scholarly journals Corrigendum: Interactions Between Ephedra sinica and Prunus armeniaca: From Stereoselectivity to Deamination as a Metabolic Detoxification Mechanism of Amygdalin

2022 ◽  
Vol 12 ◽  
Author(s):  
Yan Qin ◽  
Shanshan Wang ◽  
Qiuyu Wen ◽  
Quan Xia ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Prunus Armeniaca ◽  
Ephedra Sinica ◽  
Detoxification Mechanism ◽  
Metabolic Detoxification

scholarly journals Interactions Between Ephedra sinica and Prunus armeniaca: From Stereoselectivity to Deamination as a Metabolic Detoxification Mechanism of Amygdalin

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Qin ◽  
Shanshan Wang ◽  
Qiuyu Wen ◽  
Quan Xia ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Rat Liver ◽  
Metabolic Pathways ◽  
Liver Microsomes ◽  
Prunus Armeniaca ◽  
Rat Liver Microsomes ◽  
Microbial Enzymes ◽  
Ephedra Sinica ◽  
Metabolic Detoxification ◽  
Detoxification Pathway

Mahuang–Xingren (MX, Ephedra sinica Stapf-Prunus armeniaca L.) is a classic herb pair used in traditional Chinese medicine. This combined preparation reduces the toxicity of Xingren through the stereoselective metabolism of its main active ingredient amygdalin. However, whether stereoselectivity is important in the pharmacokinetic properties of amygdalin either in the traditional decoction or in the dispensing granules is unclear. Amygdalin is hydrolyzed to its metabolite, prunasin, which produces hydrogen cyanide by degradation of the cyano group. A comprehensive study of the metabolic pathway of amygdalin is essential to better understand the detoxification process. In this article, the potential detoxification pathway of MX is further discussed with regard to herb interactions. In this study, the pharmacokinetic parameters and metabolism of amygdalin and prunasin were investigated by comparing the traditional decoction and the dispensing granule preparations. In addition, several potential metabolites were characterized in an incubation system with rat liver microsomes or gut microbial enzymes. The combination of Xingren with Mahuang reduces exposure to D-amygdalin in vivo and contributes to its detoxification, a process that can be further facilitated in the traditional decoction. From the in vitro co-incubation model, 15 metabolites were identified and classified into cyanogenesis and non-cyanogenesis metabolic pathways, and of these, 10 metabolites were described for the first time. The level of detoxified metabolites in the MX traditional decoction was higher than that in the dispensing granules. The metabolism of amygdalin by the gut microbial enzymes occurred more rapidly than that by the rat liver microsomes. These results indicated that combined boiling both herbs during the preparation of the traditional decoction may induce several chemical changes that will influence drug metabolism in vivo. The gut microbiota may play a critical role in amygdalin metabolism. In conclusion, detoxification of MX may result 1) during the preparation of the decoction, in the boiling phase, and 2) from the metabolic pathways activated in vivo. Stereoselective pharmacokinetics and deamination metabolism have been proposed as the detoxification pathway underlying the compatibility of MX. Metabolic detoxification of amygdalin was quite different between the two combinations, which indicates that the MX decoctions should not be completely replaced by their dispensing granules.

Metabolic Detoxification: Mechanism of Insect Resistance to Plant Psoralens

Science ◽  
1983 ◽  
Vol 221 (4608) ◽  
pp. 374-376 ◽  
Author(s):  
G. W. IVIE ◽  
D. L. BULL ◽  
R. C. BEIER ◽  
N. W. PRYOR ◽  
E. H. OERTLI
Keyword(s):  
Insect Resistance ◽  
Detoxification Mechanism ◽  
Metabolic Detoxification

Evaluation of Resistance to Different Insecticides and Metabolic Detoxification Mechanism by Use of Synergist in the Common Bed Bug (Heteroptera: Cimicidae)

2019 ◽  
Vol 56 (5) ◽  
pp. 1324-1330 ◽  
Author(s):  
Mariano Cáceres ◽  
Pablo L Santo-Orihuela ◽  
Claudia V Vassena
Keyword(s):  
Resistance Mechanisms ◽  
Economic Costs ◽  
Bed Bugs ◽  
Monooxygenase Activity ◽  
Bed Bug ◽  
Resistant Phenotype ◽  
Detoxification Mechanism ◽  
Metabolic Detoxification ◽  
The Common ◽  
Synergism Effect

AbstractBed bugs have become a common urban pest with consequences on human health and economic costs to the hotel and tourism sectors. Insecticide resistance is considered an important factor in the current bed bug resurgence, and multiple resistance mechanisms could be working in the resistant bed bug populations. In the present study, we determined the resistance profile to four insecticides with a different mode of action in Cimex lectularius L. (Heteroptera: Cimicidae) field-collected colonies from Argentina. Furthermore, the synergism effect of piperonyl butoxide (PBO) with deltamethrin was investigated to explore the contribution of detoxification metabolism to resistance. Our results showed that most of the field-collected colonies are extremely resistant to deltamethrin and propoxur, much more than to azametiphos and imidacloprid. The differences in resistance ratios among field-collected colonies could be associated with different modes of action of insecticides used in control pest and the mechanisms involved in the resistance. PBO pretreatment led to a significantly decreased RR in pyrethroid-resistant colonies, suggesting an upturn of monooxygenase activity for deltamethrin detoxification. However, the high RR detected could involve other mechanisms as part of the whole resistant phenotype in colonies of C. lectularius resistant to pyrethroids.

PHYTOMONITORING AS A METOD OF THE ASSESSMENT OF ATMOSPHERIC AIR POLLUTION BY URBAN ENVIRONMENT BY FINE DUST

2019 ◽  
pp. 42-53
Author(s):  
Irina Glinyanova ◽  
Valery Azarov ◽  
Valery Fomichev
Keyword(s):  
Urban Environment ◽  
Urban Areas ◽  
Fine Particles ◽  
Prunus Armeniaca ◽  
Dust Particles ◽  
Fine Dust ◽  
Control Zone ◽  
Atmospheric Air ◽  
Random Functions ◽  
The City

Fine dust: (PM2.5, PM10) is a priority pollutant that contributes to the development of numerous dis-eases in urban areas. The purpose of this scientific work is to study the dispersed composition of dust parti-cles on the leaves of apricot trees (Prúnus armeníaca) in the residential zone of Volgograd. The novelty of the work lies in the study of the dispersed composition of dust particles on the leaves of apricot trees (Prúnus armeníaca) in the residential zone in the city of Volgograd near the construction industry enterprise, me-chanical engineering, leather production and railway transport line in comparison with the conditionally clean (control) zone of the SNT “Orocenets” ”(Sovetsky District, Volgograd) from the standpoint of random functions expressed by integral distribution curves of the mass of particles over their equivalent diameters. As a result of the research, the dispersed composition of dust on the leaves of apricot trees (Prúnus ar-meníaca) in the residential area of Volgograd was revealed. Fine particles were found: PM2.5, PM10 in each of the studied points, which by their values, both in their number and mass fraction, significantly exceed the data on fine dust in a conditionally clean area (control) in the SNT “Oroshanets” (Sovetsky district Volgo-grad), which creates certain environmental risks for local residents. The dispersed analysis of particles from the standpoint of random functions in the future will allow with a sufficiently high degree of accuracy to pre-dict the dust content of urban atmospheric air in the range of monthly and / or seasonal average values compared to the traditional measurement of fine dust concentration in atmospheric air of the urban environ-ment as the maximum single or daily average. At the same time, further studies of dust on the leaves of plants in an urban environment, namely, the study of the density of its sedimentation, will also reveal a group of ur-ban plants that are best suited to retain PM2.5 and PM10 on leaf plates in this region, which can significantly increase the quality of the atmospheric air of the urban environment and be of a recommendatory nature for the state-owned landscaping services of the city of Volgograd when improving the green areas of a megacity.

scholarly journals Effect of Methyl Jasmonate, Cytokinin, and Lavender Oil on Antioxidant Enzyme System of Apricot Fruit (Prunus armeniaca L.)

2021 ◽  
Vol 13 (15) ◽  
pp. 8565
Author(s):  
Seyda Cavusoglu ◽  
Nurettin Yilmaz ◽  
Firat Islek ◽  
Onur Tekin ◽  
Halil Ibrahim Sagbas ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Methyl Jasmonate ◽  
Prunus Armeniaca ◽  
Lavender Oil ◽  
Defense Systems ◽  
Antioxidant Enzyme System ◽  
Prunus Armeniaca L ◽  
Antioxidant Defense Systems ◽  
And Storage

Various treatments are carried out in order to extend both the shelf life and storage life of fresh fruit and vegetables after harvest and among them non-toxic for humans, environmentally and economically friendly alternative treatments are gained more importance. In the current study, methyl jasmonate (MeJA), cytokinin, and lavender oil which are eco-friendly and safe for human health were applied on apricot fruit. The treated fruit were stored at 0 °C and 90–95% relative humidity for 25 days and catalase (CAT), superoxide dismutase (SOD), and ascorbate peroxidase (APX) enzyme activities and lipid peroxidation of apricots after treatments were studied. According to the findings obtained from the study, it was observed that 5 ppm cytokinin and 1000 ppm lavender oil treatments of apricot fruit gave better APX and CAT enzyme activity, respectively. In addition, better SOD enzyme activity in fruit was obtained with MeJA+lavender oil treatments. As a result, it can be emphasized that the product quality of apricot fruit is preserved as both the eco-friendly application of MeJA, cytokinin, and lavender oil separately from each other and the treatment of combinations between these compounds activate the enzymatic antioxidant defense systems of apricot fruit after harvest.

Analysis of phenotypic diversity of apricot (Prunus armeniaca L.) accessions from Jammu and Kashmir, India

2021 ◽  
pp. 1-13
Author(s):  
Showkat A. Zargar ◽  
Aijaz A. Wani ◽  
M. I. S. Saggoo
Keyword(s):  
Fruit Quality ◽  
Quantitative Traits ◽  
Fruit Weight ◽  
Kernel Weight ◽  
Prunus Armeniaca ◽  
Quality Traits ◽  
Jammu And Kashmir ◽  
Fruit Length ◽  
Upgma Dendrogram ◽  
Fruit Quality Traits

Abstract Apricot (Prunus armeniaca L.) is a world-wide highly appreciated fruit, with its attractive colour, soft texture and typical flavour. In the current investigation, 68 apricot accessions collected from Jammu and Kashmir, India were analysed to determine the measure of variation using 12 qualitative and 16 quantitative traits with an aim to identify superior apricot accessions with excellent fruit quality traits. High phenotypic variability was observed among the studied apricot accessions with significant differences among most of the qualitative and quantitative traits. Fruit-related characteristics including fruit weight, fruit length, fruit ratio, fruit firmness, fruit shape, fruit suture, stone weight, kernel weight and stone shape were the most diverse with a high coefficient of variation (>30%). One way analysis of variance showed significant differences (P < 0.0001) among all the quantitative traits. Significant positive and negative correlations were observed between all the agronomically important fruit quality traits. The principal component analysis (PCA) revealed that 75.34% of the variability was defined by the first eight components. The unweighted pair group method with arithmetic mean (UPGMA) dendrogram, based on all traits measured grouped the accessions into two main clusters with several sub-clusters. Both UPGMA dendrogram and PCA scatter plot formed a cluster of 14 accessions, having the highest values regarding most important fruit quality traits such as fruit weight, fruit length and width, fruit ratio, stone weight and kernel weight can be treated as potentially superior accessions. These accessions can be used directly for cultivation and in future apricot breeding programmes. The present findings are promising for genetic resource management, cultivar improvement and commercial applications of apricot in Jammu and Kashmir, India.

Investigating the effect of oxalic acid and salicylic acid treatments on the post-harvest life of temperate grown apricot varieties (Prunus armeniaca) during controlled atmosphere storage

2021 ◽  
pp. 108201322110320
Author(s):  
Mariya Batool ◽  
Omar Bashir ◽  
Tawheed Amin ◽  
Sajad Mohd Wani ◽  
FA Masoodi ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Oxalic Acid ◽  
Chilling Injury ◽  
Quality Attributes ◽  
Prunus Armeniaca ◽  
Soluble Solids ◽  
Carotenoid Content ◽  
Total Phenolic ◽  
Controlled Atmosphere ◽  
Injury Index

This study aimed at investigating the influence of different postharvest treatments with oxalic acid (OA) and salicylic acid (SA) on quality attributes and postharvest shelf life of temperate grown apricot varieties stored under controlled atmosphere (CA) storage conditions. After each treatment was given, the samples were stored in CA store maintained at a temperature of 0 °C, 90 ± 5% relative humidity, 5% oxygen and 15% carbon dioxide for 30 days. Results indicated that both OA and SA treatments significantly (p ≤ 0.05) retained total soluble solids, titratable acidity, color profile, ascorbic acid content and total phenolic content of apricot varieties and had a positive effect on antioxidant activity and texture of samples compared to control. However, carotenoid content was found to be higher in control. Both the treatments reduced chilling injury index, weight loss and decay percentage of samples. Moreover, it was found that SA treatment was the most effective treatment in maintaining visual color of apricots while OA maintained fruit firmness and effectively decreased the decay percentage and chilling injury index of apricot varieties. In conclusion, it was found that both OA and SA have the potential to extend storage life of apricots and maintain quality attributes of the crop during CA storage.

scholarly journals Diversity and Relationships among Neglected Apricot (Prunus armeniaca L.) Landraces Using Morphological Traits and SSR Markers: Implications for Agro-Biodiversity Conservation

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1341
Author(s):  
Giandomenico Corrado ◽  
Marcello Forlani ◽  
Rosa Rao ◽  
Boris Basile
Keyword(s):  
Prunus Armeniaca ◽  
Ex Situ ◽  
Skin Colour ◽  
Maintenance Breeding ◽  
Prunus Armeniaca L ◽  
Ex Situ Collection ◽  
Loss Of Diversity ◽  
Ssrs Markers ◽  
On Farm ◽  
Simple Sequence

Apricot (Prunus armeniaca L.) is an economically important tree species globally cultivated in temperate areas. Italy has an ample number of traditional varieties, but numerous landraces are abandoned and at risk of extinction because of increasing urbanization, agricultural intensification, and varietal renewal. In this work, we investigated the morphological and genetic diversity present in an ex-situ collection of 28 neglected varieties belonging to the so-called “Vesuvian apricot”. Our aim was to understand the level of diversity and the possible link between the promotion of specific fruit types (e.g., by public policies) and the intraspecific variation in apricot. The combination of five continuous and seven categorical traits allowed us to phenotypically distinguish the varieties; while fruit quality-related attributes displayed high variation, both apricot size and skin colour were more uniform. The twelve fluorescent-based Simple Sequence Repeats (SSRs) markers identified cultivar-specific molecular profiles and revealed a high molecular diversity, which poorly correlated with that described by the morphological analysis. Our results highlighted the complementary information provided by the two sets of descriptors and that DNA markers are necessary to separate morphologically related apricot landraces. The observed morphological and genetic differences suggest a loss of diversity influenced by maintenance breeding of specific pomological traits (e.g., skin colour and size). Finally, our study provided evidence to recommend complementary strategies to avoid the loss of diversity in apricot. Actions should pivot on both the promotion of easily identified premium products and more inclusive biodiversity-centred on-farm strategies.

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