Allergic march in children of Ukraine

Allergic diseases, which have a certain stage in their development from food allergy to bronchial asthma / allergic rhinitis, are much more common in children than in adults. The aim of this study was to analyze data on the prevalence and incidence of atopic dermatitis, bronchial asthma and allergic rhinitis as components of the allergic march, in children of Ukraine from 1994 to 2017 to determine the possible impact of adverse environmental factors on their development. During the same period, due to the influence of a number of factors, in particular environmental, there were significant changes in the structure of allergic diseases making up the stages of the allergic march due to an increase in the proportion of allergic rhinitis with the reduced one of asthma and atopic dermatitis. Within 24 years, the incidence of atopic dermatitis in children aged 0-6 years including, increased by 27.6%, in adolescents - by 40.5% and significantly decreased by 39.5% in children aged 7-14 years including. Most cases of allergic rhinitis and bronchial asthma were observed in schoolchildren (47.6 and 54.0%, respectively) with a slight decrease compared to 1994. In general, allergic diseases in recent years have become more common in children from 0 to 6 years and their detection has decreased in school-age children and adolescents. Over the past 24 years, in children of Ukraine a steady increase in the incidence and prevalence of allergic diseases that form an allergic march has been noted: the prevalence of bronchial asthma has increased by 69.3% and the incidence has increased by 22.9%; the prevalence of atopic dermatitis increased by 43.9% and the incidence increased by 8.3%; the prevalence of allergic rhinitis increased by 488.3% and the incidence of allergic rhinitis increased by 380.3%, with a predominance of detection of this pathology in children from regions with developed infrastructure and industry, where there are significant emissions of pollutants into the atmosphere, that have a direct moderate effect on the increase in the prevalence of bronchial asthma, the incidence and prevalence of allergic rhinitis in children.

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Atopic dermatitis: new horizons of therapy

Medical alphabet ◽

10.33667/2078-5631-2019-1-7(382)-29-32 ◽

2019 ◽

Vol 1 (7) ◽

pp. 29-32 ◽

Cited By ~ 4

Author(s):

L. S. Kruglova ◽

E. M. Gensler

Keyword(s):

Blood Pressure ◽

Immune Response ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Targeted Therapy ◽

Inflammatory Response ◽

Bronchial Asthma ◽

New Horizons ◽

The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

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APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

Wiadomości Lekarskie ◽

10.36740/wlek202007114 ◽

2020 ◽

Vol 73 (7) ◽

pp. 1377-1383

Author(s):

Olexandra V. Tiazhka ◽

Zoriana V. Selska

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Blood Serum ◽

Bronchial Asthma ◽

Vitamin D3 ◽

Allergic Diseases ◽

Acute Disease ◽

Disease Remission ◽

Significant Difference ◽

Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

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Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Clinical and Experimental Pediatrics ◽

10.3345/cep.2019.01291 ◽

2020 ◽

Vol 63 (7) ◽

pp. 278-283 ◽

Cited By ~ 12

Author(s):

Jihyun Ha ◽

Seung Won Lee ◽

Dong Keon Yon

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Preschool Children ◽

Allergic Diseases ◽

The Elderly ◽

Korean Population ◽

School Age Children ◽

Asthma Prevalence ◽

School Age ◽

Cross Sectional Survey

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017.Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the Korean population (n=85,006) including 2,131 infants, 4,352 preschool children, 12,919 school-age children, 44,200 adults, and 21,404 elderly adults.Results: In the 2016 to 2017 population, the estimated prevalence of asthma was 0.9% in infants, 2.3% in preschool children, 4.1% in school-age children, 2.3% in adults, and 4.1% in the elderly. The estimated prevalence of allergic rhinitis was 9.0%, 20.2%, 27.6%, 17.1%, and 6.9%, respectively. The estimated prevalence of atopic dermatitis was 5.9%, 11.3%, 14.6%, 3.9%, and 1.6%, respectively. Ten-year trends revealed a significant decrease in asthma prevalence in infants, preschool children, and the elderly. and in atopic dermatitis prevalence in infants and preschool children (<i>P</i><0.05 for all trends). Furthermore, 10-year trends demonstrated a significant increase in allergic rhinitis prevalence in school-age children, adults, and the elderly, and in atopic dermatitis prevalence in school-age children and the elderly (<i>P</i><0.05 for all trends).Conclusion: These results improve our understanding of the age-stratified epidemiology of allergic diseases in Korea and suggest the need for the development of tailored and precise strategies to prevent allergic diseases in different age groups.

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The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases

Acta Naturae ◽

10.32607/20758251-2019-11-4-54-64 ◽

2019 ◽

Vol 11 (4) ◽

pp. 54-64

Author(s):

I. P. Shilovskiy ◽

M. E. Dyneva ◽

O. M. Kurbacheva ◽

D. A. Kudlay ◽

M. R. Khaitov

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Interleukin 1 ◽

Allergic Diseases ◽

Biological Properties ◽

Negative Regulator ◽

Cellular Mechanisms ◽

Wide Range

Cytokines of the interleukin-1 (IL-1) family play an important role in the realization of the protective functions of innate immunity and are the key mediators involved in the pathogenesis of a wide range of diseases, including various manifestations of allergy. The IL-1 family includes more than 11 members. However, the functions of many of them remain to be elucidated. Recently, new members of the IL-1 family have been discovered. In 2000, several independent research groups reported the discovery of a new interleukin of this family, which was named IL-37, or IL-1F7 (according to the new nomenclature). IL-37 was assigned to the IL-1 family based on its structural similarity with other members of this family. The study of its biological properties showed that its activity changes in inflammatory diseases, such as rheumatoid arthritis, psoriasis, as well as allergic diseases (allergic rhinitis, bronchial asthma, and atopic dermatitis). However, unlike most members of the IL-1 family, IL-37 acts as a negative regulator of inflammation. Activation of IL-37 suppresses inflammation, resulting in the suppression of inflammatory cytokines and chemokines, which in turn prevents infiltration of pro-inflammatory cells, mainly eosinophils and neutrophils. The exact molecular and cellular mechanisms of the anti-inflammatory effect of IL-37 in the development of allergic diseases (AD) have not been fully studied. This review summarizes and analyzes the accumulated experimental data on the role of IL-37 in the pathogenesis of AD, such as allergic rhinitis, bronchial asthma, and atopic dermatitis.

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Effectiveness of leukotriene receptor antagonists in the treatment for atopic pathology in children

Health and Ecology Issues ◽

10.51523/2708-6011.2020-17-4-10 ◽

2020 ◽

pp. 38-42

Author(s):

A. I. Zariankina ◽

M. Kh. Mirrakhimova ◽

E. R. Shamsieva

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Eosinophil Count ◽

Allergic Diseases ◽

Receptor Antagonists ◽

Leukotriene Receptor Antagonists ◽

Leukotriene Receptor

Objective: to study the effectiveness of leukotriene receptor antagonists in the treatment foratopic pathology in children.Material and methods. 224 children with allergic diseases were prescribed to take montelucast for 3– 6 months.Results. Taking montelucast has lead to positive clinical dynamics in 75 % of the cases.A significant reduction of the eosinophil count was achieved on days 10–15 of the therapy. The Cys-LTC4/D4/E4 indices came to normal after a one-month course of montelucast therapy in 40.3 % of cases in children with bronchial asthma, in 63.3 % of cases in children with allergic rhinitis and in 60.5 % of cases in children with atopic dermatitis.Conclusions. The use of montelucast has significantly enhanced the control incidencerate ofallergic diseases in children.

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Features of sensitization to widespread allergens in residents of St. Petersburg and the Leningrad region with common allergic deseases

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja550 ◽

2013 ◽

Vol 10 (4) ◽

pp. 74-80

Author(s):

O V Aak ◽

A V Sobolev

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

Allergic Diseases ◽

Specific Ige ◽

Leningrad Region ◽

Food Allergens ◽

Significant Similarity ◽

High Degree

Background. To identify differences in sensitization to widespread allergens in patients with common allergic diseases: allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Materials and methods. Determination of sIgE in serum using commercial and domestic reagent kits («AllergoI-FA-specific IgE» and biotinylated allergens of «Alcor Bio», St. Petersburg) was conducted in patients with allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Results. There was a significant similarity between the spectrum of sensitization in patients with allergic rhinitis and asthma In atopic dermatitis patients the increasing of frequency of food and especially mold sensitization was estimated. The high degree of correlation between the moulds, plants and food allergens in atopic dermatitis was observed. Conclusion. The results obtained in the study can be interesting for physicians in allergological examination and for the researchers to identify new cross-reactive allergens.

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Biological drugs in the therapy of atopic dermatitis and bronchial asthma: focus on dupilumab

Pediatrics (Suppl Consilium Medicum) ◽

10.26442/26586630.2021.2.201053 ◽

2021 ◽

pp. 129-137

Author(s):

Vera A. Reviakina ◽

Natalia A. Geppe ◽

Aleksandr B. Malakhov ◽

Oleg V. Kaliuzhin ◽

Natalia G. Astaf'eva ◽

...

Keyword(s):

Atopic Dermatitis ◽

Targeted Therapy ◽

Bronchial Asthma ◽

Inflammatory Disease ◽

Clinical Case ◽

Allergic Diseases ◽

Significant Progress ◽

Biological Drugs ◽

The Past

Significant progress has been made over the past decade in the treatment of allergic diseases such as atopic dermatitis and bronchial asthma. Dupilumab, which targets interleukin IL-4 and IL-13, has become an innovative targeted therapy. Immunobiologic therapy with the interleukin inhibitor is indicated for patients with moderate to severe uncontrolled atopic dermatitis, moderate to severe eosinophilic phenotype of uncontrolled Bronchial asthma and patients with poorly controlled severe chronic polyposis rhinosinusitis. A clinical case and recent data on the use of dupilumab for the treatment of type 2 inflammatory disease and prospects for its use are discussed.

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Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2018-2-114-120 ◽

2018 ◽

Vol 17 (2) ◽

pp. 114-120

Author(s):

E. E. Varlamov ◽

A. N. Pampura ◽

A. N. Asmanov

Keyword(s):

Allergic Rhinitis ◽

Early Childhood ◽

Atopic Dermatitis ◽

Primary Prevention ◽

Bronchial Asthma ◽

Allergic Diseases ◽

The State ◽

Older Age ◽

Epidermal Barrier ◽

Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

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The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children ‐ Polish Mother and Child Cohort Study

Allergy and Asthma Proceedings ◽

10.2500/aap.2020.41.190020 ◽

2020 ◽

Vol 41 (1) ◽

pp. e19-e25

Author(s):

Monika Bobrowska-Korzeniowska ◽

Joanna Jerzyńska ◽

Kinga Polańska ◽

Jolanta Gromadzińska ◽

Wojciech Hanke ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Cord Blood ◽

Antioxidant Defense ◽

Allergic Diseases ◽

School Age Children ◽

School Age ◽

Early School ◽

Mother And Child ◽

Early School Age

Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess the associations among cord blood concentrations of zinc (Zn); copper (Cu); selenium (Se); β-carotene; and vitamin A, E, and D, and the occurrence of atopic dermatitis, food allergy, allergic rhinitis, and asthma in early school-age children. Methods: We evaluated 211 children, 7‐9 years old, from the Polish Mother and Child Cohort Study. the women were interviewed during pregnancy to collect demographic and socioeconomic data, and the medical and reproductive history. At delivery, umbilical cord blood plasma was sampled. Seven to nine years after the birth, the child's exposure and health status (including skin-prick test and spirometry for allergy assessment and urine sample for cotinine level) were examined. In the analyses, a multivariable model was applied. Results: Statistically significant relationships were found among Zn; Cu; Se; and vitamin A, E, and D concentrations in cord blood; and the prevalence of food allergy, allergic rhinitis, atopic dermatitis, and asthma in children ages 7‐9 years after adjustment for several confounders. Conclusion: We showed an imbalance in the antioxidant defense system in cord blood, which may lead to the occurrence of allergic diseases later in life. The maternal diet may have substantial potential to modify immune tolerance and, consequently, the development of allergic disease in the offspring.Clinical trial NCT01861548, <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</ext-link>

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PREVALENCE OF ALLERGIC DISEASES SYMPTOMS AMONG CHILDREN OF THE GRODNO REGION (REPUBLIC OF BELARUS)

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja525 ◽

2014 ◽

Vol 11 (5) ◽

pp. 46-50

Author(s):

R N Khokha

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Bronchial Asthma ◽

International Study ◽

Allergic Diseases ◽

School Students ◽

Russian Version ◽

Childhood Program ◽

Asthma And Allergy

Background. To study the prevalence of symptoms of allergic diseases among school students of the Grodno region (Republic of Belarus). Methods. Researches conducted a questioning method by means of the Russian version of the standardized «International Study of Asthma and Allergy in Childhood» program (ISAAC). Results. Results of questioning of 1787 schoolchildren showed that the wheezing, within the last 12 months was registered in 9,3% of children of the first classes (DI: 7,5-11,5%) and in 9,1% of children of the eighth classes (DI: 7,5-11%), rhinitis symptoms without cold or flu - in 29,7% of children of the first classes (DI: 26,7-32,85%) and in 47,2% of children of the eighth classes (DI: 44-50%), symptoms of atopic dermatitis - in 8,2% of children of the first classes (DI: 6,6-10%) and in 1,9% of children of the eighth classes (DI: 1-2,97%). Frequency of clinically verified diagnosis of bronchial asthma at schoolchildren at the age of 6-7 y.o. and at the age of 13-14 y.o. was 3,9% (DI: 3-4,9%), allergic rhinitis - 5,6% (DI: 4,6-6,8%), atopic dermatitis - 6,2% (DI: 5,2-7%). Conclusion. Results of the study confirm the need of carrying out further epidemiological researches for the purpose of earlier identification of patients with allergic diseases.

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