scholarly journals Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging

2021 ◽  
Vol 8 (9) ◽  
pp. 121
Author(s):  
Marion Le Gal ◽  
Estelle Renard ◽  
Christelle Simon-Colin ◽  
Benoit Larrat ◽  
Valérie Langlois
Keyword(s):  
Imaging Techniques ◽  
Liquid Core ◽  
Acquisition Time ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Ene Reactions ◽  
Perfluorooctyl Bromide ◽  
19F Mri ◽  
19F Magnetic Resonance Imaging ◽  
Undecenoic Acid

Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, was produced by marine bacteria using coprah oil and undecenoic acid as substrates. PHA-g-(F; PEG) was prepared by two successive controlled thiol-ene reactions from PHAU with firstly three fluorinated thiols having from 3 up to 17 fluorine atoms and secondly with PEG-SH. The resulting PHA-g-(F; PEG)-based PFOB nanocapsules, with a diameter close to 250–300 nm, are shown to be visible in 19F MRI with an acquisition time of 15 min. The results showed that PFOB-nanocapsules based on PHA-g-(F; PEG) have the potential to be used as novel contrast agents for 19F MRI.

scholarly journals Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Johanne Seguin ◽  
Bich-Thuy Doan ◽  
Heldmuth Latorre Ossa ◽  
Lauriane Jugé ◽  
Jean-Luc Gennisson ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Tumour Growth ◽  
Imaging Techniques ◽  
Acquisition Time ◽  
Longitudinal Assessment ◽  
Resonance Imaging ◽  
Orthotopic Model ◽  
Short Acquisition Time ◽  
Magnetic Resonance Imaging Mri ◽  
Good Delineation

Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (<5 min) compared to MRI. Conclusion. MRI and US afforded excellent noninvasive imaging techniques to accurately follow tumour growth of ectopic and orthotopic CT26 tumours. These two techniques can be appropriately used for tumour treatment followup, with a preference for US imaging, due to its short acquisition time and simplicity of use.

scholarly journals New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 807 ◽  
Author(s):  
Gabriel Mencia ◽  
Tania Lozano-Cruz ◽  
Mercedes Valiente ◽  
Javier de la Mata ◽  
Jesús Cano ◽  
...  
Keyword(s):  
Self Assembly ◽  
Focal Point ◽  
Water Soluble ◽  
Biological Applications ◽  
Resonance Imaging ◽  
19F Mri ◽  
19F Magnetic Resonance Imaging ◽  
Or Gene ◽  
Supramolecular Aggregation ◽  
Dendritic Structures

The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of 19F magnetic resonance imaging (19F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by 19F-MRI.

Perfluoro-tert-butanol: a cornerstone for high performance 19F magnetic resonance imaging

2021 ◽  
Author(s):  
Tingjuan Wu ◽  
Anfeng Li ◽  
Kexin Chen ◽  
Xingxing Peng ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Performance ◽  
Imaging Spectroscopy ◽  
Resonance Imaging ◽  
Background Interference ◽  
Tert Butanol ◽  
19F Mri ◽  
Valuable Complement ◽  
19F Magnetic Resonance Imaging

As a valuable complement to its proton-based counterpart (1H MRI/NMR), fluorine-based magnetic resonance imaging/spectroscopy (19F MRI/NMR) provides quantitative images or spectroscopy without background interference, which has become an extensively used...

Chitosan-coated poly(lactic-co-glycolic acid) perfluorooctyl bromide nanoparticles for cell labeling in 19F magnetic resonance imaging

2016 ◽  
Vol 136 ◽  
pp. 936-944 ◽  
Author(s):  
Hieu Vu-Quang ◽  
Mads Sloth Vinding ◽  
Dan Xia ◽  
Thomas Nielsen ◽  
Marcus Görge Ullisch ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Glycolic Acid ◽  
Cell Labeling ◽  
Resonance Imaging ◽  
Perfluorooctyl Bromide ◽  
19F Magnetic Resonance Imaging

scholarly journals Nickel(ii) complexes of N-CH2CF3 cyclam derivatives as contrast agents for 19F magnetic resonance imaging

2016 ◽  
Vol 45 (2) ◽  
pp. 474-478 ◽  
Author(s):  
Jan Blahut ◽  
Petr Hermann ◽  
Andrea Gálisová ◽  
Vít Herynek ◽  
Ivana Císařová ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Relaxation Rate ◽  
Nmr Relaxation ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Rate Enhancement ◽  
19F Magnetic Resonance Imaging

Nickel(ii) complexes of N,N′′-2,2,2-trifluoroethyl cyclam derivatives show significant 19F NMR relaxation rate enhancement useful for 19F MRI imaging.

Rapid 19F magnetic resonance imaging of perfluorooctyl bromide in vivo

1988 ◽  
Vol 6 (1) ◽  
pp. 61-64 ◽  
Author(s):  
D.M. Freeman ◽  
H.H. Muller ◽  
R.E. Hurd ◽  
S.W. Young
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Perfluorooctyl Bromide ◽  
19F Magnetic Resonance Imaging

Immunszintigraphie mit 111ln-DTPA-markierten monoklonalen Antikörpern: Vergleich zwischen ECT und planarer Szintigraphie

1987 ◽  
Vol 26 (06) ◽  
pp. 258-262
Author(s):  
J. Happi ◽  
R. P. Baum ◽  
J. Frohn ◽  
B. Weimer ◽  
A. Halbsguth ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Diagnostic Procedures ◽  
Undifferentiated Carcinoma ◽  
Whole Body ◽  
Acquisition Time ◽  
Planar Imaging ◽  
Primary Tumors ◽  
Intraindividual Comparison ◽  
Single Detector ◽  
Increased Sensitivity

The present study was done in order to examine if the use of111ln-DTPA- labeled MAb fragments in place of 131l-labeled MAb fragments increases the sensitivity of tomographic immunoscintigraphy to reach the level of that of planar imaging techniques. In 11 patients with various primary tumors, local recurrences or metastases [colorectal carcinoma (n = 7), ovarian carcinoma (n = 2), papillary thyroid carcinoma (n = 1), undifferentiated carcinoma of the lung (n = 1)], immunoscintigraphy (IS) was carried out using 111ln-DTPA- labeled F(ab’)2 fragments of various MAbs (anti-CEA, OC 125, anti-hTG) and planar and tomographic imaging were compared intraindividually. By conventional diagnostic procedures, the presence of a tumor mass was confirmed (transmission computer tomography, ultrasound) or verified (131l whole-body scintigraphy, histology) in all cases. Immunoscintigraphy was positive in 9 out of 11 cases by ECT and in 10 out of 11 cases by planar imaging. When using 111 In-labeled MAb fragments, intraindividual comparison of ECT and planar imaging resulted in a similar sensitivity. The increased sensitivity of ECT using this tracer in contrast to 131l-labeled MAb fragments may be attributed to the fact that the physical properties of111 In are much more suitable for the gamma cameras most commonly used (single detector, 3/8” crystal); using 111 In-labeled MAb fragments, count rates sufficient for ECT can be obtained within a reasonable acquisition time. This allows to combine IS with the advantages of ECT regarding tumour localization and prevention of artefacts due to superposition of background.

Fault Localization and Functional Testing of ICs by Lock-in Thermography

2002 ◽  
Author(s):  
O. Breitenstein ◽  
J.P. Rakotoniaina ◽  
F. Altmann ◽  
J. Schulz ◽  
G. Linse
Keyword(s):  
Spatial Resolution ◽  
Electronic Device ◽  
Imaging Techniques ◽  
Heat Diffusion ◽  
Acquisition Time ◽  
Temperature Modulation ◽  
Heat Sources ◽  
Ir Camera ◽  
Free Running ◽  
Lock In

Abstract In this paper new thermographic techniques with significant improved temperature and/or spatial resolution are presented and compared with existing techniques. In infrared (IR) lock-in thermography heat sources in an electronic device are periodically activated electrically, and the surface is imaged by a free-running IR camera. By computer processing and averaging the images over a certain acquisition time, a surface temperature modulation below 100 µK can be resolved. Moreover, the effective spatial resolution is considerably improved compared to stead-state thermal imaging techniques, since the lateral heat diffusion is suppressed in this a.c. technique. However, a serious limitation is that the spatial resolution is limited to about 5 microns due to the IR wavelength range of 3 -5 µm used by the IR camera. Nevertheless, we demonstrate that lock-in thermography reliably allows the detection of defects in ICs if their power exceeds some 10 µW. The imaging can be performed also through the silicon substrate from the backside of the chip. Also the well-known fluorescent microthermal imaging (FMI) technique can be be used in lock-in mode, leading to a temperature resolution in the mK range, but a spatial resolution below 1 micron.

19F magnetic resonance imaging using vesicles of sucrose octaoleate-F104

2008 ◽  
Vol 129 (2) ◽  
pp. 137-138 ◽  
Author(s):  
Gerald W. Buchanan ◽  
Igor Moudrakovski
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
19F Magnetic Resonance Imaging

scholarly journals Cross-sectional anatomy, computed tomography, and magnetic resonance imaging of the banded houndshark (Triakis scyllium)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang Wha Kim ◽  
Adams Hei Long Yuen ◽  
Cherry Tsz Ching Poon ◽  
Joon Oh Hwang ◽  
Chang Jun Lee ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Soft Tissues ◽  
Imaging Techniques ◽  
Evolutionary Developmental Biology ◽  
Phylogenetic Position ◽  
Ct Scanner ◽  
Resonance Imaging ◽  
Cross Sectional

AbstractDue to their important phylogenetic position among extant vertebrates, sharks are an invaluable group in evolutionary developmental biology studies. A thorough understanding of shark anatomy is essential to facilitate these studies and documentation of this iconic taxon. With the increasing availability of cross-sectional imaging techniques, the complicated anatomy of both cartilaginous and soft tissues can be analyzed non-invasively, quickly, and accurately. The aim of this study is to provide a detailed anatomical description of the normal banded houndshark (Triakis scyllium) using computed tomography (CT) and magnetic resonance imaging (MRI) along with cryosection images. Three banded houndsharks were scanned using a 64-detector row spiral CT scanner and a 3 T MRI scanner. All images were digitally stored and assessed using open-source Digital Imaging and Communications in Medicine viewer software in the transverse, sagittal, and dorsal dimensions. The banded houndshark cadavers were then cryosectioned at approximately 1-cm intervals. Corresponding transverse cryosection images were chosen to identify the best anatomical correlations for transverse CT and MRI images. The resulting images provided excellent detail of the major anatomical structures of the banded houndshark. The illustrations in the present study could be considered as a useful reference for interpretation of normal and pathological imaging studies of sharks.

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