Danggui-Shaoyao-San Improves Gut Microbia Dysbiosis and Hepatic Lipid Homeostasis in Fructose-Fed Rats

Metabolic syndrome (MetS) is a pathological state of many abnormal metabolic sections. These abnormalities are closely related to diabetes, heart pathologies and other vascular diseases. Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine formula that has been used as a therapy for Alzheimer’s disease. DSS has rarely been reported in the application of MetS and its mechanism of how it improves gut microbia dysbiosis and hepatic lipid homeostasis. In this study, three extracts of DSS were obtained using water, 50% methanol in water and methanol as extracting solvents. Their chemical substances were analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass (UPLC-Q/TOF-MS). Pharmacodynamic effect of the extracts were evaluated by comparison of biochemical factors, 16S rRNA sequencing test for gut microbiota analysis, as well as metabonomic and transcriptomic assessments on liver tissues from fructose-fed rats. This study aimed at investigating DSS’s mechanism of regulating blood lipid, anti-inflammation and reducing blood glucose. The results showed that the 50% methanol extract (HME) was more effective. It was worth noting that hydroxysteroid 17β-dehydrogenase 13 (HSD17β13) as a critical element of increasing blood lipid biomarker-triglyceride (TG), was decreased markedly by DSS. The influence from upgraded hydroxysteroid 17β-dehydrogenase 7 (HSD17β7) may be stronger than that from downgraded Lactobacillus in the aspect of regulating back blood lipid biomarker-total cholesterol (TC). The differential down-regulation of tumornecrosis factor alpha (TNF-α) and the significant up-regulation of Akkermansia showed the effective effect of anti-inflammation by DSS. The declining glycine and alanine induced the lowering glucose and lactate. It demonstrated that DSS slowed down the reaction of gluconeogenesis to reduce the blood glucose. The results demonstrated that DSS improved pathological symptoms of MetS and some special biochemical factors in three aspects by better regulating intestinal floras and improving hepatic gene expressions and metabolites.

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Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice

Endocrinology ◽

10.1210/en.2011-1527 ◽

2012 ◽

Vol 153 (2) ◽

pp. 631-646 ◽

Cited By ~ 88

Author(s):

Kebin Zhang ◽

Ling Li ◽

Yajuan Qi ◽

Xiaoping Zhu ◽

Boyi Gan ◽

...

Keyword(s):

Transcription Factors ◽

Blood Glucose ◽

Hepatic Glucose Production ◽

Elevated Serum ◽

Serum Triglyceride ◽

Lipid Homeostasis ◽

Hepatic Lipid ◽

Glucose And Lipid Homeostasis

Dysregulation of blood glucose and triglycerides are the major characteristics of type 2 diabetes mellitus. We sought to identify the mechanisms regulating blood glucose and lipid homeostasis. Cell-based studies established that the Foxo forkhead transcription factors Forkhead box O (Foxo)-1, Foxo3, and Foxo4 are inactivated by insulin via a phosphatidylinositol 3-kinase/Akt-dependent pathway, but the role of Foxo transcription factors in the liver in regulating nutrient metabolism is incompletely understood. In this study, we used the Cre/LoxP genetic approach to delete the Foxo1, Foxo3, and Foxo4 genes individually or a combination of two or all in the liver of lean or db/db mice and assessed the role of Foxo inactivation in regulating glucose and lipid homeostasis in vivo. In the lean mice or db/db mice, hepatic deletion of Foxo1, rather than Foxo3 or Foxo4, caused a modest reduction in blood glucose concentrations and barely affected lipid homeostasis. Combined deletion of Foxo1 and Foxo3 decreased blood glucose levels, elevated serum triglyceride and cholesterol concentrations, and increased hepatic lipid secretion and caused hepatosteatosis. Analysis of the liver transcripts established a prominent role of Foxo1 in regulating gene expression of gluconeogenic enzymes and Foxo3 in the expression of lipogenic enzymes. Our findings indicate that Foxo1 and Foxo3 inactivation serves as a potential mechanism by which insulin reduces hepatic glucose production and increases hepatic lipid synthesis and secretion in healthy and diabetic states.

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Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice

Chemico-Biological Interactions ◽

10.1016/j.cbi.2010.05.006 ◽

2010 ◽

Vol 186 (3) ◽

pp. 316-322 ◽

Cited By ~ 89

Author(s):

Myoung-Nam Woo ◽

Seon-Min Jeon ◽

Hye-Jin Kim ◽

Mi-Kyung Lee ◽

Su-Kyung Shin ◽

...

Keyword(s):

Lipid Metabolism ◽

Blood Glucose ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

High Fat ◽

Hepatic Lipid Metabolism ◽

Hepatic Lipid

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The role of small heterodimer partner in hepatic lipid homeostasis

Annals of Hepatology ◽

10.1016/s1665-2681(19)30794-x ◽

2015 ◽

Vol 14 (2) ◽

pp. 286-287 ◽

Cited By ~ 2

Author(s):

Beatriz Barranco-Fragoso ◽

Paloma Almeda-Valdes ◽

Nancy Aguilar-Olivos ◽

Nahum Méndez-Sánchez

Keyword(s):

Lipid Homeostasis ◽

Hepatic Lipid ◽

Small Heterodimer Partner

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LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity

JCI Insight ◽

10.1172/jci.insight.96151 ◽

2018 ◽

Vol 3 (5) ◽

Cited By ~ 14

Author(s):

Diego A. Miranda ◽

William C. Krause ◽

Amaury Cazenave-Gassiot ◽

Miyuki Suzawa ◽

Hazel Escusa ◽

...

Keyword(s):

Lipid Homeostasis ◽

Hepatic Lipid

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ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-5-29-33 ◽

2013 ◽

Vol 12 (5) ◽

pp. 29-33

Author(s):

S. A. Matveeva

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipoprotein Cholesterol ◽

Blood Lipid Profile ◽

Glucose Levels ◽

Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.

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The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

Nutrients ◽

10.3390/nu14010175 ◽

2021 ◽

Vol 14 (1) ◽

pp. 175

Author(s):

Dana Hasan Alkhatib ◽

Abdul Jaleel ◽

Maryam Naveed Muhammad Tariq ◽

Jack Feehan ◽

Vasso Apostolopoulos ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Dietary Supplements ◽

Bioactive Compounds ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Preventive Measure ◽

Blood Lipid ◽

Lifestyle Changes

Metabolic syndrome (MetS) is a combination of physiologically dysregulated parameters that can include elevated fasting blood glucose, high blood pressure, central obesity, increased triglyceride levels, insulin resistance, diabetes, elevated low density lipoprotein levels, and reduced high density lipoprotein levels in the blood. Effective clinical management of MetS is critical as it is strongly associated with long lasting and fatal complications in patients. Alongside standard care of lifestyle changes and medication, dietary supplements derived from herbal resources could be an alternative therapeutic strategy that is safe, efficient, culturally acceptable, and has few side effects. Of the dietary supplements, spicy foods have always been considered a great source of functional bioactive compounds. Herbal therapy is broadly used in many countries as a treatment or as a preventive measure in the management of MetS risk factors, including blood glucose, blood pressure, and blood lipid levels. Herein, an attempt is made to evaluate the recent studies in the management of MetS with herbal alternatives, and to explore the possibility of their use as therapeutic treatments or supplements.

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Serum apolipoprotein A-1 is related to inflammatory factors in the acute phase of gout

10.21203/rs.3.rs-80620/v1 ◽

2020 ◽

Author(s):

Baoyu Zhang ◽

Yuan Wang ◽

Xiaoxia Jia ◽

Lin Mu ◽

Xiaobo Wang

Keyword(s):

Uric Acid ◽

Blood Glucose ◽

Acid Level ◽

Serum Uric Acid Level ◽

Blood Lipid ◽

Inflammatory Factors ◽

Control Group ◽

Apolipoprotein A ◽

Increase Blood Glucose ◽

Liver And Kidney

Abstract BACKGROUNDTo observe the correlation between serum apolipoprotein A-1(apoA-1) and inflammatory factors in patients with gouty arthritis. METHODSFrom February to September 2020, 97 patients with gout (gout group) and 70 healthy controls (control group) were selected as the study subjects，who were admitted to the outpatient department of Beijing lu he hospital affiliated to capital medical university.97 patients in the gout group were in the acute phase. Serum concentrations of apoA-1, NLRP3 inflammasome （NACHT-LRR-PYD protein 3,NLRP3), interleukin-1 (IL-1) and interleukin-9 (IL-9) were detected. The correlation of serum apoA-1 concentration, gout related inflammatory factors (NLRP3, IL-1 beta, IL-9) and other clinical and laboratory indicators was analyzed. RESULTSThe serum apoA-1 concentration in the gout group was lower than that in the control group (P<0.05). With the increase of serum uric acid level, serum apoA-1 concentration decreased（R2=-0.3160，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc, and the correlation remained（OR=-3.36，P<0.05）. With the increase of serum IL-1 beta concentration, serum apoA-1 concentration decreased（R2=-0.3993，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc., and the correlation remained（OR=-2.95，P<0.05）. CONCLUSIONSIn the acute stage of gout, as the serum uric acid level increases, the serum IL-1β concentration increases and the apoA-1 concentration gradually decreases, which may indicate that apoA-1 participates in the inflammatory response of gout to a certain extent.

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The effect of concurrent aerobic-resistance training on thyroid hormones, blood glucose hemostasis, and blood lipid indices in overweight girls with hypothyroidism

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2019-0031 ◽

2019 ◽

Vol 40 (3) ◽

Cited By ~ 1

Author(s):

Sahar Mohammadi Sefat ◽

Ramin Shabani ◽

Marzieh Nazari

Keyword(s):

Blood Glucose ◽

Resistance Training ◽

Blood Sugar ◽

Adolescent Girls ◽

Blood Lipid ◽

T Test ◽

Model Assessment ◽

Fat Percentage ◽

Significant Difference ◽

Experimental Group

Abstract Background The present study aimed to explore the effect of 8 weeks of concurrent aerobic-resistance training on thyroid stimulating hormone (TSH), thyroxine (T4), blood lipid profile, and blood glucose hemostasis in adolescent girls with hypothyroidism. Materials and methods In this clinical trial, 20 adolescent girls with hypothyroidism [age: 12.10 ± 1.94 years; body mass index (BMI): 25.25 ± 2.91 kg/m2] were selected and randomly assigned to experimental and control groups. The experimental group was treated with 8 weeks of concurrent aerobic [60–80% heart rate reserve (HHR)] and resistance (40–65% of 1RM) training. Blood was sampled before and after training. Data were analyzed using a pairwise t-test and an independent t-test (α < 0.05). Results Within-group comparison revealed significant decline of body index, BMI, fat percentage, fasting blood sugar, and homeostatic model assessment (HOMA) in the experimental group (p = 0.002, p = 0.001, p = 0.001, p = 0.03, and p = 0.02, respectively). Also, inter-group comparisons indicated significant differences in weight, BMI, fat percentage and HOMA (p = 0.001). But, no significant difference was observed in the blood sugar index (p > 0.05). Conclusion A short-term period of concurrent aerobic-resistance training may improve blood glucose hemostasis and body composition of adolescent girls with hypothyroidism. However, further research is necessary.

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