scholarly journals Pinostilbene Hydrate Inhibits the Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Downregulating MMP-2 Expression and Suppressing Epithelial–Mesenchymal Transition Through the Mitogen-Activated Protein Kinase Signaling Pathways

2019 ◽  
Vol 9 ◽  
Author(s):  
Pao-Yu Tseng ◽  
Yen-Tze Liu ◽  
Chia-Chieh Lin ◽  
Yi-Ching Chuang ◽  
Yu-Sheng Lo ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Nasopharyngeal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mitogen Activated Protein Kinase ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Human Nasopharyngeal Carcinoma ◽  
Mitogen Activated Protein ◽  
Protein Kinase Signaling

scholarly journals The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Ting Gui ◽  
Yujing Sun ◽  
Aiko Shimokado ◽  
Yasuteru Muragaki
Keyword(s):  
Growth Factors ◽  
Protein Kinase ◽  
Epithelial Mesenchymal Transition ◽  
Mapk Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Important Process ◽  
Mesenchymal Transition ◽  
Mitogen Activated Protein ◽  
And Function ◽  
External Signals

The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond appropriately, especially during the epithelial-mesenchymal transition (EMT). EMT is an important process during embryonic development, fibrosis, and tumor progression in which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. TGF-β signaling is the first pathway to be described as an inducer of EMT, and its relationship with the Smad family is already well characterized. Studies of four members of the MAPK family in different biological systems have shown that the MAPK and TGF-β signaling pathways interact with each other and have a synergistic effect on the secretion of additional growth factors and cytokines that in turn promote EMT. In this paper, we present background on the regulation and function of MAPKs and their cascades, highlight the mechanisms of MAPK crosstalk with TGF-β signaling, and discuss the roles of MAPKs in EMT.

Paclitaxel-Containing Nano-Apoliposomes Attenuate the Growth and Epithelial-Mesenchymal Transition of Cisplatin-Resistant Nasopharyngeal Carcinoma Cells

2021 ◽  
Vol 13 (9) ◽  
pp. 1637-1643
Author(s):  
Zhenxi Cai
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Neck Region ◽  
Clinical Treatment ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Mrna Levels ◽  
Mesenchymal Transition ◽  
Cell Behaviors

Nasopharyngeal carcinoma, a type of malignant tumor of the head and neck region, has strong resistance to anticancer drugs, which seriously hinders clinical treatment. In this study, we investigated the effects of different concentrations of paclitaxel-containing nano-apoliposomes on cisplatin (DDP)-resistant nasopharyngeal carcinoma cells in vitro, referred to as CNE1/DDP and CNE2/DDP. Cell behaviors were then analyzed, including proliferation, migration, and invasion abilities. In addition, levels of proteins related to apoptosis and the epithelial-mesenchymal transition (EMT) were analyzed using western blot assays and mRNA levels of EMT-related genes were measured using qRT-PCR. Our results demonstrated that paclitaxel-containing nano-apoliposomes decrease proliferation, migration, invasion, and EMT of CNE1/DDP and CNE2/DDP cells, demonstrating their inhibitory effects on cisplatin-resistant nasopharyngeal carcinoma cells. This work demonstrates the potential value of paclitaxe-containing nano-apoliposomes in the clinical treatment of drug-resistant nasopharyngeal carcinoma.

scholarly journals ZNRF3 Inhibits the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma Cells by Inactivating the Wnt/β-Catenin Pathway

2017 ◽  
Vol 25 (4) ◽  
pp. 571-577 ◽  
Author(s):  
Zhongwei Wang ◽  
Yali Wang ◽  
Hongtao Ren ◽  
Yingying Jin ◽  
Ya Guo
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Ring Finger ◽  
Carcinoma Cells ◽  
Tumor Xenograft ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
And Function

Zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligase family, is involved in the progression and development of cancer. However, the expression and function of ZNRF3 in human nasopharyngeal carcinoma (NPC) remain unclear. Thus, the aim of this study was to investigate the role of ZNRF3 in human NPC. Our results showed that ZNRF3 was downregulated in NPC cell lines. Restoration of ZNRF3 significantly inhibited the proliferation of NPC cells and tumor xenograft growth in vivo. In addition, overexpression of ZNRF3 suppressed migration and invasion, as well as attenuated the epithelial‐mesenchymal transition (EMT) process in NPC cells. Furthermore, restoration of ZNRF3 obviously downregulated the expression levels of β-catenin, cyclin D1, and c-Myc in NPC cells. In conclusion, these data suggest that ZNRF3 inhibited the metastasis and tumorigenesis via suppressing the Wnt/β-catenin signaling pathway in NPC cells. Thus, ZNRF3 may act as a novel molecular target for the treatment of NPC.

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