scholarly journals Effect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 741
Author(s):  
Zheng Wang ◽  
Ge Yang ◽  
Biao Ren ◽  
Yuan Gao ◽  
Xian Peng ◽  
...  
Keyword(s):  
Enterococcus Faecalis ◽  
Therapeutic Effect ◽  
Root Canal ◽  
Apical Periodontitis ◽  
Control Group ◽  
Root Canal Sealer ◽  
Root Canal Filling ◽  
First Time ◽  
Cone Beam Computer Tomography ◽  
Better Than

The infection of Enterococcus faecalis and its interacting microorganisms in the root canal could cause persistent apical periodontitis (AP). Antibacterial root canal sealer has favorable prospects to inhibit biofilms. The purpose of this study was to investigated the antibacterial effect of root canal sealer containing dimethylaminododecyl methacrylate (DMADDM) on persistent AP in beagle dogs for the first time. Persistent AP was established by a two-step infection with Enterococcus faecalis and multi-bacteria (Enterococcus faecalis, Lactobacillus acidophilus, Actinomycesnaeslundii, Streptococcus gordonii). Root canal sealer containing DMADDM (0%, 1.25%, 2.5%) was used to complete root canal filling. The volume of lesions and inflammatory grade in the apical area were evaluated by cone beam computer tomography (CBCT) and hematoxylin-eosin staining. Both Enterococcus-faecalis- and multi-bacteria-induced persistent AP caused severe apical destruction, and there were no significant differences in pathogenicity between them. DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade compared with the control group, among them, the therapeutic effect of the 2.5% group was better than the 1.25% group. In addition, E.faecalis-induced reinfection was more sensitive to the 2.5% group than multi-bacteria reinfection. This study shows that root canal sealer containing DMADDM had a remarkable therapeutic effect on persistent AP, especially on E. faecalis-induced reinfection.

scholarly journals Periapical status and prevalence of apical periodontitis in patients with type 2 Diabetes mellitus

2021 ◽  
Vol 10 (12) ◽  
pp. e142101220135
Author(s):  
Juliana Érnica Bernardo ◽  
Caroline Loureiro ◽  
Ana Paula Fernandes Ribeiro ◽  
Júlia Guerra de Andrade ◽  
Gladiston William Lobo Rodrigues ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Root Canal ◽  
Apical Periodontitis ◽  
Endodontic Treatment ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Endodontically Treated Teeth ◽  
Root Canal Filling

Diabetes mellitus (DM) is a chronic systemic disease that affects the immunoinflammatory response, leading the patient more susceptible to the development of oral diseases, such as apical periodontitis (AP). Thus, this study aimed to clinically and radiographically analyze the periapical status and prevalence of AP in diabetic patients compared to healthy patients. A total of 100 patients were selected and divided into two groups (n = 50): diabetic group - patients with type 2 DM, and control group - systemically healthy patients. Periapical status was analyzed by the periapical index. The quality of the root canal filling and restoration was also evaluated. Difference between the prevalence of AP among the groups were performed by using the Chi-square test or Fisher's exact test (p < 0.05). The total number of teeth was lower in diabetic group (p = 0.049). Teeth without previous endodontic treatment with AP were higher in diabetic group (p = 0.006). However, the number of endodontically treated teeth with AP was greater in the control group (p = 0.027). AP in teeth with previous endodontic treatment was associated with unsatisfactory root canal filling and restoration quality (p < 0.01). The presence of pain showed significantly higher values in the diabetic group (p = 0.003). In conclusion, this study showed an association between the presence of AP and DM in cases of teeth without endodontic treatment. Besides, the presence of pain was significantly higher in diabetic patients. However, healthy patients showed more cases of AP in endodontically treated teeth.

scholarly journals Comparison of Antimicrobial Activity of Sodium Hypochlorite (NaOCI) 2.5%, Microemulsion of Myrtus 10%, Microemulsion of Thyme 0.6% on the Enterococcus Faecalis After Root Canal Filling

2021 ◽  
Vol 24 (3) ◽  
pp. 424-437
Author(s):  
Forough Khodadadnejad ◽  
◽  
Majid Akbari ◽  
Fateme Abdolalian ◽  
Mahboube Daneshvar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Enterococcus Faecalis ◽  
Sodium Hypochlorite ◽  
Root Canal ◽  
Negative Control Group ◽  
Negative Control ◽  
Endodontic Treatment ◽  
Control Group ◽  
Root Canal Filling ◽  
Anterior Teeth

Background and Aim: The success of endodontic treatment depends on the complete elimination of pathogenic bacteria inside the root canal. Enterococcus faecalis, a gram-positive, pathogenic, and anaerobic cocci, are the primary etiology of root canal infection in treated and untreated teeth and are highly associated with endodontic treatment failure. This study aimed to compare the antimicrobial activity of Sodium hypochlorite 2.5%, microemulsion of Myrtus 10%, and microemulsion of Thyme 0.6% on the E. faecalis after root canal filling. Methods & Materials: In this experimental study, 25 extracted single canal human anterior teeth were collected, and their crowns were cut. Then after washing and cleaning, and filling, the sterilization was done using an autoclave. Then, except 5 teeth (negative control group), the teeth were smeared with E. faecalis and then divided into 5 groups randomly represented the irrigation by Sodium hypochlorite 2.5%, microemulsion of Myrtus 10%, and microemulsion of Thyme 0.6%, with a positive control group and negative control group. The teeth were filled with gutta-percha and then incubated in an incubator for 90 days at a temperature of 37°C. Finally, the comparison of CFU in the groups due to abnormal data distribution was performed using the Kruskal-Wallis test. Ethical Considerations: The Ethics Committee of Arak University of Medical Sciences approved this study (Code: IR.ARAKMU.REC.1398.297). Results: According to the results of this study, the correlation between the groups of cultured teeth was not significant(P>0.05). The specimens washed with microemulsion of the Thyme 0.6% had the highest positive number of cultures; the specimens washed by Sodium hypochlorite 2.5% had the lowest number of cultures. Conclusion: This study showed that no statistically significant difference exists in their antimicrobial activity after root canal therapy after the use of different wash solutions.

scholarly journals Antimicrobial Susceptibility of Enterococcus faecalis Isolated From Root Canal: An In Vitro Study

2020 ◽  
Vol 1 (2) ◽  
pp. 60-64
Author(s):  
Nazanin Zargar ◽  
Mohammad J Nasiri ◽  
Hengameh Ashraf ◽  
Bahareh Hajikhani ◽  
Shirin Etminani Esfahani ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Enterococcus Faecalis ◽  
Root Canal ◽  
Antimicrobial Effect ◽  
Good Choice ◽  
Control Group ◽  
Study Results ◽  
Significant Difference ◽  
Better Than

Background: One of the major causes of failure in root canal treatment is microorganisms like Enterococcus faecalis. Methods: This study aimed to examine the effectiveness of triple antibiotic paste (TAP) containing ciprofloxacin, metronidazole, and minocycline in comparison with modified TAP (MTAP) containing metronidazole, ciprofloxacin, and clindamycin and calcium hydroxide on Enterococcus strains isolated from root canal of tooth associated with pre-apical lesion. Moreover, we evaluated the E. faecalis resistance and antibiotic susceptibility. To do so, 25 patients with previous failure of endodontic treatment were enrolled in this study. Results: The antimicrobial effect of MTAP10%, MTAP1%, TAP10%, TAP1%, and CaOH was significantly better than the positive control group (P <0.05). There was no significant difference between antimicrobial effect of TAP1% and MTAP1%, and CaOH was the least effective one. The antimicrobial effect of TAP10% was significantly better than MTAP10% (P = 0.007). Out of 11 E. faecalis samples, 1 sample was resistant to MTAP1% and MTAP10%, though it was sensitive to other drugs; meanwhile, it showed the highest sensitivity to TAP10%. Conclusion: TAP10% was the most effective choice followed by MTAP10%, but calcium hydroxide was not effective compared to other choices. Thus, MTAP might be a good choice for root canal medicament instead of TAP

scholarly journals Prevalence evaluation of apical periodontitis and its relationship with endodontic and restorative treatment in a community in Southern Brazil

2020 ◽  
Vol 23 (1) ◽  
Author(s):  
Julia Machado Saporiti ◽  
Andressa Gomes ◽  
Melissa Feres Damian ◽  
Nadia De Souza Ferreira
Keyword(s):  
Root Canal ◽  
Apical Periodontitis ◽  
Endodontic Treatment ◽  
Endodontically Treated Teeth ◽  
Chi Square ◽  
Root Canal Filling ◽  
Restorative Treatment ◽  
Anterior Teeth ◽  
Chi Square Test

Objective: The aim of this study was evaluate radiographically prevalence of apical periodontitis (AP) in endodontically treated teeth (ETT) and relate with demographic factors, quality of endodontic treatment and coronal restoration. Material and methods: Data were collected from dental records wich contained full-mouth radiographic series. In ETT, arch, dental group and presence of AP were evaluated. Quality of root canal filling, presence and quality of coronal restoration and type of restorative material were also collected. Data were evaluated using descriptive statistics and Chi-square Test. Results: Of 70 patients included in the final sample, the majority were female (54.3%) and age ranged from 13 to 77 years (47.14 ± 13.18). Of 1,333 teeth evaluated, 73 (5.4%) had endodontic treatment, being the majority maxillary (74%) and anterior teeth (52.1%). Of teeth without endodontic treatment, 320 (25.4%) had AP. Failure rate was high (52.8%) and quality of root canal filling and coronal restoration were considered inadequate in majority cases (58.3% and 47.7%, respectively). Dental group had a statistically significant relationship with presence of AP in ETT, being more frequent in anterior teeth (p = 0.019). Conclusion: It was concluded that prevalence of AP in ETT was high and dental group was the factor that most influenced prevalence of AP in ETT.KeywordsApical periodontitis; Radiography; Root canal filling.

Crown Discoloration Induced by Endodontic Sealers: Spectrophotometric Measurement of Commission International de I'Eclairage's L*, a*, b* Chromatic Parameters

2013 ◽  
Vol 38 (3) ◽  
pp. E91-E102 ◽  
Author(s):  
K Ioannidis ◽  
P Beltes ◽  
T Lambrianidis ◽  
D Kapagiannidis ◽  
V Karagiannis
Keyword(s):  
Root Canal ◽  
Statistical Significance ◽  
Glass Ionomer Cement ◽  
Computer Software ◽  
Control Group ◽  
Root Canal Filling ◽  
Clinical Issue ◽  
Filling Materials ◽  
Thorough Debridement ◽  
Endodontic Sealers

ABSTRACT Despite the improvement of endodontic materials, crown discoloration induced by root canal sealers remains a concerning clinical issue. The aim of this study is the measurement of the alterations in CIE L*, a*, b* chromatic parameters of tooth crowns after placement of commonly used and new-generation endodontic sealers in pulp chambers. Eighty intact, fully developed third mandibular molars were randomly assigned in five groups. Crowns were cross-sectioned from the root complex 1 mm below the cement-enamel junction. The internal axial walls of the pulp chambers were debrided and coated with endodontic sealers (Roth-811, AH-26, Guttaflow, Epiphany SE). The apical access was sealed with glass-ionomer cement. The control group was only debrided. Crowns were stored in individually marked vials in standard conditions (100% humidity, 37°C). The spectral reflectance lines were recorded with a UV-Vis spectrophotometer in the visual spectrum. The CIE L*a*b* parameters were obtained by a linked computer software before sealer placement (baseline), after one week, one, three, and six months, respectively. Statistical analysis was performed with two-way mixed ANOVA models. The level of statistical significance was set at p&lt;0.05. With the exception of the control group, experimental groups presented varying chromatic alterations. Among all experimental groups, Roth-811 sealer induced the most severe alterations in CIE L*, a*, b* chromatic parameters, during all observation periods. After root canal obturation, the clinician should be aware of the presence of remaining root canal filling materials. Thorough debridement of the pulp chamber is essential for the prevention of sealer-induced discoloration.

scholarly journals Healing of a tooth with an overinstrumented apex, extensive transportation and periapical lesion using a 5 mm calcium hydroxide apical plug: an 8-year follow-up report

2012 ◽  
Vol 23 (5) ◽  
pp. 608-611
Author(s):  
Ronaldo Araújo Souza ◽  
Yara T. Corrêa Silva-Sousa ◽  
Suely Colombo ◽  
Maurício Lago ◽  
Marco Antonio Hungaro Duarte ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Apical Periodontitis ◽  
Filling Material ◽  
Root Canal Filling ◽  
Apical Constriction ◽  
Gutta Percha ◽  
Open Apices ◽  
Canal Transportation

Besides the risk of filling material extrusion throughout the apex, a satisfactory apical seal can be difficult to achieve in canals with open apices or iatrogenic enlargements of the apical constriction. These situations pose a challenge to root canal filling. This paper describes the root canal filling of a maxillary right canine with an overinstrumented apex, complete loss of the apical stop, extensive canal transportation and apical periodontitis. A 5 mm calcium hydroxide apical plug was placed before root canal filling. The plug was made by soaking paper points with saline, dipping the points in calcium hydroxide powder and then applying it to the apex several times, until a consistent apical plug was obtained. The canal was then irrigated with saline in order to remove any residual calcium hydroxide from the root canal walls, dried with paper points and obturated with an inverted #80 gutta-percha cone and zinc oxide-eugenol based sealer by the lateral condensation technique. An 8-year radiographic follow-up showed formation of mineralized tissue sealing the apical foramen, apical remodeling and no signs of apical periodontitis.

scholarly journals Outcome of Root Canal Treatment of Necrotic Teeth with Apical Periodontitis Filled with a Bioceramic-Based Sealer

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Kawther Bel Haj Salah ◽  
Sabra Jaâfoura ◽  
Mahdi tlili ◽  
Marwa Ben Ameur ◽  
Saida Sahtout
Keyword(s):  
Treatment Group ◽  
Root Canal ◽  
Apical Periodontitis ◽  
Root Canal Treatment ◽  
Inclusion Criteria ◽  
Root Canal Filling ◽  
Radiographic Findings ◽  
Periapical Lesions ◽  
Single Cone

Introduction. Apical periodontitis is among the most common pathologies in endodontics. The treatment of apical periodontitis has always been an important occupation in the modern practice of endodontics, and the failure has been associated with nonhermetic root canal filling. With that in mind, bioceramic-based sealers have been incorporated into endodontic practice. The purpose of this study was to evaluate the outcome of nonsurgical root canal treatment (RCT), using a single-cone and Bioroot RCS filling of necrotic teeth with apical periodontitis. Materials and Methods. This follow-up study included patients treated in the department of Restorative Dentistry and Endodontics in the Dental Clinic of Monastir, from January 2018 to December 2019. The study intended to include all adult patients presenting a symptomatic or asymptomatic apical periodontitis. Once the diagnosis was performed, the patients were divided into two groups: a one-session treatment group and a two-session treatment group. All cases were obtured with BioRoot using a single-cone technique with a minimum of a 6-month recall. At 6-month follow-ups, teeth were classified as healed, healing (success), or not healed (failure), based on clinical and radiographic findings. Results. Twelve patients met the inclusion criteria, six patients per group. Seven patients returned for follow-ups. At 6-month follow-ups, the overall success rate was 100%, with 57.1% determined to be “healed” and 42.8% determined to be “healing.” All the PAI scores decreased compared to the baseline situation. Conclusion. The results obtained showed the contribution of BioRoot RCS in the healing of periapical lesions. Accordingly, bioceramic-based sealers seem to optimize the prognosis of root canal treatments.

scholarly journals Perbedaan daya antiglukan NaOCl 2,5% dan ekstrak kulit manggis (Garcinia mangostana L.) 0,09% terhadap Enterococcus faecalis (Comparison of antiglucan activity between NaOCl 2.5% and mangosteen pericarp extract (Garcinia mangostana Linn) 0.09% against Enterococcus faecalis)

2019 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Nabiela Rahardia ◽  
M Rulianto ◽  
Dian Agustin Wahjuningrum
Keyword(s):  
Enterococcus Faecalis ◽  
Root Canal ◽  
Bacterial Biofilm ◽  
Control Group ◽  
Garcinia Mangostana ◽  
Control Group Design ◽  
Root Canals ◽  
Viable Cells ◽  
Experimental Laboratory ◽  
The Difference

Background. Failure of endodontic treatment is commonly caused by the persistent microorganisms remaining in the root canal such as Enterococcus faecalis. Enterococcus faecalis can form a biofilm in tough environmental conditions within the root canals and caused biofilm-mediated infections which needs more complicated treatment due to the increasing of antimicrobial resistance. The biofilm formation initial and most important step is bacteria adherence to the solid surface that is mediated by glucan. NaOCl 2.5% is a commonly used root canal medicaments but can cause injury of periapical tissue. Mangosteen pericarp extract contains flavonoid, tannin, and xanthone have mechanism for inhibiting adherence of bacterial biofilm. Difference of antibacterial activity between NaOCl 2.5% and mangosteen pericarp extract 0.09% can be determined by experimental laboratory to determine the adherence of bacteria in each treatment. Purpose. The aim of this study was to assess the difference of antiglucan activity between NaOCl 2.5% and mangosteen pericarp extract 0.09% on Enterococcus faecalis. Method. This study was designed as an experimental laboratory study with post  test only control group design using Enterococcus faecalis ATCC 29212. Mangosteen pericarp was extracted using maceration method. Adherence analysis was observed after 24 hours by examining the viable cells in suspension. These viable cells are measured by UV-Vis spectrophotometer to compare the suspensions’ turbidity. Using the Independent T-Test, significantly less bacteria were found adhering to the mangosteen pericarp extract. Results. Absorbancy difference level by mangosteen pericarp extract 0.09% is significantly greater than the NaOCl 2.5% (p<0.05). Conclusion. Antiglucan activity that generated by mangosteen pericarp extract 0.09% is greater than NaOCl 2.5%

scholarly journals Efficacy of finisher files in the removal of calcium hydroxide paste from the root canal system – preliminary results

2021 ◽  
Vol 90 (2) ◽  
pp. e499
Author(s):  
Agata Koprowicz ◽  
Piotr Koprowicz
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Control Group ◽  
Sodium Hypochlorite Solution ◽  
Human Teeth ◽  
Filling Materials ◽  
Number Of Factors ◽  
Root Canal System ◽  
Post Hoc ◽  
Better Than

Introduction. Successful endodontic treatment is affected by a number of factors associated with the disinfection and filling of the root canal. The chemical-mechanical root canal preparation consists in a thorough removal of any content from the pulp space, including inflamed pulp, bacteria, as well as canal filling materials. Aim. The aim of the study was to analyse the efficacy of the XP-endo Finisher and the Brush-Finisher on the removal of a calcium hydroxide dressing. Material and Methods. The study was conducted using extracted single-rooted human teeth prepared according to sample standardization. Calcium hydroxide with iodoform was inserted into the canals. After two weeks, canal cleaning was performed with the use of 2% sodium hypochlorite solution and both finisher files. A conventional endodontic needle and syringe (SNI) were used in the control group. Following rinsing activation, two projection radiographs were performed and uploaded to software developed specifically for the study. The graphic files were evaluated in terms of the remaining amount of dressing. In order to analyse whether the percentage of the canal area that remained untreated was statistically significant, the Kruskal-Wallis ANOVA test with Dunn’s post-hoc test were employed. Results. The intracanal dressing was most effectively removed in the XP-endo Finisher group (in both projections 96.32% and 91.35%), and its removal was considerably better than that in the control group (p<0.0001), although not significantly different from the Brush-Finisher group (89.68% and 81.85%). Conclusions. Supplementary irrigant activation with either the XP-endo Finisher or the Brush-Finisher improved the removal of calcium hydroxide from the root canal walls.

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