scholarly journals Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity

2022 ◽  
Vol 13 ◽  
Author(s):  
Keyi Wu ◽  
Huamin Liu ◽  
Jiazhen Zheng ◽  
Lianwu Zou ◽  
Shanyuan Gu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Free Group ◽  
Normal Weight ◽  
Diabetic Patients ◽  
Diabetes Treatment ◽  
Middle Aged ◽  
Diabetes Group ◽  
The Relationship ◽  
Age Disparity ◽  
Better Than

Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (< 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabetes and untreated-diabetes, in which the diabetes-free group was regarded as reference specially. Cognitive function was assessed by two interview-based measurements for mental intactness and episodic memory.Results: Compared with the participants in the diabetes-free group, the older participants in the treated-diabetes group had better performance in terms of mental intactness (β = 0.37, 95% CI = 0.04–0.70). No significant association was observed in the middle-aged participants. In the subgroup analyses, the lower cognitive score was only observed in people without depression, who had never smoked and drunk, and with a normal weight (body mass index: 18.5–23.9 kg/m2).Conclusion: The cognitive function of actively treated diabetic patients was better than that of patients without diabetes, but the improvement was significant only in elderly people. Depression, smoking, drinking, and an abnormal weight may attenuate this effect.

scholarly journals Relevance of the body mass index in the cognitive status of diabetic patients with different alcohol-drinking patterns

2014 ◽  
Vol 66 (1) ◽  
pp. 347-353
Author(s):  
Serban Lacramioara ◽  
Cristina Toarba ◽  
Simona Hogas ◽  
A. Covic ◽  
A. Ciobica ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Alcohol Drinking ◽  
The Body ◽  
Control Group ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Drinking Patterns ◽  
Alcohol Drinking Patterns ◽  
The Relationship

Nowadays the general relevance of alcohol consumption in diabetes is extremely controversial. There are recent reports that alcohol consumption could result in a decreased incidence of diabetes, as well as other studies demonstrating a positive association between alcohol consumption and type 2 diabetes; there are also reports arguing for an inverse association between the two or for no correlation at all. The different results obtained in these studies could be explained by the existence of several confounders that could influence the outcome of the aforementioned studies. In this paper, we studied the possible relevance of BMI as a confounder in the relationship between alcohol consumption in diabetes and cognitive function, by analyzing the correlations between BMI values in diabetic patients with different alcohol drinking patterns and the subdomains from some main psychometric tests, such as MMSE (Mini-Mental State Examination) and MOCA (Montreal Cognitive Assessment). Our results provide evidence for BMI as a possible confounder of the relationship between alcohol consumption in diabetes and cognitive function. We found a significant increase (p<0.0001) in BMI values in patients with diabetes compared to our control group. Most importantly, significant correlations between BMI parameters in alcohol-consuming diabetic patients and most of the subdomains for psychometric testing.

scholarly journals Obesity and Overweight Are Independently Associated with Greater Survival in Critically Ill Diabetic Patients: A Retrospective Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Wentao Huang ◽  
Yongsong Chen ◽  
Guoshu Yin ◽  
Nasui Wang ◽  
Chiju Wei ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Critically Ill ◽  
Cox Regression ◽  
Normal Weight ◽  
Diabetic Patients ◽  
Weight Group ◽  
Normal Weight Group ◽  
Obesity And Overweight ◽  
Overweight Group ◽  
The Relationship

Background. The relationship between obesity and the outcomes of critically ill diabetic patients is not completely clear. We aimed to assess the effects of obesity and overweight on the outcomes among diabetic patients in the intensive care unit (ICU). Methods. Critically ill diabetic patients in the ICU were classified into three groups according to their body mass index. The primary outcomes were 30-day and 90-day mortality. ICU and hospital length of stay (LOS) and incidence and duration of mechanical ventilation were also assessed. Cox regression models were developed to evaluate the relationship between obesity and overweight and mortality. Results. A total of 6108 eligible patients were included. The 30-day and 90-day mortality in the normal weight group were approximately 1.8 times and 1.5 times higher than in the obesity group and overweight group, respectively ( P < 0.001 , respectively). Meanwhile, the ICU (median (IQ): 2.9 (1.7, 5.3) vs. 2.7 (1.6, 4.8) vs. 2.8 (1.8, 5.0)) and hospital (median (IQ): 8.3 (5.4, 14.0) vs. 7.9 (5.1, 13.0) vs. 8.3 (5.3, 13.6)) LOS in the obesity group and overweight group were not longer than in the normal weight group. Compared with normal weight patients, obese patients had significantly higher incidence of mechanical ventilation (58.8% vs. 64.7%, P < 0.001 ) but no longer ventilation duration (median (IQ): 19.3 (7.0, 73.1) vs. 19.0 (6.0, 93.7), P = 1 ). Multivariate Cox regression showed that obese and overweight patients had lower 30-day (HR (95% CI): 0.62 (0.51, 0.75); 0.76 (0.62, 0.92), respectively) and 90-day (HR (95% CI): 0.60 (0.51, 0.70); 0.79 (0.67, 0.93), respectively) mortality risks than normal weight patients. Conclusions. Obesity and overweight were independently associated with greater survival in critically ill diabetic patients, without increasing the ICU and hospital LOS. Large multicenter prospective studies are needed to confirm our findings and the underlying mechanisms warrant further investigation.

scholarly journals Roles of drinking and diet in the U-shaped relationship between smoking and BMI in middle-aged and elderly Chinese rural adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Da Pan ◽  
Shaokang Wang ◽  
Ming Su ◽  
Jie Wei ◽  
Kai Wang ◽  
...  
Keyword(s):  
Rural Population ◽  
Age Groups ◽  
Normal Weight ◽  
Dietary Factors ◽  
Middle Aged ◽  
Cross Sectional ◽  
Elderly Chinese ◽  
The Relationship ◽  
Overweight Or Obesity ◽  
Rural Adults

Abstract The study aimed to investigate the relationship between smoking and BMI, from the perspective of the roles of alcohol drinking and dietary factors in a rural population. We analysed cross-sectional data from 10,837 middle-aged and elderly Chinese rural adults who completed a questionnaire that included questions on demographic characteristics, dietary intake, and detailed smoking and drinking status. Results showed that current smokers had lower BMI and consumed foods less frequently (except coriander, onion, garlic, hawthorn and fermented bean curd) than non-smokers. The relationship between smoking amount and the risk of overweight or obesity was U-shaped, and the trends were also similar by stratum of baseline age groups (all p for interaction < 0.001). Heavy smokers tended to have drinking habits, which was associated with increased BMI (all p for trend < 0.001). Additionally, despite the lower risk of overweight or obesity for current smokers, normal weight individuals were found to have the minimum smoking amount. In conclusion, smoking may cause suppression of appetite but smokers tend to have other unhealthy habits relating to increased BMI. Dietary factors and alcohol use play important roles in the U-shaped relationship between smoking behaviours and BMI in the middle-aged and elderly Chinese rural population.

scholarly journals The relationship between plasma free fatty acids, cognitive function and structural integrity of the brain in middle-aged healthy humans

Aging ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 22078-22091
Author(s):  
Markus Herrmann ◽  
Sebastian Simstich ◽  
Günter Fauler ◽  
Edith Hofer ◽  
Eva Fritz-Petrin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Free Fatty Acids ◽  
Structural Integrity ◽  
Middle Aged ◽  
Plasma Free Fatty Acids ◽  
Healthy Humans ◽  
The Relationship ◽  
The Brain

T5. The Relationship Between Olfaction and Cognitive Function in a Sample of Healthy Middle-Aged Adults

2019 ◽  
Vol 85 (10) ◽  
pp. S131
Author(s):  
Kirsten Cline ◽  
Erin McGlade ◽  
Deborah Yurgelun-Todd ◽  
Chandni Sheth
Keyword(s):  
Cognitive Function ◽  
Middle Aged ◽  
Middle Aged Adults ◽  
The Relationship

scholarly journals Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men

2020 ◽  
pp. 1-13
Author(s):  
Riki E. Slayday ◽  
Daniel E. Gustavson ◽  
Jeremy A. Elman ◽  
Asad Beck ◽  
Linda K. McEvoy ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Episodic Memory ◽  
Apoe Genotype ◽  
Middle Aged ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption ◽  
Ε4 Allele ◽  
Middle Aged Adults ◽  
The Relationship

Abstract Objective: Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) ε4 allele, a risk factor for Alzheimer’s disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would show better cognitive performance than heavy drinkers or non-drinkers. Additionally, we hypothesized that the association between alcohol use and cognitive function would differ by ApoE genotype (ε4+ vs. ε4−). Method: Participants were 1266 men from the Vietnam Era Twin Study of Aging (VETSA; M age = 56; range 51–60) who completed a neuropsychological battery assessing seven cognitive abilities: general cognitive ability (GCA), episodic memory, processing speed, executive function, abstract reasoning, verbal fluency, and visuospatial ability. Alcohol consumption was categorized into five groups: never, former, light, moderate, and heavy. Results: In fully adjusted models, there was no significant main effect of alcohol consumption on cognitive functions. However, there was a significant interaction between alcohol consumption and ApoE ε4 status for GCA and episodic memory, such that the relationship of alcohol consumption and cognition was stronger in ε4 carriers. The ε4+ heavy drinking subgroup had the poorest GCA and episodic memory. Conclusions: Presence of the ε4 allele may increase vulnerability to the deleterious effects of heavy alcohol consumption. Beneficial effects of light or moderate alcohol consumption were not observed.

scholarly journals Intergenerational Ties in Context: Association between Caring for Grandchildren and Cognitive Function in Middle-Aged and Older Chinese

2020 ◽  
Vol 18 (1) ◽  
pp. 21
Author(s):  
Shiming Liao ◽  
Ling Qi ◽  
Jie Xiong ◽  
Jie Yan ◽  
Ruoxi Wang
Keyword(s):  
Longitudinal Study ◽  
Cognitive Function ◽  
Cultural Context ◽  
Gender Disparity ◽  
Three Dimensions ◽  
Moderate Intensity ◽  
Middle Aged ◽  
Assessment Protocol ◽  
Older Chinese ◽  
The Relationship

Grandchild caregiving is suggested to improve the elderly’s cognitive function, but the specific relationship remains under-investigated. Considering gender disparity, this study aimed to understand the relationship between grandchild caregiving and cognition. In total, 7236 Chinese residents (≥45 years old) were selected from the 2015 China Health and Retirement Longitudinal Study (CHARLS). The China Health and Retirement Longitudinal Study Harmonized Cognitive Assessment Protocol (CHARLS-HCAP) was used to measure cognition. Grandparenting was measured from three dimensions: caregiving frequency, intensity, and the number of grandchildren cared for. The relationship was examined by multivariate linear regression, with age as a moderator. The results showed that the majority of respondents provided care to their grandchildren, especially grandmothers. Grandchild caregiving was positively associated with cognition (β = 0.686, 95% CI = 0.334–1.038), especially in the older-aged group. Moderate, not regular grandparenting, or caring for one grandchild was more positively associated with cognitive function. However, intensive and regular grandchild care was significantly associated with cognition only in men. No moderating effects of age were found in women. The study confirmed that moderate intensity and frequency of caregiving was related to better cognitive function in middle-aged and older Chinese population, whereas cultural context and gender differences could be considered when designing targeted policies.

Sign in / Sign up

Export Citation Format

Share Document