scholarly journals Immunity against COVID-19: Potential role of Ayurveda: A Review

2021 ◽  
Vol 8 (3) ◽  
pp. 989-992
Author(s):  
Mula Ram Suthar ◽  
◽  
Manjry Anshumala Barla ◽  
Rakesh Roushan ◽  
◽  
...  
Keyword(s):  
Infectious Disease ◽  
Potential Role ◽  
Defense Mechanism ◽  
Well Being ◽  
Communicable Diseases ◽  
The Body ◽  
Disease Concept ◽  
First Case ◽  
Modern Perspective

The Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is an infectious disease caused by coronavirus disease 2019 (COVID-19) and has affected people's lives globally, since first case was detected in Wuhan, China in December 2019. The coronavirus pandemic has turned the world’s attention to the immune system, the body’s defense mechanism against disease. Concept of Ojas is well explained in all ayurvedic classics, in modern perspective it is considered as immunity (Vyadhikshamatava). Ojas is necessary for well-being of the body, and mind. In Ayurveda textbook, the epidemics and along with their management are discussed under the term of Janapadodhvansa. The preventive and curative treatments for communicable diseases of the Janapadodhvansa (epidemics) are Panchkarma (five bio-purification therapies), Rasayana Chikitsa (rejuvenation treatment), Achara Rasayana (good conducts), and migrate to the place, free from communicable diseases. The intake of all types Rasayanas leads to increase of Ojas and reduce all psychological (mainly stress and emotional) disorder, thereby causes increase immunity responses and help to fight against covid-19. Key Words: Ayurveda, Covid-19, Immunity, Janapadodhvansa, Ojas, Rasayana Chikitsa.

scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Biofilm Formation ◽  
Potential Role ◽  
Phage Therapy ◽  
Well Being ◽  
Treatment Alternative ◽  
Surgical Interventions ◽  
Social And Emotional ◽  
Promising Treatment

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

How perceived information transparency and psychological attitude impact on the financial well-being: mediating role of financial self-efficacy

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Muhammad Zia-ur-Rehman ◽  
Khalid Latif ◽  
Muhammad Mohsin ◽  
Zahid Hussain ◽  
Sajjad Ahmad Baig ◽  
...  
Keyword(s):  
Financial Institutions ◽  
Self Efficacy ◽  
Well Being ◽  
The Body ◽  
Main Concern ◽  
Productivity Level ◽  
Content Type ◽  
Information Transparency ◽  
Psychological Attitude

PurposeThe basic intention of this research is to investigate the role of information transparency of financial institutions and psychological attitude of the individuals toward their attention to saving and borrowing. This study also tries to know how an individual's psychological factor affects a person's attitude to motivate them to save or borrow and contribute to well-being by giving them confidence that they can face financial challenges. So, the main concern of this study is to explore different factors that ultimately contribute to the financial well-being (FWB) of individual.Design/methodology/approachA survey was conducted by using a well-structured questionnaire to collect data and test the developed hypotheses by using SmartPLS. Data were collected from 120 customers of seven different commercial banks in Pakistan.FindingsThe findings of this study show that perceived information transparency positively affects FWB. It is also because transparent shared information creates positive change in individuals' perceived self-efficacy and leads to FWB. Furthermore, an individual's psychological attitude toward borrowing and saving did not contribute to the FWB of people who belong to Pakistan.Research limitations/implicationsThe research area is limited to one city of Pakistan and analysis is done with small numbers of sample, it can be increased and more areas can be explored.Practical implicationsThis research provides significant implications for people and economists by providing awareness about the antecedents of FWB. The policymakers or managers who work in financial institutions should provide more transparent information and create less risky opportunities to improve the individual's well-being. If person, manager and financial institution can properly utilize the information of this study, then they are able to improve their FWB. By providing more transparent services and favorable experience with your dealings, it could help to obtain and retain more loyal internal (employees) and external customers. The loyal customers and sincere employees can increase the productivity level of organization. The more productive organizations in countries means better society and progress in the economy.Originality/valueThis research contributes to the body of knowledge that how perceived information transparency and psychological attitude of borrowing create improvement and upward changes in the FWB of a person.

scholarly journals Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Yanke Lin ◽  
Shuai Wang ◽  
Ziyue Zhou ◽  
Lianxia Guo ◽  
Fangjun Yu ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Drug Exposure ◽  
Defense Mechanism ◽  
Critical Role ◽  
The Body ◽  
Cellular Regulation ◽  
Circadian Expression ◽  
Distal Promoter ◽  
Daily Time

Abstract Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 deficiency decreases the mRNA, protein and microsomal activity of Cyp3a11, and blunts their circadian rhythms in mice. A screen for Cyp3a11 regulators identifies two circadian genes Dbp and Hnf4α as potential regulatory mediators. Cell-based experiments confirm that Dbp and Hnf4α activate Cyp3a11 transcription by their binding to a D-box and a DR1 element in the Cyp3a11 promoter, respectively. Bmal1 binds to the P1 distal promoter to regulate Hnf4α transcriptionally. Cellular regulation of Cyp3a11 by Bmal1 is Dbp- and Hnf4α-dependent. Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure. In summary, Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby impacting drug detoxification as a function of daily time.

scholarly journals The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2182 ◽  
Author(s):  
Oliver K Fuller ◽  
Martin Whitham ◽  
Suresh Mathivanan ◽  
Mark A Febbraio
Keyword(s):  
Physical Activity ◽  
Extracellular Vesicles ◽  
Potential Role ◽  
The Body ◽  
Therapeutic Effects ◽  
Health And Wellbeing ◽  
Systemic Factors ◽  
Diabetes And Obesity

Physical activity has systemic effects on the body, affecting almost every organ. It is important not only for general health and wellbeing, but also in the prevention of diseases. The mechanisms behind the therapeutic effects of physical activity are not completely understood; however, studies indicate these benefits are not confined to simply managing energy balance and body weight. They also include systemic factors which are released into the circulation during exercise and which appear to underlie the myriad of benefits exercise can elicit. It was shown that along with a number of classical cytokines, active tissues also engage in inter-tissue communication via extracellular vesicles (EVs), specifically exosomes and other small EVs, which are able to deliver biomolecules to cells and alter their metabolism. Thus, EVs may play a role in the acute and systemic adaptations that take place during and after physical activity, and may be therapeutically useful in the treatment of a range of diseases, including metabolic disorders such as type 2 diabetes and obesity; and the focus of this review, neurological disorders such as Alzheimer’s disease.

Non-specific protection of the body of la-boratory rats under the influence of experimental hypoxia

2020 ◽  
Vol 3 ◽  
pp. 116-123
Author(s):  
F.I. Alistratova ◽  
Keyword(s):  
Blood Cells ◽  
Blood Test ◽  
White Blood Cells ◽  
The Body ◽  
Urgent Problem ◽  
Adaptive Capabilities ◽  
First Case ◽  
Group A ◽  
Adaptive Reactions

To date, the search for the most informa-tive and simple methods for diagnose of adaptive capabilities is an urgent problem of veterinary medicine and adaptive physiolo-gy. The direction of the animal body's re-sponse to the hypoxic factor has not been sufficiently studied. Objective: the analyze of the dynamics of changes of the main indi-cators in the leukogram under the influence of hypoxia, as well as the study of the role of leukocyte, indices the analysis of the level of resistance in rats. The animals were divided into two groups: in the first case, the animals were injected with cytoflavin at a dose of 135 mg/kg before the hypoxia ses-sion, and in the second case, saline was ad-ministered at an equivalent dose. The blood test was performed on a hematological auto-matic analyzer, and the clinical parameters of peripheral blood were determined. Mathe-matically, the leukogram was used to deter-mine: the white blood cell shift index (ISLC), the lymphocyte-monocyte ratio in-dex (ISLM), and the lymphocyte-granulocyte index (ILG). The results of the study showed that the course of hypoxia contributes to a number of changes in the blood composition, for 21 days. There was an increase in the number of white blood cells in both groups, a change in the parame-ters of the leukocyte formula-a decrease in the content of lymphocytes, with a simulta-neous increase in the proportion of mono-cytes. The use of interval hypoxia caused a decrease in the content of red blood cells in animals of the first group, a decrease in the concentration of hemoglobin and hematocrit in both groups studied. The number of plate-lets increased, which also indicates the start of adaptive reactions in the body of rats. The use of leukocyte indices is the assess to the level of resistance of the body and showed their high significance and informa-tive value in modeling experimental hypoxia.

scholarly journals Clinical Evaluation of Percutaneous Vertebroplasty in a Patient with Paraplegia and Immobilization Syndrome: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Salvatore Masala ◽  
Eros Calabria ◽  
Marco Nezzo ◽  
Dominique De Vivo ◽  
Luca Neroni ◽  
...  
Keyword(s):  
Potential Role ◽  
Percutaneous Vertebroplasty ◽  
Life Quality ◽  
Osteoporotic Fractures ◽  
Well Being ◽  
Vertebral Compression Fractures ◽  
Decubitus Ulcers ◽  
Compression Fractures ◽  
Vertebral Stabilization

We will discuss a potential role of percutaneous vertebroplasty (PVP) in the management of a patient with immobilization syndrome due to paraplegia and vertebral osteoporotic fractures. While PVP is commonly used for the treatment of osteoporotic thoracolumbar vertebral compression fractures, its role in vertebral stabilization in patient with immobilization syndrome has not been reported in the literature. A 73-year-old woman affected by immobilization syndrome due to paraplegia and vertebral osteoporotic fractures was treated with PVP of vertebrae D12, L1, and L4. After PVP, the patient did not need any antalgic therapy, and there was a significant improvement regarding mobilization, performance of physiological functions, daily management of personal care, and treatment of decubitus ulcers, increasing life quality and psychological well-being.

Children as Language Brokers

2019 ◽  
Author(s):  
Rachele Antonini
Keyword(s):  
Family Relationships ◽  
Minority Groups ◽  
Research Question ◽  
Well Being ◽  
The Body ◽  
North African ◽  
Negative Effects ◽  
Language And Culture ◽  
Language Brokers

Child language brokering (CLB) is a widespread practice of linguistic and cultural mediation or brokering that is generally performed by the children of immigrant and minority groups and that takes place in all those domains that pertain to these families’ social and daily life. It is a very young topic of interest; hence the body of research and literature available on CLB is still limited and highly fragmented and discipline-based, and attempts at bringing together researchers with different disciplinary and methodological perspectives are quite recent. Nonetheless, the increased interest in this topic of study has contributed to make it a fully fledged and freestanding area of study. Until the mid-1970s, the study of CLB was never the primary research question, and any observation on its existence was considered a byproduct of research focusing on other topics and issues. In the 1980s, articles and essays describing this practice started appearing in a variety of journals and volumes from a wide array of disciplinary perspectives. In the mid-1990s, research on CLB gained momentum and shifted to other aspects and issues of CLB, namely, the who, what, and where of CLB and its positive and negative effects on the language brokers’ education, identity construction, and psychological well-being. These include parentification and adultification issues that emerge when children assume the role of the decision-maker in the family and that may have a significant impact on family relationships, the children’s acculturation and learning process, and their attitudes toward their native and/or second language and culture. The study of CLB in Europe was introduced in the late 1990s and was initially almost exclusively UK-based. Since the end of the 1990s, it has developed in other European countries too, by focusing on the communities that represent the largest migrant groups present in each country, like for instance Moroccan communities in Spain, North African and Italian immigrants in Germany, and a variety of immigrant groups in Italy. CLB is now a topic of research in, inter alia, anthropology, bi- and multilingualism studies, educational studies, interpreting and translation studies, sociolinguistics, and psychology.

The Interoceptive Mind

2018 ◽  
Keyword(s):  
Lived Experience ◽  
Philosophy Of Mind ◽  
Well Being ◽  
The Body ◽  
Mental Life ◽  
Traditional Role ◽  
Philosophical Perspective ◽  
Cognitive Neurosciences ◽  
Affect And Cognition

This volume focuses on the role of interoception for mental life and lived experience, from the perspectives of neurosciences, psychological sciences, and philosophy. Interoception is the body-to-brain axis of signals originating from the internal body and visceral organs (such as gastrointestinal, respiratory, hormonal, and circulatory systems), and plays a unique role in ensuring homeostasis. This volume goes beyond the traditional role of interoception for homeostasis and offers a state-of-the-art overview of and new insights into the role of interoception for mental life, awareness, subjectivity, affect, and cognition. Structured across three parts, this multidisciplinary volume highlights the role that interoceptive signals and awareness thereof play in our mental life (Part I), considers deficits in interoceptive processing and awareness in various mental health conditions but also the equally important role of interoception for well-being (Part II), and approaches interoception from a theoretical and philosophical perspective, representing a highly novel departure for philosophy of mind and subjectivity (Part III). The chapters share a common concern for what it means to experience oneself, for the crucial role of emotions, and for issues of health and well-being, discussed on the joint basis of our bodily existence and interoception. The research presented here will hopefully accelerate the much-anticipated coming of age of interoceptive research in psychology, cognitive neurosciences, and philosophy.

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