scholarly journals Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer’s disease: evidence for a pro-amyloidogenic role of MT1-MMP

2014 ◽  
Vol 6 ◽  
Author(s):  
Nathalie A. Py ◽  
Amandine E. Bonnet ◽  
Anne Bernard ◽  
Yannick Marchalant ◽  
Eliane Charrat ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Regulation ◽  
5Xfad Mouse ◽  
Spatio Temporal

scholarly journals Warburg-like metabolism coordinates FGF and Wnt signaling in the vertebrate embryo

2017 ◽  
Author(s):  
Masayuki Oginuma ◽  
Philippe Moncuquet ◽  
Fengzhu Xiong ◽  
Edward Karoly ◽  
Jérome Chal ◽  
...  
Keyword(s):  
Aerobic Glycolysis ◽  
Embryonic Axis ◽  
Paraxial Mesoderm ◽  
Metabolic Adaptation ◽  
Fgf Signaling ◽  
Tail Bud ◽  
Temporal Regulation ◽  
Mammalian Embryos ◽  
Spatio Temporal

Mammalian embryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in cancer cells. The role of this particular type of metabolism during vertebrate organogenesis is currently unknown. Here, we provide evidence for spatio-temporal regulation of aerobic glycolysis in the posterior region of mouse and chicken embryos. We show that a posterior glycolytic gradient is established in response to graded transcription of glycolytic enzymes downstream of FGF signaling. We demonstrate that glycolysis controls posterior elongation of the embryonic axis by regulating cell motility in the presomitic mesoderm and by controlling specification of the paraxial mesoderm fate in the tail bud. Our results suggest that Warburg metabolism in the tail bud coordinates Wnt and FGF signaling to promote elongation of the embryonic axis.

scholarly journals Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling

2021 ◽  
Vol 9 ◽  
Author(s):  
Mike F. Renne ◽  
Hanaa Hariri
Keyword(s):  
Energy Homeostasis ◽  
Acid Metabolism ◽  
Neutral Lipids ◽  
Storage Site ◽  
Metabolic Channeling ◽  
Temporal Regulation ◽  
Contact Sites ◽  
Spatio Temporal ◽  
Cellular Compartments

Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral lipids in organelles called Lipid Droplets (LDs). Upon starvation, fatty acids (FAs) released from LDs are trafficked to different cellular compartments to be utilized for membrane biogenesis or as a source of energy. Despite the biochemical pathways being known in detail, the spatio-temporal regulation of FA synthesis, storage, release, and breakdown is not completely understood. Recent studies suggest that FA trafficking and metabolism are facilitated by inter-organelle contact sites that form between LDs and other cellular compartments such as the Endoplasmic Reticulum (ER), mitochondria, peroxisomes, and lysosomes. LD-LD contact sites are also sites where FAs are transferred in a directional manner to support LD growth and expansion. As the storage site of neutral lipids, LDs play a central role in FA homeostasis. In this mini review, we highlight the role of LD contact sites with other organelles in FA trafficking, channeling, and metabolism and discuss the implications for these pathways on cellular lipid and energy homeostasis.

Reboxetine Treatment Reduces Neuroinflammation and Neurodegeneration in the 5xFAD Mouse Model of Alzheimer’s Disease: Role of CCL2

2019 ◽  
Vol 56 (12) ◽  
pp. 8628-8642 ◽  
Author(s):  
Irene L. Gutiérrez ◽  
Marta González-Prieto ◽  
Javier R. Caso ◽  
Borja García-Bueno ◽  
Juan C. Leza ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

The role of tachykinin 1 in a mouse model of trait anxiety

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
L Czibere ◽  
LA Baur-Jaronowski ◽  
P Weber ◽  
B Pütz ◽  
M Panhuysen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Trait Anxiety

scholarly journals Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

Biochimie ◽  
2021 ◽  
Author(s):  
Mélanie Dacheux ◽  
Soraya Chaouch ◽  
Alonso Joy ◽  
Amandine Labat ◽  
Christine Payré ◽  
...  
Keyword(s):  
Mouse Model ◽  
Phospholipase A2 ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Human Group ◽  
Secreted Phospholipase A2

scholarly journals CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yosuke Ono ◽  
Osamu Yoshino ◽  
Takehiro Hiraoka ◽  
Erina Sato ◽  
Akiko Furue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Diphtheria Toxin ◽  
Immunohistochemical Study ◽  
Mrna Levels ◽  
Cytokines And Chemokines ◽  
Diphtheria Toxin Receptor ◽  
Endothelial Cell Marker ◽  
Toxin Receptor ◽  
Group A

AbstractIn endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells with diphtheria toxin (DT) in an endometriosis mouse model. The depletion of CD206+ MΦ decreased the total weight of endometriotic-like lesions significantly (p < 0.05). In the endometriotic-like lesions in the DT group, a lower proliferation of endometriotic cells and the decrease of angiogenesis were observed. In the lesions, the mRNA levels of VEGFA and TGFβ1, angiogenic factors, in the DT group significantly decreased to approximately 50% and 30% of control, respectively. Immunohistochemical study revealed the expressions of VEGFA and an endothelial cell marker CD31 in lesions of the DT group, were dim compared to those in control. Also, the number of TGFβ1 expressing MΦ was significantly reduced compared to control. These data suggest that CD206+ MΦ promotes the formation of endometriotic-like lesions by inducing angiogenesis around the lesions.

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