scholarly journals Chronic Stress Effects on Tumor: Pathway and Mechanism

2021 ◽  
Vol 11 ◽  
Author(s):  
Hanqing Hong ◽  
Min Ji ◽  
Dongmei Lai
Keyword(s):  
Chronic Stress ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Emotional Experience ◽  
Stress Hormones ◽  
Chemotherapy Resistance ◽  
Immune Monitoring ◽  
The Body ◽  
Endocrine Disease ◽  
Stress Effects

Chronic stress is an emotional experience that occurs when people encounter something they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases, such as cardiovascular disease, depression, endocrine disease, inflammation and cancer. A growing body of research has shown that there is a link between chronic stress and tumor occurrence in both animal studies and clinical studies. Chronic stress activates the neuroendocrine system (hypothalamic-pituitary-adrenal axis) and sympathetic nervous system. Stress hormones promote the occurrence and development of tumors through various mechanisms. In addition, chronic stress also affects the immune function of the body, leading to the decline of immune monitoring ability and promote the occurrence of tumors. The mechanisms of chronic stress leading to tumor include inflammation, autophagy and epigenetics. These factors increase the proliferation and invasion capacity of tumor cells and alter the tumor microenvironment. Antagonists targeting adrenergic receptors have played a beneficial role in improving antitumor activity, as well as chemotherapy resistance and radiation resistance. Here, we review how these mechanisms contribute to tumor initiation and progression, and discuss whether these molecular mechanisms might be an ideal target to treat tumor.

Maternal nutrition during pregnancy and health of the offspring

2006 ◽  
Vol 34 (5) ◽  
pp. 779-782 ◽  
Author(s):  
M.S. Martin-Gronert ◽  
S.E. Ozanne
Keyword(s):  
Animal Studies ◽  
Molecular Mechanisms ◽  
Maternal Nutrition ◽  
Critical Factor ◽  
The Body ◽  
Long Term Effects ◽  
Insulin Dependent ◽  
Fetal Malnutrition ◽  
And Function ◽  
Maternal Overnutrition

The ability of mother to provide nutrients and oxygen for her baby is a critical factor for fetal health and its survival. Failure in supplying the adequate amount of nutrients to meet fetal demand can lead to fetal malnutrition. The fetus responds and adapts to undernutrition but by doing so it permanently alters the structure and function of the body. Maternal overnutrition also has long-lasting and detrimental effects on the health of the offspring. There is growing evidence that maternal nutrition can induce epigenetic modifications of the fetal genome. Only relatively recently has evidence from epidemiological and animal studies emerged suggesting that fetal responses to the intrauterine environment may underlie the prevalence of many chronic diseases of adulthood including Type 2 (non-insulin-dependent) diabetes. It is now of crucial importance to gain the understanding of the molecular mechanisms underlying the relationship between fetal alterations to the intra-uterine environment and their long-term effects on the health of an individual.

scholarly journals Evaluation of Health and Social Inequalities in the Occurrence of Different Types of Chronic Stress and Their Effect on Immunoregulation

2021 ◽  
Vol 4 (1) ◽  
pp. 3-16
Author(s):  
Mohamad Reza Vaez Mahdav ◽  
◽  
Leila Nasiri ◽  
Tooba Ghazanfari ◽  
◽  
...  
Keyword(s):  
Chronic Stress ◽  
Animal Studies ◽  
Social Inequalities ◽  
Immune Cell ◽  
Stress Hormones ◽  
Strong Relationship ◽  
Immune Cell Population ◽  
Wide Range ◽  
Inequality In Health ◽  
Stress Influences

Inequality in health and its multiple dimensions is an essential aspect of social injustice. Several studies have shown that mental and physical health in adulthood is not a phenomenon independent of one’s childhood. Those from lower socioeconomic status have higher mortality and shorter life expectancy. Individualism and utilitarianism in social relationships have led to a wide range of social instability, poverty, deprivation, and inequality in societies. In addition to widespread social effects, they have made harmful consequences on the basic vital systems and organs through interference with multiple biological processes. In modern societies, people live in highly stressful situations, and several studies have pointed a strong relationship between the higher prevalence of diseases and social and physiological stresses. Studies of normal and experimental situations also showed their significant effects on the immune response. Accordingly, increased incidence of invasive behaviors has been associated with increased cytokines and immune-cellular activity in animal studies. According to the stimulus type and contact duration, chronic stress influences both innate and acquired immune factors. Stress affects the immune system via activation of the hypothalamus-pituitary-adrenal axis and affects the innate immune agents such as monocytes, macrophages, and proinflammatory cytokines, causing the increase of stress hormones (glucocorticoid-catecholamines). Chronic stress influences the acquired immune components by changing the immune cell population and altering the balance between immune cells and their secreted cytokine levels.

Is Mental Stress the Primary Cause of Glaucoma?

2021 ◽  
Vol 238 (02) ◽  
pp. 132-145
Author(s):  
Bernhard A. Sabel ◽  
Luisa Lehnigk
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Chronic Stress ◽  
Stress Hormones ◽  
Visual Field Loss ◽  
The Body ◽  
Relaxation Techniques ◽  
Self Medication ◽  
Acute And Chronic Stress ◽  
Possible Cause

AbstractThe prognosis of going blind is very stressful for patients diagnosed with “glaucoma”. Worries and fear of losing independence is a constant mental burden, with secondary risks of depression and social isolation. But stress is not only a result of glaucoma but also a possible cause (risk factor). This should not be surprising, given that chronic stress can trigger “psychosomatic” organ dysfunctions anywhere in the body. Why should the organ “eye” be an exception? Indeed, glaucoma patients often suspect that severe emotional stress caused their visual field loss or “foggy vision”. The hypothesis that stress is a possible cause of glaucoma is supported by different observations: (i) acute and chronic stress increases intraocular pressure and (ii) long-term stress can lead to vascular dysregulation of the microcirculation in the eye and brain (“Flammerʼs syndrome”), leading to partial hypoxia and hypoglycaemia (hypo-metabolism). Even if nerve cells do not die, they may then become inactive (“silent” neurons). (iii) Degenerative changes have been reported in the brain of glaucoma patients, affecting not only anterograde or transsynaptic areas of the central visual pathway, but degeneration is also found (iv) in brain areas involved in emotional appraisal and the physiological regulation of stress hormones. There are also psychological hints indicating that stress is a cause of glaucoma: (v) Glaucoma patients with Flammerʼs syndrome show typical personality traits that are associated with low stress resilience: they often have cold hands or feet, are ambitious (professionally successful), perfectionistic, obsessive, brooding and worrying a lot. (vi) If stress hormone levels and inflammation parameters are reduced in glaucoma patients by relaxation with meditation, this correlates with normalisation of intraocular pressure, and yet another clue is that (vii) visual field improvements after non-invasive current stimulation therapy, that are known to improve circulation and neuronal synchronisation, are much most effective in patients with stress resilient personalities. An appreciation of stress as a “cause” of glaucoma suggests that in addition to standard therapy (i) stress reduction through relaxation techniques should be recommended (e.g. meditation), and (ii) self-medication compliance should not be induced by kindling anxiety and worries with negative communication (“You will go blind!”), but communication should be positive (“The prognosis is optimistic”).

Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain

2007 ◽  
Vol 87 (3) ◽  
pp. 873-904 ◽  
Author(s):  
Bruce S. McEwen
Keyword(s):  
Chronic Stress ◽  
Brain Region ◽  
Behavioral Interventions ◽  
Allostatic Load ◽  
Acute Stress ◽  
Stress Hormones ◽  
The Body ◽  
Pharmaceutical Therapy ◽  
Short Run ◽  
The Brain

The brain is the key organ of the response to stress because it determines what is threatening and, therefore, potentially stressful, as well as the physiological and behavioral responses which can be either adaptive or damaging. Stress involves two-way communication between the brain and the cardiovascular, immune, and other systems via neural and endocrine mechanisms. Beyond the “flight-or-fight” response to acute stress, there are events in daily life that produce a type of chronic stress and lead over time to wear and tear on the body (“allostatic load”). Yet, hormones associated with stress protect the body in the short-run and promote adaptation (“allostasis”). The brain is a target of stress, and the hippocampus was the first brain region, besides the hypothalamus, to be recognized as a target of glucocorticoids. Stress and stress hormones produce both adaptive and maladaptive effects on this brain region throughout the life course. Early life events influence life-long patterns of emotionality and stress responsiveness and alter the rate of brain and body aging. The hippocampus, amygdala, and prefrontal cortex undergo stress-induced structural remodeling, which alters behavioral and physiological responses. As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.

Wnt/beta-catenin and PI3K/Akt/mTOR Signaling Pathways in Glioblastoma: Two Main Targets for Drug Design: A Review

2020 ◽  
Vol 26 (15) ◽  
pp. 1729-1741 ◽  
Author(s):  
Seyed H. Shahcheraghi ◽  
Venant Tchokonte-Nana ◽  
Marzieh Lotfi ◽  
Malihe Lotfi ◽  
Ahmad Ghorbani ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Cellular Proliferation ◽  
Chemotherapy Resistance ◽  
Wnt Signaling Pathway ◽  
Therapeutic Interventions ◽  
Beta Catenin ◽  
Clinical Prognosis ◽  
Invasion And Migration ◽  
And Migration

: Glioblastoma (GBM) is the most common and malignant astrocytic glioma, accounting for about 90% of all brain tumors with poor prognosis. Despite recent advances in understanding molecular mechanisms of oncogenesis and the improved neuroimaging technologies, surgery, and adjuvant treatments, the clinical prognosis of patients with GBM remains persistently unfavorable. The signaling pathways and the regulation of growth factors of glioblastoma cells are very abnormal. The various signaling pathways have been suggested to be involved in cellular proliferation, invasion, and glioma metastasis. The Wnt signaling pathway with its pleiotropic functions in neurogenesis and stem cell proliferation is implicated in various human cancers, including glioma. In addition, the PI3K/Akt/mTOR pathway is closely related to growth, metabolism, survival, angiogenesis, autophagy, and chemotherapy resistance of GBM. Understanding the mechanisms of GBM’s invasion, represented by invasion and migration, is an important tool in designing effective therapeutic interventions. This review will investigate two main signaling pathways in GBM: PI3K/Akt/mTOR and Wnt/beta-catenin signaling pathways.

Alcohol Consumption and Risk of Uterine Fibroids

2020 ◽  
Vol 20 (4) ◽  
pp. 247-258 ◽  
Author(s):  
Hajra Takala ◽  
Qiwei Yang ◽  
Ahmed M. Abd El Razek ◽  
Mohamed Ali ◽  
Ayman Al-Hendy
Keyword(s):  
Alcohol Consumption ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Legal Status ◽  
Current Knowledge ◽  
Uterine Fibroids ◽  
Future Directions ◽  
Working Adults ◽  
The Us ◽  
Alcohol Related Problems

Lifestyle factors, such as alcohol intake, have placed a substantial burden on public health. Alcohol consumption is increasing globally due to several factors including easy accessibility of this addictive substance besides its legal status and social acceptability. In the US, alcohol is the third leading preventable cause of death (after tobacco, poor diet and physical inactivity) with an estimated 88,000 people dying from alcohol-related causes annually, representing 1 in 10 deaths among working adults. Furthermore, the economic burden of excess drinking costs the US around $249 billion ($191.1 billion related to binge drinking). Although men likely drink more than women do, women are at much higher risk for alcohol-related problems. Alcohol use is also considered to be one of the most common non-communicable diseases, which affects reproductive health. This review article summarizes the current knowledge about alcohol-related pathogenesis of uterine fibroids (UFs) and highlights the molecular mechanisms that contribute to the development of UFs in response to alcohol consumption. Additionally, the effect of alcohol on the levels of various factors that are involved in UFs pathogenesis, such as steroid hormones, growth factors and cytokines, are summarized in this review. Animal studies of deleterious alcohol effect and future directions are discussed as well.

Toxicology

2017 ◽  
Author(s):  
Robert Laumbach ◽  
Michael Gochfeld
Keyword(s):  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Toxicity Testing ◽  
The Body ◽  
Toxic Substances ◽  
Basic Principles ◽  
Practical Applications ◽  
Mechanisms Of Toxicity ◽  
Body Distribution ◽  
Threshold Doses

This chapter describes the basic principles of toxicology and their application to occupational and environmental health. Topics covered include pathways that toxic substances may take from sources in the environment to molecular targets in the cells of the body where toxic effects occur. These pathways include routes of exposure, absorption into the body, distribution to organs and tissues, metabolism, storage, and excretion. The various types of toxicological endpoints are discussed, along with the concepts of dose-response relationships, threshold doses, and the basis of interindividual differences and interspecies differences in response to exposure to toxic substances. The diversity of cellular and molecular mechanisms of toxicity, including enzyme induction and inhibition, oxidative stress, mutagenesis, carcinogenesis, and teratogenesis, are discussed and the chapter concludes with examples of practical applications in clinical evaluation and in toxicity testing.

scholarly journals A Maximal Understanding of Sacrifice: Bataille, Richard Wagner, Pilgrimage and the Bayreuth Festival

Religions ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 48
Author(s):  
Philip Smith ◽  
Florian Stoll
Keyword(s):  
Emotional Experience ◽  
The Body ◽  
Richard Wagner ◽  
Mixed Methods Study ◽  
Historical Research ◽  
Structured Interviews ◽  
Paradigm Case ◽  
Comparative Sociology ◽  
Sacred Spaces ◽  
Classical Work

This paper calls for a broad conception of sacrifice to be developed as a resource for cultural sociology. It argues the term was framed too narrowly in the classical work of Hubert and Mauss. The later approach of Bataille permits a maximal understanding of sacrifice as non-utilitarian expenditures of money, energy, passion and effort directed towards the experience of transcendence. From this perspective, pilgrimage can be understood as a specific modality of sacrificial activity. This paper applies this understanding of sacrifice and pilgrimage to the annual Bayreuth “Wagner” Festival in Germany. Drawing on a multi-year mixed-methods study involving ethnography, semi-structured interviews and historical research, the article traces sacrificial expenditures at the level of individual festival attendees. These include financial costs, arduous travel, dedicated research of the artworks, and disciplines of the body. Some are lucky enough to experience transcendence in the form of deep emotional experience, and a sense of contact with sacred spaces and forces. Our study is intended as an exemplary paradigm case that can be drawn upon analogically by scholars. We suggest that other aspects of social experience, including many that are more ‘everyday’, can be understood through a maximal model of sacrifice and that a rigorous, wider comparative sociology could be developed using this tool.

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