The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer
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Microtubules are tubulin polymers that constitute the structure of eukaryotic cells. They control different cell functions that are often deregulated in cancer, such as cell shape, cell motility and the intracellular movement of organelles. Here, we focus on the crucial role of tubulin modifications in determining different cancer characteristics, including metastatic cell migration and therapy resistance. We also discuss the influence of microtubule modifications on the autophagic process—the cellular degradation pathway that influences cancer growth. We discuss findings showing that inducing microtubule modifications can be used as a means to kill cancer cells by inhibiting autophagy.
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1992 ◽
Vol 50
(1)
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pp. 480-481
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2019 ◽
Vol 47
(5)
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pp. 1543-1555
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