Serum apolipoprotein A-1 is related to inflammatory factors in the acute phase of gout

2020 ◽  
Author(s):  
Baoyu Zhang ◽  
Yuan Wang ◽  
Xiaoxia Jia ◽  
Lin Mu ◽  
Xiaobo Wang
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Blood Lipid ◽  
Inflammatory Factors ◽  
Control Group ◽  
Apolipoprotein A ◽  
Increase Blood Glucose ◽  
Liver And Kidney

Abstract BACKGROUNDTo observe the correlation between serum apolipoprotein A-1(apoA-1) and inflammatory factors in patients with gouty arthritis. METHODSFrom February to September 2020, 97 patients with gout (gout group) and 70 healthy controls (control group) were selected as the study subjects，who were admitted to the outpatient department of Beijing lu he hospital affiliated to capital medical university.97 patients in the gout group were in the acute phase. Serum concentrations of apoA-1, NLRP3 inflammasome （NACHT-LRR-PYD protein 3,NLRP3), interleukin-1 (IL-1) and interleukin-9 (IL-9) were detected. The correlation of serum apoA-1 concentration, gout related inflammatory factors (NLRP3, IL-1 beta, IL-9) and other clinical and laboratory indicators was analyzed. RESULTSThe serum apoA-1 concentration in the gout group was lower than that in the control group (P<0.05). With the increase of serum uric acid level, serum apoA-1 concentration decreased（R2=-0.3160，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc, and the correlation remained（OR=-3.36，P<0.05）. With the increase of serum IL-1 beta concentration, serum apoA-1 concentration decreased（R2=-0.3993，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc., and the correlation remained（OR=-2.95，P<0.05）. CONCLUSIONSIn the acute stage of gout, as the serum uric acid level increases, the serum IL-1β concentration increases and the apoA-1 concentration gradually decreases, which may indicate that apoA-1 participates in the inflammatory response of gout to a certain extent.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

scholarly journals Evaluating serum uric acid levels in patients with acute myocardial infarction

2020 ◽  
Vol 7 (8) ◽  
pp. 1256
Author(s):  
Piyush Gosar ◽  
Ajay Pal Singh ◽  
Pravi Gosar ◽  
Bhawana Rani
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cardiovascular Morbidity And Mortality ◽  
History Of

Background: Elevated levels of serum uric acid are associated with increased cardiovascular morbidity and mortality. However, this association with cardiovascular diseases is still unclear, and perhaps controversial. The objective of study was to assess the serum uric acid level in patients with Acute Myocardial Infarction (AMI).Methods: Sixty patients with AMI were studied in Department of Medicine/ Department of Cardiology, J.A. Group of Hospitals between 2016 -2018.Details of age, sex, smoking, alcohol consumption and history of ischemic heart disease (IHD) was obtained and recorded. Serum uric acid level was estimated and compared with control group (healthy subjects).Results: Serum uric acid level was significantly higher among AMI patients (6.43±2.60) as compared to control group (4.05±0.95) (p<0.001). Majority (46.7%) of the AMI patients had uric acid level of >7.1 followed by 20% patients who had uric acid level between 4.5-5.9 (p<0.001). Uric acid level was comparable between smoker and non-smokers (p=0.803), alcoholic and non-alcoholic (p=0.086), hypertensive and non-hypertensive (p=0.668), patients with and without diabetes (p=0.278) and patients with a history of IHD and without history of IHD (p=0.403).Conclusions: Serum uric acid may be useful for prognostication among those with pre-existing AMI.

scholarly journals EFFECT OF RED ONION (ALLIUM CEPA VAR. AGGREGATUM G. DON) ON SERUM URIC ACID LEVEL AND TOTAL ANTIOXIDANT STATUS IN NORMAL AND INDUCED HYPERURICEMIC RATS

2018 ◽  
Vol 11 (3) ◽  
pp. 178
Author(s):  
Asmah Rahmat ◽  
Choo Yen Leng ◽  
Fazleen Izzany Abu Bakar ◽  
Mohd Fadzelly Abu Bakar
Keyword(s):  
Uric Acid ◽  
Protective Effect ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Antioxidant Status ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Total Antioxidant Status ◽  
Total Antioxidant ◽  
Liver And Kidney

 Objective: This study aimed to investigate the effect of onion (Allium cepa var. aggregatum G. Don) on serum uric acid level and total antioxidant status of normal and induced hyperuricemic rats.Methods: A total of 36 male Sprague-Dawley rats were divided equally into six groups, and 250 mg/kg of potassium oxonate was injected intraperitoneally on day 1, 3, and 7 to induce hyperuricemia in rats. 7 d consecutively of treatment were given to the rats by oral gavage. Serum uric acid level was measured 2 h after the induction on day 1, 3, 7, and 14. Blood plasma was obtained at day 14 to measure its total antioxidant status. The rats were sacrificed by taking out their liver and kidney for histopathological evaluation.Results: The results showed that onion juice lowered the serum uric acid level in dose-dependent manner. The highest dose (10.5 g/kg/day) appeared to possess the inhibitory effect almost similar to allopurinol. There was an increase in total antioxidant status in a hyperuricemic group treated with onion juice compared to control groups but insignificant. By viewing the histological profile, onion showed to have a protective effect toward the liver damage by hyperuricemia. However, this was not happened in kidney.Conclusion: Onion lowered the serum uric acid level, but its protective effect toward liver and kidney remained ambiguous. Further investigation with the increase of parameters and inclusion of analytical test of bioactive compound in red onion is recommended for the future studies.

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

CORRELATION OF SERUM URIC ACID LEVEL WITH GLYCAEMIC STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS IN DARBHANGA

2021 ◽  
pp. 68-70
Author(s):  
Mritunjay Kumar ◽  
Sheela Kumari ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

Objectives : Our study was to detect the correlation of serum uric acid level with glycaemic status and with lipid prole. And also evaluate the various biochemical parameters, anthropometric measurements, blood pressure, serum uric acid level and associated factors. Methods: A 100 subjects with type 2 diabetes mellitus as a case and 100 subjects with non diabetics as control with age group greater than 40 years were enrolled in this study. A detail history, dietary pattern, clinical examination and relevant investigation were performed. Anthropometric examination like as measurement of BMI, measurement of waist-hip ratio and biochemical investigations like as blood glucose, serum HbA1c estimation, serum uric acid and serum lipid prole were performed to all subjects. Results : Data was analyzed by using SPSS software. Mean±SD was observed. P value was taken ≤0.05 for signicant differences. Conclusion : Type 2 diabetes mellitus patients is a strong negative correlation between blood glucose level and serum uric acid level. So that serum uric acid can be used as an important parameter to assess future cardiovascular risk in a type 2 diabetes mellitus patient.

scholarly journals Study of the Treatment Effects of Compound Tufuling Granules in Hyperuricemic Rats Using Serum Metabolomics

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Peng Wu ◽  
Jing Li ◽  
Xianxian Zhang ◽  
Fuling Zeng ◽  
Yingwan Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Rat Model ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Inflammatory Factors ◽  
Metabolic Profiles ◽  
Group Model ◽  
Model Group

The study aimed to investigate the mechanism of the effect of Compound Tufuling Granules (CTG) to lower the serum uric acid level in a rat model of hyperuricemia. The rat model was established by administering hypoxanthine through oral gavage and potassium oxonate through intraperitoneal injection. Rats were divided into the normal group, model group, CTG group, and allopurinol group. Serum uric acid, creatinine, urea nitrogen, and inflammatory cytokine levels were determined in each group. In the model group, ultrahigh performance liquid chromatography-mass spectrometry was used to analyze the metabolic profiles and delineate the action mechanism of CTG; in addition, the orthogonal projection method was used to perform latent structure-discrimination analysis to screen the related metabolites. The results indicated significant differences in the metabolic profiles between the model and normal groups. A total of seven related metabolites were identified through screening in the model group, mainly related to the pathways of bile secretion, pyrimidine, purine, and phenylalanine metabolism, pantothenate and CoA biosynthesis, and pentose and glucuronate interconversions; these related pathways were reversed in the CTG group. In the metabolic networks, uracil and acetyl-coenzyme A were the nodal molecules. In addition, the test results of the evaluation of serum biochemical and inflammatory factors confirmed that CTG had significant effect in reducing the levels of serum uric acid and protecting renal function. These results confirmed that CTG primarily regulated the recruitment of nodal molecules to achieve anti-inflammatory effects, reduced uric acid level, and renal protection.

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

scholarly journals The Correlation Analysis Between the Blood Lipids, Glycosylated Protein Level and Inflammatory Factors of Pregnant Women with GDM During Pregnancy and the Weight of Newborn

2021 ◽  
Author(s):  
Changhua Hu ◽  
Lirong Wu ◽  
Juan Fang
Keyword(s):  
Blood Glucose ◽  
Pregnant Women ◽  
Research Group ◽  
Blood Lipids ◽  
Fasting Blood Glucose ◽  
Blood Lipid ◽  
Adverse Outcomes ◽  
Inflammatory Factors ◽  
Control Group ◽  
Inflammatory Factor

Abstract The study was carried to explore the correlation between blood lipids, blood glucose levels, inflammatory factor and weight of newborn, to provide reference for control of blood glucose in pregnant women with gestational diabetes mellitus (GDM) and early screening of macrosomia. Fifty pregnant women (give birth to newborn) with GDM were selected as research group, and 55 normal pregnant women (give birth to newborn) as control group. Blood lipid levels of TC, TG, HDL-C, LDL-C, the fasting blood glucose (FPG), HbAlc, glycosylated albumin (GA), and expression of inflammatory factor TLR4 of pregnant women in the two groups were monitored. The levels of TG, FPG, HbA1c and GA in pregnant women, the levels of TLR4 in cord blood of newborn, the relative expression of TLR4 protein and TLR4mRNA in the placenta were higher than in control group, and level of HDL-C was lower than the control group. The levels of TC and LDL-C of pregnant women were higher than in control group. Weight of newborn was positively correlated with these all except HDL-C levels (negatively correlated) and no correlation was found with TC and LDL-C. The weight of newborn and incidence of macrosomia in research group were higher compared to control group, and scores of newborns at 1 min and 5 min were lower compared to control group. The results revealed that strengthening the detection of blood lipid and blood glucose during pregnancy can prevent adverse outcomes such as giant babies and improve the quality of birth.

scholarly journals STUDY OF SERUM ADENOSINE DEAMINASE ACTIVITY IN TYPE 2 DIABETES MELLITUS AND ITS CORRELATION WITH SERUM URIC ACID AND GLYCATED HEMOGLOBIN.

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Supriya Singh ◽  
Arpita Suri ◽  
Maheep Sinha ◽  
Bushra Fiza
Keyword(s):  
Uric Acid ◽  
Glycemic Control ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Glycated Hemoglobin ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Good Glycemic Control

Background & Objectives: Diabetes Mellitus (DM) is a metabolic disorder characterized by an absolute or relative deficiency of insulin and insulin resistance or both. Adenosine deaminase (ADA) is an enzyme, that catalyses the irreversible hydrolytic deamination of adenosine to uric acid. The present study was undertaken to evaluate the level of serum ADA, serum uric acid and correlate it with Blood Sugar Fasting and Glycated Hemoglobin in patients of Type 2 DM. Material and Methods: A total of 100 patients diagnosed for type 2 DM visiting the Outpatient Department of General Medicine and Endocrinology at Mahatma Gandhi Medical College & Hospital, Jaipur were enrolled for the study based on predefined inclusion and exclusion criteria. Blood samples were collected for all enrolled patients and analysed for the investigations like Serum BSF, HbA1c Serum ADA and serum Uric acid. Results: In the study, all the parameters BSF, mean HbA1c, serum ADA and serum uric acid level were significantly higher in diabetic group in comparison to control group (p=0.000). The diabetic group were further subdivided on the basis of HbA1c levels, HbA1c ≤ 8% as good glycemic control and HbA1c > 8% as poor glycemic control. BSF, mean HbA1c, serum ADA and serum uric acid levels were observed to be significantly higher in poor glycemic control group as compared to that of good glycemic control. A significant positive correlation between S. ADA and HbA1c activity (r= 0.388) and between S. ADA and serum uric acid was also seen (r=0.252). Conclusion: From the present study, it is concluded that there is an increase in serum ADA levels and serum uric acid level with increase in Glycated hemoglobin levels (HbA1c > 8%). Increase in serum ADA level was found to be associated with increase in Glycated hemoglobin levels which may play an important role in determining the glycemic status in diabetes. Further, increase in serum uric acid in levels could be due to increased activity of ADA, an enzyme that convert adenosine to uric acid. Hence, by analysing ADA levels and uric acid level in diabetes, glycemic control and insulin resistance can be assessed.  

scholarly journals Association of Serum Uric Acid level in Patients with Alzheimer’s Disease

2017 ◽  
Vol 33 (2) ◽  
pp. 83-88
Author(s):  
Mohammad Saifullah Ahtesam ◽  
Md Ahsan Habib ◽  
Md Rafiqul Islam ◽  
Md Rezaul Karim Khan ◽  
Hasan Zahidur Rahman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Control Group

Background: Alzheimer’s disease is the most common cause of dementia. Uric acid is the end product of purine metabolism in humans and acts as a natural antioxidant, accounting up to 60% of the free radical scavenging activity in human blood to prevent free radicals induced oxidative cell injury. This study aimed to explore the association between serum uric acid level and cognitive impairment of Alzheimer’s disease patients compared to those of the non-demented age and sex matched controls. Methods: This case control study was carried out in the department of neurology, BSMMU, Dhaka. Total 116 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 58 were grouped as case and rest 58 were control. All blood samples for serum uric acid were measured in the Biochemistry lab, Department of Biochemistry, BSMMU, Dhaka. Results: A signiûcant reduction of serum uric acid levels in the AD group was found compared to those of the control group (4.35±1.59 Vs 6.89±1.68) which was statistically significant (p<0.001). We also found a positive correlation between serum uric acid levels with severity of Alzheimer’s disease (rp = 0.633, P<0.001). Among demographic variables educational qualification was statistically significant (p=0.006) in AD patients. Conclusion: This study showed that oxidative injuries have an important role in the pathogenesis of AD. Higher levels of uric acid are associated with a decreased risk of dementia and better cognitive function later in life. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 83-88

Sign in / Sign up

Export Citation Format

Share Document