The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice

Monoamine neurotransmitter activity in brain reward, limbic, and motor areas play key roles in the motivation to misuse alcohol and can become modified by exercise in a manner that may affect alcohol craving. This study investigated the influence of daily moderate physical activity on monoamine-related neurochemical concentrations across the mouse brain in response to high volume ethanol ingestion. Adult female C57BL/6J mice were housed with or without 2.5 h of daily access to running wheels for 30 days. On the last 5 days, mice participated in the voluntary binge-like ethanol drinking procedure, “Drinking in the dark” (DID). Mice were sampled immediately following the final episode of DID. Monoamine-related neurochemical concentrations were measured across brain regions comprising reward, limbic, and motor circuits using ultra High-Performance Liquid Chromatography (UHPLC). The results suggest that physical activity status did not influence ethanol ingestion during DID. Moreover, daily running wheel access only mildly influenced alcohol-related norepinephrine concentrations in the hypothalamus and prefrontal cortex, as well as serotonin turnover in the hippocampus. However, access to alcohol during DID eliminated wheel running-related decreases of norepinephrine, serotonin, and 5-HIAA content in the hypothalamus, but also to a lesser extent for norepinephrine in the hippocampus and caudal cortical areas. Finally, alcohol access increased serotonin and dopamine-related neurochemical turnover in the striatum and brainstem areas, regardless of physical activity status. Together, these data provide a relatively thorough assessment of monoamine-related neurochemical levels across the brain in response to voluntary binge-patterned ethanol drinking, but also adds to a growing body of research questioning the utility of moderate physical activity as an intervention to curb alcohol abuse.

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Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0280 ◽

2017 ◽

Vol 42 (2) ◽

pp. 148-156 ◽

Cited By ~ 23

Author(s):

Megan E. Rosa-Caldwell ◽

David E. Lee ◽

Jacob L. Brown ◽

Lemuel A. Brown ◽

Richard A. Perry ◽

...

Keyword(s):

Physical Activity ◽

Quality Control ◽

Protein Content ◽

Wheel Running ◽

Western Diet ◽

Moderate Physical Activity ◽

Diet Induced Obesity ◽

Mrna Content ◽

Normal Chow ◽

Hepatic Fat

Obesity is a known risk factor for the development of hepatic disease; obesity-induced fatty liver can lead to inflammation, steatosis, and cirrhosis and is associated with degeneration of the mitochondria. Lifestyle interventions such as physical activity may ameliorate this condition. The purpose of this study was to investigate regulation of mitochondrial and autophagy quality control in liver following Western diet-induced obesity and voluntary physical activity. Eight-week-old C57BL/6J mice were fed a Western diet (WD) or normal chow (NC, control) for 4 weeks; afterwards, groups were divided into voluntary wheel running (VWR) or sedentary (SED) conditions for an additional 4 weeks. WD-SED animals had a median histology score of 2, whereas WD-VWR was not different from NC groups (median score 1). There was no difference in mRNA of inflammatory markers Il6 and Tnfa in WD animals. WD animals had 50% lower mitochondrial content (COX IV and Cytochrome C proteins), 50% lower Pgc1a mRNA content, and reduced content of mitochondrial fusion and fission markers. Markers of autophagy were increased in VWR animals, regardless of obesity, as measured by 50% greater LC3-II/I ratio and 40% lower p62 protein content. BNIP3 protein content was 30% less in WD animals compared with NC animals, regardless of physical activity. Diet-induced obesity results in derangements in mitochondrial quality control that appear to occur prior to the onset of hepatic inflammation. Moderate physical activity appears to enhance basal autophagy in the liver; increased autophagy may provide protection from hepatic fat accumulation.

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Voluntary physical activity protects against olanzapine-induced hyperglycemia

Journal of Applied Physiology ◽

10.1152/japplphysiol.00876.2020 ◽

2020 ◽

Author(s):

Hesham Shamshoum ◽

Greg Lawrence McKie ◽

Kyle D. Medak ◽

Kristin E. Ashworth ◽

Bruce E. Kemp ◽

...

Keyword(s):

Physical Activity ◽

Blood Glucose ◽

Glucose Metabolism ◽

Wheel Running ◽

Whole Body ◽

Light Cycle ◽

Triglyceride Accumulation ◽

Insulin Tolerance ◽

Voluntary Physical Activity ◽

Running Wheels

Olanzapine (OLZ) is used in the treatment of schizophrenia and a growing number of "off‐label" conditions. While effective in reducing psychoses, OLZ causes rapid impairments in glucose and lipid homeostasis. The purpose of this study was to investigate if voluntary physical activity via wheel running (VWR) would protect against the acute metabolic side effects of OLZ. Male C57BL/6J mice remained sedentary or were provided with running wheels overnight, prior to treatment with OLZ either at the beginning of the light cycle, or 7 or 24 hours following the cessation of VWR. Prior VWR protected against OLZ-induced hyperglycemia immediately and 7 hours following a bout of overnight wheel running. Protection against, hyperglycemia immediately following VWR was associated with increased insulin tolerance and an attenuated OLZ-induced increase in the serum glucagon:insulin ratio. The protective effect of VWR against OLZ-induced increases in hyperglycemia and glucagon:insulin ratio were maintained in high fat fed, and AMPK b1 deficient mice, models which display a potentiated OLZ-induced increase in blood glucose. Repeated OLZ treatment did not impair VWR performance and protection against the acute effects of OLZ on blood glucose was present after 1 week of daily OLZ treatment in mice given access to running wheels. In contrast to the effects on glucose metabolism, VWR, for the most part, did not impact OLZ induced perturbations in lipolysis, liver triglyceride accumulation or whole-body substrate oxidation. Collectively our findings demonstrate the efficacy of voluntary physical activity as an approach to protect against OLZ-induced impairments in glucose metabolism.

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812 Hemodynamic response during moderate physical activity in patients undergoing resynchronization therapy

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(05)80517-x ◽

2005 ◽

Vol 4 (1) ◽

pp. 187-188

Keyword(s):

Physical Activity ◽

Hemodynamic Response ◽

Moderate Physical Activity ◽

Resynchronization Therapy

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Sport, science and politics in Indonesia: challenges in epistemology within an evolving global context

International Sports Studies ◽

10.30819/iss.42-e.02 ◽

2020 ◽

Vol 42 (3) ◽

pp. 4-17

Author(s):

John Saunders ◽

Rusli Lutan

Keyword(s):

Physical Activity ◽

Physical Education ◽

High Performance ◽

Health Sector ◽

Health Science ◽

Current Status ◽

Sport Science ◽

Economic Entity ◽

Science And Politics ◽

International Sport

This paper considers the current status of physical education and sport science in Indonesia from the perspective of the development of the professional knowledge base and research culture surrounding its practice. It seeks to place the field’s development within the broader context of international sport studies from 1945 to 2020. It identifies as major influences the process of globalisation and the growth of international sport as a significant political and economic entity. Physical education is acknowledged as a common historical base for the three modern strands within contemporary sports studies – medical /and health science, high performance studies, and sports business management. Future developments are considered in the context of the current pandemic. Covid19 and the world’s response to it has impacted on some key dimensions which underpin the current global sports economy – namely easy and convenient travel and the gathering of crowds in the widespread consumption of live sport. It is suggested that this might cause a major reset in the conduct of elite sport and sport festivals. The continuing growth of the physical activity and health sector is predicted and in the context of the serious challenges facing the sporting sector a case is made for increased resources to be moved back into the educational study and practice of sport and physical activity as a universal good.

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HUBUNGAN AKTIVITAS FISIK DENGAN FUNGSI KOGNITIF LANSIA DI PANTI WREDHA YAYASAN SOSIAL SALIB PUTIH SALATIGA

Jurnal Kesehatan Kusuma Husada ◽

10.34035/jk.v10i2.389 ◽

2019 ◽

pp. 137-143

Author(s):

Dennys Christovel Dese ◽

Cahyo Wibowo

Keyword(s):

Physical Activity ◽

Cognitive Function ◽

The Elderly ◽

Moderate Physical Activity ◽

Cross Sectional ◽

Significance Level ◽

The Social ◽

Normal Cognitive Function ◽

Intellectual Capacity ◽

Independent Variable

Peningkatan jumlah lansia setiap tahunnya harus dijadikan perhatian, akibat adanya peningkatan jumlah lansia masalah yang dihadapi akan menjadi semakin kompleks, salah satunya adalah masalah yang berkaitan dengan gejala penuaan. Menurunnya kapasitas intelektual berhubungan erat dengan fungsi kognitif pada lansia. Aktivitas fisik diidentifikasi sebagai salah satu faktor yang mempengaruhi fungsi kognitif. Aktivitas fisik bermanfaat untuk lansia sebagai pencegahan dan demensia. Penelitian ini merupakan penelitian analitik observasional dengan menggunakan pendekatan cross sectional. Penelitian dilakukan di yayasan sosial Panti Wredha Salib Putih Salatiga pada bulan Juni 2018. Populasi dalam penelitian ini adalah lansia yang berumur ?60 tahun. Subjek pada penelitian ini berjumlah 16 responden. Variabel independen dalam penelitian ini adalah aktivitas fisik yang dinilai dengan menggunakan instrument GPAQ. Sedangkan variabel dependen dalam penelitian ini adalah fungsi kognitif yang dinilai dengan instrument MMSE. Terdapat 4 orang (25%) yang masuk dalam kategori fungsi kognitif normal dengan kategori aktifitas fisik sedang 1 orang dan aktifitas berat 3 orang, kemudian yang termasuk dalam kategori gangguan fungsi kognitif ringan sebanyak 11 orang (68,75%), dengan kategori aktifitas fisik sedang 8 orang dan aktifitas ringan 3 orang. Sedangkan yang termasuk dalam kategori gangguan fungsi kognitif berat, terdapat 1 orang (6,25%) dengan kategori aktifitasnya ringan. Taraf signifikansi antar variabel tingkat aktifitas fisik dan fungsi kognitif pada lansia adalah p=0.007 atau p<0,05, sehingga dapat disimpulkan ada hubungan antara tingkat aktifitas fisik dengan fungsi kognitif pada lansia. Increasing the number of elderly people every year should be a concern, due to an increase in the number of elderly problems faced will become increasingly complex, one of which is a problem related to the symptoms of aging. Decreased intellectual capacity is closely related to cognitive function in the elderly. Physical activity is identified as one of the factors that influence cognitive function. Physical activity is beneficial for the elderly as prevention and dementia. This study was an observational analytic study using a cross sectional approach. The study was conducted at the social foundation nursing home in the white cross in June 2018. The population in this study was elderly aged â‰¥60 years. The subjects in this study were 16 respondents. The independent variable in this study is physical activity that is assessed using the GPAQ instrument. While the dependent variable in this study was cognitive function which was assessed by the MMSE instrument. There are 4 people (25%) who fall into the category of normal cognitive function with moderate physical activity categories 1 person and heavy activities 3 people, then those included in the category of mild cognitive function disorders are 11 people (68.75%), with the category of physical activity being 8 people and 3 light activities. While those included in the category of severe cognitive function disorders, there is 1 person (6.25%) with a mild activity category. The significance level between the level of physical activity and cognitive function in the elderly is p = 0.007 or p <0.05, so it can be concluded that there is a relationship between the level of physical activity and cognitive function in the elderly.

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Lifestyle, Maternal Nutrition and Healthy Pregnancy

Current Vascular Pharmacology ◽

10.2174/1570161118666200401112955 ◽

2020 ◽

Vol 19 (2) ◽

pp. 132-140

Author(s):

Alfonso Mate ◽

Claudia Reyes-Goya ◽

Álvaro Santana-Garrido ◽

Carmen M. Vázquez

Keyword(s):

Physical Activity ◽

Maternal Nutrition ◽

Muscle Tone ◽

Maternal Diet ◽

Perinatal Outcomes ◽

Psychosocial Health ◽

World Health ◽

Large For Gestational Age ◽

Moderate Physical Activity ◽

Healthy Pregnancy

: Healthy lifestyle habits spanning from preconception to postpartum are considered as a major safeguard for achieving successful pregnancies and for the prevention of gestational diseases. Among preconception priorities established by the World Health Organization (WHO) are healthy diet and nutrition, weight management, physical activity, planned pregnancy and physical, mental and psychosocial health. Most studies covering the topic of healthy pregnancies focus on maternal diet because obesity increases the risks for adverse perinatal outcomes, including gestational diabetes mellitus, large for gestational age newborns, or preeclampsia. Thus, foods rich in vegetables, essential and polyunsaturated fats and fibre-rich carbohydrates should be promoted especially in overweight, obese or diabetic women. An adequate intake of micronutrients (e.g. iron, calcium, folate, vitamin D and carotenoids) is also crucial to support pregnancy and breastfeeding. Moderate physical activity throughout pregnancy improves muscle tone and function, besides decreasing the risk of preeclampsia, gestational diabesity (i.e. diabetes associated with obesity) and postpartum overweight. Intervention studies claim that an average of 30 min of exercise/day contributes to long-term benefits for maternal overall health and wellbeing. Other factors such as microbiome modulation, behavioural strategies (e.g. smoking cessation, anxiety/stress reduction and sleep quality), maternal genetics and age, social class and education might also influence the maternal quality of life. These factors contribute to ensure a healthy pregnancy, or at least to reduce the risk of adverse maternal and foetal outcomes during pregnancy and later in life.

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Radionuclide monitoring of left ventricular function after sublingual nifedipine administration at rest and during moderate physical activity

Journal of Nuclear Cardiology ◽

10.1067/mnc.2001.118070 ◽

2001 ◽

Vol 8 (6) ◽

pp. 669-676 ◽

Cited By ~ 3

Author(s):

A Ferro

Keyword(s):

Physical Activity ◽

Left Ventricular Function ◽

Ventricular Function ◽

Left Ventricular ◽

Moderate Physical Activity ◽

Sublingual Nifedipine

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Exercise referral to promote cardiovascular health in stroke and TIA patients: a pilot feasibility study

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2020-000929 ◽

2020 ◽

Vol 6 (1) ◽

pp. e000929

Author(s):

Sheharyar Baig ◽

Bethany Moyle ◽

Jessica Redgrave ◽

Arshad Majid ◽

Ali Ali

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Perceived Exertion ◽

Cardiovascular Health ◽

Rating Of Perceived Exertion ◽

Moderate Physical Activity ◽

Post Intervention ◽

Related Quality ◽

Exercise Programmes

ObjectivesExercise programmes studied after stroke often involve specialist supervision. Determine the feasibility and safety for people with stroke (PwS) or transient ischaemic attack (TIA) participating in readily accessible, non-stroke specialised, community-based exercise programmes.MethodsParticipants were recruited into a structured, group-based, 12-week programme of aerobic and resistance exercise delivered two times per week at one of five local leisure centres. Completion rates, successful attainment of intended exercise intensity (Borg Rating of Perceived Exertion (RPE)) and safety outcomes were recorded. Measures of physical activity (International Physical Activity Questionnaire), health-related quality of life (EQ-5D) and blood pressure (BP) were recorded at baseline and day 1 post intervention.Results79% of participants completed >75% of the intended sessions, with >90% attainment of intended RPE. Exercise was safe with no serious and very few minor adverse events related to exercise. Exercise led to significant increases in EQ-5D (Best of Health p<0.001), levels of weekly moderate physical activity (p<0.001) and decreases in systolic BP (mean change [95% CI]=−5.4 mmHg [−2.84 to −7.96]; p<0.001).ConclusionGeneralised exercise programmes delivered through existing local services, appears feasible, safe and may improve quality of life, physical activity and systolic BP, for PwS and TIA.

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