scholarly journals A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 436
Author(s):  
Eman S. Mostafa ◽  
Ahmed Maher ◽  
Dalia A. Mostafa ◽  
Sameh S. Gad ◽  
Mahmoud A.M. Nawwar ◽  
...  
Keyword(s):  
Prunus Persica ◽  
Antioxidant Activities ◽  
Skin Permeation ◽  
Total Phenolic ◽  
Scoring Method ◽  
Solid Lipid ◽  
Skin Delivery ◽  
Kaempferol Glycoside ◽  
Cytotoxicity Studies ◽  
By Products

Polyphenols are known dietary antioxidants. They have recently attracted considerable interest in uses to prevent skin aging and hyperpigmentation resulting from solar UV-irradiation. Prunus persica (L.) leaves are considered by-products and were reported to have a remarkable antioxidant activity due to their high content of polyphenols. This study aimed at the development of a cosmeceutical anti-aging and skin whitening cream preparation using ethanol leaves extract of Prunus persica (L.) (PPEE) loaded in solid lipid nanoparticles (SLNs) to enhance the skin delivery. Chemical investigation of PPEE showed significantly high total phenolic and flavonoids content with notable antioxidant activities (DPPH, ABTS, and β-carotene assays). A unique acylated kaempferol glycoside with a rare structure, kaempferol 3-O-β-4C1-(6″-O-3,4-dihydroxyphenylacetyl glucopyranoside) (KDPAG) was isolated for the first time and its structure fully elucidated. It represents the first example of acylation with 3,4-dihydroxyphenyl acetic acid in flavonoid chemistry. The in-vitro cytotoxicity studies against a human keratinocytes cell line revealed the non-toxicity of PPEE and PPEE-SLNs. Moreover, PPEE, PPEE-SLNs, and KDPAG showed good anti-elastase activity, comparable to that of N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone. Besides, PPEE-SLNs and KDPAG showed significantly (p < 0.001) higher anti-collagenase and anti-tyrosinase activities in comparison to EDTA and kojic acid, respectively. Different PPEE-SLNs cream formulae (2% and 5%) were evaluated for possible anti-wrinkle activity against UV-induced photoaging in a mouse model using a wrinkle scoring method and were shown to offer a highly significant protective effect against UV, as evidenced by tissue biomarkers (SOD) and histopathological studies. Thus, the current study demonstrates that Prunus persica leaf by-products provide an interesting, valuable resource for natural cosmetic ingredients. This provides related data for further studying the potential safe use of PPEE-SLNs in topical anti-aging cosmetic formulations with enhanced skin permeation properties.

scholarly journals Chemical Composition of Leaves and Hull from Pistacia Vera L. an Evaluation of Phenolic Content and Antioxidant Properties of their Extracts

2020 ◽  
Author(s):  
Manel Elakremi ◽  
Leyre Sillero ◽  
Lazher Ayed ◽  
Jalel Labidi ◽  
Younes Moussaoui
Keyword(s):  
Phenolic Content ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Chemical Characterization ◽  
Total Phenolic ◽  
Pistacia Vera ◽  
Phenolic And Flavonoid ◽  
By Products ◽  
Comprehensive Study

Abstract The pistachio industry in Tunisia generates a high amount of waste every year due to the large pistachio production. This, together with the good properties of the compounds that can be extracted from these by-products, makes it necessary a comprehensive study of their potential. Because of that, the aim of this work was to analyze the chemical characterization of male and female leaves and hull of Pistacia vera L. and their ethanol-water extracts. With that purpose, the total phenolic and flavonoid contents of the extracts were determined and their antioxidant activities were investigated using DPPH, ABTS and FRAP methods. The total phenolic content varied from 218to533mg GAE/g DE, and the total flavonoid content varied from119to 397 mg CE/g DE. In general, the antioxidant activity showed significant values. The DPPH assay and the ABTS assay were in the range of 332–704 mg TE/g DE and 427and 1394 mg TE/g DE, respectively .In the case of FRAP, male leaves extract had the best result, being the TE value 808 mg TE/g DE. All the extracts were rich in phenolic compounds and possess valuable antioxidant activities. Therefore, leaves and hull of Pistacia vera L. could be used as cheap natural antioxidant in different applications.

scholarly journals Assessment of Antioxidant Activity and Neuroprotective Capacity on PC12 Cell Line ofFrankenia thymifoliaand Related Phenolic LC-MS/MS Identification

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Rim Ben Mansour ◽  
Wided Megdiche Ksouri ◽  
Stéphanie Cluzet ◽  
Stéphanie Krisa ◽  
Tristan Richard ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Total Phenolic ◽  
Chemical Compositions ◽  
Medicinal Species ◽  
Phenolic Contents ◽  
Amyloid A ◽  
Aerial Parts ◽  
Kaempferol Glycoside ◽  
Etoac Fraction ◽  
First Time

This work aimed to investigate the richness of a Tunisian xerohalophyteFrankenia thymifoliaaerial and root parts on phenolics and to evaluate the antioxidant and neuroprotective properties of this medicinal species. After fractionation using increasing and different solvent polarities, results displayed five fractions, where ethyl acetate (EtOAc) shoot and root fractions possess considerable total phenolic contents (221 and 308 mg of GAE/g of E, resp.) related to their important antioxidant activities such as ORAC (918 and 713 mg of TE/g of E), DPPH (282 and 821 mg of TE/g), and ABTS (778 and 1320 mg of TE/g) tests. Then, the identification of the main compounds by HPLC-DAD-ESI-MS and neuroprotective property of the most active fraction EtOAc were assessed. A total of 14 molecules were identified, which have been described for the first time inF. thymifolia. The major compounds identified were pinoresinol and kaempferol glycoside in aerial parts and gallic acid and ellagitannin in roots. Neuroprotective capacity againstβ-amyloid (Aβ) peptide induced toxicity in PC12 cells of EtOAc fraction showed a significant protective activity at lower concentration (25 and 50 µM). The relevant antioxidant and neuroprotective activities ofF. thymifoliaEtOAc fraction corroborated their chemical compositions.

scholarly journals Addition of Grape Skin and Stems Extracts in Wines during the Storage to Reduce the Sulfur Dioxide: Impact on Red Wine Quality

2021 ◽  
Vol 18 (5) ◽  
pp. 2783
Author(s):  
Rocío Casquete ◽  
María José Benito ◽  
Francisco Pérez-Nevado ◽  
Ana Martínez ◽  
Alberto Martín ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Red Wine ◽  
Antioxidant Activities ◽  
Wine Industry ◽  
Total Phenolic ◽  
Skin Extract ◽  
Red Wines ◽  
Wine Production ◽  
Microbiological Stability ◽  
By Products

This study aimed to evaluate the usefulness of bioactive extracts obtained from red wine by-products, such as grape skins and stems, for reducing or eliminating the use of SO2 in red wine production. Special attention was focused on guaranteeing the microbiological stability of the red wines and protecting them against oxidation. Therefore, the antioxidant and antimicrobial activities of the extracts and red wines were studied. Red grape stems and skins, by-products of the wine industry, from six types of monovarietal wines, were used. Extracts obtained from stems displayed higher concentrations of total phenolic compounds and higher in vitro antioxidant activity. Both stem and skin extracts demonstrated higher antimicrobial activity against pathogenic bacteria and lower activity against yeasts. In the wines produced, higher antimicrobial and antioxidant activities were observed, mainly in the skin extract batches. This study highlights that bioactive extracts obtained from by-products of wine making could be used to reduce or eliminate the use of SO2 in wine production. In this way, healthier red wines could be obtained while guaranteeing their microbiological stability and protecting them from oxidation. Furthermore, the use of these by-products is strongly associated with the circular economy, as they could help to reduce the environmental impact of the wine industry.

Biological Activities and Dermal Penetration of Liposome-Containing Coprinus atramentraris Extract

2019 ◽  
Vol 819 ◽  
pp. 124-129
Author(s):  
Parapat Sobharaksha ◽  
Ratana Indranupakorn ◽  
Sonmkamol Manchan
Keyword(s):  
Particle Size ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Skin Permeation ◽  
Ethanolic Extract ◽  
Entrapment Efficiency ◽  
Strong Relationship ◽  
Antioxidant Property ◽  
Total Phenolic

The total phenolic content and antioxidant activities of five edible mushrooms (Pleurotus djamor, Agaricus bisporus, Hericlum erinaceus, Coprinus atramentraris and P. ostreatus) were evaluated. The Coprinus atramentraris ethanolic extract (CE) showed the promising antioxidant property and had a strong relationship with phenolic compound content. Liposome-containing CE formulations, were prepared with various lipid composition. The liposome formulation, L1, which composed of phospholipids and cholesterol at ratio of 6:4 gave the highest entrapment efficiency (24.03%), small particle size (143.03 nm) and favorable particle size distribution (0.311) with small values of zeta potential (-30.2 mV). L1 showed good anti-elastase property (IC50 0.029) and no cytotoxicity effect to the human skin fibroblasts and melanoma cells even at the highest concentration of 1 mg/mL compared to the unformulated extract. The in vitro skin permeation studies, using human cadaver skin and modified Franz-diffusion cells, showed that the L1 was able to considerably increase the rate of permeation of phenolic compounds in L1 compared to the CE solution. These results reflect the use of L1 as active agents in cosmeceuticals.

scholarly journals Oxidative stability of soybean oil enriched with ethyl acetate extract of olive by-products

2020 ◽  
Vol 8 (6) ◽  
pp. 1373-1379
Author(s):  
Semra Turan ◽  
Deniz Günal Köroğlu
Keyword(s):  
Soybean Oil ◽  
Oxidative Stability ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Phenolic Contents ◽  
Total Phenolic Contents ◽  
Phenolic Profiles ◽  
Linoleic Acid Emulsion ◽  
By Products

In this study, oxidative stability of soybean oil (SBO) enriched with ethyl ecetate extracts of olive by-products was investigated. Total phenolic contents, phenolic profiles and antioxidant activities of olive wastewater (OMWW) and olive pomace (OP) extracts were also determined. Total phenolic contents of extracts obtained from OMWW and OP were 134.45 and 281.43 mg gallic acid equivalent (GAE)/g extract, respectively. While antioxidant activities of OMWW extracts in the linoleic acid emulsion were in the range of 85.79 % and 88.54 %, OP extracts had 83.30 % and 90.09 % at different concentrations (0.5, 1, 2 ve 3 mg/mL) after incubation at 37 °C. β-carotene bleaching activities of the extracts at 50 °C were found as 26.80-66.63% in OMWW extracts and 18.76-53.32% in OP extracts, respectively. 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities of OP extracts were higher than those of OMWW extracts and ranged from 30.6% to 87.7% in OP extracts and 16.6% to 54.1% in OMWW extracts at these concentrations. Both the antioxidant and antiradical activities of extracts significantly increased with increased concentration (p

COMPARATIVE STUDY OF ANTIOXIDANT ACTIVITIES, COSMECEUTICAL PROPERTIES AND PHENOLIC ACIDS COMPOSITION OF FERMENTED RICE BRAN AND COCONUT TESTA

2016 ◽  
Vol 78 (11-2) ◽  
Author(s):  
Dang Lelamurni Abd Razak ◽  
Anisah Jamaluddin ◽  
Nur Yuhasliza Abd. Rashid ◽  
Shaiful Adzni Sharifudin ◽  
Kamariah Long
Keyword(s):  
Solid State ◽  
Rice Bran ◽  
Solid State Fermentation ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Inhibition Activity ◽  
Reducing Ability ◽  
By Products

Malaysia produces large number of agro-industrial products annually including rice and coconut. Along with the production, rice bran and coconut testa are also abundantly generated as by-products. Solid state fermentation (SSF) is a simple biotechnological technique that has been employed for production of bioactive compounds. The use of SSF on agro-industrial by-products is economically viable and helps to reduce the environmental impact of the by-products disposal. In this present study, rice bran (RB), coconut testa (CT) and a combination of rice bran and coconut testa (RBCT) were fermented with single culture of Aspergillus oryzae and Rhizopus oligosporus. The effect of fungal SSF on the cosmeceutical-related activities and phenolic acid content of the fermented RB, CT and RBCT extracts was determined. The results showed that total phenolic content (TPC) as well as antioxidant activity measured using the ferric reducing ability of plasma (FRAP) of all substrates increased upon fermentation. Contrary to the TPC and FRAP assays results, the radical-scavenging activity of the fermented samples as measured by using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, were varied. Tyrosinase inhibition activity was found to be the highest in the extract of RB fermented with A. oryzae (56.18%) compared to other extracts. The same extract showed the highest elastase inhibition activity with a value of 60.27%. High performance liquid chromatography (HPLC) analyses showed ferulic, sinapic, caffeic and protocatechuic acids were significantly increased in RB fermented with A. oryzae. The results of this study suggest that fungal solid-state fermentation of rice bran may have the potential to be exploited in producing different types of active metabolites that are useful for cosmeceutical industries

Comparative Study of Antioxidant Activities and Total Phenolic Content of Selected Edible Wild Mushrooms

2011 ◽  
Vol 13 (3) ◽  
pp. 245-255 ◽  
Author(s):  
Hip Seng Yim ◽  
Fook Yee Chye ◽  
Mee Yee Lee ◽  
Patricia Matanjun ◽  
Siew Eng How ◽  
...  
Keyword(s):  
Comparative Study ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Wild Mushrooms ◽  
Edible Wild Mushrooms

Phytochemical composition and antioxidant activity of Malus baccata (L.) Borkh. fruits

2020 ◽  
Vol 3 (1) ◽  
pp. 47
Author(s):  
Nadezhda Petkova ◽  
Manol Ognyanov ◽  
Blaga Inyutin ◽  
Petar Zhelev ◽  
Panteley Denev
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Activities ◽  
Ethanol Extract ◽  
Titratable Acidity ◽  
Total Phenolic ◽  
Total Phenolic Compounds ◽  
Frap Assay ◽  
Phytochemical Composition ◽  
Malus Baccata

Crab apple (Malus baccata (L.) Borkh.) was mainly distributed in Europe as an ornamental plant, but the nutritional properties of its edible fruits were not fully revealed. The aim of the current study was to characterize the phytochemical composition of ripen carb apple fruits and to evaluate their nutritional and antioxidant potentials. The fruits were assayed for moisture and ash content, proteins, lipids, carbohydrates, titratable acidity (TA), pH, total phenolic compounds and natural pigments. Among the analyzed carbohydrates cellulose was found in the highest content (6% dw), followed by sugars (sucrose, glucose and fructose) and 1.8 % dw uronic acids. The total chlorophylls and carotenoids contents in their fruits were 6.51 and 4.80 μg/g fw, respectively. Total monomeric anthocyanins were not detected. The highest content of total phenolic compounds (2.67 mg GAE/g fw) was found in 95 % ethanol extract from fruits, while the total flavonoids were relatively low – 0.1 mg QE/g fw. DPPH assay (17.27 mM TE/g fw) and FRAP assay (14.34 mM TE/g fw) demonstrated in vitro antioxidant activities of crabapple. Malus baccata fruits were evaluated as a rich source of dietary fibers and phenolic compounds with significant antioxidant potential that could be used in human nutrition.

SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN DAN ANTITUMOR 20 TUMBUHAN OBAT ASAL KABUPATEN MANOKWARI

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Bimo Budi Santoso
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Antitumor Activity ◽  
Traditional Method ◽  
Extraction Efficiency ◽  
Phenolic Content ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Phenolic Contents ◽  
Total Phenolic Contents

<strong><em>Flavanoid, steroid, and terpenoid contents of 20 Manokwari medicinal plants were analyzed.  The antioxidant activity, total phenolic contents and antitumor activity of 20 Manokwari medicinal plants were also evaluated. The result shows that 83% positif to flavanoid test, 59% positif to terpenoid test and only 25% positif steroid. Antioxidant activity and total phenolic contents evaluated using Ferric Thiocianate (FTC) and Folin-Ciocalteu methods respectively. Antioxidant activity and total phenolic contents of medicinal plants were extracted by the traditional method, boiling in water and also in 80% methanol. Twenty plants evaluated in both exstracts have significantly varies of antioxidant activities and phenolic contents,  A significant and linier correlation coefficient between the antioxidant activity and the total phenolic content was found in both aqueous (R<sup>2</sup>= 0,77) and methanol (R<sup>2</sup> = 0,85). Antitumor activity was tested using cell maurine P-388 and only 2 of medicinal plants are active to inhibit cell maurine P-388. Comparing extraction efficiency of the two methods, the methanol extracted phenolic compounds more efficiently, and antioxidant activity of the extract was higher.</em></strong>

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