Selection of Unique Molecules for Cancer Treatment by Distance-Based Method: Hypericin Effect on Respiratory Chain

The heterogeneous composition of tumors presents a significant obstacle to the selection of a single molecule as a potential universal inhibitor of tumor growth. Lipid signaling and cellular metabolism have become the main targets of anticancer treatment in recent years. The protein kinase C (PKC) regulators Gö6976, rottlerin, hypericin, and phorbol myristyl acetate have been identified as agents affecting cellular metabolism. Measurable parameters describing metabolism, endocytosis, and respiration were subjected to a distance-based computational procedure for higher dimensions to complement and extend the knowledge gained from experimental data. The mutual distances of the parameters of the substances applied to the cancer cells in the presence and absence of lipids were calculated within the Lp spaces. The distance-based methods and comparisons of the generalized distances suggested to us the exceptional role of hypericin in heterogeneous systems. Furthermore, our results are confirmed by Western blotting of the levels of respiratory chain proteins and enzymes active in oxidative stress defense in cancer cell monolayers and spheroids. PKCα and PKCδ have been studied for lipid-activated cell signaling. In this study, we attempt to apply the concept of parametric distance in cell signal transduction and activation where the above methods have not yet been used.

Download Full-text

The interrelation of the angiotensin and endothelin systems on the modulation of NAD(P)H oxidaseThis paper is one of a selection of papers published in this Special issue, entitled Young Investigator's Forum.

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y05-146 ◽

2006 ◽

Vol 84 (1) ◽

pp. 21-28 ◽

Cited By ~ 14

Author(s):

Marc-André Laplante ◽

Jacques de Champlain

Keyword(s):

Superoxide Anion ◽

Nicotinamide Adenine Dinucleotide Phosphate ◽

Cellular Membrane ◽

Kinase C ◽

Therapeutic Tools ◽

Produce Superoxide Anion ◽

Selection Of

The NAD(P)H oxidase is an enzyme assembled at the cellular membrane able to produce superoxide anion from NADH or NAD(P)H (nicotinamide adenine dinucleotide phosphate). It is one of the main sources of superoxide anion in cardiovascular tissues and its role in a variety of cardiovascular disorders such as atherosclerosis, cardiac hypertrophy, and endothelial dysfunction was recently proposed. Although, many factors and receptors were shown to lead to the activation of the enzyme, particulary the type 1 angiotensin receptor, the pathways involved are still widely unknown. Despite the identification of factors such as c-Src and protein kinase C implicated in the acute activation of NAD(P)H oxidase, the signalling involved in the sustained activation of the enzyme is probably far more complex than was previously envisioned. In this review, we describe the role of endothelin-1 in NAD(P)H oxidase signalling after a sustained stimulation by angiotensin II. Since most pathologies caused by an NAD(P)H oxidase overactivation develop over a relatively long period of time, it is necessary to better understand the long-term signalling of the enzyme for the development or use of more specific therapeutic tools.

Download Full-text

The Role of Objects in the Selection of Mental Sets

PsycEXTRA Dataset ◽

10.1037/e501882009-274 ◽

2000 ◽

Author(s):

Ulrich Mayr

Keyword(s):

Selection Of

Download Full-text

Faculty selection of textbooks: Key variables and the role of teaching experience

PsycEXTRA Dataset ◽

10.1037/e741372011-051 ◽

2010 ◽

Author(s):

Aja Taitano ◽

Bradley Smith ◽

Cade Hulbert ◽

Kristin Batten ◽

Lalania Woodstrom ◽

...

Keyword(s):

Teaching Experience ◽

Key Variables ◽

Faculty Selection ◽

Selection Of

Download Full-text

The role of HLA-DM for loading and selection of the peptide repertoire of MHC class-II molecules

Immunology Letters ◽

10.1016/s0165-2478(97)87775-9 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 236

Author(s):

H Kropshofer

Keyword(s):

Mhc Class Ii ◽

Class Ii ◽

Mhc Class Ii Molecules ◽

Selection Of

Download Full-text

Posttransplant CMV infection and the role of immunosuppression (Sponsor: Novartis Pharma GmbH, Nürnberg)

Therapieforum Transplant ◽

10.1055/a-0711-9047 ◽

2016 ◽

Vol 04 (01) ◽

pp. 4-10

Keyword(s):

Lower Incidence ◽

Paradigm Shift ◽

Mtor Inhibitor ◽

De Novo ◽

Expert Panel ◽

Risk Of Infection ◽

Cmv Infection ◽

Expert Meeting ◽

Selection Of

AbstractImmunosuppression permits graft survival after transplantation and consequently a longer and better life. On the other hand, it increases the risk of infection, for instance with cytomegalovirus (CMV). However, the various available immunosuppressive therapies differ in this regard. One of the first clinical trials using de novo everolimus after kidney transplantation [1] already revealed a considerably lower incidence of CMV infection in the everolimus arms than in the mycophenolate mofetil (MMF) arm. This result was repeatedly confirmed in later studies [2–4]. Everolimus is now considered a substance with antiviral properties. This article is based on the expert meeting “Posttransplant CMV infection and the role of immunosuppression”. The expert panel called for a paradigm shift: In a CMV prevention strategy the targeted selection of the immunosuppressive therapy is also a key element. For patients with elevated risk of CMV, mTOR inhibitor-based immunosuppression is advantageous as it is associated with a significantly lower incidence of CMV events.

Download Full-text

Energy Efficiency Analysis in ERA using NFL-BA Algorithm

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst207477 ◽

2020 ◽

pp. 340-348

Author(s):

Palky Mehta ◽

H. L. Sharma

Keyword(s):

Cluster Head ◽

Vital Role ◽

Wireless Sensor ◽

Energy Usage ◽

Cluster Heads ◽

Comparison Results ◽

Current Scenario ◽

Energy Efficiency Analysis ◽

Selection Of

In the current scenario of Wireless Sensor Network (WSN), power consumption is the major issue associated with nodes in WSN. LEACH technique plays a vital role of clustering in WSN and reduces the energy usage effectively. But LEACH has its own limitation in order to search cluster head nodes which are randomly distributed over the network. In this paper, ERA-NFL- BA algorithm is being proposed for selects the cluster heads in WSN. This algorithm help in selection of cluster heads can freely transform from global search to local search. At the end, a comparison has been done with earlier researcher using protocol ERA-NFL, which clearly shown that proposed Algorithm is best suited and from comparison results that ERA-NFL-BA has given better performance.

Download Full-text

Tauchnitz for Translators. The Circulation of English-language Literature in Finland

Comparative Critical Studies ◽

10.3366/ccs.2019.0325 ◽

2019 ◽

Vol 16 (2-3) ◽

pp. 161-179

Author(s):

Outi Paloposki

Keyword(s):

Foreign Language ◽

English Language ◽

Book History ◽

Language Skills ◽

Point Of View ◽

Book Production ◽

German Publisher ◽

Language Literature ◽

Selection Of

The article looks at book production and circulation from the point of view of translators, who, as purchasers and readers of foreign-language books, are an important mediating force in the selection of literature for translation. Taking the German publisher Tauchnitz's series ‘Collection of British Authors’ and its circulation in Finland in the nineteenth and early twentieth century as a case in point, the article argues that the increased availability of English-language books facilitated the acquiring and honing of translators' language skills and gradually diminished the need for indirect translating. Book history and translation studies meet here in an examination of the role of the Collection in Finnish translators' work.

Download Full-text

The Adult as Foe or Friend?: Childism in Guus Kuijer's Criticism and Fiction

International Research in Children s Literature ◽

10.3366/ircl.2013.0099 ◽

2013 ◽

Vol 6 (2) ◽

pp. 205-217 ◽

Cited By ~ 3

Author(s):

Vanessa Joosen

Keyword(s):

Children's Literature ◽

Children’S Literature ◽

Age Groups ◽

Children's Books ◽

Children’S Books ◽

Memorial Award ◽

Adult Reader ◽

Shed Light ◽

Selection Of

Compared to the attention that children's literature scholars have paid to the construction of childhood in children's literature and the role of adults as authors, mediators and readers of children's books, few researchers have made a systematic study of adults as characters in children's books. This article analyses the construction of adulthood in a selection of texts by the Dutch author and Astrid Lindgren Memorial Award winner Guus Kuijer and connects them with Elisabeth Young-Bruehl's recent concept of ‘childism’ – a form of prejudice targeted against children. Whereas Kuijer published a severe critique of adulthood in Het geminachte kind [The despised child] (1980), in his literary works he explores a variety of positions that adults can take towards children, with varying degrees of childist features. Such a systematic and comparative analysis of the way grown-ups are characterised in children's texts helps to shed light on a didactic potential that materialises in different adult subject positions. After all, not only literary and artistic aspects of children's literature may be aimed at the adult reader (as well as the child), but also the didactic aspect of children's books can cross over between different age groups.

Download Full-text