scholarly journals Evidence from a Series of 104 Equine Sarcoids Suggests That Most Sarcoids in New Zealand Are Caused by Bovine Papillomavirus Type 2, although Both BPV1 and BPV2 DNA Are Detectable in around 10% of Sarcoids

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3093
Author(s):  
John S. Munday ◽  
Geoff Orbell ◽  
Rob A. Fairley ◽  
Michael Hardcastle ◽  
Bernie Vaatstra
Keyword(s):  
New Zealand ◽  
North America ◽  
Pcr Primers ◽  
Ovis Aries ◽  
Bovine Papillomavirus ◽  
Detection Rates ◽  
Mesenchymal Neoplasms ◽  
Common Causes ◽  
Time Periods

Equine sarcoids are common mesenchymal neoplasms of horses that are caused by cross-species infection by deltapapillomaviruses. While bovine papillomavirus (BPV) 1 and 2 are the most common causes, there are differences between countries regarding which of these BPV types cause the majority of sarcoids. Additionally, no causative PV can be detected in a subset of sarcoids, suggesting that other PV types could be rarer causes of these neoplasms. In the present study, consensus PCR primers and PCR primers specific for the five deltapapillomavirus types currently known to cause mesenchymal neoplasia (BPV1, BPV2, BPV13, BPV14, and Ovis aries PV2 DNA) were used to investigate the presence of PV DNA in 104 sarcoids from three defined regions in New Zealand and from two distinct time periods separated by 15 years. PV DNA was detected in 94 (90.4%) sarcoids. Of the sarcoids containing PV DNA, 83 (88.3%) contained only BPV2 DNA, 9 (9.6%) BPV1 and BPV2 DNA, and 2 (2.1%) only BPV1 DNA. No other PV types were detected. The predominance of BPV2 is consistent with studies of sarcoids from North America but dissimilar to studies of sarcoids from Europe and Australia. Detection rates of BPV1 and BPV2 were similar in sarcoids from different regions of New Zealand and in sarcoids from different time periods. These results suggest that most equine sarcoids in New Zealand are caused by BPV2 and thus if vaccines are developed to prevent sarcoids, vaccines that provide good protection against BPV2 will be required in this country.

scholarly journals The Development of Novel Primer Sets to Specifically Amplify Each of the Five Different Deltapapillomaviruses That Cause Neoplasia after Cross-Species Infection

2021 ◽  
Vol 8 (10) ◽  
pp. 208
Author(s):  
John S. Munday ◽  
Kristene Gedye ◽  
Cíntia Daudt ◽  
Flavio Chaves Da Silva
Keyword(s):  
Pcr Primers ◽  
Ovis Aries ◽  
Sensitive Detection ◽  
Malignant Neoplasms ◽  
Mixed Infections ◽  
Bovine Papillomavirus ◽  
Regional Variability ◽  
Fixed Tissue ◽  
Formalin Fixed Tissue ◽  
Primer Sets

Bovine papillomavirus (BPV) types 1 and 2 are recognized as the main cause of equine sarcoids. However, some studies report that up to a quarter of these tumors do not contain detectible BPV1 or BPV2 DNA. The absence of detectible BPV1 or BPV2 in these sarcoids suggests the possible involvement of other papillomavirus types. Currently, five deltapapillomaviruses are recognized to cause mesenchymal neoplasia after cross-species infection. In addition to BPV1 and BPV2, BPV13 has been associated with equine sarcoids in Brazil, BPV14 has been associated with feline sarcoids, and Ovis aries papillomavirus 2 caused a sarcoid-like lesion in a pig. To investigate the cause of equine sarcoids, PCR primers were developed to specifically amplify each of the five different deltapapillomaviruses that have been associated with mesenchymal neoplasia. The specificity of these primers was confirmed using samples of formalin-fixed tissue known to contain each PV type. These primers allow rapid and sensitive detection of deltapapillomavirus DNA in equine sarcoids. As studies have revealed marked regional variability in the cause of equine sarcoids, these primers will be useful to determine the predominant PV type causing sarcoids in a region. Additionally, there is a single report describing mixed infections by BPV1 and BPV2 in equine sarcoids. The specific primer sets are expected to enable more sensitive detection of mixed infections in equine sarcoids. Determining the cause of equine sarcoids is important as vaccines are developed to prevent these common malignant neoplasms.

Greenhouses, hot water bottles, cycles and the future of New Zealand climate

2009 ◽  
pp. 61-67
Author(s):  
W.P. De Lange
Keyword(s):  
New Zealand ◽  
Thermal Energy ◽  
Infrared Radiation ◽  
Little Ice Age ◽  
Hot Water ◽  
Ice Age ◽  
The Sun ◽  
Weather Patterns ◽  
Time Periods ◽  
Almost All

The Greenhouse Effect acts to slow the escape of infrared radiation to space, and hence warms the atmosphere. The oceans derive almost all of their thermal energy from the sun, and none from infrared radiation in the atmosphere. The thermal energy stored by the oceans is transported globally and released after a range of different time periods. The release of thermal energy from the oceans modifies the behaviour of atmospheric circulation, and hence varies climate. Based on ocean behaviour, New Zealand can expect weather patterns similar to those from 1890-1922 and another Little Ice Age may develop this century.

Gene-environment Interaction on the Risk of Type 2 Diabetes Among Ethnic Minority Populations Living in Europe and North America: A Systematic Review

2020 ◽  
Vol 16 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Mohammad H. Zafarmand ◽  
Parvin Tajik ◽  
René Spijker ◽  
Charles Agyemang
Keyword(s):  
Type 2 Diabetes ◽  
North America ◽  
Ethnic Minority ◽  
Ethnic Minorities ◽  
Minority Groups ◽  
Environment Interaction ◽  
Ethnic Minority Groups ◽  
Gene Environment Interaction ◽  
Gene Environment

Background: The body of evidence on gene-environment interaction (GEI) related to type 2 diabetes (T2D) has grown in the recent years. However, most studies on GEI have sought to explain variation within individuals of European ancestry and results among ethnic minority groups are inconclusive. Objective: To investigate any interaction between a gene and an environmental factor in relation to T2D among ethnic minority groups living in Europe and North America. Methods: We systematically searched Medline and EMBASE databases for the published literature in English up to 25th March 2019. The screening, data extraction and quality assessment were performed by reviewers independently. Results: 1068 studies identified through our search, of which nine cohorts of six studies evaluating several different GEIs were included. The mean follow-up time in the included studies ranged from 5 to 25.7 years. Most studies were relatively small scale and few provided replication data. All studies included in the review included ethnic minorities from North America (Native-Americans, African- Americans, and Aboriginal Canadian), none of the studies in Europe assessed GEI in relation to T2D incident in ethnic minorities. The only significant GEI among ethnic minorities was HNF1A rs137853240 and smoking on T2D incident among Native-Canadians (Pinteraction = 0.006). Conclusion: There is a need for more studies on GEI among ethnicities, broadening the spectrum of ethnic minority groups being investigated, performing more discovery using genome-wide approaches, larger sample sizes for these studies by collaborating efforts such as the InterConnect approach, and developing a more standardized method of reporting GEI studies are discussed.

scholarly journals Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e019572
Author(s):  
Vanessa Selak ◽  
Tereki Stewart ◽  
Yannan Jiang ◽  
Jennifer Reid ◽  
Taria Tane ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
New Zealand ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Determinants Of Health ◽  
Pacific People ◽  
Cluster Randomised ◽  
Randomised Controlled

IntroductionType 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people.Methods and analysisThe Mana Tū programme was developed by a Māori-led collaborative of primary healthcare workers and researchers, and codesigned with whānau (patients and their families) in order to address this gap. The programme is based in primary care and has three major components: a Network hub, Kai Manaaki (skilled case managers who work with whānau with poorly controlled diabetes) and a cross-sector network of services to whom whānau can be referred to address the wider determinants of health. The Network hub supports the delivery of the intervention through training of Kai Manaaki, referrals management, cross-sector network development and quality improvement of the programme. A two-arm cluster randomised controlled trial will be conducted to evaluate the effectiveness of the Mana Tū programme among Māori, Pacific people or those living in areas of high socioeconomic deprivation who also have poorly controlled diabetes (glycated haemoglobin, HbA1c, >65 mmol/mol (8%)), compared with being on a wait list for the programme. A total of 400 participants will be included from 10 general practices (5 practices per group, 40 participants per practice). The primary outcome is HbA1c at 12 months. Secondary outcomes include blood pressure, lipid levels, body mass index and smoking status at 12 months. This protocol outlines the proposed study design and analysis methods.Ethics and disseminationEthical approval for the trial has been obtained from the New Zealand Health and Disability Ethics Committee (17/NTB/249). Findings will be presented to practices and their patients at appropriate fora, and disseminated widely through peer-reviewed publications and conference presentations.Trial registration numberACTRN12617001276347; Pre-result.

Cancer detection rates following enrolment in a disease management programme for type 2 diabetes

Diabetologia ◽  
2013 ◽  
Vol 56 (9) ◽  
pp. 1944-1948 ◽  
Author(s):  
A. S. Geier ◽  
J. Wellmann ◽  
I. Wellmann ◽  
H. Kajüter ◽  
O. Heidinger ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Disease Management ◽  
Cancer Detection ◽  
Disease Management Programme ◽  
Management Programme ◽  
Detection Rates

scholarly journals Evaluating cessation of the type 2 oral polio vaccine by modeling pre- and post-cessation detection rates

Vaccine ◽  
2017 ◽  
Vol 35 (42) ◽  
pp. 5674-5681 ◽  
Author(s):  
Steve J. Kroiss ◽  
Michael Famulare ◽  
Hil Lyons ◽  
Kevin A. McCarthy ◽  
Laina D. Mercer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Detection Rates ◽  
Polio Vaccine

Return of the Natives: Explaining the Development and Non-Development of Political Action by Indigenous Peoples in Democratic Political Systems

2012 ◽  
Vol 19 (4) ◽  
pp. 453-480
Author(s):  
Lee E. Dutter
Keyword(s):  
New Zealand ◽  
North America ◽  
Indigenous Peoples ◽  
Political Action ◽  
The Political ◽  
Political Systems ◽  
Present Treatment ◽  
Or Groups ◽  
Torres Strait ◽  
Political Actions

Studies of individuals or groups who might use violence or terrorism in pursuit of political goals often focus on the specific actions which these individuals or groups have taken and on the policies which defenders (that is, governments of states) against such actions may adopt in response. Typically, less attention is devoted to identifying the relevant preconditions of political action and possible escalation to violence and how or why potential actions may be obviated before they occur. In the context of democratic political systems, the present analysis addresses these issues via examination of indigenous peoples, who typically constitute tiny fractions of the population of the states or regions in which they reside, in terms of their past and present treatment by governments and the political actions, whether non-violent or violent, which individuals from these peoples have engaged or may engage. The specific peoples examined are Aborigines and Torres Strait Islanders of Australia, Haudenosaunee of North America, Inuit of Canada, Maori of New Zealand, and Saami of Scandinavia.

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