scholarly journals A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model

2021 ◽  
Vol 12 ◽  
Author(s):  
Michael J. Hubbard ◽  
Jonathan E. Mangum ◽  
Vidal A. Perez ◽  
Rebecca Williams
Keyword(s):  
Global Health ◽  
Extracellular Fluid ◽  
Childhood Illness ◽  
Future Research ◽  
Medical Prevention ◽  
New Type ◽  
Research And Education ◽  
Education Network ◽  
First Time ◽  
Molar Hypomineralisation

Popularly known as “chalky teeth”, molar hypomineralisation (MH) affects over 1-in-5 children worldwide, triggering massive amounts of suffering from toothache and rapid decay. MH stems from childhood illness and so offers a medical-prevention avenue for improving oral and paediatric health. With a cross-sector translational research and education network (The D3 Group; thed3group.org) now highlighting this global health opportunity, aetiological understanding is urgently needed to enable better awareness, management and eventual prevention of MH. Causation and pathogenesis of “chalky enamel spots” (i.e., demarcated opacities, the defining pathology of MH) remain unclear despite 100 years of investigation. However, recent biochemical studies provided a pathomechanistic breakthrough by explaining several hallmarks of chalky opacities for the first time. This article outlines these findings in context of previous understanding and provides a working model for future investigations. The proposed pathomechanism, termed “mineralisation poisoning”, involves localised exposure of immature enamel to serum albumin. Albumin binds to enamel-mineral crystals and blocks their growth, leading to chalky opacities with distinct borders. Being centred on extracellular fluid rather than enamel-forming cells as held by dogma, this localising pathomechanism invokes a new type of connection with childhood illness. These advances open a novel direction for research into pathogenesis and causation of MH, and offer prospects for better clinical management. Future research will require wide-ranging inputs that ideally should be coordinated through a worldwide translational network. We hope this breakthrough will ultimately lead to medical prevention of MH, prompting global health benefits including major reductions in childhood tooth decay.

Cut Flowers Being Sold as Impulse Items: A Look at Factors Affecting Impulse Product Merchandising

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 558c-558
Author(s):  
Jennifer B. Neujahr ◽  
Karen L.B. Gast
Keyword(s):  
Consumer Behavior ◽  
Marketing Strategies ◽  
Easy Access ◽  
Future Research ◽  
Grocery Stores ◽  
Cut Flowers ◽  
Factors Affecting ◽  
New Type ◽  
The 1950S ◽  
The Way

Consumer behavior research seems to play an big role in determining the wants and needs of an industry. This research helps to shape the way we market to the consumers and helps make marketing strategies more effective. In the 1950s grocery stores began to sell horticulture products in order to alleviate the growers' surplus. Supermarkets now have seem to found their niche in this market due to the fact that they can influence their consumers to buy their flowers right along with their bread, and get all of their shopping done at once. This new type of sale, commonly referred to as the impulse sale, can relate directly to how well the store is merchandised and maintained. A study was conducted at a local supermarket, to determine the following: good locations for impulse sales items, special conditions affecting impulse sales items, and what types of things could affect demand for impulse items. It was discovered that certain locations make better sales than other locations. Locations that were front and center and allowed easy access to seeing the mixed flower bouquet without having to touch it yielded the best results. The variables used to show a change in demand showed little to some variability and has raised some questions which may be used to conduct future research.

A Relationship Between the Factor Indivisibility and the Output Elasticity of the Indivisible Factor

2021 ◽  
pp. 232102222098516
Author(s):  
Dipankar Das
Keyword(s):  
Production Function ◽  
Limit Point ◽  
Mathematical Proof ◽  
Wage Equation ◽  
Marginal Value ◽  
Output Elasticity ◽  
New Type ◽  
First Time ◽  
Jel Classifications

The paper puts forth a notion and derives a special type of production function where labour is an indivisible factor and is in the integer space. Thus, Newtonian calculus is not an appropriate method of deriving the marginal value because limit point does not exist. This shows that indivisibility determines the output elasticity. In the first part, the paper propounds a notion regarding how indivisibility determines curvature of the production function. In the second part, the paper incorporates the findings within a production function and derives a new type accordingly. Moreover, it formally derives the standard wage equation considering all the entitlements of labour, namely (a) normal wages, (b) interest and (c) rent of ability. So far, no such mathematical proof is there to support this wage composition. This paper, for the first time, derives this wage equation considering indivisibility of labour. JEL Classifications: J23, J24, J31, D24, C61, E24, L8

A Bibliometric Review on Outcome-Based Learning for Graduate Employability: Mapping the Research Front

2021 ◽  
pp. 002205742110164
Author(s):  
Mohammad Zahir Raihan ◽  
Md. Abul Kalam Azad
Keyword(s):  
Research Trend ◽  
Future Research ◽  
Research Front ◽  
Important Research ◽  
R Software ◽  
Future Research Agenda ◽  
Graduate Employability ◽  
Important Research Topic ◽  
Bibliometric Review ◽  
First Time

The outcome-based learning for graduate employability in higher education has been an important research topic among the policymakers, academicians, and researchers over the years. Yet, no bibliometric review on this topic has been published. This study, for the first time, examines bibliometric analysis on this topic examining current research trend and future research agenda. The bibliometrix package in R software and VOSviewer software are used for visualization and interpretation of results. A content analysis is performed to manually examine the bibliometric results.

scholarly journals Exploring Secondary Metabolite Profiles of Stachybotrys spp. by LC-MS/MS

Toxins ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 133 ◽  
Author(s):  
Annika Jagels ◽  
Viktoria Lindemann ◽  
Sebastian Ulrich ◽  
Christoph Gottschalk ◽  
Benedikt Cramer ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Future Research ◽  
Structural Modifications ◽  
Metabolite Profiles ◽  
The Individual ◽  
First Time ◽  
Analytical Standards ◽  
Respective Species

The genus Stachybotrys produces a broad diversity of secondary metabolites, including macrocyclic trichothecenes, atranones, and phenylspirodrimanes. Although the class of the phenylspirodrimanes is the major one and consists of a multitude of metabolites bearing various structural modifications, few investigations have been carried out. Thus, the presented study deals with the quantitative determination of several secondary metabolites produced by distinct Stachybotrys species for comparison of their metabolite profiles. For that purpose, 15 of the primarily produced secondary metabolites were isolated from fungal cultures and structurally characterized in order to be used as analytical standards for the development of an LC-MS/MS multimethod. The developed method was applied to the analysis of micro-scale extracts from 5 different Stachybotrys strains, which were cultured on different media. In that process, spontaneous dialdehyde/lactone isomerization was observed for some of the isolated secondary metabolites, and novel stachybotrychromenes were quantitatively investigated for the first time. The metabolite profiles of Stachybotrys species are considerably influenced by time of growth and substrate availability, as well as the individual biosynthetic potential of the respective species. Regarding the reported adverse effects associated with Stachybotrys growth in building environments, combinatory effects of the investigated secondary metabolites should be addressed and the role of the phenylspirodrimanes re-evaluated in future research.

scholarly journals Psychodynamics of imagination failures: Reflections on the 20th anniversary of 9/11

2021 ◽  
pp. 135050762110097
Author(s):  
Amy L Fraher
Keyword(s):  
Lessons Learned ◽  
Macro Level ◽  
Future Research ◽  
September 11Th ◽  
Empire Building ◽  
Public Inquiry ◽  
The Us ◽  
New Type ◽  
20Th Anniversary ◽  
Psychodynamic Understanding

This article aims to advance the psychodynamic understanding of imagination failures by studying lessons learned in the US government’s public inquiry into September 11th, 2001 (9/11). Analyzing the findings of The 9/11 Report, I theorize that two forms of macro-level hubris—America’s “hubris of empire-building” and Al Qaeda’s “hubris-nemesis complex”—amalgamated in a uniquely generative manner leading to events on 9/11. Previous studies of public inquiries often demonstrate that inquiry reports are monological story-telling performances used to create sense-making narratives that function hegemonically to impose a simplified version of reality to assign blame and depoliticize events in order to facilitate closure after shocking events. In contrast, findings here suggest that by constructing a critical narrative, The 9/11 Report may serve as a new type of public inquiry report that invites learning about the complex factors that underpin crisis. The article concludes by identifying fruitful areas of future research and ways to theorize further about the collective psychodynamics of macro-level hubris and the psychodynamic factors that hinder learning and contribute to imagination failures.

scholarly journals Deservingness for "Family 500 +" Benefit in Poland: Qualitative Study of Internet Debates

2021 ◽  
Author(s):  
Piotr Michoń
Keyword(s):  
Future Research ◽  
Online Forums ◽  
Time Data ◽  
Social Surveys ◽  
Cash Benefit ◽  
Internet Forums ◽  
Welfare Attitudes ◽  
New Criterion ◽  
First Time ◽  
The Relationship

AbstractThe need for qualitative research of deservingness perception is strongly emphasised in the literature. This article studies the perception of deservingness for a "Family 500 +"—cash benefit in Poland. For the first time, data from online forums was used in the studies of deservingness and welfare attitudes. It allowed to avoid numerous limitations associated with social surveys. The qualitative analysis showed how participants of Internet debates perceive the criteria of deservingness: control, attitude, reciprocity, identity, need, and what are the relations between the criteria. The impurity of all deservingness criteria was indicated and a new criterion “adequacy” was proposed. Moreover due to the fact that the study concerned a concrete, non-abstract family cash benefit addressed the relationship between the perceived deservingness of children and their parents was pointed out. The vast majority of posts on Internet forums referred to deservingness of parents, not children. This is particularly evident in relation to the criteria of control and reciprocity. Presenting the hypothesis of jealousy and scapegoat strategy, the article also shows the direction of future research on deservingness.

scholarly journals A Novel Six-Rhodopsin System in a Single Archaeon

2010 ◽  
Vol 192 (22) ◽  
pp. 5866-5873 ◽  
Author(s):  
Hsu-Yuan Fu ◽  
Yu-Cheng Lin ◽  
Yung-Ning Chang ◽  
Hsiaochu Tseng ◽  
Ching-Che Huang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Global Environment ◽  
Diverse Group ◽  
Ion Transporters ◽  
Haloarcula Marismortui ◽  
Resource Limited ◽  
New Type ◽  
Ion Transportation ◽  
Proton Transporters ◽  
First Time

ABSTRACT Microbial rhodopsins, a diverse group of photoactive proteins found in Archaea, Bacteria, and Eukarya, function in photosensing and photoenergy harvesting and may have been present in the resource-limited early global environment. Four different physiological functions have been identified and characterized for nearly 5,000 retinal-binding photoreceptors, these being ion transporters that transport proton or chloride and sensory rhodopsins that mediate light-attractant and/or -repellent responses. The greatest number of rhodopsins previously observed in a single archaeon had been four. Here, we report a newly discovered six-rhodopsin system in a single archaeon, Haloarcula marismortui, which shows a more diverse absorbance spectral distribution than any previously known rhodopsin system, and, for the first time, two light-driven proton transporters that respond to the same wavelength. All six rhodopsins, the greatest number ever identified in a single archaeon, were first shown to be expressed in H. marismortui, and these were then overexpressed in Escherichia coli. The proteins were purified for absorption spectra and photocycle determination, followed by measurement of ion transportation and phototaxis. The results clearly indicate the existence of a proton transporter system with two isochromatic rhodopsins and a new type of sensory rhodopsin-like transducer in H. marismortui.

Research on the Key Technologies for New Large Dual-Platen High-Precision Clamping System

2010 ◽  
Vol 97-101 ◽  
pp. 64-68
Author(s):  
Jian Chen ◽  
Jin Wang ◽  
Guo Dong Lu ◽  
Zheng Qi Ling
Keyword(s):  
High Precision ◽  
Large Scale ◽  
New Technologies ◽  
Impact Factors ◽  
Adaptive Correction ◽  
Hydraulic Servo ◽  
New Type ◽  
Clamping System ◽  
Plastic Parts ◽  
First Time

High- precision and large scale are the developing trend for injection molding machine clamping system .This paper compared the characteristics of three-platen toggle and dual-platen hydraulic clamping system. The key impact factors that effecting plastic parts` precision from clamping system were discussed systematically first time. Based on these analyses, a new clamping system has been proposed and manufactured to improve the plastics parts` precision, including three new technologies: new type dual-platen structure, parallelism adaptive correction technology and numerical controlled hydraulic servo system technology. It has been applied in practical machine successfully, and experiment result proves that it is effective enough to satisfying the high-precision molding of large plastics parts.

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