scholarly journals Working Memory and Cross-Frequency Coupling of Neuronal Oscillations

2021 ◽  
Vol 12 ◽  
Author(s):  
Mohammed Abubaker ◽  
Wiam Al Qasem ◽  
Eugen Kvašňák
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Brain Stimulation ◽  
Large Body ◽  
Cognitive Outcomes ◽  
Essential Component ◽  
Non Invasive ◽  
Transcranial Alternating Current Stimulation ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

Working memory (WM) is the active retention and processing of information over a few seconds and is considered an essential component of cognitive function. The reduced WM capacity is a common feature in many diseases, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), mild cognitive impairment (MCI), and Alzheimer's disease (AD). The theta-gamma neural code is an essential component of memory representations in the multi-item WM. A large body of studies have examined the association between cross-frequency coupling (CFC) across the cerebral cortices and WM performance; electrophysiological data together with the behavioral results showed the associations between CFC and WM performance. The oscillatory entrainment (sensory, non-invasive electrical/magnetic, and invasive electrical) remains the key method to investigate the causal relationship between CFC and WM. The frequency-tuned non-invasive brain stimulation is a promising way to improve WM performance in healthy and non-healthy patients with cognitive impairment. The WM performance is sensitive to the phase and rhythm of externally applied stimulations. CFC-transcranial-alternating current stimulation (CFC-tACS) is a recent approach in neuroscience that could alter cognitive outcomes. The studies that investigated (1) the association between CFC and WM and (2) the brain stimulation protocols that enhanced WM through modulating CFC by the means of the non-invasive brain stimulation techniques have been included in this review. In principle, this review can guide the researchers to identify the most prominent form of CFC associated with WM processing (e.g., theta/gamma phase-amplitude coupling), and to define the previously published studies that manipulate endogenous CFC externally to improve WM. This in turn will pave the path for future studies aimed at investigating the CFC-tACS effect on WM. The CFC-tACS protocols need to be thoroughly studied before they can be considered as therapeutic tools in patients with WM deficits.

scholarly journals Virtual Reality Meets Non-invasive Brain Stimulation: Integrating Two Methods for Cognitive Rehabilitation of Mild Cognitive Impairment

2020 ◽  
Vol 11 ◽  
Author(s):  
Valentina Mancuso ◽  
Chiara Stramba-Badiale ◽  
Silvia Cavedoni ◽  
Elisa Pedroli ◽  
Pietro Cipresso ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Stimulation ◽  
Cognitive Rehabilitation ◽  
Non Invasive

scholarly journals Ventral Capsule/Ventral Striatum Deep Brain Stimulation Does Not Consistently Diminish Occipital Cross-Frequency Coupling

2016 ◽  
Vol 80 (7) ◽  
pp. e59-e60 ◽  
Author(s):  
Alik S. Widge ◽  
Samuel Zorowitz ◽  
Katherine Link ◽  
Earl K. Miller ◽  
Thilo Deckersbach ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Frequency Coupling ◽  
Cross Frequency Coupling ◽  
Deep Brain

scholarly journals Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease

Brain ◽  
2020 ◽  
Vol 143 (11) ◽  
pp. 3393-3407
Author(s):  
Muthuraman Muthuraman ◽  
Manuel Bange ◽  
Nabin Koirala ◽  
Dumitru Ciolac ◽  
Bogdan Pintea ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Gamma Oscillations ◽  
Stimulation Frequency ◽  
Frequency Coupling ◽  
Cross Frequency Coupling ◽  
Deep Brain

Abstract The disruption of pathologically enhanced beta oscillations is considered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in Parkinson’s disease. However, a specific modulation of other distinct physiological or pathological oscillatory activities could also play an important role in symptom control and motor function recovery during deep brain stimulation. Finely tuned gamma oscillations have been suggested to be prokinetic in nature, facilitating the preferential processing of physiological neural activity. In this study, we postulate that clinically effective high-frequency stimulation of the subthalamic nucleus imposes cross-frequency interactions with gamma oscillations in a cortico-subcortical network of interconnected regions and normalizes the balance between beta and gamma oscillations. To this end we acquired resting state high-density (256 channels) EEG from 31 patients with Parkinson’s disease who underwent deep brain stimulation to compare spectral power and power-to-power cross-frequency coupling using a beamformer algorithm for coherent sources. To show that modulations exclusively relate to stimulation frequencies that alleviate motor symptoms, two clinically ineffective frequencies were tested as control conditions. We observed a robust reduction of beta and increase of gamma power, attested in the regions of a cortical (motor cortex, supplementary motor area, premotor cortex) and subcortical network (subthalamic nucleus and cerebellum). Additionally, we found a clear cross-frequency coupling of narrowband gamma frequencies to the stimulation frequency in all of these nodes, which negatively correlated with motor impairment. No such dynamics were revealed within the control posterior parietal cortex region. Furthermore, deep brain stimulation at clinically ineffective frequencies did not alter the source power spectra or cross-frequency coupling in any region. These findings demonstrate that clinically effective deep brain stimulation of the subthalamic nucleus differentially modifies different oscillatory activities in a widespread network of cortical and subcortical regions. Particularly the cross-frequency interactions between finely tuned gamma oscillations and the stimulation frequency may suggest an entrainment mechanism that could promote dynamic neural processing underlying motor symptom alleviation.

scholarly journals Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis

2020 ◽  
Vol 50 (15) ◽  
pp. 2465-2486
Author(s):  
Marieke J. Begemann ◽  
Bodyl A. Brand ◽  
Branislava Ćurčić-Blake ◽  
André Aleman ◽  
Iris E. Sommer
Keyword(s):  
Working Memory ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Verbal Learning ◽  
The Other ◽  
Brain Disorders ◽  
Brain Disorder ◽  
Cognitive Domains ◽  
Domain Specific ◽  
Non Invasive

AbstractBackgroundCognition is commonly affected in brain disorders. Non-invasive brain stimulation (NIBS) may have procognitive effects, with high tolerability. This meta-analysis evaluates the efficacy of transcranial magnetic stimulation (TMS) and transcranial Direct Current Stimulation (tDCS) in improving cognition, in schizophrenia, depression, dementia, Parkinson's disease, stroke, traumatic brain injury, and multiple sclerosis.MethodsA PRISMA systematic search was conducted for randomized controlled trials. Hedges' g was used to quantify effect sizes (ES) for changes in cognition after TMS/tDCS v. sham. As different cognitive functions may have unequal susceptibility to TMS/tDCS, we separately evaluated the effects on: attention/vigilance, working memory, executive functioning, processing speed, verbal fluency, verbal learning, and social cognition.ResultsWe included 82 studies (n = 2784). For working memory, both TMS (ES = 0.17, p = 0.015) and tDCS (ES = 0.17, p = 0.021) showed small but significant effects. Age positively moderated the effect of TMS. TDCS was superior to sham for attention/vigilance (ES = 0.20, p = 0.020). These significant effects did not differ across the type of brain disorder. Results were not significant for the other five cognitive domains.ConclusionsOur results revealed that both TMS and tDCS elicit a small trans-diagnostic effect on working memory, tDCS also improved attention/vigilance across diagnoses. Effects on the other domains were not significant. Observed ES were small, yet even slight cognitive improvements may facilitate daily functioning. While NIBS can be a well-tolerated treatment, its effects appear domain specific and should be applied only for realistic indications (i.e. to induce a small improvement in working memory or attention).

scholarly journals Cross-frequency coupling supports multi-item working memory in the human hippocampus

2010 ◽  
Vol 107 (7) ◽  
pp. 3228-3233 ◽  
Author(s):  
N. Axmacher ◽  
M. M. Henseler ◽  
O. Jensen ◽  
I. Weinreich ◽  
C. E. Elger ◽  
...  
Keyword(s):  
Working Memory ◽  
Human Hippocampus ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

scholarly journals Gamma Entrainment Improves Synchronization Deficits in Dementia Patients

2021 ◽  
Author(s):  
Mojtaba Lahijanian ◽  
Hamid Aghajan ◽  
Zahra Vahabi ◽  
Arshia Afzal
Keyword(s):  
Oscillatory Activity ◽  
Therapeutic Effects ◽  
Phase Coupling ◽  
Non Invasive ◽  
Temporal Phase ◽  
Dementia Patients ◽  
Frequency Coupling ◽  
Phase Amplitude ◽  
Cross Frequency Coupling

AbstractNon-invasive gamma entrainment has shown promising results in alleviating cognitive symptoms of Alzheimer’s disease in mice and humans. In this study, we examine improvements in the synchronization characteristics of the brain’s oscillations induced by 40Hz auditory stimulation based on electroencephalography data recorded from a group of dementia patients. We observed that when the quality of entrainment surpasses a certain level, several indicators of brain synchronization significantly improve. Specifically, the entrained oscillatory activity maintains temporal phase stability in the frontal, parietal, and occipital regions, and persistent spatial phase coupling between them. In addition, notable theta-gamma phase-amplitude coupling is observed in these areas. Interestingly, a high theta power at rest predicts the quality of entrainment. We identify differentiating attributes of temporal/spatial synchronization and cross-frequency coupling in the data of two groups with entrained and non-entrained responses which point to enhanced network synchronization caused by entrainment and can explain its potential therapeutic effects.

Sign in / Sign up

Export Citation Format

Share Document