scholarly journals The Biodegradation Role of Saccharomyces cerevisiae against Harmful Effects of Mycotoxin Contaminated Diets on Broiler Performance, Immunity Status, and Carcass characteristics

Animals ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 238 ◽  
Author(s):  
Muhammad Arif ◽  
Atia Iram ◽  
Muhammad A. K. Bhutta ◽  
Mohammed A. E. Naiel ◽  
Mohamed E. Abd El-Hack ◽  
...  

A feeding trial (35 days) was carried out to investigate the effect of Saccharomyces cerevisiae cell wall as a mycotoxin biodegradation agent on the performance, feed efficiency, carcass traits, and immunity response against diseases in broilers fed aflatoxin B1 contaminated diets. For this purpose, 200 one day old broilers were randomly allotted into four groups, each with five replicates (10 birds per replicate). Four starter and finisher experimental rations were formulated by using (A) 0, (B) 1.25, (C) 2.5, and (D) 3.75 g kg−1 of Saccharomyces cerevisiae. Experimental diets were contaminated with aflatoxin B1 (100 ppb kg−1 diet). The experimental chicks were kept under standard managerial conditions, and the vaccination program was followed against infectious bursal disease (IBD), infectious bronchitis (IB), and Newcastle disease (ND) diseases. At the end of the feeding trial, carcass, organ weight, and blood samples were collected randomly to determine the carcass traits and antibody titer against ND and IBD viruses. Throughout the experiment, the addition of 3.75 g kg−1 of the Saccharomyces cerevisiae cell wall (Group-D) in feed resulted in the highest weight gain, final weight, feed intake, and the lowest FCR values followed by C group compared with the other groups. All carcass traits were significantly (p > 0.05) improved by increasing the inclusion levels of Saccharomyces cerevisiae in broiler diets. It could be concluded that the broiler diet supplemented with 2.5 or 3.75 g kg−1 of Saccharomyces cerevisiae as a biodegrading agent resulted in improved growth performance, immunity activity and carcass traits, and supplementation with Saccharomyces cerevisiae at these levels can be used effectively in broiler diets without negatively affecting bird health status.

LWT ◽  
2020 ◽  
Vol 126 ◽  
pp. 109306
Author(s):  
A.S. Fochesato ◽  
A. Cristofolini ◽  
V.L. Poloni ◽  
A. Magnoli ◽  
C.I. Merkis ◽  
...  

Author(s):  
Maldhure Niteen Arvind ◽  
R. Richard Churchil

Effect of esterified glucomannan (E-GM), a new generation toxin binder enzymatically extracted from the cell wall of certain stains of Saccharomyces cerevisiae in counteracting the deleterious effects of aflatoxin in broiler chicken was investigated. Broilers fed 1ppm aflatoxin-B1 recorded significantly (Psignificantly (Ped the ill effects on weight gain and feed consumption, while the feed efficiency was restored to normal. High mortality in broilers caused by aflatoxin, was slightly reduced by the addition of E-GM.


2021 ◽  
Vol 52 (2) ◽  
pp. 512-526
Author(s):  
M. M. Mustafa ◽  
F. Karadas ◽  
I. T. Tayeb

This study was conducted to estimate the effect of adding different levels of turmeric powder and curcumin on broiler performance, carcass traits, and immunity response and jejunum histology. A total of 750 Ross day old chicks obtained from a local hatchery and distributed into two rearing conditions (normal and heat stress condition) with five treatments 3 replicate for each one had (25 chicks). Dietary supplements of turmeric powder and curcumin significantly (P ≤ 0.05) improved performance under normal and heat stress conditions. Moreover, treatments significantly (P ≤ 0.05) increased the total titter antibody against Newcastle and infectious bursal disease compared to control. Concerning histology of jejunum treatments significantly (P≤0.01) improved jejunum histology. Regarding the effect of rearing condition heat stress conditions significantly (P ≤ 0.01) decreased performance compared to normal rearing condition. Small intestine percent from live body weight significantly (P ≤ 0.01) decreased compared to normal rearing conditions. Moreover, heat stress significantly (P≤0.01) affected the total antibody titer against Newcastle disease and infectious bursal disease. Jejunum histology significantly (P ≤ 0.01) affected by rearing conditions. 


Toxins ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 209
Author(s):  
Alexandros Yiannikouris ◽  
Juha Apajalahti ◽  
Osmo Siikanen ◽  
Gerald Patrick Dillon ◽  
Colm Anthony Moran

Mycotoxins are naturally occurring toxins that can affect livestock health and performance upon consumption of contaminated feedstuffs. To mitigate the negative effects of mycotoxins, sequestering agents, adsorbents, or binders can be included to feed to interact with toxins, aiding their passage through the gastrointestinal tract (GI) and reducing their bioavailability. The parietal cell wall components of Saccharomyces cerevisiae have been found to interact in vitro with mycotoxins, such as, but not limited to, aflatoxin B1 (AFB1), and to improve animal performance when added to contaminated diets in vivo. The present study aimed to examine the pharmacokinetics of the absorption of radiolabeled AFB1 in rats in the presence of a yeast cell wall-based adsorbent (YCW) compared with that in the presence of the clay-based binder hydrated sodium calcium aluminosilicate (HSCAS). The results of the initial pharmacokinetic analysis showed that the absorption process across the GI tract was relatively slow, occurring over a matter of hours rather than minutes. The inclusion of mycotoxin binders increased the recovery of radiolabeled AFB1 in the small intestine, cecum, and colon at 5 and 10 h, revealing that they prevented AFB1 absorption compared with a control diet. Additionally, the accumulation of radiolabeled AFB1 was more significant in the blood plasma, kidney, and liver of animals fed the control diet, again showing the ability of the binders to reduce the assimilation of AFB1 into the body. The results showed the potential of YCW in reducing the absorption of AFB1 in vivo, and in protecting against the damaging effects of AFB1 contamination.


Author(s):  
Gerrit J. P. Dijkgraaf ◽  
Huijuan Li ◽  
Howard Bussey

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Liang Sun ◽  
Jae Won Lee ◽  
Sangdo Yook ◽  
Stephan Lane ◽  
Ziqiao Sun ◽  
...  

AbstractPlant cell wall hydrolysates contain not only sugars but also substantial amounts of acetate, a fermentation inhibitor that hinders bioconversion of lignocellulose. Despite the toxic and non-consumable nature of acetate during glucose metabolism, we demonstrate that acetate can be rapidly co-consumed with xylose by engineered Saccharomyces cerevisiae. The co-consumption leads to a metabolic re-configuration that boosts the synthesis of acetyl-CoA derived bioproducts, including triacetic acid lactone (TAL) and vitamin A, in engineered strains. Notably, by co-feeding xylose and acetate, an enginered strain produces 23.91 g/L TAL with a productivity of 0.29 g/L/h in bioreactor fermentation. This strain also completely converts a hemicellulose hydrolysate of switchgrass into 3.55 g/L TAL. These findings establish a versatile strategy that not only transforms an inhibitor into a valuable substrate but also expands the capacity of acetyl-CoA supply in S. cerevisiae for efficient bioconversion of cellulosic biomass.


Micron ◽  
2021 ◽  
pp. 103091
Author(s):  
Raissa D. Moura ◽  
Lauanda M. Carvalho ◽  
Brígida A.A. Spagnol ◽  
Tarcio Carneiro ◽  
Ane Catarine Tosi Costa ◽  
...  

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