scholarly journals Effect of Oral Allylnitrile Administration on Cochlear Functioning in Mice Following Comparison of Different Anesthetics for Hearing Assessment

2021 ◽  
Vol 3 ◽  
Author(s):  
Dorien Verdoodt ◽  
Sander Eens ◽  
Debby Van Dam ◽  
Peter Paul De Deyn ◽  
Olivier M. Vanderveken ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Vestibular Function ◽  
Frequency Region ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Distortion Product ◽  
Isoflurane Anesthesia ◽  
Hearing Thresholds ◽  
Hearing Assessment

Background: Allylnitrile is a compound found in cruciferous vegetables and has the same lethality and toxic effects as the other nitriles. In 2013, a viable allylnitrile ototoxicity mouse model was established. The toxicity of allylnitrile was limited through inhibition of CYP2E1 with trans-1,2-dichloroethylene (TDCE). The allylnitrile intoxication model has been extensively tested in the 129S1 mouse strain for vestibular function, which showed significant HC loss in the vestibular organ accompanied by severe behavioral abnormalities. However, the effect of allylnitrile on auditory function remains to be evaluated. Commonly used anesthetics to conduct hearing measurements are isoflurane and ketamine/xylazine anesthesia but the effect of these anesthetics on hearing assessment is still unknown. In this study we will evaluate the otovestibular effects of oral allylnitrile administration in mice. In addition, we will compare the influence of isoflurane and ketamine/xylazine anesthesia on hearing thresholds.Methods and Materials: Fourteen Coch+/– CBACa mice were randomly allocated into an allylnitrile (n = 8) and a control group (n = 6). Baseline measurements were done with isoflurane and 1 week later under ketamine/xylazine anesthesia. After baseline audiovestibular measurements, mice were co-administered with a single dose of allylnitrile and, to reduce systemic toxicity, three intraperitoneal injections of TDCE were given. Hearing loss was evaluated by recordings of auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). Specific behavioral test batteries for vestibular function were used to assess alterations in vestibular function.Results: Hearing thresholds were significantly elevated when using isoflurane anesthesia compared to ketamine/xylazine anesthesia for all frequencies of the ABR and the mid-to-high frequencies in DPOAE. Allylnitrile-treated mice lacked detectable ABR thresholds at each frequency tested, while DPOAE thresholds were significantly elevated in the low-frequency region of the cochlea and completely lacking in the mid-to high frequency region. Vestibular function was not affected by allylnitrile administration.Conclusion: Isoflurane anesthesia has a negative confounding effect on the measurement of hearing thresholds in mice. A single oral dose of allylnitrile induced hearing loss but did not significantly alter vestibular function in mice. This is the first study to show that administration of allylnitrile can cause a complete loss of hearing function in mice.

scholarly journals Cochlear And Vestibular Involvement In Children With Henoch Schönlein Vasculitis

2021 ◽  
Author(s):  
Abdulkadir Bucak ◽  
Ayşegül Bükülmez ◽  
Selcuk Kuzu ◽  
Çağlar Günebakan ◽  
Erkan Yıldız ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Vestibular Function ◽  
Tertiary Hospital ◽  
Control Group ◽  
Healthy Children ◽  
Vestibular Evoked Myogenic Potential ◽  
Distortion Product ◽  
Significant Difference ◽  
And Control

Abstract Purpose: In this study, our purpose is to evaluate cochlear and vestibular function in juveniles with HSV using audiometry, DPOAEs, and cVEMP tests.Methods: 40 children diagnosed with HSV from the pediatry clinic and 40 age and sex-matched healthy children were evaluated with distortion product otoacoustic emissions, audiometry, and cervical vestibular evoked myogenic potential (cVEMP) test in a tertiary hospital.Results: The audiometry average values ​​for both ears of HSV group and the control subjects were compared, and as a result, median 4.7 dB sensorineural hearing loss (SHL) was found for HSV group compared to control group at 250 Hz and it was statistically significant (p <0.001). An average of 6.4 dB SHL was detected at 8000 Hz (p <0.001). There was a statistically significant difference among HSV and control group regarding measurement results of average p1-n1 latency time of both ears (0.9 milliseconds (ms) increase, P = 0.035). In HSV patients, the median amplitude difference of both ears' average p1 n1 was found to be 5,6 millivolt, statistically significantly decreased compared to the control group (p = 0.003).Conclusion: This study, firstly in literature, demonstrated that HSV may cause hearing loss and vestibular dysfunction in children. We think this might be due to autoimmune mechanisms.

Comparison of auditory electrophysiological responses in normal-hearing patients with and without tinnitus

2011 ◽  
Vol 125 (7) ◽  
pp. 668-672 ◽  
Author(s):  
S Singh ◽  
S K Munjal ◽  
N K Panda
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Distortion Product ◽  
Significant Difference ◽  
Central Activity ◽  
Middle Latency

AbstractIntroduction:Tinnitus is a disturbing symptom and is often the main reason for otology referral. It is usually associated with hearing loss of varying aetiology, and is thought to begin in the cochlea, with later abnormal central activity. We hypothesise that tinnitus without hearing loss may be caused by central and subcortical abnormalities and altered outer hair cell function.Aim:To compare the auditory brainstem responses, middle latency responses and otoacoustic emissions in normal-hearing individuals with and without tinnitus.Methodology:The audiological test results of 25 normal hearing subjects with tinnitus (age 18–45 years) were determined, and compared with those of a control group.Results:A statistically significant difference was found between study group tinnitus ears vs control group ears, as regards wave I latency prolongation, shortening of wave V and absolute I–III and I–V interpeak latency, enlargement of wave Na and Pa amplitude, and distortion product and transient evoked otoacoustic emission signal-to-noise ratios. There was no statistically significant difference between unilateral vs bilateral tinnitus ears.Conclusion:The pathogenesis and optimum management of tinnitus are still unclear. It often occurs with primary ear disease, usually associated with hearing loss, but may occur in patients with normal hearing. Observed changes in auditory brainstem and middle latency responses indicate central auditory alterations. Tinnitus involves both peripheral and central activity, and complete audiological and neurophysiological investigation is required. Management should be based on both audiological and neurophysiological findings.

Vocal Performance Teachers and Hearing Loss

2015 ◽  
Vol 16 (1) ◽  
pp. 15-24
Author(s):  
Vance Gunnell ◽  
Jeff Larsen
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Noise Exposure ◽  
Vocal Performance ◽  
Occupational Noise ◽  
Hearing Conservation ◽  
Occupational Noise Exposure ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
Performance Teachers

Hearing thresholds and distortion product otoacoustic emissions were measured for teachers of vocal performance who were gathered for a national conference. Results showed mean audiometric thresholds to be consistent with noise induced hearing loss, more than what would be expected with normal aging. Years of instruction and age were considered as factors in the hearing loss observed. It was concluded that hearing conservation should be initiated with this group to help raise awareness and protect them from hearing loss due to occupational noise exposure.

scholarly journals Protective effect of Nigella sativa oil on acoustic trauma induced hearing loss in rats

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Belde Culhaoglu ◽  
Selim S. Erbek ◽  
Seyra Erbek ◽  
Evren Hizal
Keyword(s):  
Hearing Loss ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Acoustic Trauma ◽  
Female Rats ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Study Group ◽  
Intensity Level ◽  
Hearing Thresholds

Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of <em>Nigella sativa</em> (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR). To create acoustic trauma, the rats were then exposed to white band noise of 4 kHz with an intensity level of 107 dB in a soundproof testing room. On Day 1 following acoustic trauma, hearing threshold measurements were repeated. The rats were divided into two groups as the study group (n: 10) and the controls (n: 10). 2 mL/kg/day of <em>Nigella sativa</em> oil was given to the rats in the study group orally. On Day 4 following acoustic trauma, ABR measurements were repeated again. There was no difference between the baseline hearing thresholds of the rats before acoustic trauma (P&gt;0.005). After the acoustic trauma, hearing thresholds were increased and there was no significant statistically difference between the hearing thresholds of the study and control groups (P=0.979). At the 4<sup>th</sup> day following acoustic trauma, hearing thresholds of the rats in control group were found to be higher than those in the study group (P=0.03). Our results suggest that <em>Nigella sativa</em> oil has a protective effect against acoustic trauma in early period. This finding should be supported with additional experimental and clinical studies, especially to determine the optimal dose, duration and frequency of potential <em>Nigella sativa</em> oil therapy.

Distortion Product Emissions in Normal-Hearing and Low-Frequency Hearing Loss Carriers of Genes for Waardenburg's Syndrome

1997 ◽  
Vol 106 (3) ◽  
pp. 220-225 ◽  
Author(s):  
Xue Zhong Liu ◽  
Valerie E. Newton
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Low Frequency ◽  
Normal Hearing ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product ◽  
Initial Results

Eight patients with Waardenburg's syndrome (WS) with normal hearing and 3 additional patients exhibiting a low-frequency hearing loss were tested for the level of the acoustic distortion product 2f1-f2 by means of the Otodynamics Distortion Product Analyser (ILO92). Wide notches in distortion product otoacoustic emissions (DPOAEs) between 1,000 and 3,000 Hz were found in 7 (12 ears, 87.5%) examined patients with normal audiograms, which was a significantly higher rate than that found in the control group (10%). The 3 patients with low-frequency hearing loss gave a consistent pattern in audiometric configuration shown by both pure tone audiograms and DPOAEs. It is concluded from these initial results that DPOAEs may be a useful approach to identifying subclinical pathologic aberrations in the inner ear in WS patients, and may be a predictor of low-frequency sensorineural hearing loss.

scholarly journals Analysis of Chronic Tinnitus in Noise-Induced Hearing Loss and Presbycusis

2021 ◽  
Vol 10 (8) ◽  
pp. 1779
Author(s):  
Hee Jin Kang ◽  
Dae Woong Kang ◽  
Sung Su Kim ◽  
Tong In Oh ◽  
Sang Hoon Kim ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Chronic Tinnitus ◽  
Noise Induced Hearing Loss ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
Brainstem Response

The most frequent causes of tinnitus associated with hearing loss are noise-induced hearing loss and presbycusis. The mechanism of tinnitus is not yet clear, although several hypotheses have been suggested. Therefore, we aimed to analyze characteristics of chronic tinnitus between noise-induced hearing loss and presbycusis. Materials and Methods: This paper is a retrospective chart review and outpatient clinic-based study of 248 patients with chronic tinnitus from 2015 to 2020 with noise-induced or presbycusis. Pure tone audiometry (PTA), auditory brainstem response (ABR), distortion product otoacoustic emissions (DPOAE), transient evoked otoacoustic emissions (TEOAE), and tinnitograms were conducted. Results: PTA showed that hearing thresholds at all frequencies were higher in patients with noise-induced hearing loss than the presbycusis group. ABR tests showed that patients with presbycusis had longer wave I and III latencies (p < 0.05 each) than patients with noise-induced hearing loss. TEOAE tests showed lower values in patients with noise-induced hearing loss than presbycusis at 1.5, 2, 3, and 4 kHz (p < 0.05 each). DPOAE tests showed that response rates in both ears at 1.5, 2, and 3 kHz were significantly higher in patients with presbycusis than noise-induced hearing loss (p < 0.05 each). Discussion: This study showed that hearing thresholds were higher, the loudness of tinnitus was smaller, and the degree of damage to outer hair cells was lower in patients with presbycusis than with noise-induced hearing loss. Moreover, wave I and III latencies were more prolonged in patients with presbycusis despite their having lower hearing thresholds. These phenomena may reflect the effects of aging or degeneration of the central nervous system with age. Further studies are needed to evaluate the etiologies of tinnitus.

The effect of simultaneous exposure to cigarette smoke and noise on distortion product otoacoustic emissions in rats

2019 ◽  
Vol 35 (5) ◽  
pp. 349-357 ◽  
Author(s):  
Raheleh Hashemi Habybabady ◽  
Mahdi Mohammadi ◽  
Seyed Bagher Mortazavi ◽  
Ali Khavanin ◽  
Ramazan Mirzaei ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cigarette Smoking ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Simultaneous Exposure ◽  
Distortion Product ◽  
Male Wistar Rats ◽  
Baseline Values ◽  
The Impact

Cigarette smoking is a possible risk factor for hearing loss. However, the impact of simultaneous exposure to noise and smoke on hearing has remained controversial. This study investigated the combined effect of exposure to cigarette smoking and noise on hearing loss. Three groups of male Wistar rats (275 ± 25 g) were subjected to white noise (102 ± 0.5 dB), cigarette smoking (20 cigarettes), and both cigarette smoking and noise for 8 h and 10 days inside the exposure chamber. The control group was exposed to neither noise nor smoke. Distortion product otoacoustic emissions (DPOAE) were measured before any intervention, and it was repeated 1, 7, and 21 days after the last exposure. One-day postexposure to noise, cigarette smoking, and both cigarette smoking and noise, the mean of DPOAE amplitudes decreased significantly ( p < 0.05) between, respectively, 5.7–30.7, 1.5–7.5, and 5.2–32.6 dB within the frequency range of 4620–9960. Temporal DPOAE change in rats exposed to noise or both cigarette smoking and noise was not significantly different ( p > 0.05). DPOAE amplitudes returned to the baseline values in the group subjected to smoking 21 days postexposure. The most permanent change was observed in rats exposed to both cigarette smoking and noise. Accordingly, simultaneous subacute exposure to noise and cigarette smoking increases the effect of noise on permanent hearing loss. Therefore, smoking workers exposed to noise might be at a greater risk of developing hearing loss, and it is recommended that authorities in charge take note of this evidence.

Protective effects of vitamins E, B and C and l-carnitine in the prevention of cisplatin-induced ototoxicity in rats

2012 ◽  
Vol 126 (5) ◽  
pp. 464-469 ◽  
Author(s):  
S Alıcura Tokgöz ◽  
E Vuralkan ◽  
N D Sonbay ◽  
M Çalişkan ◽  
C Saka ◽  
...  
Keyword(s):  
Vitamin E ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Control Group ◽  
Albino Rats ◽  
Vitamin B ◽  
Signal To Noise ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
Brainstem Response

AbstractObjective:This experimental study aimed to investigate the effects of vitamins E, B and C and l-carnitine in preventing cisplatin-induced ototoxicity.Methods:Twenty-five adult, male, Wistar albino rats were randomly allocated to receive intraperitoneal cisplatin either alone or preceded by vitamins B, E or C or l-carnitine. Auditory brainstem response (i.e. hearing thresholds and wave I–IV intervals) and distortion product otoacoustic emissions (i.e. signal-to-noise ratios) were recorded before and 72 hours after cisplatin administration.Results:The following statistically significant differences were seen: control group pre- vs post-treatment wave I–IV interval values (p < 0.05); control vs vitamin E and B groups' I–IV interval values (p < 0.05); control vs other groups' hearing thresholds; vitamin E vs vitamin B and C and l-carnitine groups' hearing thresholds (p < 0.05); and vitamin B vs vitamin C and l-carnitine groups' hearing thresholds (p < 0.05). Statistically significant decreases were seen when comparing the initial and final signal-to-noise ratios in the control, vitamin B and l-carnitine groups (2000 and 3000 Hz; p < 0.01), and the initial and final signal-to-noise ratios in the control group (at 4000 Hz; p < 0.01).Conclusion:Vitamins B, E and C and l-carnitine appear to reduce cisplatin-induced ototoxicity in rats. The use of such additional treatments to decrease cisplatin-induced ototoxicity in humans is still under discussion.

scholarly journals The influence of the use of earphones in the of young people’s hearing

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Juelma Tavares ◽  
Cristina Nazaré
Keyword(s):  
Hearing Loss ◽  
Young People ◽  
Otoacoustic Emissions ◽  
Warning Sign ◽  
High Frequencies ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Abstract Background Listening music is extremely important in our day life, but studies indicate that young people who use earphones for long periods tend to develop hearing problems. The aim of this study was to evaluate the hearing of young people who use earphones to listen to music very often and occasionally, and observe if there are differences between them. Methods The sample was composed by 2 groups (n = 15 in each) of young people, students in higher education (18–24 years) who use earphones to listen music every week, with Group 1 using earphones occasionally and Group 2 very often. Otoscopy, pure tone audiogram (PTA: 0.125–8 kHz), high frequencies (HF: 9–12.5 kHz) and distortion product otoacoustic emissions (DPOAEs: 2–10 kHz) was performed. Results There were statistically significant differences between groups in PTA (0.125 and 0.5 kHz in right ear - RE) and DPOAEs (7.5, 8.3, 9.1 and 10 kHz in RE and 6.2, 7.5, 10 kHz in left ear), being the means of hearing thresholds (PTA and HF) higher and the means of the DPOAE’s amplitudes lower in Group 2, in most frequencies. Despite all individuals had normal hearing thresholds in PTA, in HF at 11.2 KHz in RE, the mean of threshold in Group 2 was over 20 dBHL. Conclusions The differences found between groups can be a warning sign for future hearing loss in young people who use earphones very often to listen to music, so it is important to raise awareness among young people for the prevention of hearing loss and change behaviours.

scholarly journals Pure-Tone Hearing Thresholds and Otoacoustic Emissions in Students of Music Academies

2021 ◽  
Vol 18 (3) ◽  
pp. 1313
Author(s):  
Małgorzata Pawlaczyk-Łuszczyńska ◽  
Małgorzata Zamojska-Daniszewska ◽  
Adam Dudarewicz ◽  
Kamil Zaborowski
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Noise Exposure ◽  
Signal To Noise Ratio ◽  
Pure Tone Audiometry ◽  
Music Students ◽  
Control Group ◽  
Exposure Level ◽  
Distortion Product ◽  
Hearing Thresholds

The objective of this study was to assess the hearing of music students in relation to their exposure to excessive sounds. A standard pure-tone audiometry, transient-evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) were determined in 163 students of music academies, aged 22.8 ± 2.6 years. A questionnaire survey and sound pressure level measurements during solo and group playing were also conducted. The control group comprised 67 subjects, mainly non-music students, aged 22.8 ± 3.3 years. Study subjects were exposed to sounds at the A-weighted weekly noise exposure level (LEX,w) from 75 to 106 dB. There were no significant differences in the hearing thresholds between groups in the frequency range of 4000–8000 Hz. However, music students compared to control group exhibited lower values of DPOAE amplitude (at 6000 and 7984 Hz) and signal-to-noise ratio (SNR) (at 984, 6000, and 7984 Hz) as well as SNR of TEOAE (in 1000 Hz band). A significant impact of noise exposure level, type of instrument, and gender on some parameters of measured otoacoustic emissions was observed. In particular, music students having LEX,w ≥ 84.9 dB, compared to those with LEX,w < 84.9 dB, achieved significantly lower DPOAE amplitude at 3984 Hz. Meanwhile, both TEOAE and DPOAE results indicated worse hearing in students playing percussion instruments vs. wind instruments, and wind instrument players vs. students playing stringed instruments.

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