scholarly journals Role of Epithelium-Derived Cytokines in Atopic Dermatitis and Psoriasis: Evidence and Therapeutic Perspectives

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1843
Author(s):  
Francesco Borgia ◽  
Paolo Custurone ◽  
Lucia Peterle ◽  
Giovanni Pioggia ◽  
Sebastiano Gangemi
Keyword(s):  
Atopic Dermatitis ◽  
Target Therapy ◽  
New Class ◽  
Oxidative Stress Status ◽  
Target Therapies ◽  
Therapeutic Opportunity ◽  
Chronic Skin ◽  
Skin Conditions ◽  
And Oxidative Stress

Atopic dermatitis and psoriasis are two of the most common chronic skin conditions. Current target therapies represent viable and safe solutions for the most severe cases of these two dermatoses but, presently, several limitations exist in terms of efficacy and side effects. A new class of products, epithelium-derived cytokines (TSLP, IL-25, IL-33), show an increasing potential for use in target therapy for these patients, and demonstrate a direct link between a generalized inflammatory and oxidative stress status and the human skin. A review was conducted to better understand their role in the aforementioned conditions. Of these three molecules, TSLP led has been most often considered in studies regarding target therapies, and most of the results in the literature are related to this cytokine. These three cytokines share common stimuli and are linked to each other in both acute and chronic phases of these diseases, and have been challenged as target therapies or biomarkers of disease activity. The results lead to the conclusion that epithelium-derived cytokines could represent a therapeutic opportunity for these patients, especially in itch control. Furthermore, they might work better when paired together with currently available therapies or in combination with in-development treatments. Further studies are needed in order to verify the efficacy and safety of the biologic treatments currently under development.

Understanding the Experiences of Anger in the Onset and Progression of Psoriasis: A Qualitative Study Using Social Media (Preprint)

2021 ◽  
Author(s):  
Olivia Hughes ◽  
Rachael Hunter
Keyword(s):  
Social Media ◽  
Qualitative Interviews ◽  
Psychosocial Interventions ◽  
Skin Condition ◽  
Future Research ◽  
Social Media Platforms ◽  
Chronic Skin ◽  
Skin Conditions ◽  
The Impact

BACKGROUND Psoriasis is a chronic inflammatory skin condition, which can be affected by stress. Living with psoriasis can trigger negative emotions, which may influence quality of life. OBJECTIVE This study explored the experiences of people with psoriasis with attention to the potential role of anger in the onset and progression of the chronic skin condition. METHODS Semi-structured qualitative interviews were conducted with twelve participants (n=5 females, n=7 males) recruited online from an advert on a patient charity’s social media platforms. Data were transcribed and analysed using thematic analysis. RESULTS Four key themes were identified: (1) ‘I get really angry with the whole situation:’ anger at the self and others, (2) the impact of anger on psoriasis: angry skin, (3) shared experiences of distress, and (4) moving past anger to affirmation. CONCLUSIONS Findings suggest that anger can have a perceived impact on psoriasis through contributing to sensory symptoms and unhelpful coping cycles and point to a need for enhanced treatment with more psychological support. The findings also highlight the continued stigma which exists for people living with skin conditions and how this may contribute to, and sustain, anger for those individuals. Future research could usefully focus on developing targeted psychosocial interventions to promote healthy emotional coping with psoriasis.

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

scholarly journals Role of serum melatonin and oxidative stress in childhood atopic dermatitis: A prospective study

2020 ◽  
Vol 11 (6) ◽  
pp. 925
Author(s):  
Rashmi Sarkar ◽  
Shanthy Devadasan ◽  
KrishnaDeb Barman ◽  
Smita Kaushik
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Prospective Study ◽  
A Prospective Study ◽  
And Oxidative Stress

scholarly journals Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis

2020 ◽  
Vol 17 (4) ◽  
pp. 334-339
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchyan ◽  
Roman V. Epishev ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Main Role ◽  
Social Maladjustment ◽  
Active Components ◽  
Epidermal Barrier ◽  
New Class

Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

2012 ◽  
Vol 18 (2) ◽  
pp. 121-151 ◽  
Author(s):  
Öner Özdemir
Keyword(s):  
Atopic Dermatitis ◽  
Literature Review ◽  
Clinical Data ◽  
Allergic Diseases ◽  
Autoimmune Disorders ◽  
Clinical Findings ◽  
Therapeutic Role ◽  
Disease Etiology ◽  
Skin Conditions

“Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data,” by Öner Özdemir, Journal of Evidence-Based Complementary & Alternative Medicine, April 2013 (18:2), doi: 10.1177/2156587212461279 .This article has been retracted due to unattributed overlap with material from other sources and due to duplicate publication.The unattributed excerpts in the article were taken from the following sources: Ouwehand AC. Antiallergic effects of probiotics. J Nutr. 2007;137(3 suppl 2):794S–797S. Saavedra JM. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract. 2007;22:351–365. doi:10.1177/0115426507022003351. Rook GA, Brunet LR. Microbes, immunoregulation, and the gut. Gut. 2005;54:317–320. doi:10.1136/gut.2004.053785. Michail S. The role of probiotics in allergic diseases. Allergy Asthma Clin Immunol. 2009;5:5. doi:10.1186/1710-1492-5-5. The author also published the following works that include significant unattributed excerpts from the article: Özdemir Ö, Erol AY. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. BioMed Res Int. 2013;2013:932391. doi:10.1155/2013/932391. Özdemir Ö. The role of probiotics in atopic dermatitis prevention and therapy. In: Esparza-Gordillo J, Dekio I, eds. Atopic Dermatitis: Disease Etiology and Clinical Management. Rijeka, Croatia: InTech; 2012:353–386. doi:10.5772/25301.

scholarly journals Dressing a Demanding Body to Fit In: Clean and Decent with Ostomy or Chronic Skin Disease

2019 ◽  
Vol 7 (1) ◽  
pp. 124-135
Author(s):  
Kirsi Laitala ◽  
Ingun Grimstad Klepp
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disease ◽  
Social Life ◽  
Qualitative Interviews ◽  
Economic Resources ◽  
Chronic Skin ◽  
Skin Conditions ◽  
Chronic Skin Disease ◽  
Main Strategy

This article discusses what kind of strategies people with a stoma or various chronic skin conditions, such as psoriasis or atopic dermatitis, use to find clothes that fit and enable them to fit in. Based on qualitative interviews in Norway, we study how they manage to dress with a demanding body, a poor market and limited economic resources. This includes describing how purchases take place, which clothes fit, how much clothing is needed, and which laundry practices are used. Their main strategy was to reduce the requirements for their own appearance rather than to cleanliness and body odours. If they were unable to appear appropriately dressed, as a minimum odourless and stain free, they reduced their participation in social life.

scholarly journals Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1179
Author(s):  
Andrzej Kazimierz Jaworek ◽  
Jacek Cezary Szepietowski ◽  
Przemysław Hałubiec ◽  
Anna Wojas-Pelc ◽  
Jolanta Jaworek
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Skin Inflammation ◽  
Inflammatory Dermatosis ◽  
Sleep Abnormalities ◽  
Chronic Skin ◽  
Endogenous Substances

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possesses strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with a focus on the antioxidant and immunomodulatory effects of MT.

scholarly journals Probiotics in the Therapeutic Arsenal of Dermatologists

2021 ◽  
Vol 9 (7) ◽  
pp. 1513
Author(s):  
Vicente Navarro-López ◽  
Eva Núñez-Delegido ◽  
Beatriz Ruzafa-Costas ◽  
Pedro Sánchez-Pellicer ◽  
Juan Agüera-Santos ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Intestinal Microbiota ◽  
Gut Microbiome ◽  
Positive Influence ◽  
Therapeutic Role ◽  
Dermatological Diseases ◽  
Human Microbiota ◽  
Skin Conditions ◽  
Shed Light

During the last years, numerous studies have described the presence of significant gut and skin dysbiosis in some dermatological diseases such as atopic dermatitis, psoriasis and acne, among others. How the skin and the gut microbiome play a role in those skin conditions is something to explore, which will shed light on understanding the origin and implication of the microbiota in their pathophysiology. Several studies provide evidence for the influence of probiotic treatments that target the modulation of the skin and intestinal microbiota in those disorders and a positive influence of orally administered probiotics on the course of these dermatosis. The pathologies in which the therapeutic role of the probiotic has been explored are mainly atopic dermatitis, psoriasis and acne. This article aims to review these three dermatological diseases, their relationship with the human microbiota and specially the effect of probiotics usage. In addition, the pathophysiology in each of them and the hypotheses about possible mechanisms of the action of probiotics will be described.

scholarly journals Occupational exposure in lead and zinc mines induces oxidative stress in miners lymphocytes: Role of mitochondrial/lysosomal damage

2020 ◽  
Vol 43 (1) ◽  
pp. 154-163
Author(s):  
Enayatollah Seydi ◽  
Mahshid Soltani ◽  
Maral Ramazani ◽  
Mohammad Hadi Zarei ◽  
Jalal Pourahmad
Keyword(s):  
Oxidative Stress ◽  
Control Group ◽  
Lead And Zinc ◽  
Toxic Agents ◽  
Oxidative Stress Status ◽  
Lead Zinc ◽  
Zinc Mine ◽  
And Oxidative Stress ◽  
Mine Workers

AbstractThe purpose of this research was to determine mitochondrial and lysosomal damage and oxidative stress status in blood lymphocytes of lead-zinc miners. This research was performed in 10 mine workers who have been in contact with lead and zinc in comparison to a control group containing 10 healthy volunteers. Lymphocytes were isolated from peripheral blood using the Ficoll standard method and then mitochondrial and lysosomal damage and oxidative stress were evaluated. The level of reactive oxygen species (ROS), collapse in the mitochondrial membrane potential (MMP) collapse, and glutathione disulfide (GSSG) content, and lysosomal damage in miners were higher than the control group. Also, viability and glutathione (GSH) content were decreased. The lymphocytes of workers of a lead-zinc mine are more susceptible to oxidative stress, mitochondrial and lysosomal damage. The proper use of safety equipment can reduce the risk of toxic agents and their subsequent hazards for mine workers.

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