scholarly journals The Histaminergic System in Neuropsychiatric Disorders

Biomolecules ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1345
Author(s):  
Li Cheng ◽  
Jiaying Liu ◽  
Zhong Chen
Keyword(s):  
Neuropsychiatric Disorders ◽  
Clinical Findings ◽  
Mammalian Brain ◽  
Future Research ◽  
Appetite Regulation ◽  
Cell Type ◽  
Histaminergic System ◽  
Histaminergic Neurons ◽  
Precise Role

Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders.

Whither shore platforms?

2010 ◽  
Vol 35 (2) ◽  
pp. 183-209 ◽  
Author(s):  
Rajarshi Dasgupta
Keyword(s):  
Collaborative Work ◽  
Laboratory Simulation ◽  
Future Research ◽  
Limited Attention ◽  
Data Sets ◽  
Quantitative Analyses ◽  
Geological Control ◽  
Precise Role ◽  
Shore Platforms

This paper reviews the research on shore platforms since 1980. Although some quantitative work on platforms was conducted in the late 1970s, it was principally in the 1980s that there was a change in the research paradigm, from qualitative observations to quantitative analyses. Researchers are now closer than ever before on agreeing that no single process can produce shore platforms in itself. The last decade has seen remarkable proliferation of research interests in shore platforms. Consequently, there are much-improved data sets on the processes acting on them. Even so, it has not yet been possible to establish definitively the precise role of each individual process in shore platform evolution. Laboratory simulation of platform morphodynamics has received much less attention compared to field-based studies. There are also some other aspects, such as threshold determination, geological control, inheritance, application of geo-informatics and focus on low-energy and tropical coasts, that have received limited attention. These areas are avenues for future research. To enable a better understanding of platform dynamics in a particular area, fieldwork, laboratory simulation and numerical modelling should be carried out simultaneously. Shore platforms are a global feature, and their study should be undertaken in all parts of the world through increased collaborative work among researchers.

Role of gap junctions in CO2 chemoreception and respiratory control

2002 ◽  
Vol 283 (4) ◽  
pp. L665-L670 ◽  
Author(s):  
Jay B. Dean ◽  
David Ballantyne ◽  
Daniel L. Cardone ◽  
Joseph S. Erlichman ◽  
Irene C. Solomon
Keyword(s):  
Gap Junctions ◽  
Brain Stem ◽  
Ionic Current ◽  
Respiratory Control ◽  
Mammalian Brain ◽  
Future Research ◽  
Cell Coupling ◽  
Respiratory Rhythmogenesis ◽  
Cell Cell

Gap junctions are composed of connexins, which are organized into intercellular channels that form transmembrane pathways between neurons (cell-cell coupling), and in some cases, neurons and glia, for exchange of ions and small molecules (metabolic coupling) and ionic current (electrical coupling). Cell-cell coupling via gap junctions has been identified in brain stem neurons that function in CO2/H+ chemoreception and respiratory rhythmogenesis; however, the exact roles of gap junctions in respiratory control are undetermined. Here we review the methods commonly used to study gap junctions in the mammalian brain stem under in vitro and in vivo conditions and briefly summarize the anatomical, pharmacological, and electrophysiological evidence to date supporting roles for cell-cell coupling in respiratory rhythmogenesis and central chemoreception. Specific research questions related to the role of gap junctions in respiratory control are suggested for future research.

scholarly journals The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

2019 ◽  
Vol 78 (9) ◽  
pp. 1167-1178 ◽  
Author(s):  
Dennis G McGonagle ◽  
Iain B McInnes ◽  
Bruce W Kirkham ◽  
Jonathan Sherlock ◽  
Robert Moots
Keyword(s):  
Psoriatic Arthritis ◽  
Immune Responses ◽  
Axial Spondyloarthritis ◽  
Bone Erosion ◽  
Future Research ◽  
Cellular Origin ◽  
Interleukin 17A ◽  
Research Questions ◽  
Precise Role

Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune responses mediated by interleukin 17A (IL-17A) play a pivotal role in both diseases. This is best highlighted by the significant clinical efficacy shown with inhibitors of IL-17A in treating axSpA and PsA. Nevertheless, a number of knowledge gaps exist regarding the role of IL-17A in the pathophysiology of spondyloarthritis in man, including its cellular origin, its precise role in discrete disease processes such enthesitis, bone erosion, and bone formation, and the reasons for the discrepant responses to IL-17A inhibition observed in certain other spondyloarthritis manifestations. In this review, we focus on the latest data from studies investigating the role of IL-17A in ankylosing spondylitis (AS) and PsA that build on existing and emerging scientific knowledge in the field. Key remaining research questions are also highlighted to guide future research.

The role of the central histaminergic system in emergence from propofol anesthesia

2021 ◽  
Vol 18 ◽  
Author(s):  
Chenzhong Xia ◽  
Zexian Zhao ◽  
Lina Yu ◽  
Min Yan
Keyword(s):  
Critical Role ◽  
State Transitions ◽  
Dependent Manner ◽  
Emergence Time ◽  
Firing Activity ◽  
Excitatory Effect ◽  
Histaminergic System ◽  
Tuberomammillary Nucleus ◽  
Histaminergic Neurons

Background: The mechanisms of emergence from general anesthesia remain to be elucidated. Recent studies indicate that the central histaminergic system plays a critical role in maintaining wakefulness. Methods: Role of the central histaminergic system in emergence from propofol anesthesia using microinjections and single-unit recordings in rats was evaluated. Results: Intracerebroventricular (icv) microinjections of histamine decreased the emergence time in a dose-dependent manner and had an excitatory effect on the firing activity of medial prefrontal cortex (mPFC) neurons, while the decrease of emergence time was completely reversed by the pre-treatment with triprolidine (80 μg/5 μl) but not cimetidine (100 μg/5 μl). Moreover, the presumed histaminergic neurons fired in a state-dependent manner, and there was a dramatic increase in firing activity before regain of righting reflex. Furthermore, bidirectional manipulations of emergence were achieved through the microinjection of GABA (10 μg/side) and a potent H3 receptor inverse agonist ciproxian (1 μg/side) into the posterior hypothalamus, where the tuberomammillary nucleus (TMN) resides. Conclusion: Combining the behavioral and neurophysiologic evidence, the central histaminergic system promotes emergence from propofol anesthesia in rats. Our findings suggest an important role of the central histaminergic system in a broader field of state transitions, such as emergence from propofol anesthesia.

Coping Humor as a Mediator Between Emotional Intelligence and Job Satisfaction

2017 ◽  
Vol 16 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Peizhen Sun ◽  
Jennifer J. Chen ◽  
Hongyan Jiang
Keyword(s):  
Job Satisfaction ◽  
Emotional Intelligence ◽  
Future Research ◽  
Satisfaction Scale ◽  
Primary School Teachers ◽  
Mediating Role ◽  
Regulation Of Emotion ◽  
The Relationship ◽  
Overall Job Satisfaction

Abstract. This study investigated the mediating role of coping humor in the relationship between emotional intelligence (EI) and job satisfaction. Participants were 398 primary school teachers in China, who completed the Wong Law Emotional Intelligence Scale, Coping Humor Scale, and Overall Job Satisfaction Scale. Results showed that coping humor was a significant mediator between EI and job satisfaction. A further examination revealed, however, that coping humor only mediated two sub-dimensions of EI (use of emotion and regulation of emotion) and job satisfaction. Implications for future research and limitations of the study are discussed.

Public Administration in the Islamic World: Considering the Importance of Religion, its Values and Culture

2019 ◽  
Vol 19 (2) ◽  
pp. 23-38
Author(s):  
Daniel Hummel
Keyword(s):  
Public Administration ◽  
Core Values ◽  
Comparative Perspective ◽  
Religious Values ◽  
Future Research ◽  
Islamic World ◽  
Salient Region ◽  
The People ◽  
Comparative Public Administration

A small but growing area of public administration scholarship appreciates the influence of religious values on various aspects of government. This appreciation parallels a growing interest in comparative public administration and indigenized forms of government which recognizes the role of culture in different approaches to government. This article is at the crossroads of these two trends while also considering a very salient region, the Islamic world. The Islamic world is uniquely religious, which makes this discussion even more relevant, as the nations that represent them strive towards legitimacy and stability. The history and core values of Islam need to be considered as they pertain to systems of government that are widely accepted by the people. In essence, this is being done in many countries across the Islamic world, providing fertile grounds for public administration research from a comparative perspective. This paper explores these possibilities for future research on this topic.

Moderating Role of Gender in the Relationship between Cognitive Errors and Anxiety among Adolescents

2020 ◽  
Vol 4 (1) ◽  
pp. 86-102
Author(s):  
Tasnim Rehna ◽  
Rubina Hanif ◽  
Muhammad Aqeel
Keyword(s):  
Mental Health Problems ◽  
Adolescent Psychopathology ◽  
Future Research ◽  
Cognitive Errors ◽  
Adolescent Anxiety ◽  
Study Results ◽  
The Status ◽  
Manifest Anxiety ◽  
The Relationship

Background: Widespread social paradigms on which the status variances are grounded in any society, gender plays pivotal role in manifestation of mental health problems (Rutter, 2007). A hefty volume of research has addressed the issue in adults nonetheless, little is vividly known about the role of gender in adolescent psychopathology. Sample: A sample of 240 adolescents (125 boys, 115 girls) aging 12-18 years was amassed from various secondary schools of Islamabad with the approval of the Federal Directorate of Education (FDE), relevant authorities of the schools and the adolescents themselves. Instruments: Taylor Manifest Anxiety Scale (Taylor & Spence, 1953) and Children’s Negative Cognitive Errors Questionnaire (CNCEQ) by Leitenberg et al., (1986) were applied in present study. Results: Multiple regression analysis revealed that cognitive errors jointly accounted for 78% of variance in predicting anxiety among adolescents. Findings also exhibited that gender significantly moderated the relationship between cognitive errors and adolescent anxiety. Implications of the findings are discoursed for future research and clinical practice.

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

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