scholarly journals Negative Effects of a Multimodal Inpatient CBASP Program: Rate of Occurrence and Their Impact on Treatment Outcome in Chronic and Treatment-Resistant Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Philipp Herzog ◽  
Sophia Häusler ◽  
Claus Normann ◽  
Eva-Lotta Brakemeier
Keyword(s):  
Treatment Outcome ◽  
Treatment Program ◽  
Large Scale ◽  
Negative Impact ◽  
Chronic Depression ◽  
Systematic Research ◽  
Negative Effects ◽  
Negative Effect ◽  
Impact On Treatment

Background: A growing number of studies indicate that the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is effective in treating chronic depression. However, there is no systematic research into possible negative effects. Therefore, the objectives of the study were to investigate the rate of occurrence of negative effects of an inpatient CBASP program and their impact on treatment response.Methods: Patients with chronic depression and treatment resistance who completed the 12-week multimodal inpatient CBASP treatment program in an open trial (N = 52) retrospectively completed the Inventory for the Assessment of Negative Effects of Psychotherapy (INEP) during follow-up data collection. Severity of depressive symptoms was assessed self- and observer-rated at admission, discharge, and 6 months follow-up. Rates of occurrence of negative effects were calculated and binary logistic regression analyses were conducted to determine the relationship to treatment outcome.Results: The results indicate that 92.3% of patients reported having experienced at least one negative effect and 45.2% indicated dependence on their therapist. Stigmatization and financial concerns as well as intrapersonal changes were reported by about one-third. Only dependence on the therapist negatively impacted treatment outcome in both outcome measures.Conclusions: While almost all patients reported at least one negative effect of a multimodal inpatient CBASP treatment program, most of the reported negative effects appear to be benign. However, dependence on the therapist seems to have a negative impact on treatment outcome. If these results can be replicated in future large-scale, randomized controlled prospective studies, CBASP therapists should be aware of possible dependence and consciously address it during treatment.

scholarly journals Transvaginal Hybrid-NOTES procedures—do they have a negative impact on pregnancy and delivery?

2021 ◽  
Author(s):  
Panagiotis Thomaidis ◽  
Niklas J. Weltermann ◽  
Claudia S. Seefeldt ◽  
Dana C. Richards ◽  
Axel Sauerwald ◽  
...  
Keyword(s):  
Negative Impact ◽  
Male Partner ◽  
Current Data ◽  
Reproductive Age ◽  
Negative Effects ◽  
Desire For Children ◽  
Pregnancy And Delivery ◽  
Hybrid Notes ◽  
Type Of Delivery

Abstract Purpose We conducted a retrospective observational study in order to identify negative effects of NOTES procedures (Natural Orifice Transluminal Endoscopic Surgery) with transvaginal specimen removal on pregnancy and delivery. Methods From the total population of 299 patients in our NOTES registry, we tried to contact the 121 patients who were of reproductive age (≤ 45 years) at the time of a transvaginal NOTES procedure. They were interviewed by telephone regarding their desire for children, post NOTES-operation pregnancies, and type of delivery using a structured questionnaire. The collected data was analyzed and compared with current data. Results We were able to contact 76 patients (follow-up rate: 62.8%) with a median follow-up of 77 months after surgery (33–129 months). Twenty of 74 participating patients had a desire for children (27.0%). One of them and another's male partner were diagnosed as infertile. Regarding the remaining 18 patients, 14 became pregnant, and three of them became pregnant twice. Considering these 17 pregnancies, there was one miscarriage (5.9%) and one twin birth (5.9%). On average, childbirth occurred 44 months after the NOTES procedure. With regard to the type of delivery, 10 vaginal births (58.8%) and 7 caesarean sections (41.2%) occurred. Thus, the rate of fulfilled desire for children was 77.8%. Compared with the literature, no difference to the normal course could be detected. Conclusion There is no sign that the transvaginal approach in Hybrid-NOTES, with removal of the specimen through the vagina, has a negative effect on conception, the course during pregnancy, or the type of delivery.

УЗКОПОЛОСНАЯ ВИЗУАЛИЗАЦИЯ ПРИ РАКЕ МОЧЕВОГО ПУЗЫРЯ / NARROW BAND IMAGING FOR BLADDER CANCER

2021 ◽  
pp. 137-146
Author(s):  
David Sargsyan ◽  
Ruben Boroyan
Keyword(s):  
Bladder Cancer ◽  
Treatment Outcome ◽  
Large Scale ◽  
Narrow Band ◽  
Positive Impact ◽  
Narrow Band Imaging ◽  
New Technology ◽  
Invasive Bladder Cancer ◽  
Real Cost

Узкополосная визуализация (NBI) – это недавно разработанная технология, цель которой – предоставить дополнительную эндоскопическую информацию пациентам с раком мочевого пузыря. Этот обзор посвящен диагностической точности и результату лечения с использованием цистоскопии NBI для лечения немышечного инвазивного рака мочевого пузыря. Текущие результаты показали улучшенную чувствительность цистоскопии NBI по сравнению с обычной цистоскопией в белом свете, хотя при использовании цистоскопии NBI сообщалось о более низкой специфичности и повышенном количестве ложноположительных результатов. Результаты лечения с использованием технологии NBI при трансуретральной резекции опухоли мочевого пузыря оказали положительное влияние, в то время как сообщалось о снижении количества остаточных опухолей и рецидивов опухоли при последующем наблюдении. В будущем применение технологии NBI может усовершенствовать протокол лечения и последующего наблюдения у пациентов с немышечно-инвазивным раком мочевого пузыря. / Narrow band imaging (NBI) is a newly developed technology aiming to provide additional endoscopic information for patients with bladder cancer. This review focuses on the diagnostic accuracy and treatment outcome using NBI cystoscopy for the treatment of nonmuscle invasive bladder cancer. Current results showed improved sensitivity of NBI cystoscopy compared to conventional white light cystoscopy, although lower specificity and increased false positive results were reported using NBI cystoscopy. The treatment outcome using NBI technology in transurethral resection of bladder tumor had a positive impact while decreased number of residual tumors and tumor recurrence at follow-up were reported. In the future, the application of NBI technology might refine the treatment and follow-up protocol in patients with non-muscle invasive bladder cancer. However, these large scale prospective studies are required to confirm the real cost-effectiveness of this new technology.

Children With Encopresis: A Study of Treatment Outcome

PEDIATRICS ◽  
1976 ◽  
Vol 58 (6) ◽  
pp. 845-852 ◽  
Author(s):  
Melvin D. Levine ◽  
Harry Bakow
Keyword(s):  
Treatment Outcome ◽  
Treatment Program ◽  
Marked Improvement ◽  
Medical Center ◽  
Outcome Data ◽  
Careful Monitoring ◽  
Maintenance Program ◽  
Pediatric Treatment ◽  
One Year

A pediatric treatment program for encopresis was established in a large medical center. This consisted of counseling and education, initial bowel catharsis, a supportive maintenance program to potentiate optimum evacuation, retraining, and careful monitoring and follow-up. A group of 127 children received care for this problem. At the end of one year, outcome data were obtained on 110 patients. Of these, 51% had not had "accidents" for more than six months. Another 27% showed marked improvement and were having only rare episodes of incontinence. 14% of these children showed some improvement, but continued to have incontinence, while 8% showed no improvement whatsoever during the treatment year. These four outcome groups were compared with respect to a large number of demographic, developmental, psychosocial, and clinical variables.

scholarly journals Second primary malignancies following thyroid cancer: a population-based study in Taiwan

2013 ◽  
Vol 169 (5) ◽  
pp. 577-585 ◽  
Author(s):  
Chang-Hsien Lu ◽  
Kuan-Der Lee ◽  
Ping-Tsung Chen ◽  
Chih-Cheng Chen ◽  
Feng-Che Kuan ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Large Scale ◽  
Negative Impact ◽  
Asian Population ◽  
Population Based ◽  
Second Primary ◽  
Population Based Study ◽  
Impact On Survival ◽  
Second Primary Malignancies

ObjectiveMost studies on second primary malignancies (SPMs) after primary thyroid cancer were conducted in USA or Europe. The discrepancy between SPMs in these studies could be attributed to geographical and ethnic heterogeneity. Thus, there is a clear need for another large-scale epidemiological study, particularly in Asian countries, to define the incidence and risk of SPMs in thyroid cancer survivors.DesignA population-based study was conducted using the nation-wide database from Taiwan Cancer Registry between 1979 and 2006.MethodsWe quantified standardized incidence ratios (SIRs) and cumulative incidence of SPMs among 19 068 individuals (4205 males and 14 863 females) with primary thyroid cancer.ResultsA total of 644 cases (3.38%) developed at least a SPM during 134 678 person-years of follow-up. The risk for subsequent SPMs was significantly greater than that of the general population (SIR=1.33, 95% CI 1.23–1.44). There was a greater risk of developing major salivary glands, nasopharyngeal, lung, thymus, breast (females), bladder, and brain cancers, and leukemia and lymphoma. We observed that the risk was highest within the first 5 years of diagnosis of thyroid cancer (SIR=5.29, 1.68, and 0.68 for ≦5, 5–10, and >10 respectively) and in the younger patients (SIR=1.81 vs 1.61 for <50 and ≧50 respectively). The median overall survival for primary thyroid cancer patients was 23.28 years, but it was only 4.73 years for those who developed SPMs.ConclusionThyroid cancer is associated with a 33% risk increment of SPMs, which had a negative impact on survival. There are sites of SPMs in the Asian population that are distinctive from those in the Western population, suggesting that other genetic predisposition or environmental factors may play a role.

Massed Exposure and Fast Remission of Panic Disorder with Agoraphobia: A Case Example

2007 ◽  
Vol 35 (3) ◽  
pp. 371-375 ◽  
Author(s):  
Thomas Lang ◽  
Jürgen Hoyer
Keyword(s):  
Treatment Outcome ◽  
Panic Disorder ◽  
Male Patient ◽  
Intensive Treatment ◽  
Systematic Research ◽  
Clinical Routine ◽  
Full Remission

This case example demonstrates the role of massed exposure in optimizing treatment outcome in panic disorder with agoraphobia. Treatment of a 28-year-old male patient in a clinical routine setting is described. Full remission was achieved after an 8 day period of intensive treatment and proved to be stable at follow-up (6 months). More systematic research including controlled studies comparing massed and spaced exposure is suggested.

scholarly journals The Negative Impact of the Effects of Coronavirus on the Well-Being of Children and Families Who Are Clients of Child Protection Authorities in Finland

2021 ◽  
Vol 2 (1) ◽  
pp. 37-46
Author(s):  
J. Kuokkanen ◽  
A Tiili ◽  
A. Paasivirta
Keyword(s):  
Child Protection ◽  
Large Scale ◽  
Negative Impact ◽  
Well Being ◽  
Negative Consequences ◽  
Children And Families ◽  
Negative Effects ◽  
State Of Emergency ◽  
Large Scale Survey ◽  
Restrictive Measures

In the spring 2020, the first wave of the coronavirus pandemic quickly spread across Finland, having significant negative consequences for people’s living conditions. On March 16, 2020, the Finnish government declared a state of emergency and imposed several restrictive measures that were in effect until July 16, 2020 [13; 16]. The coronavirus and its aftermath have weakened the resilience of the Finnish welfare state, thereby challenging the welfare state’s ability to protect those most in need of its support. Recent studies have shown that the most vulnerable populations, such as children, are most affected by the negative effects of the pandemic in Finland and worldwide [5; 9; 11; 14; 18]. In autumn 2020, the Central Union for Child Welfare (CUCW) and the National Institute for Health and Welfare (THL) conducted a large-scale survey among the heads of child protection authorities (15.08.—13.10.2020), the aim of which was to find out how the consequences of the coronavirus and government restrictions have affected the well-being of children and their families who are clients of child protection authorities during the fall 2020. This article presents the main results and conclusions of the survey.

scholarly journals Seven years of experimental warming and nutrient addition causes decline of bryophytes and lichens in alpine meadow and heath communities

2014 ◽  
Author(s):  
Juha M Alatalo ◽  
Annika K Jägerbrand ◽  
Ulf Molau
Keyword(s):  
Global Change ◽  
Alpine Meadow ◽  
Negative Impact ◽  
Nutrient Addition ◽  
Negative Effects ◽  
Change Models ◽  
Alpine Regions ◽  
Negative Effect ◽  
Heath Community ◽  
Species Specific

Global change is predicted to have large and rapid impact on polar and alpine regions. Bryophytes and lichens increase their importance in terms of biomass, carbon/nutrient cycling, cover and ecosystem functioning at higher latitudes/altitudes. Here we report from a seven year factorial experiment with nutrient addition and warming on the abundance of bryophytes and lichens in an alpine meadow and heath community. Treatments had significant negative effect on relative change of total abundance bryophytes and lichens, the largest decline to the nutrient addition and the combined nutrient addition and warming treatments, bryophytes decreasing most in the meadow, lichens most in the heath. Nutrient addition, and the combined nutrient addition and warming brought rapid decrease in both bryophytes and lichens, while warming had a delayed negative impact. Of sixteen species that were included the statistical analyses, we found significant negative effects on seven species. We show that impact of simulated global change on bryophytes and lichens differ in in time and magnitude among treatments and plant communities. Our results underscore the importance of longer-term studies to improve the quality of climate change models, as short-term studies are poor predictors of longer-term responses of bryophytes and lichens, similar to what have been shown for vascular plants. Species-specific responses may differ in time, and this will likely cause changes in the dominance structures of bryophytes and lichens over time.

scholarly journals Designing for Packaging Sustainability. The Effects of Appearance and a Better Eco-Label on Consumers’ Evaluations and Choice

2019 ◽  
Vol 1 (1) ◽  
pp. 3251-3260 ◽  
Author(s):  
Sophie Krah ◽  
Tea Todorovic ◽  
Lise Magnier
Keyword(s):  
Negative Impact ◽  
Traffic Light ◽  
Negative Effects ◽  
User Perspective ◽  
Policy Makers ◽  
Negative Effect ◽  
Typical Appearance ◽  
Perceived Usability ◽  
Choice Intentions ◽  
Positive Effect

AbstractThe environmental burden of packaging is huge. However, redesigning packaging to make it more sustainable without damaging its other functions is not always easy and can have a negative impact on consumers’ choice. In this paper, we adopt a user-perspective and test the effects of packaging appearance and a better eco-label on consumers’ responses. Based on the literature, we designed an eco- label using a traffic light system with an objective sustainability score enabling to compare the sustainability of different packages. The results of our experimental study (N=120) show that while a sustainable (vs. typical) appearance in packaging has a positive effect on perceived sustainability, it has a negative effect on perceived usability. However, we demonstrate that the presence of a high score on the eco-label positively impacts the perceived sustainability of both the sustainable and the typical packages and the choice intentions. This eco-label also enabled to mitigate the negative effects of the sustainable appearance on perceived usability. Designers and policy-makers can use the results of this paper to positively influence evaluations of and choice for sustainable packaging.

To the Problem of Minimizing the Volume of Mobile Dust in the Development of Pits

2021 ◽  
pp. 28-33
Author(s):  
V.I. Golik ◽  
◽  
Z.A. Gashimova ◽  
M.Yu. Liskova ◽  
Ch.B. Kongar-Syuryun ◽  
...  
Keyword(s):  
Occupational Safety ◽  
Negative Impact ◽  
Raw Materials ◽  
Dust Emission ◽  
Mining Industry ◽  
Open Pit ◽  
Dust Formation ◽  
Negative Effects ◽  
Negative Effect ◽  
Living Organisms

Technogenic factors that have a negative effect on the environment and humans are analyzed. The integrated effect of negative impact on the environment aggravated by the number of factors is revealed. These factors include the following: gorges, river valleys and mountain landscapes. From the previously conducted studies it was concluded that the main source of negative effects on living organisms is the mineralized dust. The actual task of the study is determined, which consists in detailing the mechanisms and methods of the mineralized dust formation for improving the methods of minimizing its formation. Using the example of an open pit development of a dolomite deposit the relationship is established between the indicators of atmospheric dusting by the products of rock technological crushing and grinding. Dependence is established related to the dust emission intensity on the air flow velocity and dust concentration. It is proved that all the dust-like products formed as the result of mining and processing of the mineral raw materials have dimensions that allow them to move with the help of air masses. The results of the experiments on solving the problem of reducing dust by minimizing the output of mobile dust classes are presented (studies of the granulometric composition of rocks of various types with differentiation by type of the dust source, the mechanism of pollution using trapping screens and the development of directions for minimizing dusting of the atmosphere of the quarry and the surrounding area). The measures to reduce dust formation are proposed. The model for assessing the potential of environmental pollution by gas and dust products is developed. The proposed measures and the developed model will allow to minimize the effect of mining production on the environment of the region and the health of the workers of the mining enterprise and the residents of the region. The results obtained may be in demand when improving existing and developing new methods for improving occupational safety in the mining industry.

Cancer-Related Fatigue in Patients With and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration

2016 ◽  
Vol 34 (36) ◽  
pp. 4329-4337 ◽  
Author(s):  
Karolin Behringer ◽  
Helen Goergen ◽  
Horst Müller ◽  
Indra Thielen ◽  
Corinne Brillant ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Outcome ◽  
Hodgkin Lymphoma ◽  
Life Questionnaire ◽  
Social Reintegration ◽  
Cancer Related Fatigue ◽  
Fifth Generation ◽  
Impact On Treatment

Purpose Cancer-related fatigue occurs frequently in patients with Hodgkin lymphoma (HL) and has a major impact on their quality of life. We hypothesized that severe fatigue (sFA) might have an impact on patients’ treatment outcome and social reintegration. Methods Of 5,306 patients enrolled in the German Hodgkin Study Group’s fifth generation of clinical trials in HL (HD13, HD14, and HD15; nonqualified and older [> 60 years] patients excluded), 4,529 provided data on health-related quality of life. We describe sFA (defined as a score ≥ 50 on the 0 to 100 scale from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) before and up to 9 years after therapy and analyze its impact on treatment outcome and social reintegration. Results The proportion of patients reporting sFA was 37% at baseline and ranged from 20% to 24% during follow-up. Baseline sFA was associated with significantly impaired progression-free survival and a trend to impaired overall survival, which can be overcome in patients receiving highly effective HL therapies as applied in our fifth-generation trials. Our analysis revealed a significant negative association of sFA and employment in survivors: 5 years after therapy, 51% and 63% of female and male survivors, respectively, with sFA were working or in professional education, compared with 78% and 90% without sFA, respectively ( P < .001 adjusted for age, sex, stage, baseline employment status, and treatment outcome). sFA was also associated with financial problems and the number of visits to a general practitioner and medical specialists. Conclusion sFA is an important factor preventing survivors from social reintegration during follow-up. This observation underscores the need to address fatigue as a significant diagnosis when treating patients with and survivors of cancer.

Sign in / Sign up

Export Citation Format

Share Document