scholarly journals Current Evidence for Stereotactic Body Radiotherapy in Lung Metastases

2021 ◽  
Vol 28 (4) ◽  
pp. 2560-2578
Author(s):  
Enrique Gutiérrez ◽  
Irving Sánchez ◽  
Omar Díaz ◽  
Adrián Valles ◽  
Ricardo Balderrama ◽  
...  
Keyword(s):  
Stereotactic Body Radiation Therapy ◽  
Lung Metastases ◽  
Current Evidence ◽  
Malignant Neoplasms ◽  
Disease Course ◽  
Lung Sbrt ◽  
Technical Requirements ◽  
Metastatic Lung ◽  
The Subject ◽  
The Ideal

Lung metastases are the second most common malignant neoplasms of the lung. It is estimated that 20–54% of cancer patients have lung metastases at some point during their disease course, and at least 50% of cancer-related deaths occur at this stage. Lung metastases are widely accepted to be oligometastatic when five lesions or less occur separately in up to three organs. Stereotactic body radiation therapy (SBRT) is a noninvasive, safe, and effective treatment for metastatic lung disease in carefully selected patients. There is no current consensus on the ideal dose and fractionation for SBRT in lung metastases, and it is the subject of study in ongoing clinical trials, which examines different locations in the lung (central and peripheral). This review discusses current indications, fractionations, challenges, and technical requirements for lung SBRT.

Non-surgical Treatments for Lung Metastases in Patients with soft Tissue Sarcoma: Stereotactic Body Radiation Therapy (SBRT) and Radiofrequency Ablation (RFA)

2020 ◽  
Vol 16 ◽  
Author(s):  
Cecilia Tetta ◽  
Maria Carpenzano ◽  
Areej Tawfiq J Algargoush ◽  
Marwah Algargoosh ◽  
Francesco Londero ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Stereotactic Body Radiation Therapy ◽  
Lung Metastases ◽  
Disease Free Interval ◽  
Stereotactic Body Radiation ◽  
Free Interval ◽  
Disease Free

Background: Radio-frequency ablation (RFA) and Stereotactic Body Radiation Therapy (SBRT) are two emerging therapies for lung metastases. Introduction: We performed a literature review to evaluate outcomes and complications of these procedures in patients with lung metastases from soft tissue sarcoma (STS). Method: After selection, seven studies were included for each treatment encompassing a total of 424 patients: 218 in the SBRT group and 206 in the RFA group. Results: The mean age ranged from 47.9 to 64 years in the SBRT group and from 48 to 62.7 years in the RFA group. The most common histologic subtype was, in both groups, leiomyosarcoma. : In the SBRT group, median overall survival ranged from 25.2 to 69 months and median disease-free interval from 8.4 to 45 months. Two out of seven studies reported G3 and one G3 toxicity, respectively. In RFA patients, overall survival ranged from 15 to 50 months. The most frequent complication was pneumothorax. : Local control showed high percentage for both procedures. Conclusion: SBRT is recommended in patients unsuitable to surgery, in synchronous bilateral pulmonary metastases, in case of deep lesions and in patients receiving high-risk systemic therapies. RFA is indicated in case of a long disease-free interval, in oligometastatic disease, when only the lung is involved, in small size lesions far from large vessels. : Further large randomized studies are necessary to establish whether these treatments may also represent a reliable alternative to surgery.

PASSIVE IMMUNIZATION

PEDIATRICS ◽  
1963 ◽  
Vol 32 (4) ◽  
pp. 599-609
Author(s):  
Geoffrey Edsall
Keyword(s):  
Diphtheria Toxin ◽  
Gamma Globulin ◽  
Passive Immunization ◽  
Gas Gangrene ◽  
High Antibody ◽  
Antibody Titers ◽  
The Subject ◽  
Guiding Principles ◽  
Routine Procedures ◽  
The Ideal

Passive immunization has existed for over 70 years, ever since Von Behring and Kitasato demonstrated its effectiveness in neutralizing diphtheria toxin. In fact, at first glance one might think that there was little new to say on this subject. However, the very fact that its concepts and practices have been so long accepted and–in the minds of many–have fallen into the pattern of purely routine procedures, is in itself sufficient justification to re-examine the subject. In addition, moreover, there have been a number of changes in the range of diseases for which passive immunization may be employed, the type of antiserum used, and the guiding principles for use of such preparations. Therefore, it may be timely to deal with some of the present considerations that apply to passive immunization, its prospects, its scope, and its limitations. At the risk of repeating old and familiar cliches it appears desirable to summarize, at first, the guiding principles which apply to the effectiveness (or ineffectiveness) of passive immunization. First of all, it is well established that some techniques of passive immunization are highly effective–e.g., diphtheria prophylaxis with antitoxin; some are very useful but fall short of the ideal of routine success with the purpose intended–e.g., the use of gamma-globulin for the modification of measles; whereas others are of relatively uncertain value so that their usefulness in medical practice still continues to be debated–e.g., gas gangrene antitoxin. The reasons for such great disparity in the efficacy of different antisera cannot easily be put into generalizations, but surely the varied pathogenesis of the diseases in question must be a major factor, as well as the fact that high antibody titers can readily be obtained for some such sera, whereas they are difficult or impossible to achieve with others.

Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours

2017 ◽  
Vol 143 (7) ◽  
pp. 1293-1299 ◽  
Author(s):  
Davide Franceschini ◽  
Luca Cozzi ◽  
Fiorenza De Rose ◽  
Piera Navarria ◽  
Ciro Franzese ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Stereotactic Body Radiation Therapy ◽  
Lung Metastases ◽  
Stereotactic Body Radiation

scholarly journals KONSEP DIRI ANAK PEKERJA SEKS KOMERSIAL YANG TINGGAL DITENGAH MASYARAKAT

2017 ◽  
Vol 1 (1) ◽  
pp. 78
Author(s):  
Fatchun Nikmah
Keyword(s):  
Physical Condition ◽  
Sex Workers ◽  
Self Concept ◽  
Snowball Sampling ◽  
Ideal Self ◽  
Study Approach ◽  
Ideal Situation ◽  
The Subject ◽  
The Ideal

Abstract  Stigma in today's society considers more sex workers as the dregs of society who only regarded as an immoral person who violates the norms of religion and society, so they are not appreciated. A prostitute is almost the majority have families, both parents, brother, husband or child. Communities usually negative view sex workers family and those views may influence the psychological development of child prostitutes. This study aims to determine the child's self-concept of prostitutes who live in the community.This study uses a qualitative case study approach, which is a special phenomenon that is present in a limited context, although the boundaries between phenomenon and context are not entirely clear. Determination techniques are the subject of the researchers used snowball sampling or chain sampling. The research was conducted in two villages that are within the scope of the district in one district on the island of Java. The subject of this study were children and adolescents aged prostitute who is still undergoing formal schooling.This study found that the first subject has a good self concept. There is not much of a gap between the basic self-concept and ideal self-concept on the subject. The first subject has a perceptual self-concept is not good because the subject is not satisfied with the current physical condition and there are gaps in the basic perceptual components and ideal self-concept. As for the conceptual and attitudinal self concept self concept can be considered a good subject because there is no gap between the conceptual and attitudinal components of the basic categories and ideal self-concept. While the second subject has a poor self-concept, as there are many gaps between the basic self-concept and ideal self concept on the subject. The subject has a perceptual selfconcept is not good, because the subject was not satisfied with his physical condition and his subjects make the situation as a benchmark of the ideal situation for him. In addition, the subject has attitudinal poor self concept.  Keywords: Self-concept, children, sex workers, society, qualitative

scholarly journals Importance of serological testing in the convalescence phase in patients with pulmonary impairment due to COVID 19 - a health care workers analysis

2021 ◽  
Author(s):  
José Rodrigues Pereira ◽  
Ilka Lopes Santoro ◽  
Maria Silvia Biagioni Santos ◽  
Andreia Padilha de Toledo ◽  
Greice Elen Copelli ◽  
...  
Keyword(s):  
Serological Test ◽  
Rt Pcr ◽  
Serological Tests ◽  
Care Workers ◽  
Pulmonary Impairment ◽  
Increased Sensitivity ◽  
Pulmonary Changes ◽  
The Subject ◽  
Convalescence Phase ◽  
The Ideal

1AbstractSince its discovery, more than 37 million people have been infected by SARS-CoV-2 with deaths around 1 million worldwide. The prevalence is not known because infected individuals may be asymptomatic. In addition, the use of specific diagnostic tests is not always conclusive, raising doubts about the etiology of the disease.The best diagnostic method and the ideal time of collection remains the subject of study. The gold standard for diagnosing COVID 19 is the RT PCR molecular test, usually using an oropharynx and nasopharynx swab. Its sensitivity is 70% and drops significantly after the second week of symptoms. Serological tests, in turn, have increased sensitivity after 14 days, and can contribute to the diagnosis when SARS-CoV-2 infection is suspected, even with negative RT PCR.Our study showed sensitivity and specificity of 100% of the serological test (ELISA method) for cases of viral pneumonia caused by the new coronavirus, suggesting that this test could assist in the diagnosis of pulmonary interstitial changes that have not yet been etiologically clarified. We found a greater immune response in men, regardless of the severity of symptoms. The greater the severity, the higher the levels of IgA and IgG, mainly found in patients with multilobar impairment and in need for oxygen. We concluded that the serological test collected around 30 days after the onset of symptoms is the best diagnostic tool in the convalescence phase, not only for epidemiological purposes, but also for the etiological clarification of pulmonary changes that have not yet been diagnosed.

scholarly journals Keadilan Hukum Jeremy Bentham dan Relevansinya bagi Praktik Hukum Kontemporer

Humaniora ◽  
2012 ◽  
Vol 3 (1) ◽  
pp. 299
Author(s):  
Frederikus Fios
Keyword(s):  
Global Politics ◽  
Jeremy Bentham ◽  
Ideal Model ◽  
The Core ◽  
The Subject ◽  
Core Idea ◽  
The Universe ◽  
Universe Of Discourse ◽  
British Philosopher ◽  
The Ideal

Fair punishment for a condemned has been long debated in the universe of discourse of law and global politics. The debate on the philosophical level was no less lively. Many schools of thought philosophy question, investigate, reflect and assess systematically the ideal model for the subject just punishment in violation of the law. One of the interesting and urgent legal thought Jeremy Bentham, a British philosopher renowned trying to provide a solution in the middle of the debate was the doctrine or theory of utilitarianism. The core idea is that the fair punishment should be a concern for happiness of a condemned itself, and not just for revenge. Bentham thought has relevance in several dimensions such as dimensions of humanism, moral and utility.  

scholarly journals The Complete Genome Sequence of Bacillus anthracis Ames “Ancestor”

2008 ◽  
Vol 191 (1) ◽  
pp. 445-446 ◽  
Author(s):  
Jacques Ravel ◽  
Lingxia Jiang ◽  
Scott T. Stanley ◽  
Mark R. Wilson ◽  
R. Scott Decker ◽  
...  
Keyword(s):  
United States ◽  
Bacillus Anthracis ◽  
Genome Sequence ◽  
Cold Storage ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
The United States ◽  
Pathogenic Bacterium ◽  
The Subject ◽  
The Ideal

ABSTRACT The pathogenic bacterium Bacillus anthracis has become the subject of intense study as a result of its use in a bioterrorism attack in the United States in September and October 2001. Previous studies suggested that B. anthracis Ames Ancestor, the original Ames fully virulent plasmid-containing isolate, was the ideal reference. This study describes the complete genome sequence of that original isolate, derived from a sample kept in cold storage since 1981.

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