scholarly journals Stability of Antimicrobials in Elastomeric Pumps: A Systematic Review

Antibiotics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 45
Author(s):  
Beatriz Fernández-Rubio ◽  
Paula del Valle-Moreno ◽  
Laura Herrera-Hidalgo ◽  
Alicia Gutiérrez-Valencia ◽  
Rafael Luque-Márquez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critical Evaluation ◽  
Open Science ◽  
Current Evidence ◽  
Antimicrobial Drugs ◽  
Essential Point ◽  
Outpatient Parenteral Antimicrobial Therapy ◽  
Physicochemical Stability ◽  
Review Protocol ◽  
The Stability

Outpatient parenteral antimicrobial therapy (OPAThttp) programs have become an important healthcare tool around the world. Portable elastomeric infusion pumps are functional devices for ambulatory delivery of antimicrobial drugs, and their stability is an essential point to guarantee an appropriate infusion administration. We conducted a systematic review to provide a synthesis and a critical evaluation of the current evidence regarding antimicrobial stability in elastomeric pumps. Data sources were PubMed, EMBASE, and Web of Sciences. The review protocol was registered on the Center for Open Science, and it was carried out following the PRISMA guidelines. Studies were eligible if the aim was the evaluation of the physicochemical stability of an antimicrobial agent stored in an elastomeric device. Of the 613 papers identified, 33 met the inclusion criteria. The most studied group of antimicrobials was penicillins, followed by cephalosporins and carbapenems. In general, the stability results of the antimicrobials that have been studied in more than one article agree with each other, with the exception of ampicillin, flucloxacillin, and ceftazidime. The antibiotics that displayed a longer stability were glycopeptides and clindamycin. Regarding the stability of antifungals and antivirals, only caspofungin, voriconazole, and ganciclovir have been investigated. The information provided in this article should be considered in patient treatments within the OPAT setting. Further stability studies are needed to confirm the appropriate use of the antimicrobials included in this program to ensure optimal patient outcomes.

A SYSTEMATIC REVIEW OF CLINICAL OUTCOMES IN THE TREATMENT OF TEMPOROMANDIBULAR JOINT DYSFUNCTION USING ULTRASOUND GUIDED ARTHROCENTESIS AND CONVENTIONAL THERAPY

2021 ◽  
pp. 19-22
Author(s):  
Chirag Bhatia ◽  
Hirkani Attarde
Keyword(s):  
Systematic Review ◽  
Temporomandibular Joint ◽  
Operating Time ◽  
Mouth Opening ◽  
Risk Of Bias ◽  
Temporomandibular Joint Disorders ◽  
Current Evidence ◽  
Cochrane Library ◽  
Review Protocol ◽  
Reported Data

Objective: This systematic review aimed to compare outcomes between ultrasound (US)-guided arthrocentesis and conventional arthrocentesis for the management of temporomandibular joint disorders (TMDs). Methods: PubMed, MEDLINE, Cochrane Library, Google Scholar and th EBSCOhost databases were searched up to 30 September 2020 for randomized control trials (RCTs) comparing US-guided and conventional arthrocentesis. The review protocol followed the PRISMA guidelines and was registered in PROSPERO (CRD42020211942). The risk of bias of the studies was independently evaluated using Cochrane Risk of Bias tool. Results: Four RCTs were included. It did not demonstrate any statistically signicant difference in pain or maximal mouth opening (MMO) scores after 1 week and 1 month of follow-up between US-guided and conventional arthrocentesis. Studies also reported data on intra-operative needle relocations and operating time but with conicting results. Conclusion: This study indicates that the use of US during arthrocentesis may not improve postoperative pain and MMO in the short term. Further high-quality adequately powered RCTs are required to strengthen current evidence.

Device and non-device-guided slow breathing to reduce blood pressure in hypertensive patients: a systematic review protocol. (Preprint)

2021 ◽  
Author(s):  
Kamila Shelry Gonçalves ◽  
Ana Carolina Queiroz Godoy Daniel ◽  
José Luiz Tatagiba Lamas ◽  
Henrique Ceretta Oliveira ◽  
Renata Cristina De Campos Pereira Silveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Current Evidence ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Systematic Review Protocol ◽  
Hypertensive Patients ◽  
Gray Literature ◽  
Review Protocol ◽  
Slow Breathing

UNSTRUCTURED Introduction: Physiotherapy can include both device-guided slow breathing and device-guided slow breathing in the treatment of systemic arterial hypertension. Methods: A systematic search of all published randomized controlled trials on the effects of device-guided and non-device-guided slow breathing on hypertensive patients, without language restriction, will be carried out until January 2020 in nine databases: Pubmed / MEDLINE (Medical Literature Analysis and Retrieval System Online), Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Cumulative Index to Nursing and Allied Health Literature ( CINAHL), Scopus, Web of Science, Livivo, as well as a search of clinical trial records databases, CT.GOV (Clinical trials.Gov), and bases for the Open Grey gray literature, Gray Literature Report, ProQuest Central (Citation, Abstract or Indexing and Dissertations and Theses). In all of these databases, potentially eligible studies including completed and ongoing ECAs were researched. The quality assessment of the included studies will be conducted using the Cochrane Risk of Bias Tool for Randomized Trials. The overall quality of the evidence for each outcome will be assessed using the Grading of Recommendations, Development and Evaluation (GRADE) system. Discussion: This systematic review will provide a summary of the current evidence on the effects of both device-guided slow breathing and device-guided slow breathing on blood pressure levels. This information can contribute to decision making by health professionals related to the use of these interventions in hypertensive patients. Following the guidelines, this systematic review protocol was registered with the Prospective International Register of Systematic Reviews (PROSPERO) number CRD42020147554.

scholarly journals Economic evaluation of diagnostic sleep studies for obstructive sleep apnoea: a systematic review protocol

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Andrea N. Natsky ◽  
Andrew Vakulin ◽  
Ching Li Chai Coetzer ◽  
R. D. McEvoy ◽  
Robert J. Adams ◽  
...  
Keyword(s):  
Systematic Review ◽  
Economic Evaluation ◽  
Cost Effectiveness ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Current Evidence ◽  
Cochrane Library ◽  
Systematic Review Protocol ◽  
Obstructive Sleep ◽  
Review Protocol

Abstract Background Obstructive sleep apnoea (OSA) is a significant public health problem affecting a large proportion of the population and is associated with adverse health consequences and a substantial economic burden. Despite the existence of effective treatment, undiagnosed OSA remains a challenge. The gold standard diagnostic tool is polysomnography (PSG), yet the test is expensive, labour intensive and time-consuming. Home-based, limited channel sleep study testing (levels 3 and 4) can advance and widen access to diagnostic services. This systematic review aims to summarise available evidence regarding the cost-effectiveness of limited channel tests compared to laboratory and home PSG in diagnosing OSA. Methods Eligible studies will be identified using a comprehensive strategy across the following databases from inception onwards: MEDLINE, PsychINFO, SCOPUS, CINAHL, Cochrane Library, Emcare and Web of Science Core Collection and ProQuest databases. The search will include a full economic evaluation (i.e. cost-effectiveness, cost-utility, cost-benefit, cost-consequences and cost-minimisation analysis) that assesses limited channel tests and PSG. Two reviewers will screen, extract data for included studies and critically appraise the articles for bias and quality. Meta-analyses will be conducted if aggregation of outcomes can be performed. Qualitative synthesis using a dominance ranking matrix will be performed for heterogeneous data. Discussion This systematic review protocol uses a rigorous, reproducible and transparent methodology and eligibility criteria to provide the current evidence relating to the clinical and economic impact of limited channel and full PSG OSA diagnostic tests. Evidence will be examined using standardised tools specific for economic evaluation studies. Trial registration PROSPERO (CRD42020150130)

scholarly journals Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol

2020 ◽  
Author(s):  
Yan Yan ◽  
Ru-ya Sheng ◽  
Yu Wang ◽  
Chun-hong Zhang
Keyword(s):  
Scoping Review ◽  
Meta Analysis ◽  
Critical Evaluation ◽  
Complementary Therapy ◽  
Underlying Mechanism ◽  
Open Science ◽  
Future Studies ◽  
Scoping Reviews ◽  
Review Protocol ◽  
Science Framework

Abstract Background: Acupuncture is a widely used alternative and complementary therapy. Functional Magnetic Resonance Imaging (fMRI) is an important technique to explore the underlying mechanism of acupuncture, and the task-based fMRI can reflect the instant effects or sustained effects of acupuncture in the brain. This scoping review aims to summarize the characteristics of acupuncture mechanism studies employing Task-based fMRI and conclude a reference for future studies.Methods/design: This review will follow the Guidance for Conducting Systematic Scoping Reviews. Eligible articles will be collected from 6 databases (PubMed, Embase, Cochrane, CNKI, WanFang and VIP) with the related keywords such as “Acupuncture” and “fMRI” and those articles should be published from the establishment of the database to June 30th, 2020. Each research step will involve at least two reviewers. The PRISMA-ScR (Preferred Reporting Items for Systemic Reviews and Meta-Analysis Extension for Scoping Reviews) will be used to organize the review.Discussion: This review aims to clarify the extent of acupuncture mechanism studies employing task-based fMRI. It is supposed to make a critical evaluation or to propose quality requirements for future studies by summarizing the objectives and designs of eligible studies. What’s more, directional suggestions will be provided for further studies.Scoping review registration: Open Science Framework https://osf.io/zjrdc/.

scholarly journals Application of immersive technology interventions in sexual victims: A systematic review protocol

2021 ◽  
Author(s):  
Ashkan Ilami ◽  
◽  
Mohammadali Amini-Tehrani ◽  
Hadi Zamanian
Keyword(s):  
Systematic Review ◽  
Study Design ◽  
Current Evidence ◽  
Systematic Review Protocol ◽  
Review Protocol ◽  
Review Question ◽  
Intervention Content ◽  
Immersive Technology ◽  
Sexually Victimized

Review question / Objective: The aim of this systematic review is to critically evaluate the current evidence regarding the immersive technology interventions in sexual victims in terms of applied methodology and patient-related outcomes. Accordingly, this systematic review will address the following questions: 1) what are the general methodological features (study design, sample and related variables, intervention content and related variables, so forth) of immersive technology interventions targeting sexually victimized individuals, 2) to what extent immersive technology interventions targeting sexually victimized individuals are promising in terms of methodological outcomes (such as feasibility, safety, so forth), and 3) to what extent the immersive technology interventions have been effective in addressing biopsychosocial outcomes in sexually victimized individuals.

scholarly journals Patients’ values and other decisional factors regarding treatment of hypercalcemia of malignancy: A Systematic Review Protocol

2021 ◽  
Author(s):  
Aya Bassatne ◽  
Maya Rahme ◽  
Thomas Piggott ◽  
Mohammad H Murad ◽  
Layal Hneiny ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Drug Class ◽  
Treatment Options ◽  
Case Series ◽  
Pharmacological Therapy ◽  
Current Evidence ◽  
Drug Selection ◽  
Hypercalcemia Of Malignancy ◽  
Review Protocol

Abstract Background: Hypercalcemia of malignancy is the second most common cause of hypercalcemia and is associated with significant morbidity and mortality. Several treatment options are available including pharmacological therapy with bisphosphonates, denosumab, glucocorticoids, and calcimimetics, as well as conventional therapy with hydration and possibly calcitonin. While guidelines have previously considered treatment effects, no guideline has yet considered a range of contextual factors impacting recommendations for the management. Objective: The aim of this study is to summarize the available evidence on important decisional factors for the development of guidelines for the treatment of hypercalcemia of malignancy. These include patient’s values and preferences, cost, acceptability, feasibility, and equity. Methods/Design: This is a systematic review of observational studies, case series, trials, reviews and qualitative studies involving treatment of adult patients with hypercalcemia of malignancy. We developed and executed two independent search strategies using five databases: Pubmed, Medline (OVID), Embase.com, CINAHL (EBSCO) and Cochrane, and reviewed their combined output. Two reviewers screened titles and abstracts and full texts and will implement data abstraction from relevant studies independently and in duplicate. The outcomes of interest are the decisional factors that influence drug selection, with possible subgroup analyses by drug class or etiology of hypercalcemia of malignancy. We will present the data collected in a narrative and thematic approach. Discussion: This systematic review will identify important treatment decisional factors, and will assist guidelines panels, physicians and patients to decide on therapeutic options based on the current evidence.

scholarly journals Massive Open Online Courses (MOOCs) Dropout Rate in the World: A Systematic Review Protocol

2020 ◽  
Author(s):  
Manoosh Mehrabi ◽  
Ali Reza Safarpour ◽  
Abbas Ali Keshtkar
Keyword(s):  
Systematic Review ◽  
Online Courses ◽  
Meta Analysis ◽  
Dropout Rate ◽  
Open Science ◽  
Massive Open Online Courses ◽  
Massive Open Online ◽  
The World ◽  
Review Protocol ◽  
Science Framework

Abstract BackgroundRecently, massive open online courses (MOOCs) have received increasing popularity throughout the world. Regardless of the subject taught and the university providing the course, the dropout rate of MOOCs is one of the most important challenges ahead.Methods This systematic review will search MEDLINE/PubMed, Scopus, Web of Science (Clarivate Analytics), Embase (Embase.com), ASSIA, CINAHL, Education Research, BEI, and Eric databases systematically according to predefined criteria without language restrictions to retrieve prospective and retrospective observational studies conducted between the 1st of January 2000 and 30th of March 2020 which evaluated the frequency of leaving MOOCs throughout the world. In the absence of severe methodological heterogeneity, the data will be combined and a meta-analysis will be performed. DiscussionAs dropout rate is one of the most challenges that universities may encounter, this systematic review will help universities extend their view, save their resources or maybe design their MOOCs differently.RegistrationRegistered in Open Science Framework, available at: https://osf.io/jgyqx/

scholarly journals Device and non-device-guided slow breathing to reduce blood pressure in hypertensive patients: a systematic review protocol

2021 ◽  
Author(s):  
Kamila Shelry de Freitas Gonçalves ◽  
Ana Carolina Queiroz Godoy Daniel ◽  
José Luiz Tatagiba Lamas ◽  
Renata Cristina De Campos Pereira Silveira ◽  
Lyne Cloutier ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Current Evidence ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Systematic Review Protocol ◽  
Hypertensive Patients ◽  
Gray Literature ◽  
Review Protocol ◽  
Slow Breathing

Abstract IntroductionPhysiotherapy can include both device-guided slow breathing and device-guided slow breathing in the treatment of systemic arterial hypertension. MethodsA systematic search of all published randomized controlled trials on the effects of device-guided and non-device-guided slow breathing on hypertensive patients, without language restriction, will be carried out until January 2020 in nine databases: Pubmed / MEDLINE (Medical Literature Analysis and Retrieval System Online), Latin American and Caribbean Health Sciences Literature (LILACS), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro), Cumulative Index to Nursing and Allied Health Literature ( CINAHL), Scopus, Web of Science, Livivo, as well as a search of clinical trial records databases, CT.GOV (Clinical trials.Gov), and bases for the Open Grey gray literature, Gray Literature Report, ProQuest Central (Citation, Abstract or Indexing and Dissertations and Theses). In all of these databases, potentially eligible studies including completed and ongoing ECAs were researched. The quality assessment of the included studies will be conducted using the Cochrane Risk of Bias Tool for Randomized Trials. The overall quality of the evidence for each outcome will be assessed using the Grading of Recommendations, Development and Evaluation (GRADE) system. DiscussionThis systematic review will provide a summary of the current evidence on the effects of both device-guided slow breathing and device-guided slow breathing on blood pressure levels. This information can contribute to decision making by health professionals related to the use of these interventions in hypertensive patients. Following the guidelines, this systematic review protocol was registered with the Prospective International Register of Systematic Reviews (PROSPERO) number CRD42020147554.

scholarly journals Patients’ values and other decisional factors regarding treatment of hypercalcemia of malignancy: A Systematic Review Protocol

2020 ◽  
Author(s):  
Aya Bassatne ◽  
Maya Rahme ◽  
Thomas Piggott ◽  
Mohammad H Murad ◽  
Layal Hneiny ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Drug Class ◽  
Treatment Options ◽  
Case Series ◽  
Pharmacological Therapy ◽  
Current Evidence ◽  
Drug Selection ◽  
Hypercalcemia Of Malignancy ◽  
Review Protocol

Abstract Background Hypercalcemia of malignancy is the second most common cause of hypercalcemia and is associated with significant morbidity and mortality. Several treatment options are available including pharmacological therapy with bisphosphonates, denosumab, glucocorticoids, and calcimimetics, as well as conventional therapy with hydration and possibly calcitonin. While guidelines have previously considered treatment effects, no guideline has yet considered a range of contextual factors impacting recommendations for the management. Objective The aim of this study is to summarize the available evidence on important decisional factors for the development of guidelines for the treatment of hypercalcemia of malignancy. These include patient’s values and preferences, cost, acceptability, feasibility, and equity. Methods/Design: This is a systematic review of observational studies, case series, trials, reviews and qualitative studies involving treatment of adult patients with hypercalcemia of malignancy. We developed and executed two independent search strategies using five databases: Pubmed, Medline (OVID), Embase.com, CINAHL (EBSCO) and Cochrane, and reviewed their combined output. Two reviewers screened titles and abstracts and full texts and will implement data abstraction from relevant studies independently and in duplicate. The outcomes of interest are the decisional factors that influence drug selection, with possible subgroup analyses by drug class or etiology of hypercalcemia of malignancy. We will present the data collected in a narrative and thematic approach. Discussion This systematic review will identify important treatment decisional factors, and will assist guidelines panels, physicians and patients to decide on therapeutic options based on the current evidence.

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