scholarly journals The Spectroscopic Properties and Microscopic Imaging of Thulium-Doped Upconversion Nanoparticles Excited at Different NIR-II Light

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 148
Author(s):  
Tingting Peng ◽  
Rui Pu ◽  
Baoju Wang ◽  
Zhimin Zhu ◽  
Kai Liu ◽  
...  

Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging nanoprobes due to their excellent photostability. As one of the most commonly used lanthanide activators, Tm3+ ions have perfect ladder-type electron configuration and can be directly excited by bio-friendly near-infrared-II (NIR-II) wavelengths. Here, the emission characteristics of Tm3+-doped nanoparticles under laser excitations of different near-infrared-II wavelengths were systematically investigated. The 1064 nm, 1150 nm, and 1208 nm lasers are proposed to be three excitation strategies with different response spectra of Tm3+ ions. In particular, we found that 1150 nm laser excitation enables intense three-photon 475 nm emission, which is nearly 100 times stronger than that excited by 1064 nm excitation. We further optimized the luminescence brightness after investigating the luminescence quenching mechanism of bare NaYF4: Tm (1.75%) core. After growing an inert shell, a ten-fold increase of emission intensity was achieved. Combining the advantages of NIR-II wavelength and the higher-order nonlinear excitation, a promising facile excitation strategy was developed for the application of thulium-doped upconversion nanoparticles in nanoparticles imaging and cancer cell microscopic imaging.

Author(s):  
Tingting Peng ◽  
Rui Pu ◽  
Baoju Wang ◽  
Zhimin Zhu ◽  
Kai Liu ◽  
...  

Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging nanoprobes due to their excellent photostability. As one of the most commonly-used lanthanide activators, Tm3+ ions have perfect ladder-type electron configuration and can be directly excited by bio-friendly near-infrared-II (NIR-II) wavelengths. Here, the emission characteristics of Tm3+-doped nanoparticles under laser excitations of different near-infrared-II wavelengths were systematically investigated. The 1064 nm, 1150 nm and 1208 nm lasers are proposed to be three excitation strategies with different response spectra of Tm3+ ions. Particularly we found that 1150 nm laser excitation enables intense three-photon 475 nm emission, which is nearly 100 times stronger than that excited by 1064 nm excitation. We further optimized the luminescence brightness after investigating the luminescence quenching mechanism of bare NaYF4:Tm (1.75%) core. After growing inert shell, ten-fold increase of emission intensity was achieved. Combining the advantages of NIR-II wavelength and the higher-order nonlinear excitation, a promising facile excitation strategy was developed for the application of thulium-doped upconversion nanoparticles in single nanoparticle imaging and cancer cell microscopic imaging.


Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.


2021 ◽  
Vol 57 (15) ◽  
pp. 1927-1930
Author(s):  
Zhao Gao ◽  
Lulu Shi ◽  
Xiao Ling ◽  
Ze Chen ◽  
Qingsong Mei ◽  
...  

A hybrid supramolecular system with near-infrared photon-excited energy transfer has been successfully constructed, relying on the assistance of upconversion nanoparticles in platinum(ii)-based supramolecular polymers.


Small ◽  
2016 ◽  
Vol 12 (13) ◽  
pp. 1732-1743 ◽  
Author(s):  
Akshaya Bansal ◽  
Haichun Liu ◽  
Muthu Kumara Gnanasammandhan Jayakumar ◽  
Stefan Andersson-Engels ◽  
Yong Zhang

2013 ◽  
Vol 26 (15) ◽  
pp. 2424-2430 ◽  
Author(s):  
Li Zhou ◽  
Zhaowei Chen ◽  
Kai Dong ◽  
Meili Yin ◽  
Jinsong Ren ◽  
...  

2016 ◽  
Vol 128 (13) ◽  
pp. 4352-4356 ◽  
Author(s):  
Ming He ◽  
Xinchang Pang ◽  
Xueqin Liu ◽  
Beibei Jiang ◽  
Yanjie He ◽  
...  

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.


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