A New Supported Manganese-Based Coordination Complex as a Nano-Catalyst for the Synthesis of Indazolophthalazinetriones and Investigation of Its Antibacterial Activity

A new magnetic supported manganese-based coordination complex (Fe3O4@SiO2@CPTMS@MBOL@ Mn) was prepared in consecutive stages and characterized via various techniques (VSM, SEM, TEM, XRD, FT-IR, EDX, TG-DTA, and ICP). To evaluate its application, it was used for synthesis of divers Indazolophthalazinetriones in a simple procedure via the one-pot three-component condensation reaction of aldehydes, dimedone, and phthalhydrazide in ethanol under reflux conditions. The Mn catalyst can be recycled without any noticeable loss in catalytic activity. Additionally, the antibacterial properties of the nano-catalyst were studied against some bacterial strains.

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A New Supported Manganese-Based Coordination Complex as a Nano-Catalyst for the Synthesis of Indazolophthalazinetriones and Investigation of Its Antibacterial Activity

10.21203/rs.3.rs-510455/v1 ◽

2021 ◽

Author(s):

maryam ariannezhad ◽

davood habibi ◽

somayyeh heydari ◽

vahideh khorram Abadi

Keyword(s):

Condensation Reaction ◽

Antibacterial Properties ◽

Reaction Times ◽

Coordination Complex ◽

Bacterial Strains ◽

Fast Reaction ◽

One Pot ◽

Nano Catalyst ◽

Ft Ir ◽

The One

Abstract A new magnetic supported manganese-based coordination complex (Fe3O4@SiO2@CPTMS@MBOL@ Mn) was prepared in consecutive stages, characterized via various techniques (VSM, SEM, TEM, XRD, FT-IR, EDX, TG-DTA and ICP) and used as a capable nano-catalyst for the fast and green synthesis of divers 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones in a simple and efficient procedure from the one pot three-component condensation reaction of aldehydes, dimedone and phthalhydrazide in refluxed ethanol in excellent yields and fast reaction times. The Mn catalyst can be recycled and reused without notable loss of the catalytic activity. Also, the antibacterial properties of the Mn supported nano-catalyst were studied against a number of gram-positive and gram-negative bacterial strains.

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Chemical Indices and Antibacterial Properties of Some Essential Oils of Apiaceae and Lauraceae Spices in Southwest of Algeria

Asian Journal of Dairy and Food Research ◽

10.18805/ajdfr.dr-130 ◽

2019 ◽

Author(s):

Dalila Razni ◽

Linda Rouisset ◽

Elhassan Benyagoub

Keyword(s):

Antibacterial Activity ◽

Essential Oil ◽

Essential Oils ◽

Enterococcus Faecalis ◽

Antibacterial Properties ◽

Independent Effect ◽

Diffusion Method ◽

Bacterial Strains ◽

Cinnamon Essential Oil ◽

The One

This study is a part of the valorization of extract from three most commonly used Algerian spices, namely; caraway and cumin seeds and cinnamon bark. On the one hand, it aims at characterizing the chemical indices of extracted essential oils and evaluating the antibacterial activity of each essential oil by titration and disc diffusion method respectively. On the other hand, it attempts at evaluating the combined action of essential oils against four reference pathogenic bacterial strains, namely Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis by well and Chabbert-type diffusion method. The essential oils obtained by the hydrodistillation method have a relatively average extraction about 1.43, 2.3 and 2.5%, respectively for caraway, cumin, and cinnamon. The acid index indicates the behavior and amount of free acids present in the essential oil, in which the acid and saponification indices of cinnamon essential oil indicate a value of 4.48 and 168.56 respectively. It can also inform us about the susceptibility of the oil to undergo alterations. The antibacterial activity results showed that cinnamon essential oil (EO) proved to be the most active against the tested bacterial strains; caraway EO was active against Enterococcus faecalis, and the antibacterial action of cumin EO was the lowest. However, the association of the extracted essential oils has a higher synergistic effect than the independent effect of each essential oil, in which the MIC value found was estimated at 10 to 20 (V/V), 40 to 50 (V/V) and 50 to 70 (V/V) respectively for cinnamon, cumin and caraway. The obtained results show that the response to the antibacterial activity varies according to the plant species used and the extract tested alone or in combination.

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Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds

10.20944/preprints202006.0219.v1 ◽

2020 ◽

Author(s):

Khurram Shahzad ◽

Faheem Abbas ◽

DIGVIJAY PANDEY ◽

Sanila Ajmal ◽

Mudassar Khadim ◽

...

Keyword(s):

Condensation Reaction ◽

Biological Evaluation ◽

Primary Amines ◽

Significant Activity ◽

Bacterial Strains ◽

Conductivity Method ◽

One Pot ◽

New Class ◽

Ft Ir ◽

Imidazole Compounds

A new class of tetrasubstituted imidazole based compounds was synthesized using a multicomponent one-pot synthesis scheme through a cyclo condensation reaction of benzil, aromatic primary amines, aldehydes and ammonium acetate in glacial acetic acid. The synthesized compounds have been analyzed and characterized by melting point, color, conductivity method, CHN analysis, FT-IR, and UV-Visible. The reaction proceeding was examined by TLC after regular intervals of period. To test biological activity, the synthesized compounds have been examined against various bacterial strains. From the analysis of the antibacterial activity of these synthesized compounds demonstrated that all three imidazole compounds have considerable to significant activity against the strains, and compound K2 was found potent comparatively.

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Ultrasonic Assisted Synthesis of 2, 3-Dihydroquinazolin-4(1H)-ones Involving Three-Component Reaction of Isatoic Anhydride, Amines and Pyrazole Carbaldehydes Catalyzed by [γ-Fe2O3@HAp-SO3H]

Letters in Organic Chemistry ◽

10.2174/1570178616666190401183953 ◽

2019 ◽

Vol 17 (1) ◽

pp. 24-30

Author(s):

Kiana F. Sina ◽

Asieh Yahyazadeh ◽

Nosrat O. Mahmoodi ◽

Kurosh R. Moghadam ◽

Mohammad Nikpassand ◽

...

Keyword(s):

Reaction Times ◽

Isatoic Anhydride ◽

Bacterial Strains ◽

One Pot ◽

Three Component Reaction ◽

Ultrasonic Assisted ◽

Ft Ir ◽

Novel Method ◽

The One ◽

Work Up

The combination of [γ-Fe2O3@HAp-SO3H] as a catalyst and ultrasonic effect catalyzed the synthesis of diverse derivatives of 2, 3-dihydroquinazolin-4(1H)-ones which is reported in this study. The products were synthesized via the one-pot three-component reaction of isatoic anhydride, amines and pyrazole carbaldehydes in water: EtOH catalyzed by recoverable [γ-Fe2O3@HAp-SO3H]. This paper conducted an investigation of the effect of various solvents, temperatures and catalysts on the reactions. Short reaction times, mild reaction conditions, simple work-up, the desired yields and the use of an appropriate catalyst are the advantages of this novel method. The new derivatives were validated by using FT-IR, 1HNMR, and 13CNMR. Moreover, the synthesized compounds were screened for their antimicrobial activity against bacterial strains.

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Clean one-pot multicomponent synthesis of pyrans using a green and magnetically recyclable heterogeneous nanocatalyst

SynOpen ◽

10.1055/a-1469-6721 ◽

2021 ◽

Author(s):

Mina Ghassemi ◽

Ali Maleki

Keyword(s):

Room Temperature ◽

Significant Loss ◽

Copper Ferrite ◽

Multicomponent Synthesis ◽

Thermo Gravimetric ◽

Sem Images ◽

One Pot ◽

Three Component Reaction ◽

Ft Ir ◽

The One

Copper ferrite (CuFe2O4) magnetic nanoparticles (MNPs) were synthesized via thermal decomposition method and applied as a reusable and green catalyst in the synthesis of functionalized 4H-pyran derivatives using malononitrile, an aromatic aldehyde and a β-ketoester in ethanol at room temperature. Then it was characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX) analysis, scanning electron microscopy (SEM) images, thermo gravimetric and differential thermo gravimetric (TGA/DTG) analysis. The catalyst was recovered from the reaction mixture by applying an external magnet and decanting the mixture. Recycled catalyst was reused for several times without significant loss in its activity. Running the one-pot three-component reaction at room temperature, no use of eternal energy source and using a green solvent provide benign, mild, and environmentally friendly reaction conditions; as well, ease of catalyst recovering, catalyst recyclability, no use of column chromatography and good to excellent yields are extra advantages of this work.

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Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes

Materials ◽

10.3390/ma14143854 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3854

Author(s):

Joanna Czechowska ◽

Ewelina Cichoń ◽

Anna Belcarz ◽

Anna Ślósarczyk ◽

Aneta Zima

Keyword(s):

Gold Nanoparticles ◽

Antibacterial Activity ◽

Tricalcium Phosphate ◽

Setting Time ◽

Antibacterial Properties ◽

Bone Substitutes ◽

Bacterial Strains ◽

Setting Times ◽

Biological Studies

Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against S. epidermidis, E. coli, and S. aureus was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies.

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Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

Molecules ◽

10.3390/molecules23123109 ◽

2018 ◽

Vol 23 (12) ◽

pp. 3109 ◽

Cited By ~ 3

Author(s):

Andres Bernal-Ballen ◽

Jorge Lopez-Garcia ◽

Martha-Andrea Merchan-Merchan ◽

Marian Lehocky

Keyword(s):

Antibacterial Activity ◽

Polyvinyl Alcohol ◽

Statistical Significance ◽

Antibacterial Properties ◽

Intermolecular Forces ◽

Polymeric System ◽

Bacterial Strains ◽

Natural Polymers ◽

The Matrix ◽

The Individual

Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.

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Antibacterial Properties of Biofilm Schiff Base Derived from Dialdehyde Cellulose and Chitosan

Indonesian Journal of Chemistry ◽

10.22146/ijc.34721 ◽

2019 ◽

Vol 19 (2) ◽

pp. 405

Author(s):

Agung Pratama ◽

Firman Sebayang ◽

Rumondang Bulan Nasution

Keyword(s):

Tensile Strength ◽

Antibacterial Activity ◽

Schiff Base ◽

Antibacterial Properties ◽

Oxidized Cellulose ◽

Natural Polymers ◽

Dialdehyde Cellulose ◽

Ft Ir ◽

Ir Analysis

Cellulose and chitosan are natural polymers that have been used as biocomposite. The aim of this research is to obtain biofilms from chitosan and oxidized cellulose crosslinks. This research is divided into three steps, i.e., isolation of cellulose from oil palm trunk and oxidation of cellulose using NaIO4 (0.2; 0.4; 0.6; 0.8; 1.0 mg/mL) to obtain dialdehyde cellulose (DAC), crosslink of oxidized cellulose with chitosan (DD = 72.85%) to obtain biofilm of chitosan/DAC (CDAC), and characterization of biofilms. The crosslinked reaction was confirmed by FT-IR analysis that showed the spectrum of Schiff base C=N group at 1651 cm–1. Tensile strength increased gradually when the NaIO4 concentration used was 0.2–0.6 mg/mL, but after those concentrations, the tensile strength slightly decreased. The morphology analysis showed that CDAC had smoother morphology than DAC, which was shown rough and showed some particle indicated the presence of unreacted cellulose. CDAC biofilms that prepared with 1.0 mg/mL NaIO4 showed the greatest antibacterial activity.

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An efficient and recyclable acid–base bifunctional core–shell nano-catalyst for the one-pot deacetalization–Knoevenagel tandem reaction

New Journal of Chemistry ◽

10.1039/c8nj01934g ◽

2018 ◽

Vol 42 (14) ◽

pp. 11610-11615 ◽

Cited By ~ 10

Author(s):

Zitao Wang ◽

Xiaofeng Yuan ◽

Qi’an Cheng ◽

Tichun Zhang ◽

Jun Luo

Keyword(s):

Tandem Reaction ◽

Core Shell ◽

Acid Base ◽

One Pot ◽

Recoverable Catalyst ◽

Nano Catalyst ◽

The One

An acid–base bifunctional nano-catalyst was synthesized and applied as an efficient and recoverable catalyst in the one-pot deacetalization–Knoevenagel tandem reaction.

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