scholarly journals Donor Age and Red Cell Age Contribute to the Variance in Lorrca Indices in Healthy Donors for Next Generation Ektacytometry: A Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ankie M. van Cromvoirt ◽  
Simone Fenk ◽  
Ario Sadafi ◽  
Elizaveta V. Melnikova ◽  
Denis A. Lagutkin ◽  
...  
Keyword(s):  
Pilot Study ◽  
Red Cell ◽  
Projected Area ◽  
Density Fractions ◽  
Mild Disease ◽  
Age Related ◽  
Healthy Donors ◽  
And Gender ◽  
Multi Center Study ◽  
The Impact

The ability of red blood cells (RBCs) to transport gases, their lifespan as well as their rheological properties invariably depend on the deformability, hydration, and membrane stability of these cells, which can be measured by Laser optical rotational red cell analyser (Lorrca® Maxsis, RR Mechatronics). The osmoscan mode of Lorrca is currently used in diagnosis of rare anemias in clinical laboratories. However, a broad range of normal values for healthy subjects reduces the sensitivity of this method for diagnosis of mild disease phenotype. In this pilot study, we explored the impact of age and gender of 45 healthy donors, as well as RBC age on the Lorrca indices. Whereas gender did not affect the Lorrca indices in our study, the age donors had a profound effect on the O_hyper parameter. To study the impact of RBC age on the osmoscan parameters, we have isolated low (L)-, medium (M)-, or high (H)- density fractions enriched with young, mature, and senescent RBCs, respectively, and evaluated the influence of RBC age-related properties, such as density, morphology, and redox state, on the osmoscan indices. As before, O_hyper was the most sensitive parameter, dropping markedly with an increase in RBC density and age. Senescence was associated with a decrease in deformability (EI_max) and tolerability to low and high osmolatites (Area). L-fraction was enriched with reticulocytes and cells with high projected area and EMA staining, but also contained a small number of cells small in projected area and most likely, terminally senescent. L-fraction was on average slightly less deformable than mature cells. The cells from the L-fraction produced more oxidants and NO than all other fractions. However, RBCs from the L-fraction contained maximal levels of reduced thiols compared to other fractions. Our study suggests that reference values for O_hyper should be age-stratified, and, most probably, corrected for the average RBC age. Further multi-center study is required to validate these suggestions before implementing them into clinical practice.

scholarly journals Gender and generation in household labor supply in Jordan [Arabic]

2000 ◽  
Author(s):  
Mary Kawar
Keyword(s):  
Labor Supply ◽  
Single Women ◽  
Female Employment ◽  
Related Factors ◽  
Age Related ◽  
Gender And Age ◽  
The Social ◽  
And Gender ◽  
The Impact ◽  
Employment Characteristics

This paper examines gender and age differences in the labor supply of households in Jordan, and the impact of young women’s employment on gender and generation relations. The objective of the study is to address the issues of gender and generation as factors influencing accessibility to labor markets, and to provide a broader understanding of female employment by exploring age-related factors. Empirically, the study looks at the disproportionate workforce participation of young urban single women in Amman, Jordan, and argues that this generation of working women is evidence of a new stage in the lives of Jordanian women: single employed adulthood. It looks at a specific “time” in the social and economic lives of households and individuals. Within this context, the paper constructs a profile of employment characteristics of adult household members to explore the intersecting influences of age and gender and the specific positions of young women. It then addresses how normative gender and generation hierarchies within households respond to these phenomena of young women’s work, their prolonged single status, and their expanding horizons.

scholarly journals Age and Gender Differences in Performance at Cross Triathlon World Championships

2018 ◽  
Vol 25 (3) ◽  
pp. 17-22 ◽  
Author(s):  
Oscar Romero-Ramos ◽  
Emilio Fernández-Rodríguez ◽  
Rafael Merino-Marbán ◽  
Daniel Mayorga-Vega ◽  
Robert Podstawski
Keyword(s):  
Age Groups ◽  
Performance Ratio ◽  
Age Group ◽  
Men And Women ◽  
Race Time ◽  
Age Related ◽  
And Performance ◽  
And Gender ◽  
High Level ◽  
The Impact

Abstract Introduction. Cross triathlon is a sport consisting of three segments: swimming, off-road cycling, and running. Our study analyses the differences in performance between genders and changes in performance in selected age categories at the ITU Cross World Championships held between 2011 and 2016. Material and methods. During this period, a total of 1,933 triathletes were analysed (1,472 men and 461 women). Two-way analyses of variance (ANOVA) were used to examine the impact of sex differences and age-related changes on performance (time, percentage of time, and performance ratio) in swimming, cycling, running, and total race. Results. The age groups with the highest level of participation were persons aged 40-44 and 45-49 years among men and women, respectively. With regards to performance in the different age groups, in men and women, its high level was maintained between 25 and 49 years, and it decreased significantly from the age of 50-54. In men, the best results in cycling and total race time were obtained in the 30-34 age group and in swimming and running in the 40-44 group. Women obtained the best results in running in the 25-29 age group, in cycling in the 30-34 group, and in swimming and total race time in the 35-39 group. Conclusions. The results of the study have confirmed that there is a demand for sports in 40+ age groups. As for performance in the different age groups, it was on a high level between 25 and 49 years and decreased significantly from the age of 50-54 onwards. According to these results, the sports training of these triathletes should be oriented so that they obtain their best results between 30 and 35 years of age.

Similarity of Perceptions of Bereavement Experiences between Widows and Professionals

1991 ◽  
Vol 23 (1) ◽  
pp. 37-51 ◽  
Author(s):  
Shoshanna E. Williams Conway ◽  
Bert Hayslip ◽  
Ruth E. Tandy
Keyword(s):  
Help Seeking ◽  
Negative Impact ◽  
Coping Mechanisms ◽  
Conjugal Bereavement ◽  
Help Seeking Behaviors ◽  
Funeral Directors ◽  
Self Perceptions ◽  
Age Related ◽  
And Gender ◽  
The Impact

Widows and four groups of professionals (clergy, physicians, counselors, and funeral directors) were compared in regards to their perceptions of conjugal bereavement. Results suggested consistent differences between widows' self-perceptions and professionals' views regarding the impact of bereavement and the necessity for adaptative coping mechanisms to deal with loss. Professionals saw bereavement as having a more negative impact and requiring the use of coping skills to a greater extent than did widows. Such differences remained when age at bereavement or length of widowhood were taken into account. Professionals' perceptions of conjugal bereavement were similar to one another. Help-seeking behaviors, age at bereavement, and length of bereavement differentiated widows, while experience in counseling widows failed to separate professionals. Both age-related experiential differences with loss and gender differences in coping with loss may explain these findings. These data underscore the importance of efforts to bring widows and professionals into direct contact with one another in order to lessen misperceptions of conjugal bereavement.

scholarly journals Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Greta Gedvilaite ◽  
Kriste Kaikaryte ◽  
Loresa Kriauciuniene
Keyword(s):  
Macular Degeneration ◽  
Protective Factor ◽  
Protective Role ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Exudative Amd ◽  
Age Related ◽  
Increased Risk ◽  
And Gender ◽  
The Impact

Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls. The genotyping of HTRA1 rs11200638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 was carried out using the RT-PCR method. Results. Our study showed that single-nucleotide polymorphisms rs3793784 and rs11200638 were associated with increased odds of early and exudative AMD, and the variant in KCTD10 (rs56209061) was found to be associated with decreased odds of early and exudative AMD development after adjustments for age and gender in early AMD analysis and after adjustments only for age in exudative AMD. The haplotype containing two minor alleles C-A and the G-A haplotype in rs3793784-rs11200638 were statistically significantly associated with an increased risk of exudative AMD development after adjustment for age, while the G-G haplotype showed a protective role against early and exudative AMD and the haplotype C-G in rs3793784-rs11200638 was associated with a decreased risk only of exudative AMD development. Conclusions. Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development. The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.

Voter Sex, Party, and Gender-Salient Issues: Attitudes about Sexual Harassment and Brett Kavanaugh in the 2018 Elections

2020 ◽  
Vol 48 (5) ◽  
pp. 532-542 ◽  
Author(s):  
Michael A. Hansen ◽  
Kathleen Dolan
Keyword(s):  
Pilot Study ◽  
Sexual Harassment ◽  
American Politics ◽  
Electoral Behavior ◽  
Relative Impact ◽  
Supreme Court Justice ◽  
And Gender ◽  
The Impact ◽  
Confirmation Hearings ◽  
Dominant Influence

Since the election of President Trump and the dawning of the #MeToo movement, gender-salient issues have had a primary place in recent American politics. This was particularly evident in 2018 in the wake of Supreme Court Justice Brett Kavanaugh’s confirmation hearings amid accusations that he has sexually assaulted a classmate. Previous research suggests that women should be more concerned about issues like sexual harassment and mobilized to participate in elections in which these issues are prominent. Yet, American politics has become more polarized in the last 25 years, requiring us to re-examine the impact of gender-salient issues on women’s electoral behavior. Employing data from a 2018 ANES pilot study, we examine the relative impact of gender and party on attitudes toward sexual harassment, Brett Kavanaugh, and participation in the 2018 elections. We find that, while gender plays some role in 2018, partisanship is still the dominant influence in these elections.

Age Trajectories of Depressive Symptoms by Age at Immigration among Older Men and Women of Mexican Descent: The Role of Social Resources

2018 ◽  
Vol 61 (4) ◽  
pp. 513-534 ◽  
Author(s):  
Maria A. Monserud ◽  
Kyriakos S. Markides
Keyword(s):  
Depressive Symptoms ◽  
Immigrant Women ◽  
Epidemiologic Study ◽  
Late Life ◽  
The Elderly ◽  
Mexican Descent ◽  
Growth Curve Models ◽  
Age Related ◽  
And Gender ◽  
The Impact

Drawing on eight waves of data from the Hispanic Established Population for the Epidemiologic Study of the Elderly, this study uses growth curve models to provide a better understanding of the impact of age at immigration and gender on age trajectories of depressive symptoms among older adults of Mexican descent (aged 65+). The findings reveal that (1) regardless of immigrant status and age at immigration, men have similar age trajectories of depressive symptoms; (2) compared with U.S.-born women, late-life (beyond age 50) immigrant women report more depressive symptoms at age 65, whereas midlife (between ages 20 and 49) immigrant women experience steeper increases in these symptoms with age; (3) controlling for socioeconomic status leads to advantages in mental health at age 65, but steeper age-related increases in depressive symptoms among midlife (between ages 20 and 49) immigrant men and fewer depressive symptoms among late-life (beyond age 50) immigrant women.

scholarly journals Zamierzenia prokreacyjne a możliwość ich realizacji w kontekście czynników biologicznych

2013 ◽  
pp. 11-33 ◽  
Author(s):  
Krzysztof Tymicki
Keyword(s):  
Waiting Time ◽  
Fertility Intentions ◽  
Biological Factors ◽  
Time To Pregnancy ◽  
Main Hypothesis ◽  
Age Related ◽  
Increased Risk ◽  
Reproductive Ageing ◽  
And Gender ◽  
The Impact

The article presents both theoretical and empirical aspects of studies on fertility intentions in the context of factors shaping fecundity. In most contemporary societies couples declare their preference for two children. These declarations stand in opposition to registered total fertility rates, both period and cohort rates, which rarely reach value of 2 in Europe. The gap between fertility intentions and their realization might be partially explained by the impact of reproductive ageing (biological factors) which may play an increasingly significant role due to postponement of childbearing. A natural pattern of a decrease in fecundity over age might influence on reproductive outcome of women who postpone to conceive a child, and consequently results in an increased risk of involuntary childlessness or lower parity progression ratios. The data coming from the Generations and Gender Survey in Poland (GGS-PL) makes it possible to check the main hypothesis about an age-specific decrease in fecundity, which is manifested by a prolonged waiting time to pregnancy. The data were collected via the retrospective questions included into the GGS-PL questionnaire. Results show that there is a significant increase in waiting time to pregnancy among women older than 34 years. This finding supports theoretical predictions concerning the age-related decrease in fecundity. Its relevance is discussed by referring to explanations of the gap between fertility intentions and completed fertility in terms of voluntary and involuntary childlessness, as well as biological factors related to reproductive ageing.

scholarly journals Gender and generation in household labor supply in Jordan

2000 ◽  
Author(s):  
Mary Kawar
Keyword(s):  
Labor Supply ◽  
Single Women ◽  
Female Employment ◽  
Related Factors ◽  
Age Related ◽  
Gender And Age ◽  
The Social ◽  
And Gender ◽  
The Impact ◽  
Employment Characteristics

This paper examines gender and age differences in the labor supply of households in Jordan, and the impact of young women’s employment on gender and generation relations. The objective of the study is to address the issues of gender and generation as factors influencing accessibility to labor markets, and to provide a broader understanding of female employment by exploring age-related factors. Empirically, the study looks at the disproportionate workforce participation of young urban single women in Amman, Jordan, and argues that this generation of working women is evidence of a new stage in the lives of Jordanian women: single employed adulthood. It looks at a specific “time” in the social and economic lives of households and individuals. Within this context, the paper constructs a profile of employment characteristics of adult household members to explore the intersecting influences of age and gender and the specific positions of young women. It then addresses how normative gender and generation hierarchies within households respond to these phenomena of young women’s work, their prolonged single status, and their expanding horizons.

scholarly journals Outcome of COVID19 in Patients With Osteogenesis Imperfecta: A Retrospective Multicenter Study in Saudi Arabia

2022 ◽  
Vol 12 ◽  
Author(s):  
Abeer N. Alshukairi ◽  
Hazem Doar ◽  
Afaf Al-Sagheir ◽  
Mona A. Bahasan ◽  
Anas A. Sultan ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Osteogenesis Imperfecta ◽  
Genetic Disorder ◽  
Genetic Diseases ◽  
Severe Illness ◽  
Mineral Density ◽  
Restrictive Lung Disease ◽  
Mild Disease ◽  
Multi Center Study ◽  
The Impact

BackgroundAlthough genetic diseases are rare, children with such conditions who get infected with COVID-19 tend to have a severe illness requiring hospitalization. Osteogenesis imperfecta (OI) is a rare genetic disorder of collagen resulting in fractures and skeletal deformities. Kyphoscoliosis, restrictive lung disease, and pneumonia worsen the prognosis of patients with OI. The use of bisphosphonate improves bone mineral density (BMD) and reduces fractures in OI. There is no literature describing the impact of COVID-19 in patients with OI.MethodologyA retrospective multi-center study was performed in three hospitals in Jeddah and Riyadh, Saudi Arabia, from March 1st, 2020, until August 31st, 2021, aiming to evaluate the outcome of COVID-19 in patients with OI. Demographics, vaccination status, underlying kyphoscoliosis, functional status, use of bisphosphonate, BMD, and COVID-19 severity, and course were recorded for all patients.ResultsTwelve cases of confirmed COVID-19 were identified among 146 patients with OI. 9 (75%) of patients were less than 18 years, 6 (50%) were male, 5 (41%) had kyphoscoliosis, and 5 (41%) were wheelchair-bound. 6 (50%) received bisphosphonate, and 7(58%) had normal BMD. All patients had mild disease and did not require hospitalization. None of OI the patients with COVID-19 were fully vaccinated before the infection, and some were ineligible for vaccination.ConclusionPatients with OI and COVID-19 in our study recovered without complications, unlike patients with other genetic diseases. Young age and mild illness contributed to the favorable outcome. Half of the patients received bisphosphonate and had normal BMD.

scholarly journals The Prevalence of Alcohol-Impaired Driving in Edmonton, Alberta: 1991 – 2009

2012 ◽  
Vol 1 (1) ◽  
pp. 6-26
Author(s):  
Abu Sadat Nurullah
Keyword(s):  
Personnes Âgées ◽  
Policy Implications ◽  
Self Report ◽  
Impaired Driving ◽  
Age Related ◽  
Alcohol Impaired Driving ◽  
Report Data ◽  
Self Report Data ◽  
And Gender ◽  
The Impact

This study explores the changes in alcohol-impaired driving among a representative sample of Edmontonians from 1991 to 2009. Based on self-report data from the annual Alberta Surveys of 1991, 1992, 1997, and 2009, this study also traces the shift in the impact of standard demographic factors on alcohol-impaired driving in Edmonton, Alberta. Findings show that self-reported alcohol-impaired driving has decreased substantially over the years (10.6% in 1991, 8.4% in 1992, 7.2% in 1997, and 3.7% in 2009). However, there have been little changes in designated driving. In addition, there have been a shift in age-related impaired driving, i.e., people aged 55-65+ report impaired driving more in 2009 (4.8%) compared to 1991 (2.0%) and 1992 (2.2%); while individuals aged 18-34 and 35-54 report impaired driving less in 2009 (4.8% and 2.6%, respectively) compared to 1991 (12.7% and 13.0%, respectively). Logistic regression analyses indicate that gender is a significant predictor of alcohol-impaired driving in 1991 (OR = 3.29, 95% CI = 1.52–7.16), but not in 2009. However, the interaction between age and gender is not significant. The policy implications of the findings are discussed.   Cette étude porte sur les changements dans la conduite affaiblie par l’alcool chez un échantillon représentatif de résidents d’Edmonton entre 1991 et 2009. Fondée sur des déclarations fournies par les automobilistes à l’occasion d’enquêtes annuelles menées en Alberta en 1991, 1992, 1997 et 2009, l’étude décrit aussi des fluctuations dans la portée de facteurs démographiques standard sur la conduite avec facultés affaiblies par l’alcool à Edmonton (Alberta). Les conclusions démontrent une diminution considérable des déclarations de conduite avec facultés affaiblies par l’alcool sur plusieurs années (10,6% en 1991, 8,4% en 1992, 7,2% en 1997, et 3,7% en 2009). Néanmoins, peu de changements ont été observés dans le recours aux conducteurs désignés. En outre, la fréquence de la conduite avec facultés affaiblies a connu des variations dans les différents groupes d’âge. Par exemple, les personnes âgées de 55 ans et plus ont plus souvent déclaré avoir conduit avec des facultés affaiblies en 2009 (4,8%) qu’en 1991 (2,0%) et en 1992 (2,2%), tandis que les personnes âgées de 18 à 34 ans et de 35 à 54 ans ont déclaré moins souvent avoir conduit avec les facultés affaiblies en 2009 (4,8% et 2,6%, respectivement) qu’en 1991 (12,7% et 13,0%, respectivement). Des analyses de régression logistique indiquent que le sexe a été une importante variable explicative de la conduits avec facultés affaiblies en 1991 (OR = 3,29, 95% CI = 1,52–7.16), ce qui n’a pas été le cas en 2009. Malgré cela, l’interaction entre l’âge et le sexe n’est pas significative. L’étude comprend une analyse des répercussions de ses conclusions sur certaines politiques.  

Sign in / Sign up

Export Citation Format

Share Document