Exploring the Relation between Atopic Diseases and Lifestyle Patterns among Adolescents Living in Greece: Evidence from the Greek Global Asthma Network (GAN) Cross-Sectional Study

Introduction: Diet and physical activity might be associated with the risk of allergic diseases in childhood. However, evidence in literature is sparse and diverse. We aim to examine the associations between four healthy dietary consumption pattern drinks, plus the adherence to a physically active lifestyle with atopic diseases (asthma, allergic rhinitis and eczema) in adolescence and their relative importance. Methods: A total of 1934 adolescents (921 boys, 47.5%) and their parents completed a validated questionnaire assessing atopic diseases’ symptoms prevalence in the past 12 months, as well as nutritional and physical activity information. Four healthy dietary and one physical active lifestyle patterns were identified and logistic regression was applied to assess their relation with allergic diseases. Results: A high weekly consumption of fruits, vegetables and pulses and low consumption of unhealthy foods was negatively associated with all atopic symptoms while adherence to a physical active lifestyle was inversely associated with asthma and allergic rhinitis symptoms and dairy products with asthma and eczema symptoms in the past 12 months after adjustment for several confounders (all p < 0.05). Fruits, vegetables and pulses consumption per week emerged as the most important lifestyle pattern negatively associated for all atopic diseases, after the adjustment for all the remaining lifestyle patterns and confounders (all p < 0.05) Conclusions: Our findings suggest that a high fruit, vegetable and pulse intake should be the first lifestyle intervention every clinician and public health care worker evolving in the management of atopic adolescents should encourage and promote.

Download Full-text

The Role of Allergens in Atopic Dermatitis

Journal of Dr Behcet Uz Children s Hospital ◽

10.5222/buchd.2020.37980 ◽

2020 ◽

Author(s):

Suna Asilsoy ◽

Serdar Al

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Allergic Diseases ◽

Skin Lesions ◽

Atopic Diseases ◽

Chronic Skin ◽

Genetic And Environmental Factors ◽

Inhalant Allergens ◽

Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

Download Full-text

Clinical manifestations of atopy in children up to two years of age

Vojnosanitetski pregled ◽

10.2298/vsp1108690i ◽

2011 ◽

Vol 68 (8) ◽

pp. 690-695 ◽

Cited By ~ 1

Author(s):

Nevenka Ilic ◽

Vesna Velickovic ◽

Dragoljub Djokic ◽

Nebojsa Rankovic ◽

Gordana Kostic ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Developed Countries ◽

Specific Ige ◽

Food Allergies ◽

Atopic Diseases ◽

Ige Antibodies ◽

Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

Download Full-text

Allergic march in children of Ukraine

Medicni perspektivi (Medical perspectives) ◽

10.26641/2307-0404.2021.4.248227 ◽

2021 ◽

Vol 26 (4) ◽

pp. 181-188

Author(s):

О.P. Volosovets ◽

Yu.K. Bolbot ◽

G.V. Beketova ◽

V.S. Berezenko ◽

T.R. Umanets ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Allergic Diseases ◽

School Age Children ◽

Steady Increase ◽

The Past ◽

Number Of Factors ◽

Allergic March ◽

Analyze Data

Allergic diseases, which have a certain stage in their development from food allergy to bronchial asthma / allergic rhinitis, are much more common in children than in adults. The aim of this study was to analyze data on the prevalence and incidence of atopic dermatitis, bronchial asthma and allergic rhinitis as components of the allergic march, in children of Ukraine from 1994 to 2017 to determine the possible impact of adverse environmental factors on their development. During the same period, due to the influence of a number of factors, in particular environmental, there were significant changes in the structure of allergic diseases making up the stages of the allergic march due to an increase in the proportion of allergic rhinitis with the reduced one of asthma and atopic dermatitis. Within 24 years, the incidence of atopic dermatitis in children aged 0-6 years including, increased by 27.6%, in adolescents - by 40.5% and significantly decreased by 39.5% in children aged 7-14 years including. Most cases of allergic rhinitis and bronchial asthma were observed in schoolchildren (47.6 and 54.0%, respectively) with a slight decrease compared to 1994. In general, allergic diseases in recent years have become more common in children from 0 to 6 years and their detection has decreased in school-age children and adolescents. Over the past 24 years, in children of Ukraine a steady increase in the incidence and prevalence of allergic diseases that form an allergic march has been noted: the prevalence of bronchial asthma has increased by 69.3% and the incidence has increased by 22.9%; the prevalence of atopic dermatitis increased by 43.9% and the incidence increased by 8.3%; the prevalence of allergic rhinitis increased by 488.3% and the incidence of allergic rhinitis increased by 380.3%, with a predominance of detection of this pathology in children from regions with developed infrastructure and industry, where there are significant emissions of pollutants into the atmosphere, that have a direct moderate effect on the increase in the prevalence of bronchial asthma, the incidence and prevalence of allergic rhinitis in children.

Download Full-text

O Uso dos Probióticos nas Doenças Alérgicas: Revisão de Literatura/The Use of Probiotics on Allergic Diseases: Literature Review

REVISTA CIÊNCIAS EM SAÚDE ◽

10.21876/rcsfmit.v4i2.235 ◽

1970 ◽

Vol 4 (2) ◽

pp. 108-119

Author(s):

Isabela Maria Anselmo Ribeiro Simões ◽

Helba Heliane Toledo ◽

José Henrique Pereira Pinto

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Food Allergy ◽

Literature Review ◽

Scientific Community ◽

Allergic Diseases ◽

Progressive Increase ◽

Atopic Diseases ◽

Significant Clinical Improvement ◽

Probiotic Strains

Nas últimas décadas, observou-se o aumento progressivo das doenças alérgicas e assim, novas alternativas preventivas e de tratamento têm sido buscadas. Neste âmbito, é notável o crescimento no número de pesquisas na comunidade científica destinadas a investigar se a suplementação com substancias probióticas seria capaz de reduzir a incidência e severidade das atopias clínicas, bem como seus possíveis efeitos como estratégia de tratamento. O artigo consistiu em uma revisão bibliográfica com o objetivo de analisar a eficácia dos probióticos nas atopias clínicas como asma, rinite alérgica, dermatite atópica e alergia alimentar, bem como seus efeitos. Apesar de relatos consistentes apontarem que cepas probióticas específicas quando usadas em determinados casos produzem melhora clínica significante, ainda se faz de extrema importância novos estudos, visando verificar e esclarecer precisamente os demais efeitos produzidos, incluindo efeitos colaterais, determinação de uma dosagem adequada, bem como a população alvo.Palavras-chave: probióticos, alergia, hipersensibilidade. ABSTRACTIn the last decades, it was observed a progressive increase of allergic diseases and consequently researchers are looking for new preventive and alternative treatments. In this context it is remarkable the growth of researcher in the scientific community,aiming to investigate whether the supplementation with probiotics substances would be able to reduce the incidence and severity of clinical atopy and its effects as a treatment strategy. The study consisted of a literature review with the aim of evaluate the clinical efficacy of probiotics in atopic diseases such as asthma, allergic rhinitis, atopic dermatitis and food allergy as well as its effects.Despite consistent reports suggest that specific probiotic strains when used in certain cases produce significant clinical improvement, it is still extremely important to have new studies in order to verify and clarify precisely other effects, including side effects, the appropriate dosage as well as the target population.Keywords: probiotics, allergy, hypersensitivity.

Download Full-text

Impact of Environmental Factors on the Prevalence Changes of Allergic Diseases in Elementary School Students in Ulsan, Korea: A Longitudinal Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17238831 ◽

2020 ◽

Vol 17 (23) ◽

pp. 8831

Author(s):

Jiho Lee ◽

Seokhyun Yun ◽

Inbo Oh ◽

Min-ho Kim ◽

Yangho Kim

Keyword(s):

Physical Activity ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Environmental Factors ◽

Elementary School Students ◽

Allergic Conjunctivitis ◽

Allergic Diseases ◽

School Students ◽

Weekly Physical Activity ◽

Low Levels

We examined the effect of long-term changes in environmental factors on the prevalence of allergic diseases in elementary school students in Ulsan, Korea. This longitudinal study was conducted among 390 students who were enrolled from three elementary schools in Ulsan in both the first (2009–2010) and second survey (2013–2014). The International Study of Asthma and Allergies in Childhood questionnaire was used to determine the prevalence of allergic diseases and hazardous environmental factors. Generalized estimating equations (GEE) were used to investigate the impact of environmental factors on the change in the prevalence of allergic diseases. The survey revealed that an increased risk of allergic rhinitis was associated with exposure to secondhand smoke, the remodeling of a room, the replacement of wallpaper or flooring, the use of a humidifier, and irritation symptoms of air pollution. Atopic dermatitis was associated with the relocation to or repairs of a new house, and allergic conjunctivitis was associated with low levels of weekly physical activity, the use of insecticides, and irritation symptoms of air pollution. The results indicate that (1) allergic rhinitis and atopic dermatitis are associated with indoor pollution, (2) allergic conjunctivitis is associated with exposure to indoor chemical compounds and low levels of weekly physical activity. This study suggested that the proper evaluation and decrease in the number of environmental risk factors could effectively manage allergic diseases.

Download Full-text

Atopie als Vorbote von Autoimmunerkrankungen - Nicht aus dem (zweiten) Blick verlieren

Karger Kompass Dermatologie ◽

10.1159/000486978 ◽

2018 ◽

Vol 6 (2) ◽

pp. 85-86

Author(s):

David Brandt

Keyword(s):

Allergic Rhinitis ◽

Large Scale ◽

Past History ◽

Systemic Vasculitis ◽

Allergic Diseases ◽

Control Group ◽

Atopic Diseases ◽

Cross Sectional ◽

Large Scale Study ◽

History Of

Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. Methods: We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. Results: The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). Conclusion: KD is associated with allergic diseases. This association increases with the severity of the disease.

Download Full-text

Sociodemographic and family correlates of dietary-lifestyle patterns in young men: cross-sectional study (MeDiSH Project)

Proceedings of The Nutrition Society ◽

10.1017/s0029665120001512 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Marta Lonnie ◽

Lidia Wadolowska ◽

Joanna Kowalkowska ◽

Elzbieta Bandurska-Stankiewicz

Keyword(s):

Physical Activity ◽

Rural Areas ◽

Educational Level ◽

Young Men ◽

Cottage Cheese ◽

Fast Foods ◽

Fried Food ◽

Lower Educational Level ◽

The Past ◽

Lifestyle Patterns

AbstractThe aim of this study was to identify the sociodemographic and family correlates associated with dietary and lifestyle patterns in young men. In all, 367 men from the Warmia and Mazury region (Poland), aged 19–40 years old participated in the study. Data regarding sociodemographic, family status, dietary and lifestyle characteristics were collected through structured interviews using food frequency questionnaire KomPAN (Jezewska-Zychowicz et al. 2018, http://www.knozc.pan.pl). Dietary and lifestyle patterns were derived using Principal Component Analysis (PCA). In total, 25 dietary and 6 lifestyle standardised variables were included in the PCA. The associations were verified using logistic regression. Four DLPs were derived, explaining 33% of the variance. Men from the upper tertile of “Protein food, fried-food and recreational physical activity” pattern (characterised by frequent intake of white meat, white rice, eggs, red meat, fried food, groats, higher number of meals a day and recreational activity) were more likely to be under 30 years old (odds ratio, OR = 2.20, 95% confidence interval, 95%CI: 1.30–3.70) than men from the bottom tertile. Men from the upper tertile of “Sandwiches and convenience foods” pattern (characterised by frequent intake of cold meats and smoked sausages, white bread, butter, cheese, sweets and tinned meat) were more likely to be in a relationship (1.95, 1.14–3.34) than men from the bottom tertile. Men from the upper tertile of “Fast foods and stimulants” pattern (characterised by frequent intake of sweetened beverages, energy drinks, alcohol, fast foods, and smoking currently or/and in the past) were more likely to be under 30 years old (2.46, 1.46–4.14), to live in towns and rural areas (2.07, 1.21–3.55) and to have lower educational level (2.01, 1.20–3.36) in comparison to men from the bottom tertile. Men from the upper tertile of “Healthy diet, activity at work, former smoking” pattern (characterised by frequent intake of fruit, vegetables, fermented milk products, wholegrain bread, fish, cottage cheese, milk, groats, legumes, higher number of meals a day, physical activity at work and smoking in the past) were more likely to work physically (2.06, 1.22–3.47) and be in a relationship (1.93, 1.12–3.32). Sociodemographic and family correlates were strongly associated with dietary and lifestyle patterns, both healthy and unhealthy, in our sample of young men. The results demonstrate that diet and lifestyle interventions should be particularly targeted at men under 30 years old, those living in small towns and rural areas and with lower educational level.

Download Full-text

Kawasaki Disease and Atopic Diseases: A Systematic Review and Meta-Analysis of Observational Studies

International Archives of Allergy and Immunology ◽

10.1159/000520045 ◽

2021 ◽

pp. 1-9

Author(s):

Zihan Wang ◽

Jintao Zhang ◽

Hao Yan ◽

Liang Dong

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Kawasaki Disease ◽

Observational Studies ◽

Allergic Conjunctivitis ◽

Meta Analysis ◽

Allergic Diseases ◽

Cardiovascular Disorder ◽

Atopic Diseases ◽

Cross Sectional

Introduction: The etiology of Kawasaki disease (KD), an inflammatory and cardiovascular disorder, remains largely unexplained after more than 50 years of intensive research. In recent years, the association between KD and atopic diseases had been explored by some observational studies. We systematically reviewed and summarized the literature on the relationship between KD and atopic diseases. Methods: MEDLINE and EMBASE were searched to identify observational studies on the association between KD and atopic diseases from inception to May 2021. Odds ratio (OR) was pooled using random-effects models. Heterogeneity was assessed using the I2 and Cochran Q statistics. Primary outcomes were to compare the prevalence of KD among individuals with atopic diseases to nonatopic disease controls and the prevalence of atopic diseases among individuals with KD to non-KD controls. Results: Thirteen studies, including 12,651 cases and 170,708 controls, were included in this meta-analysis. In cross-sectional studies, KD was associated with allergic rhinitis (n = 6; OR, 1.69; 95% CI, 1.52–1.87), asthma (n = 3; OR, 1.72; 95% CI, 1.38–2.14), allergic conjunctivitis (n = 2; OR, 1.95; 95% CI, 1.68–2.27), and atopic dermatitis (n = 3; OR, 1.35; 95% CI, 1.22–1.49). In case-control and cohort studies, KD was associated with allergic rhinitis (n = 3; OR, 1.35; 95% CI, 1.28–1.43), asthma (n = 8; OR, 1.40; 95% CI, 1.19–1.65), allergic conjunctivitis (n = 1; OR, 1.74; 95% CI, 1.45–2.09), and atopic dermatitis (n = 3; OR, 1.39; 95% CI, 1.26–1.53). Conclusion: KD diagnosed was associated with four common atopic diseases. Among the four allergic diseases, allergic conjunctivitis and asthma have the highest correlation with KD, which may provide a direction for exploring the etiology of KD.

Download Full-text

Prevalence of bronchial asthma, allergic rhinitis, atopic dermatitis in children in Lesnoy area of Sverdlovsk region

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja685 ◽

2012 ◽

Vol 9 (3) ◽

pp. 14-17

Author(s):

N A Volkova ◽

E K Beltyukov

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Age Groups ◽

International Study ◽

Allergic Diseases ◽

Preschool Age ◽

Atopic Diseases ◽

Younger Age ◽

Further Development

A research of prevalence of allergic diseases in children from 0 to 6 years has been carried out using a standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC) in town Lesnoy in 2010. Background. To define the prevalence and structure of atopic diseases in different age groups in children of preschool age in town Lesnoy. Methods. Standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC). Results. Formation of atopic march is defined, in early age — atopic dermatitis and later respiratory form of allergy. Conclusion. Treatment of atopic dermatitis as risk factor of further development of allergic rhinitis and bronchial asthma can promote preventive maintenance of respiratory forms of allergy in children of younger age.

Download Full-text

Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v20i3.6331 ◽

2021 ◽

Author(s):

Zahra Nafei ◽

Nasrin Behniafard ◽

Mohsen Mirzaei ◽

Mehran Karimi ◽

Elahe Akbarian

Keyword(s):

Allergic Rhinitis ◽

Allergic Diseases ◽

Gender Preference ◽

The Past ◽

Increasing Trend ◽

Yazd City ◽

Allergic Disorders ◽

Impaired Quality ◽

Severe Atopic Eczema

Allergic rhinitis and eczema are two common global diseases that can lead to impaired quality of life. Determining the prevalence of these allergic disorders can be useful in planning prevention and treatment. This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Using an electronic questionnaire based on the Global Asthma Network (GAN) core questionnaire, 5141 adolescents aged 13–14 years were cross-sectionallysurveyed. The prevalence of current symptoms of rhinitis turned out to be 36.3%, proving significantly higher in boys (p=0.009). Moreover, the prevalence of allergic rhinitis and rhinoconjunctivitis in the past year leveled at 12.4% and 10.5%, respectively; however, the former was significantly higher in females (p=0.014). Additionally, severe rhinoconjunctivitis was observed in 0.2% of the participants with no gender preference (p=0.09). Confirmed hay fever by a doctor was reported in 13.2% of adolescents, significantly higher in males (p<0.001). The prevalence of current itchy rash and current eczema was found to be 5.5%, and 2.9%, respectively, with no difference in terms of gender. Severe atopic eczema and eczema confirmed by a doctor were seen in 0.4% and 5% of the participants, no gender preference was identified. Concurrent prevalence of current rhinoconjunctivitis and eczema was detected in 1% of the participants. Despite the increasing trend of allergic diseases in most parts of the world, the prevalence of rhinoconjunctivitis and eczema in adolescents has not increased in Yazd in the last two decades, and this city is located in a low to moderate prevalence area.

Download Full-text