium from a simulated wastewater using rotating tubular packed bed of woven screens electrode was investigated. The effect of weight present of each metal on the removal efficiency and current efficiency was studied. The experiments were carried out at current 1.5 A, rotation speed 450 rpm, pH=2, and total concentration of metals (300 ppm) at different weight percent of each metal. The results showed that the removal efficiency of copper increased from 93.5 % to 99.33% as its weight percent increased from 20% to100%. In a similar fashion, the removal efficiency of cadmium increased from 80% to 90% as its weight percent increased from 20% to100 %. The results confirmed that the removal efficiency of any metals decreased in the presence of other metal. The results established that current efficiency for the simultaneous removal of copper and cadmium decreased with increasing of electrolysis time and Cd percent weight or decreasing of Cu weight percent. Current efficiency is higher at the initial stage of electrolysis and then declined with increasing time for all weight percent of metals.

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