scholarly journals Synthesis, Spectroscopic Characterization and Photoactivity of Zr(IV) Phthalocyanines Functionalized with Aminobenzoic Acids and Their GO-Based Composites

2019 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Leili Tahershamsi ◽  
Yuriy Gerasymchuk ◽  
Anna Wedzynska ◽  
Maciej Ptak ◽  
Iryna Tretyakova ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Graphite Oxide ◽  
Biomedical Applications ◽  
Spectroscopic Characterization ◽  
Oxygen Species ◽  
Optical Technique ◽  
Photoluminescence Spectra ◽  
Aminobenzoic Acids ◽  
Photochemical Properties

Two complexes of bis(aminobenzoato)zirconium(IV) phthalocyanine and their graphite oxide-based composites were synthesized and characterized in respect of their photochemical properties. Structures of phthalocyanines were confirmed by Mass and infrared spectroscopies. The absorption and photoluminescence spectra were investigated to show various behavior of the complexes in different media (dimethyl sulfoxide and saline). Optical technique (monitoring variation of absorption spectra of diphenylisobenzofuran used as an indicator) was used to prove the generation of reactive oxygen species (ROS) by under light irradiation in the range of the first biological window. The photoactivity of the materials was compared and discussed in terms of their potential ability to be used in biomedical applications, for example, as photosensitizers in photodynamic therapy.

Coating gold nanorods with silica prevents the generation of reactive oxygen species under laser light irradiation for safe biomedical applications

2022 ◽  
Author(s):  
Sarra Mitiche ◽  
Syrine Gueffrache ◽  
Sylvie Marguet ◽  
Jean-Frédéric Audibert ◽  
Robert Bernard Pansu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Laser Light ◽  
Reactive Oxygen ◽  
Light Irradiation ◽  
Oxygen Species ◽  
Pulsed Light

Gold nanoparticles can produce reactive oxygen species (ROS) under the action of ultrashort pulsed light. While beneficial for photodynamic therapy, this phenomenon is prohibitive for other biomedical applications such as...

scholarly journals Mechanisms of Reactive Oxygen Species Generated by Inorganic Nanomaterials for Cancer Therapeutics

2021 ◽  
Vol 9 ◽  
Author(s):  
Lizhen Zhang ◽  
Chengyuan Zhu ◽  
Rongtao Huang ◽  
Yanwen Ding ◽  
Changping Ruan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Cancer Therapeutics ◽  
Surface Characteristics ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Dynamic Therapy ◽  
Inorganic Nanomaterials ◽  
Generation Mechanisms

Recently, inorganic nanomaterials have received considerable attention for use in biomedical applications owing to their unique physicochemical properties based on their shapes, sizes, and surface characteristics. Photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemical dynamic therapy (CDT), which are cancer therapeutics mediated by reactive oxygen species (ROS), have the potential to significantly enhance the therapeutic precision and efficacy for cancer. To facilitate cancer therapeutics, numerous inorganic nanomaterials have been developed to generate ROS. This mini review provides an overview of the generation mechanisms of ROS by representative inorganic nanomaterials for cancer therapeutics, including the structures of engineered inorganic nanomaterials, ROS production conditions, ROS types, and the applications of the inorganic nanomaterials in cancer PDT, SDT, and CDT.

scholarly journals Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1345
Author(s):  
Sherif Ashraf Fahmy ◽  
Hassan Mohamed El-Said Azzazy ◽  
Jens Schaefer
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Adverse Effects ◽  
Cellular Uptake ◽  
Treatment Effectiveness ◽  
State Of The Art ◽  
Oxygen Species ◽  
Chemotherapeutic Drugs ◽  
Invasive Strategy ◽  
Non Invasive

Photodynamic therapy (PDT) is a promising non-invasive strategy in the fight against that which circumvents the systemic toxic effects of chemotherapeutics. It relies on photosensitizers (PSs), which are photoactivated by light irradiation and interaction with molecular oxygen. This generates highly reactive oxygen species (such as 1O2, H2O2, O2, ·OH), which kill cancer cells by necrosis or apoptosis. Despite the promising effects of PDT in cancer treatment, it still suffers from several shortcomings, such as poor biodistribution of hydrophobic PSs, low cellular uptake, and low efficacy in treating bulky or deep tumors. Hence, various nanoplatforms have been developed to increase PDT treatment effectiveness and minimize off-target adverse effects. Liposomes showed great potential in accommodating different PSs, chemotherapeutic drugs, and other therapeutically active molecules. Here, we review the state-of-the-art in encapsulating PSs alone or combined with other chemotherapeutic drugs into liposomes for effective tumor PDT.

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

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