scholarly journals One Health Approaches to Trace Mycobacterium leprae’s Zoonotic Potential Through Time

2021 ◽  
Vol 12 ◽  
Author(s):  
Christian Urban ◽  
Alette A. Blom ◽  
Saskia Pfrengle ◽  
Kathleen Walker-Meikle ◽  
Anne C. Stone ◽  
...  
Keyword(s):  
One Health ◽  
Historical Analysis ◽  
Mycobacterium Leprae ◽  
South East Asia ◽  
Archaeological Remains ◽  
Interdisciplinary Approaches ◽  
Medieval Europe ◽  
Current Potential ◽  
Social Behaviours

Hansen’s disease (leprosy), mainly caused by infection with Mycobacterium leprae, has accompanied humanity for thousands of years. Although currently rare in Europe, there are over 200,000 new infections annually in South East Asia, Africa, and South America. Over the years many disciplines – palaeopathology, ancient DNA and other ancient biomolecules, and history – have contributed to a better understanding of leprosy’s past, in particular its history in medieval Europe. We discuss their contributions and potential, especially in relation to the role of inter-species transmission, an unexplored phenomenon in the disease’s history. Here, we explore the potential of interdisciplinary approaches that understand disease as a biosocial phenomenon, which is a product of both infection with M. leprae and social behaviours that facilitate transmission and spread. Genetic evidence of M. leprae isolated from archaeological remains combined with systematic zooarchaeological and historical analysis would not only identify when and in what direction transmission occurred, but also key social behaviours and motivations that brought species together. In our opinion, this combination is crucial to understand the disease’s zoonotic past and current potential.

Editor's Note

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Emily Kaliel
Keyword(s):  
Civil War ◽  
Public Memory ◽  
Historical Memory ◽  
Historical Analysis ◽  
Red River ◽  
Cultural Institutions ◽  
Economic Rights ◽  
The Past ◽  
Relationship Of

The articles published in our Fall 2016 edition are connected loosely under the themes of public memory and the uses of identity in the past. We are thrilled to present to you three excellent articles in our Fall 2016 edition: The article "Dentro de la Revolución: Mobilizing the Artist in Alfredo Sosa Bravo's Libertad, Cultura, Igualdad (1961)" analyzes Cuban artwork as multi-layered work of propaganda whose conditions of creation, content, and exhibition reinforce a relationship of collaboration between artists and the state-run cultural institutions of post-revolutionary Cuba; moving through fifty years of history “’I Shall Never Forget’: The Civil War in American Historical Memory, 1863-1915" provides a captivating look at the role of reconciliationist and emancipationist intellectuals, politicians, and organizations as they contested and shaped the enduring memory of the Civil War; and finally, the article “Politics as Metis Ethnogenesis in Red River: Instrumental Ethnogenesis in the 1830s and 1840s in Red River” takes the reader through a historical analysis of the development of the Metis identity as a means to further their economic rights. We wholly hope you enjoy our Fall 2016 edition as much as our staff has enjoyed curating it. Editors  Jean Middleton and Emily Kaliel Assistant Editors Magie Aiken and Hannah Rudderham Senior Reviewers Emily Tran Connor Thompson Callum McDonald James Matiko Bronte Wells

International Legal Thought

2017 ◽  
Author(s):  
Thomas Kleinlein
Keyword(s):  
International Law ◽  
Historical Analysis ◽  
Critical Potential ◽  
Self Reflection ◽  
Legal Thought ◽  
History Of ◽  
Nineteenth And Twentieth Centuries

This contribution reflects on the role of tradition-building in international law, the implications of the recent ‘turn to history’ and the ‘presentisms’ discernible in the history of international legal thought. It first analyses how international legal thought created its own tradition in the nineteenth and twentieth centuries. These projects of establishing a tradition implied a considerable amount of what historians would reject as ‘presentism’. Remarkably, critical scholars of our day and age who unsettled celebratory histories of international law and unveiled ‘colonial origins’ of international law were also criticized for committing the ‘sin of anachronism’. This contribution therefore examines the basis of this critique and defends ‘presentism’ in international legal thought. However, the ‘paradox of instrumentalism’ remains: The ‘better’ historical analysis becomes, the more it loses its critical potential for current international law. At best, the turn to history activates a potential of disciplinary self-reflection.

scholarly journals The Lockean Influence on Newman’s Epistemology: An Historical Analysis Describing Newman’s Engagement with Locke’s Ideas

2019 ◽  
Vol 84 (1) ◽  
pp. 77-91
Author(s):  
Becky Walker
Keyword(s):  
Historical Analysis ◽  
Positive Contribution ◽  
Deductive Logic ◽  
Personal Nature ◽  
Christian Message

This article discusses John Locke’s positive contribution to Newman’s epistemology throughout the latter’s career. Beginning with one of Newman’s earliest published works, his Essay on Miracles, he borrowed and further developed ideas from Locke’s A Discourse on Miracles regarding the necessity of miracles to validate the Christian message and the personal nature and cumulative method of weighing evidence. Later, in Newman’s most mature epistemological work, An Essay in Aid of a Grammar of Assent, one can discern Locke’s influence on Newman’s views on the weaknesses of deductive logic, the personal nature of knowledge, and the role of connecting ideas to arrive at knowledge.

‘Our passion for legality’: international law and imperialism in late nineteenth-century Britain

2008 ◽  
Vol 34 (3) ◽  
pp. 403-423 ◽  
Author(s):  
CASPER SYLVEST
Keyword(s):  
Nineteenth Century ◽  
International Law ◽  
South African ◽  
Historical Analysis ◽  
World Politics ◽  
Late Nineteenth Century ◽  
Contemporary World ◽  
Late Nineteenth ◽  
Congo Free State

AbstractThis article deploys a historical analysis of the relationship between law and imperialism to highlight questions about the character and role of international law in global politics. The involvement of two British international lawyers in practices of imperialism in Africa during the late nineteenth century is critically examined: the role of Travers Twiss (1809–1897) in the creation of the Congo Free State and John Westlake’s (1828–1913) support for the South African War. The analysis demonstrates the inescapably political character of international law and the dangers that follow from fusing a particular form of liberal moralism with notions of legal hierarchy. The historical cases raise ethico-political questions, the importance of which is only heightened by the character of contemporary world politics and the attention accorded to international law in recent years.

scholarly journals Using chemical biology to assess and modulate mitochondria: progress and challenges

2017 ◽  
Vol 7 (2) ◽  
pp. 20160151 ◽  
Author(s):  
Angela Logan ◽  
Michael P. Murphy
Keyword(s):  
Mitochondrial Function ◽  
Chemical Biology ◽  
Biomedical Sciences ◽  
Interdisciplinary Approaches ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
The Many ◽  
Opening Up

Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field.

Reflections from the Margins: Complexities, Transitions and Developmental Challenges - The Case of the Eastern Cape Province, South Africa

2021 ◽  
Keyword(s):  
Citizen Participation ◽  
Historical Analysis ◽  
The State ◽  
Eastern Cape ◽  
The People ◽  
Role Of The State ◽  
Leadership Accountability ◽  
Multiple Challenges ◽  
Colonial Oppression

Since the dawn of colonialism in Southern Africa, the province of the Eastern Cape emerged as the cradle of African resistance against colonial oppression. A closer look at the province reveals opportunities for progress and ultimate resurgence of economic and social development, yet conflated by a myriad of challenges. This book brings together different perspectives and realities of the post-apartheid Eastern Cape to provide an in-depth exploration of the developmental dilemmas that the province faces. This book provides insightful reflections on development and its sustainability some 25 years since democracy, and specifically focuses on sociological and demographic realities in the areas of migration and its impact on families. The book further grapples with the role of the state in developing culture and heritage in the province, pointing to fundamental and multiple challenges of deprivation, unemployment and subsequent community resilience in a variety of sectors including health and education. While it provides a historical analysis of contextual issues facing the province, the book also highlights the agency of the people of the Eastern Cape in confronting challenges in leadership, accountability, citizen participation and service provision. The book will be useful for development scholars and practitioners who are interested in understanding the state of the province, and similar settings, and the degree to which it has emerged from the shadows of its colonial and apartheid legacies.

scholarly journals Subnationalism and Social Development: A Comparative Analysis of Indian States

2015 ◽  
Vol 67 (3) ◽  
pp. 506-562 ◽  
Author(s):  
Prerna Singh
Keyword(s):  
Historical Analysis ◽  
Developmental Outcomes ◽  
Uttar Pradesh ◽  
Political Community ◽  
Growing Up ◽  
Indian States ◽  
Shared Identity ◽  
Comparative Historical Analysis

The quality of life that a person leads depends critically on where it is led. Even taking into account levels of economic development, the chances of an individual surviving through infancy, growing up literate, or living a healthy, long life vary dramatically across regions of the world, in different countries, and within the same country. What are the causes of such variation in wellbeing? This article points to a factor that has been virtually ignored in the vast scholarship on social welfare and development—the solidarity that emerges from a sense of shared identity. The argument marks an important departure from the traditional emphasis on the role of class and electoral politics, as well as from the dominant view of the negative implications of identity for welfare. Combining statistical analyses of all Indian states and a comparative historical analysis of two Indian provinces, Kerala and Uttar Pradesh, this article demonstrates how the strength of attachment to the subnational political community—subnationalism—can drive a progressive social policy and improve developmental outcomes.

scholarly journals Tropospheric CO vertical profiles measured by IAGOS aircraft in 2002–2017 and the role of biomass burning

2018 ◽  
pp. 1-41
Author(s):  
Hervé Petetin ◽  
Bastien Sauvage ◽  
Mark Parrington ◽  
Hannah Clark ◽  
Alain Fontaine ◽  
...  
Keyword(s):  
East Asia ◽  
Long Range ◽  
Biomass Burning ◽  
South India ◽  
Long Range Transport ◽  
Anthropogenic Emissions ◽  
South East Asia ◽  
Vertical Profiles ◽  
Range Transport

<p><strong>Abstract.</strong> This study investigates the role of biomass burning and long-range transport in the anomalies of carbon monoxide (CO) regularly observed along the tropospheric vertical profiles measured in the framework of IAGOS. Considering the high interannual variability of biomass burning emissions and the episodic nature of pollution long-range transport, one strength of this study is the amount of data taken into account, namely 30,000 vertical profiles at 9 clusters of airports in Europe, North America, Asia, India and southern Africa over the period 2002&amp;ndash;2017. </p> <p> As a preliminary, a brief overview of the spatio-temporal variability, latitudinal distribution, interannual variability and trends of biomass burning CO emissions from 14 regions is provided. The distribution of CO mixing ratios at different levels of the troposphere is also provided based on the entire IAGOS database (125 million CO observations). </p> <p> This study focuses on the free troposphere (altitudes above 2<span class="thinspace"></span>km) where the long-range transport of pollution is favoured. Anomalies at a given airport cluster are here defined as departures from the local seasonally-averaged climatological vertical profile. The intensity of these anomalies varies significantly depending on the airport, with maximum (minimum) CO anomalies of 110&amp;ndash;150 (48)<span class="thinspace"></span>ppbv in Asia (Europe). Looking at the seasonal variation of the frequency of occurrence, the 25<span class="thinspace"></span>% strongest CO anomalies appears reasonably well distributed along the year, in contrast to the 5<span class="thinspace"></span>% or 1<span class="thinspace"></span>% strongest anomalies that exhibit a strong seasonality with for instance more frequent anomalies during summertime in northern United-States, during winter/spring in Japan, during spring in South-east China, during the non-monsoon seasons in south-east Asia and south India, and during summer/fall at Windhoek, Namibia. Depending on the location, these strong anomalies are observed in different parts of the free troposphere. </p> <p> In order to investigate the role of biomass burning emissions in these anomalies, we used the SOFT-IO v1.0 IAGOS added-value products that consist of FLEXPART 20-days backward simulations along all IAGOS aircraft trajectories, coupled with anthropogenic (MACCity) and biomass burning (GFAS) CO emission inventories and vertical injections. SOFT-IO estimates the contribution (in ppbv) of the recent (less than 20 days) primary worldwide CO emissions, tagged per source region. Biomass burning emissions are found to play an important role in the strongest CO anomalies observed at most airport clusters. The regional tags indicate a large contribution from boreal regions at airport clusters in Europe and North America during summer season. In both Japan and south India, the anthropogenic emissions dominate all along the year, except for the strongest summertime anomalies observed in Japan that are due to Siberian fires. The strongest CO anomalies at airport clusters located in south-east Asia are induced by fires burning during spring in south-east Asia and during fall in equatorial Asia. In southern Africa, the Windhoek airport was mainly impacted by fires in southern hemisphere Africa and South America. </p> <p> To our knowledge, no other studies have used such a large dataset of in situ vertical profiles for deriving a climatology of the impact of biomass burning versus anthropogenic emissions on the strongest CO anomalies observed in the troposphere, in combination with information on the source regions. This study therefore provides both qualitative and quantitative information for interpreting the highly variable CO vertical distribution in several regions of interest.</p>

Doing Things with Legal History

2018 ◽  
pp. 922-940
Author(s):  
Alfred L. Brophy
Keyword(s):  
Property Rights ◽  
Historical Analysis ◽  
First Century ◽  
Unequal Distribution ◽  
Alternative Vision ◽  
Early Twenty ◽  
History Of ◽  
Support Property ◽  
Late Twentieth

This chapter discusses the role of historical analysis in property law. The history of property has been used to offer support for property rights. Their long history makes the distribution of property look normal, indeed natural and something that cannot or should not be challenged. However, historically in the U.S there have been competing visions of property. From the Progressive era onward especially, the history of property has been used to show the unequal distribution of property and to offer an alternative vision that expands the rights of non-owners of property. In the late twentieth and early twenty-first century, the history of opposition to feudalism and protection of the rights of non-owners was used to protect the rights of non-owners. Thus, the history of property has been a tool of judges and legislators to support property rights and it has also been, less frequently, a tool of critique.

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