scholarly journals Comprehensive Imaging Characterization of Colorectal Liver Metastases

2021 ◽  
Vol 11 ◽  
Author(s):  
Drew Maclean ◽  
Maria Tsakok ◽  
Fergus Gleeson ◽  
David J. Breen ◽  
Robert Goldin ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Imaging Techniques ◽  
Management Strategies ◽  
Disease Assessment ◽  
Future Research ◽  
Phenotypic Characterisation ◽  
Challenges And Opportunities ◽  
Advanced Analysis

Colorectal liver metastases (CRLM) have heterogenous histopathological and immunohistochemical phenotypes, which are associated with variable responses to treatment and outcomes. However, this information is usually only available after resection, and therefore of limited value in treatment planning. Improved techniques for in vivo disease assessment, which can characterise the variable tumour biology, would support further personalization of management strategies. Advanced imaging of CRLM including multiparametric MRI and functional imaging techniques have the potential to provide clinically-actionable phenotypic characterisation. This includes assessment of the tumour-liver interface, internal tumour components and treatment response. Advanced analysis techniques, including radiomics and machine learning now have a growing role in assessment of imaging, providing high-dimensional imaging feature extraction which can be linked to clinical relevant tumour phenotypes, such as a the Consensus Molecular Subtypes (CMS). In this review, we outline how imaging techniques could reproducibly characterize the histopathological features of CRLM, with several matched imaging and histology examples to illustrate these features, and discuss the oncological relevance of these features. Finally, we discuss the future challenges and opportunities of CRLM imaging, with a focus on the potential value of advanced analytics including radiomics and artificial intelligence, to help inform future research in this rapidly moving field.

Instructional video for in vivo ICG-fluorescence guided detection of tumor margins during minimal invasive resections of colorectal liver metastases

ASVIDE ◽  
2020 ◽  
Vol 7 ◽  
pp. 276-276
Author(s):  
Friso B. Achterberg ◽  
Babs G. Sibinga Mulder ◽  
Ruben P. J. Meijer ◽  
Bert A. Bonsing ◽  
Henk H. Hartgrink ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Minimal Invasive ◽  
Instructional Video ◽  
Tumor Margins

scholarly journals Futuristic Sustainable Energy Management in Smart Environments: A Review of Peak Load Shaving and Demand Response Strategies, Challenges, and Opportunities

2020 ◽  
Vol 12 (14) ◽  
pp. 5561 ◽  
Author(s):  
Bhagya Nathali Silva ◽  
Murad Khan ◽  
Kijun Han
Keyword(s):  
Energy Management ◽  
Demand Response ◽  
Energy Demand ◽  
Management Strategies ◽  
Peak Load ◽  
Critical Discussion ◽  
Future Research ◽  
Smart Environments ◽  
Challenges And Opportunities ◽  
Management Approaches

The emergence of the Internet of Things (IoT) notion pioneered the implementation of various smart environments. Smart environments intelligibly accommodate inhabitants’ requirements. With rapid resource shrinkage, energy management has recently become an essential concern for all smart environments. Energy management aims to assure ecosystem sustainability, while benefiting both consumers and utility providers. Although energy management emerged as a solution that addresses challenges that arise with increasing energy demand and resource deterioration, further evolution and expansion are hindered due to technological, economical, and social barriers. This review aggregates energy management approaches in smart environments and extensively reviews a variety of recent literature reports on peak load shaving and demand response. Significant benefits and challenges of these energy management strategies were identified through the literature survey. Finally, a critical discussion summarizing trends and opportunities is given as a thread for future research.

scholarly journals Endomicroscopy of the Pancreaticobiliary System

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shajan Peter ◽  
Ji Young Bang ◽  
Klaus Mönkemuller ◽  
Shyam Varardarajulu ◽  
C. Mel Wilcox
Keyword(s):  
Imaging Techniques ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Future Research ◽  
Imaging Tool ◽  
Long Term Impact ◽  
Improved Accuracy ◽  
Precise Interpretation

It is often difficult to accurately differentiate between benign and malignant pancreaticobiliary strictures, and some are interpreted as indeterminate despite ERCP, EUS, or radiological imaging techniques, thereby making it difficult for the clinician to make appropriate management decisions. Probe-based confocal laser endomicroscopy (pCLE) is an innovative imaging tool integrating real-time in vivo imaging of these difficult-to-interpret strictures in the pancreaticobiliary system during endoscopy. Recent studies of endomicroscopy have shown a promising role with improved accuracy in distinguishing these lesions, thus paving the way for future research addressing improving precise interpretation, training, and long long-term impact.

Lean Management and Supply Chain Management

2014 ◽  
pp. 304-337 ◽  
Author(s):  
Pedro J. Martínez-Jurado ◽  
José Moyano-Fuentes
Keyword(s):  
Supply Chain ◽  
Supply Chain Management ◽  
Management Strategies ◽  
Future Research ◽  
Lean Management ◽  
Chain Management ◽  
Main Research ◽  
Lean Principles ◽  
Aerospace Sector ◽  
Challenges And Opportunities

This chapter evaluates the state-of-the-art of research on Lean Management and Supply Chain Management strategies in the aerospace sector using Systematic Literature Review methodology. The complementary aims are: a) to identify the topic set studied and to propose a criterion for classifying the literature, and b) to discuss the empirical evidence that identifies existing interrelationships. The analysis has enabled three main topics to be identified: a) adoption and implementation of lean management, b) development of supply chain management, and c) deployment of lean principles and practices across the supply chain. A number of more specific lines of research are also proposed that have been assigned to each of these three main research topics. Finally, a set of challenges and opportunities for future research are set out, along with a range of academic and professional implications that could be useful not only for the aerospace sector but also for other industrial sectors that share similar contingent factors.

Management strategies for colorectal liver metastases — Part I

1997 ◽  
Vol 6 (1) ◽  
pp. 19-30 ◽  
Author(s):  
Thomas J. Hugh ◽  
Anne R. Kinsella ◽  
Graeme J. Poston
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Management Strategies

Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging

2013 ◽  
Vol 185 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Andreas Thalheimer ◽  
Doreen Korb ◽  
Lars Bönicke ◽  
Armin Wiegering ◽  
Bettina Mühling ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Liver Metastases ◽  
In Vivo Imaging ◽  
Colorectal Liver Metastases ◽  
Xenograft Model

scholarly journals In vivo imaging and tracking of exosomes for theranostics

2021 ◽  
pp. 2130005
Author(s):  
Ning Ma ◽  
Changfeng Wu ◽  
Zihui Meng
Keyword(s):  
Clinical Application ◽  
In Vivo Imaging ◽  
Photoacoustic Imaging ◽  
Imaging Techniques ◽  
Cell Communication ◽  
Nuclear Imaging ◽  
Future Research ◽  
Uptake Mechanism ◽  
Lipid Bilayer Vesicles

Exosomes are lipid bilayer vesicles released by cells and serve as natural carriers for cell–cell communication. Exosomes provide a promising approach to the diagnosis and treatment of diseases and are considered as an alternative to cell therapy. However, one main restriction in their clinical application is that the current understanding of these vesicles, especially their in vivo behaviors and distributions, remains inadequate. Here, we reviewed the current and emerging methods for in vivo imaging and tracking of exosomes, including fluorescence imaging, bioluminescence imaging, nuclear imaging, X-ray imaging, magnetic resonance imaging, photoacoustic imaging, and multimodal imaging. In vivo imaging and tracking of exosomes by these methods can help researchers further understand their uptake mechanism, biodistribution, migration, function, and therapeutic performance. The pioneering studies in this field can elucidate many unknown exosomal behaviors at different levels. We discussed the advantages and limitations of each labeling and imaging strategy. The advances in labeling and in vivo imaging will expand our understanding of exosomes and promote their clinical application. We finally provide a perspective and discuss several important issues that need to be explored in future research. This review highlights the values of efficient, sensitive, and biocompatible exosome labeling and imaging techniques in disease theranostics.

scholarly journals CONTRAST-ENHANCED ULTRASOUND IMAGING OF COLORECTAL LIVER METASTASES

2017 ◽  
pp. 32-36
Author(s):  
L. A. Mitina ◽  
S. O. Stepanov ◽  
D. V. Sidorov ◽  
O. V. Guts ◽  
L. O. Petrov ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Imaging Techniques ◽  
Treatment Options ◽  
Tumor Resection ◽  
Contrast Enhanced Ultrasound ◽  
Term Survival ◽  
Contrast Enhanced ◽  
Aggressive Surgical Approach

At present, aggressive surgical approach in combination with perioperative chemotherapy allows to extend indications for surgical intervention in patients with metastatic colorectal cancer, since only a radical liver resection provides better long-term survival. Contrast enhancement imaging techniques are important before considering treatment options to identify patients with resectable and potentially resectableliver metastases. Our study evaluated the qualitative and quantitative parameters of thedynamic enhancement pattern of liver metastases. This review will be analyzed the results of liver contrast-enhanced ultrasound studies in 104 patients with secondary colorectal liver metastases before primary tumor resection, as well as the monitoring of systemic chemotherapy and post-ablation follow-up to access treatment respond.

scholarly journals Advances in Radiopharmaceutical Sciences for Vascular Inflammation Imaging: Focus on Clinical Applications

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7111
Author(s):  
Kevin Prigent ◽  
Jonathan Vigne
Keyword(s):  
Molecular Imaging ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Inflammatory Diseases ◽  
Imaging Techniques ◽  
Vascular Inflammation ◽  
Future Research ◽  
Molecular Features ◽  
18F Fdg

Biomedical imaging technologies offer identification of several anatomic and molecular features of disease pathogenesis. Molecular imaging techniques to assess cellular processes in vivo have been useful in advancing our understanding of several vascular inflammatory diseases. For the non-invasive molecular imaging of vascular inflammation, nuclear medicine constitutes one of the best imaging modalities, thanks to its high sensitivity for the detection of probes in tissues. 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) is currently the most widely used radiopharmaceutical for molecular imaging of vascular inflammatory diseases such as atherosclerosis and large-vessel vasculitis. The combination of [18F]FDG and positron emission tomography (PET) imaging has become a powerful tool to identify and monitor non-invasively inflammatory activities over time but suffers from several limitations including a lack of specificity and avid background in different localizations. The use of novel radiotracers may help to better understand the underlying pathophysiological processes and overcome some limitations of [18F]FDG PET for the imaging of vascular inflammation. This review examines how [18F]FDG PET has given us deeper insight into the role of inflammation in different vascular pathologies progression and discusses perspectives for alternative radiopharmaceuticals that could provide a more specific and simple identification of pathologies where vascular inflammation is implicated. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies. Future research is needed to realize the true clinical translational value of PET imaging in vascular inflammatory diseases.

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