Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

Background: Melasma is a common hyperpigmentation disorder, characterized by light-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of this study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing Pinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF sunscreen in 30 women with mild-to-moderate facial melasma. Methods: Efficacy was assessed by measurement of the Melasma Area and Severity Index (MASI), instrumental analysis of the lesions (Mexameter®, VISIA®)) and Patient’s and Physician’s Global Assessment (PGA). Results: The MASI score decreased significantly compared with baseline at days 28, 56, and 84. Mexameter® analysis showed a significant decrease of ∆M (difference in the melanin index between melasma and adjacent area). VISIA® results also showed a reduction in the number and areas of UV pigmented spots and in the areas of melasma overtime. Both the Patient’s and Physician’s Global Assessment showed that the product led to an improvement of the lesions in terms of depigmentation and had positive cosmetic features without adverse events. Conclusion: The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma.

Download Full-text

Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus

Molecules ◽

10.3390/molecules26072099 ◽

2021 ◽

Vol 26 (7) ◽

pp. 2099

Author(s):

Lenka Sochorova ◽

Mojmir Baron ◽

Katerina Dadakova ◽

Tomas Kasparovsky ◽

Jiri Sochor

Keyword(s):

Free Radicals ◽

Biochemical Markers ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

The Body ◽

Biologically Active ◽

Active Components ◽

Grapevine Cultivar ◽

Wide Range

Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.

Download Full-text

Effect of Grape Seed Extract in Minimizing the Harmful Effects of Monosodium Glutamate on the Chicken Embryonic Retina to Show Scientific Miracles In the Holy Quran

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i2530819 ◽

2020 ◽

pp. 7-18

Author(s):

Fawzya Al- Gamdi ◽

Nouf Al- Harbi

Keyword(s):

Negative Impact ◽

Monosodium Glutamate ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

The Body ◽

Control Group ◽

Beverage Industry ◽

Potential Improvement ◽

Grape Seed Extracts

In 1969, a Canadian laboratory announced that its studies on synthetic alkaline (cyclamate) proved to be a carcinogen despite its use for more than twenty years in the beverage industry. There are many additives that have raised the controversy about the large extent of safety to consumers and the most famous controversy and consumption is the article of monosodium glutamate (MSG) which touched research on the negative impact on samples of research experiments. This research aims to study the effect (MSG) on the formation of retina in chicken embryos and the potential improvement effects of GSE grape seed extracts during incubation as part of the solutions provided in the event of the long term use of MSG and its accumulation in the body Human. The experimental groups were divided into 4 groups based on the injection period and the injected substances. The first control group(Injected with saline), the second group, treated with MSG, the 3rd group were treated with Monosoudim glutamate and grape seed extract at days 0,1 of incubation, whereas the 4thgroup,was treated with MSG and then the GSE (M – G) were given at3,4 days post MSG . The effect of the experimental materials on the development of the retina at the age of 14 was investigated in the current work. The results showed that the treatment of embryos with MSG dose (0.1 ml) caused many of the abnormalities at the level of tissue formation of the retina, and after the treatment of the fetus with GSE was noted to reduce the damage to the tissue of the retina. The results showed that the treatment of embryos with MSG dose (0.1 ml) caused many of the abnormalities at the level of tissue form of the retina, and after the treatment of the fetus with GSE was noted to reduce the damage to the tissue of the retina.

Download Full-text

Maternal dietary supplementation with grape seed extract in reproductive hens increases fertility in females but decreases semen quality in males of the F1 generation

PLoS ONE ◽

10.1371/journal.pone.0246750 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0246750

Author(s):

Jérémy Grandhaye ◽

François Lecompte ◽

Pascal Chartrin ◽

Maryse Leconte ◽

Antonella Riva ◽

...

Keyword(s):

Oxidative Stress ◽

Egg Quality ◽

Semen Quality ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

The Body ◽

Male And Female ◽

F1 Generation

Genetic selection in parental broiler breeders has increased their susceptibility to metabolic disorders and reproductive dysfunction. We have recently shown that maternal dietary grape seed extract (GSE) supplementation in hens improves fertility parameters, egg quality, oxidative stress in different tissues and the quality of F1 chicks. Here, we analysed the growth and fertility (both female and male) of the F1 generation animals and the quality of their offspring (F2 generation). Eggs issued from hens supplemented with GSE presented lower ROS production than control hens, suggesting a change in the embryonic environment. However, this did not affect the growth nor the body composition of male and female F1s from hatching to adulthood (37 weeks of age). At 37 weeks of age, the biochemistry analysis of the GSE-F1 muscle has revealed an increase in sensitivity to oxidative stress and a slight change in lipid composition. Both male and female F1-GSE groups presented a delay in puberty with a lower testis volume at 30 weeks of age and lower ovary development at 26 weeks of age. Adult GSE-F1 males did not present histological alterations of seminiferous tubules or semen production, but the semen quality was degraded due to higher oxidative stress and DNA-damaged spermatozoa compared with control F1 animals. In adult GSE-F1 females, despite the delay in puberty, the females laid more eggs of better quality (fewer broken eggs and a higher hatching rate). At hatching, the weight of the chicks from GSE-F1 females was reduced, and this effect was stronger in F2 male chicks (F2) compared with F2 control chicks (F2), because of the lower muscle volume. In conclusion, we can raise the hypothesis that maternal dietary GSE supplementation produces eggs with change in embryonic metabolism, which may affect in adulthood the fertility. The data obtained from the F1-GSE group pointed to a sex-specific modification with higher egg quality in females but semen sensitive to stress in males. Finally, male F2 chicks were leaner than control chicks. Thus, maternal dietary grape seed extract (GSE) supplementation in hens may impact on the fertility of the offspring in a sex-specific manner in subsequent generations.

Download Full-text

Grape Seeds Extract as Brain Food: A Review

International Journal of Pharmaceutical and Clinical Research ◽

10.25258/ijpcr.v9i1.8270 ◽

2017 ◽

Vol 9 (1) ◽

Author(s):

Souad El Gengaihi ◽

Doha H. Abou Baker

Keyword(s):

Antioxidant Activities ◽

Complex Mixture ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Amyloid Peptide ◽

Grape Seeds ◽

Potential Benefits ◽

Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

Download Full-text

Grape Seed Extract Complex (FFM-GS) Inhibits Postmenopausal Symptoms: In Vitro and In Vivo S

Journal of the Korean Society of Food Science and Nutrition ◽

10.3746/jkfn.2019.48.3.297 ◽

2019 ◽

Vol 48 (3) ◽

pp. 297-305

Author(s):

Minhee Lee ◽

Da-Eun Nam ◽

Soo-Jeung Park ◽

Dakyung Kim ◽

Jeong-Moon Yun ◽

...

Keyword(s):

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Postmenopausal Symptoms

Download Full-text

Comparative Evaluation of Immediate Bond Strength to Bleached Enamel Following Application of Various Antioxidant Solutions

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672088 ◽

2017 ◽

Vol 05 (02) ◽

pp. 084-089

Author(s):

Alisha Dhingra ◽

Ashu Gupta ◽

Anshu Minocha ◽

Nayantara Sen

Keyword(s):

Bond Strength ◽

Shear Bond Strength ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

The Other ◽

Sodium Ascorbate ◽

Group V ◽

Group I ◽

Significant Difference

Abstract Aim: The aim of this study was to compare the reversal of shear bond strength of composite to bleached enamel immediately after bleaching followed by application of various antioxidant solutions. Material and Methods: Seventy central incisors were divided into seven groups. Groups I and II served as unbleached and bleached controls respectively. Groups III, IV, V, VI and VII served as the experimental groups and were subjected to 37.5% hydrogen peroxide bleaching followed by 10 min application of 10% sodium ascorbate, 25% alpha-tocopherol, 6.5% grape seed extract, 5% lycopene and 5% green tea extract respectively. Following composite bonding, shear bond strength was determined and the results were analyzed using ANOVA followed by Post Hoc Multiple Comparisons test. Results: The bond strength values for Group I (positive control) were maximum and significantly different than all the other groups except Grape seed extract group (Group V). When compared to Group II (bleached control), all the groups showed significantly higher bond strength. Significant difference in the bond strength values were seen between Group III (10% sodium ascorbate) and Group V. Also values for Group V were significantly different from Group VI (5% lycopene). All the other values showed insignificantly different results. Conclusion: All the antioxidant solutions improved the shear bond strength values after bleaching but only Grape seed extract application reversed the values to the non bleached levels. Lycopene was least effective. Other antioxidants showed comparable results.

Download Full-text