scholarly journals Diuretic Effect and Metabolomics Analysis of Crude and Salt-Processed Plantaginis Semen

2020 ◽  
Vol 11 ◽  
Author(s):  
Chao Li ◽  
Rou Wen ◽  
De Wen Liu ◽  
Qiang Liu ◽  
Li Ping Yan ◽  
...  
Keyword(s):  
Clinical Application ◽  
Urine Volume ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Underlying Mechanism ◽  
Diuretic Effect ◽  
Health Products ◽  
Sphingosine 1 Phosphate ◽  
Ethanol Extracts ◽  
Plantaginis Semen

Plantaginis Semen (PS) is well recognized in traditional Chinese medicine (TCM) and health products. Crude PS (CPS) and salt-processed CPS (SPS) are the two most commonly used decoction pieces of PS, and are included in the 2020 edition of Chinese Pharmacopoeia. Although they all have multiple effects, the mechanisms for treating diseases are different and remain unclear, the processing mechanism of SPS is also indeterminate, which hinders their clinical application to a certain extent. In order to solve these problems and further develop PS in the clinical application. Here, we used saline-loaded model rats for experiments, and utilized an integrated approach consisting of pharmacological methods and metabolomics, which could assess the diuretic impact of CPS and SPS ethanol extracts on saline-loaded rats and elucidate the underlying mechanism. The results showed that CPS and SPS both produced increased urine volume excretion and urine electrolyte excretion, but the levels of aldosterone (ALD) and aquaporin 2 (AQP2) were decreased. And 30 differential metabolites such as linoleic acid, lysoPC(O-18:0), sphingosine-1-phosphate, lysoPC(18:0) were found, mainly involving three metabolic pathways. In conclusion, CPS and SPS both have a diuretic effect, and that of SPS is better. This work investigated the possible diuretic mechanisms of CPS and SPS which may also be the mechanism of PS for anti-hypertension. In addition, a holistic approach provided novel and helpful insights into the underlying processing mechanisms of TCM.

scholarly journals Diuretic activity and mechanism of Mosla chinensis Maxim. cv. Jiangxiangru in normal Rats

2020 ◽  
Author(s):  
Longxue Li ◽  
Suyun Xiao ◽  
Weiqi Liu ◽  
Dan Lei ◽  
Weiyue Deng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Urine Volume ◽  
Water Extract ◽  
Underlying Mechanism ◽  
Volatile Oil ◽  
Positive Control ◽  
Control Group ◽  
Diuretic Effect ◽  
Protein Levels ◽  
The Difference

Abstract Background: Jiangxiangru, a commonly used clinical Chinese medicine, has been investigated mainly over its effects on Summer heatstroke and the dampness inside the spleen and stomach. This study focuses on the diuretic effect of Jiangxiangru in normal rats as well as the underlying mechanism.Methods: 48 rats were randomly divided into the model group (saline), the positive control group (furosemide 0.02g/kg), low and high dosage of water decoction of Jiangxiangru group (0.2 g/ml and 1g/ml), low and high dosage of water extract of Jiangxiangru group (0.1463g/ml and 0.7317g/ml), and the low and high dosage of volatile oil of Jiangxiangru group (0.1791g/ml and 1.4328g/ml). Each group was assigned 6 rats. Thirty minutes after the successful establishment of the model, the rats were treated orally with corresponding doses of drugs at 10 ml/kg. The control group received an equivalent amount of water. After administration, Urine volume at each time point was measured and urine K+, Na+, Cl- content were measured. The contents of ALD, ANP, ADH, Na+-K+-ATPase, the gene expression and protein levels of AQP1, AQP2 and AQP3 in urine of rats in each group were determined. SPSS22.0 statistical software was used to analyze the experimental data. One way ANOVA and multiple comparisons between LSD groups were performed. The difference is considered significant When p < 0.05 or p < 0.01.Results: Our results showed that Jiangxiangru decoction group has the strongest diuretic effect, followed by water extract, then the volatile oil. The diuretic mechanism of Jiangxiangru may affect the kidney in addition to the hormone level related to the change of body fluid metabolism. The distal convoluted tubules are related to the content of aquaporin AQP in the collecting tube, thereby inhibiting water reabsorption.Conclusion: The contents of Na+, K+, and Cl- and PH in urine of rats don’t change significantly in this experiment. The diuretic effect of Jiangxiangru could not cause electrolyte disturbance and other adverse reactions. This fully reflects the complex composition of traditional Chinese medicine, the role of multi-target characteristics.

scholarly journals Selection and Micropropagation of an Elite Melatonin Rich Tulsi (Ocimum sanctum L.) Germplasm Line

Agronomy ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 207
Author(s):  
Mukund R. Shukla ◽  
Annaliese Kibler ◽  
Christina E. Turi ◽  
Lauren A. E. Erland ◽  
J. Alan Sullivan ◽  
...  
Keyword(s):  
In Vitro Selection ◽  
Integrated Approach ◽  
Antioxidant Potential ◽  
Ocimum Sanctum ◽  
Natural Health Products ◽  
Seed Population ◽  
Health Products ◽  
Potential Applications ◽  
Medicinal Properties

Tulsi (Ocimum sanctum L.) is a sacred plant of medicinal and spiritual significance in many cultures. Medicinal properties of Tulsi are ascribed to its phytochemicals with antioxidant capabilities. The current study was undertaken to screen a large seed population of Tulsi to select germplasm lines with high antioxidant potential and to standardize protocols for micropropagation and biomass production to produce a phytochemically consistent crop. A total of 80 germplasm lines were established under in vitro conditions and screened for their antioxidant potential determined with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) bioassay. The micropropagation of a selected line, named Vrinda, was established using nodal cultures grown on Murashige and Skoog medium containing benzylaminopurine (1.1 µM), gibberellic acid (0.3 µM), and activated charcoal (0.6%). The antioxidant phytohormones melatonin and serotonin were quantified in the field and greenhouse grown tissues of Vrinda and melatonin levels were found to be consistent in both conditions with higher serotonin levels under field conditions. This integrated approach combining the in vitro selection and propagation offers potential applications in the development of safe, effective, and novel natural health products of Tulsi, and many other medicinal plant species.

scholarly journals Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters

2013 ◽  
Vol 305 (10) ◽  
pp. F1491-F1497 ◽  
Author(s):  
Li Zhou ◽  
Gang Liu ◽  
Zhanjun Jia ◽  
Kevin T. Yang ◽  
Ying Sun ◽  
...  
Keyword(s):  
Plasma Volume ◽  
Volume Expansion ◽  
Urine Volume ◽  
Plasma Osmolality ◽  
Underlying Mechanism ◽  
Fluid Retention ◽  
Receptor Subtype ◽  
Fluorescent Nanoparticles ◽  
Peroxisome Proliferator ◽  
Plasma Volume Expansion

Thiazolidinediones (TZDs), which are synthetic peroxisome proliferator-activated receptor subtype-γ (PPARγ), agonists are highly effective for treatment of type 2 diabetes. However, the side effect of fluid retention has significantly limited their application. Most of the previous studies addressing TZD-induced fluid retention employed healthy animals. The underlying mechanism of this phenomenon is still incompletely understood, particularly in the setting of disease state. The present study was undertaken to examine rosiglitazone (RGZ)-induced fluid retention in db/db mice and to further investigate the underlying mechanism. In response to RGZ treatment, db/db mice exhibited an accelerated plasma volume expansion as assessed by hematocrit (Hct) and fluorescent nanoparticles, in parallel with a greater increase in body weight, compared with lean controls. In response to RGZ-induced fluid retention, urinary Na+ excretion and urine volume were significantly increased in lean mice. In contrast, the natriuretic and diuretic responses were significantly blunted in db/db mice. RGZ db/db mice exhibited a parallel decrease in plasma Na+ concentration and plasma osmolality, contrasting to unchanged levels in lean controls. Imunoblotting analysis showed downregulation of renal aquaporin (AQP) 2 expression in response to RGZ treatment in lean mice but not in db/db mice. Renal AQP3 protein expression was unaffected by RGZ treatment in lean mice but was elevated in db/db mice. In contrast, the expression of Na+/H+ exchanger-3 (NHE3) and NKCC2 was unchanged in either mouse strain. Together these results suggest that compared with the lean controls, db/db mice exhibited accelerated plasma volume expansion that was in part due to the inappropriate response of renal water transporters.

scholarly journals An Integrated Approach to Deal with Mental Health Issues of Children and Adolescent during COVID-19 Pandemic

2020 ◽  
Author(s):  
Mousumi Sethy ◽  
Reshmi Mishra
Keyword(s):  
Mental Health ◽  
Children And Adolescents ◽  
Adult Life ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Well Being ◽  
Childhood And Adolescence ◽  
Health Issues ◽  
Children And Adolescent ◽  
Mental Health Issues

The pandemic caused by COVID-19 has left few countries untouched. It is a far-reaching implication on humankind, with children and adolescents, being no exception. Although the prevalence and fatality are negligible among children, a possible impact on their psychological and mental health cannot be disregarded. The unprecedented change in the way of living is bound to be having some psychological consequences on children and adolescents. The experiences gathered in childhood and adolescence are known to contribute to shaping the physical, emotional, and social well-being in adult life. Children are highly susceptible to environmental stressors. The present situation has the potential of adversely affecting the physical and mental well-being of children. To save the children from the long term consequences of this pandemic, a holistic approach integrating biological, psychological, social and spiritual methods of enhancing mental health have become essential. A concerted effort of government, Non Government Organisations (NGOs), parents, teachers, schools, psychologists, counselors and physicians are required to deal with the mental health issues of children and adolescents. This paper discusses the possible role of these agencies in the holistic intervention of this crisis.

scholarly journals The social mandate of the holistic/integrated approach to learning

2021 ◽  
Author(s):  
Tatiana Callo ◽  
Keyword(s):  
Functional Integration ◽  
Social Process ◽  
Real Life ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Current Status ◽  
The Social ◽  
Key Competencies ◽  
Specificity Of Learning ◽  
Relationship Of

The specific elements in the ontological planning of the social require the holistic approach of the social process, but also of the educational ones. The whole-part dichotomy as a relationship of complementarity raises the issue of the specificity of learning integration, starting from the educational purpose, marked by the formation of key competencies, recorded by knowledge, skills, attitudes. The current status of integration, of the action to make something full, complete, very complex, generates a series of renovations, including the issue of this article, focused on the idea of the need for a model of bio- (or eco-) functional integration, designating a useful process for the student in the sense of his real life or his concrete environment.

Educational Leadership and Integrated Support for Students with Autism Spectrum Disorders

2016 ◽  
pp. 101-114
Author(s):  
Yefim Kats
Keyword(s):  
Special Education ◽  
Autism Spectrum Disorders ◽  
Educational Leadership ◽  
Instructional Technology ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Autism Spectrum ◽  
Systematic Research ◽  
Instructional Use ◽  
Spectrum Disorders

This chapter addresses the integrated approach to the support of children diagnosed with Autism Spectrum Disorders (ASD). In this context we, first, discuss the legislative background, providing legal basis for autism support in an educational environment. We further briefly outline psychological and neurological aspects of ASD diagnostics. We consider how legislative and psychological issues impact special education methods and instructional technology support for ASD. The technology tools addressed include mobile devices and applications, virtual reality, and robotics. The chapter concludes with a report on the development of college-level course in instructional technology for technology facilitators and special education teachers working with ASD students. Considering that systematic research in the instructional use of affordable robotics is still lacking, the case study focuses primarily on the instructional use of popular LEGO robots. The holistic approach to ASD support, combining educational leadership, counseling, special education methods and technological factors, is emphasized throughout the chapter.

Integrated Support of Students With Autism Spectrum Disorders and Learning Disabilities

2021 ◽  
pp. 1-14
Author(s):  
Yefim Kats
Keyword(s):  
Special Education ◽  
Learning Disabilities ◽  
Autism Spectrum Disorders ◽  
Instructional Technology ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Autism Spectrum ◽  
Technology Support ◽  
Educational Environments ◽  
Spectrum Disorders

This chapter outlines the integrated approach to support children and young adults diagnosed with learning disabilities and autism spectrum disorders (ASD). In this context, the authors, first, discuss the legislative background providing legal basis for the disability support in educational environments. They, further, address psychological and neurological aspects of learning disabilities and ASD diagnostics and consider how legislative and neurological issues influence special education methods, counseling, and instructional technology support. The educational tools addressed include mobile devices and applications, virtual reality, and robotics. The chapter concludes with a report on the development of college-level course in instructional technology, intended for technology facilitators and teachers working with the ASD students. The case study focuses primarily on the use of the affordable and popular LEGO robots. The holistic approach to support of those with disabilities, outlined in the chapter, combines educational leadership issues, psychological and job counseling, special education methods, and instructional technology.

Intelligent Cities

2021 ◽  
pp. 216-250
Author(s):  
Kwesi Atta Sakyi
Keyword(s):  
Sustainable Development ◽  
Monitoring And Evaluation ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Environmental Friendliness ◽  
The World ◽  
Development Goals ◽  
Crime Detection ◽  
Intelligent Cities ◽  
Medicine Education

This chapter focuses on a systematic and integrated approach to managing cities using multidisciplinary and technology-based approach and drawing on integrated knowledge from different fields. The chapter aims to discuss and analyse issues in an organic and holistic approach. It explores theory and combines praxis, applications, and futuristic conjectures. Emphasis is placed on issues of ethics, human rights, environmental friendliness, sustainability, and compliance with the 17 UN Sustainable Development Goals (SDGs). While the chapter has considerable input from existing scholarship, it adopts a narrative that is innovative and creative and engages with novel ideas and propositions for future progress. It also charts the breakthrough in transportation, commerce, medicine, education, the world of work, and contemporary health, with particular emphasis on issues relating to safety, confidentiality, privacy, facial recognition, city policing, crime detection, monitoring and evaluation, forecasting, and future of AI.

Integrated Support of Students With Autism Spectrum Disorders and Learning Disabilities

2022 ◽  
pp. 539-552
Author(s):  
Yefim Kats
Keyword(s):  
Special Education ◽  
Learning Disabilities ◽  
Autism Spectrum Disorders ◽  
Instructional Technology ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Autism Spectrum ◽  
Technology Support ◽  
Educational Environments ◽  
Spectrum Disorders

This chapter outlines the integrated approach to support children and young adults diagnosed with learning disabilities and autism spectrum disorders (ASD). In this context, the authors, first, discuss the legislative background providing legal basis for the disability support in educational environments. They, further, address psychological and neurological aspects of learning disabilities and ASD diagnostics and consider how legislative and neurological issues influence special education methods, counseling, and instructional technology support. The educational tools addressed include mobile devices and applications, virtual reality, and robotics. The chapter concludes with a report on the development of college-level course in instructional technology, intended for technology facilitators and teachers working with the ASD students. The case study focuses primarily on the use of the affordable and popular LEGO robots. The holistic approach to support of those with disabilities, outlined in the chapter, combines educational leadership issues, psychological and job counseling, special education methods, and instructional technology.

Treating skin conditions: a holistic approach in dermatology

2020 ◽  
Vol 9 (2) ◽  
pp. 58-64
Author(s):  
Emma Coleman
Keyword(s):  
Traditional Medicine ◽  
Skin Disease ◽  
Holistic Approach ◽  
Integrated Approach ◽  
Current Evidence ◽  
Holistic Approaches ◽  
Disease Therapy ◽  
The Future ◽  
Skin Conditions

This article is a review of current evidence to both support and refute holistic approaches to dermatological cases, including analysis of data linked to psychodermatology, psychosocial and lifestyle influences. A case for taking an integrated approach adjuvant to traditional medicine in skin disease therapy, how this could save time, money and reduce pressure on resources will be discussed. Overall, the research is promising; however, there are gaps in knowledge and there is a need for long-term, larger scale studies in the future. Also, an improved understanding of the processes that lead to inflammatory cutaneous diseases in the future will enable practitioners to make better treatment choices.

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