scholarly journals Spitz nevus with Features of Clark Nevus, So-Called SPARK Nevus: Case Series Presentation with Emphasis on Cytological and Histological Features

2021 ◽  
Vol 8 (4) ◽  
pp. 525-530
Author(s):  
Antonietta Cimmino ◽  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Eugenio Maiorano ◽  
Lucia Lospalluti ◽  
...  
Keyword(s):  
Case Studies ◽  
Current Literature ◽  
Case Series ◽  
Inclusion Criteria ◽  
Histological Features ◽  
Spitz Nevus ◽  
Definition Of

Background: SPARK nevus represents a little-known and characterized entity, with few case series available in the literature. Methods and results: we present a case series of 12 patients (6 F and 6 M) between January 2005 and December 2020 and conduct a review of the current literature. Ten articles were selected on the basis of the adopted inclusion criteria and the PRISMA guidelines. Conclusions: The definition of histopathological and dermoscopic criteria are important to allow for an agreement to be reached among dermopathologists, and for the development of a consensus on higher case studies. To our knowledge, there are not many case series in the literature, and ours is part of the attempt to increase the knowledge of an entity that remains little-known and characterized.

scholarly journals What is the Co-Creation of New Knowledge? A Content Analysis and Proposed Definition for Health Interventions

2020 ◽  
Vol 17 (7) ◽  
pp. 2229 ◽  
Author(s):  
Tania Pearce ◽  
Myfanwy Maple ◽  
Anthony Shakeshaft ◽  
Sarah Wayland ◽  
Kathy McKay
Keyword(s):  
Content Analysis ◽  
Current Literature ◽  
Qualitative Content Analysis ◽  
Health Interventions ◽  
Inclusion Criteria ◽  
Research And Practice ◽  
Collaborative Processes ◽  
New Knowledge ◽  
Speed Up ◽  
Definition Of

Co-creation of new knowledge has the potential to speed up the discovery and application of new knowledge into practice. However, the progress of co-creation is hindered by a lack of definitional clarity and inconsistent use of terminology. The aim of this paper is to propose a new standardised definition of co-creation of new knowledge for health interventions based on the existing co-creation literature. The authors completed a systematic search of electronic databases and Google Scholar using 10 of the most frequently used co-creation-related keywords to identify relevant studies. Qualitative content analysis was performed, and two reviewers independently tested the categorisation of papers. Of the 6571 papers retrieved, 42 papers met the inclusion criteria. Examination of the current literature on co-creation demonstrated how the variability of co-creation-related terms can be reduced to four collaborative processes: co-ideation, co-design, co-implementation and co-evaluation. Based on these four processes, a new definition of co-creation of new knowledge for health interventions is proposed. The analysis revealed the need to address the conceptual ambiguity of the definition of “co-creation of new knowledge”. The proposed new definition may help to resolve the current definitional issues relating to co-creation, allowing researchers and policymakers to progress the development of co-creation of new knowledge in research and practice.

Comparison Between 18F-Dopa and 18F-Fet PET/CT in Patients with Suspicious Recurrent High Grade Glioma: A Literature Review and Our Experience

2019 ◽  
Vol 12 (3) ◽  
pp. 220-228 ◽  
Author(s):  
Laura Evangelista ◽  
Lea Cuppari ◽  
Luisa Bellu ◽  
Daniele Bertin ◽  
Mario Caccese ◽  
...  
Keyword(s):  
Case Series ◽  
High Grade Glioma ◽  
High Grade ◽  
True Negative ◽  
Fet Pet ◽  
Positron Emission ◽  
Pet Ct ◽  
Magnetic Resonance Imaging Mri ◽  
Definition Of ◽  
Sensitivity Specificity

Purpose: The aims of the present study were to: 1- critically assess the utility of L-3,4- dihydroxy-6-18Ffluoro-phenyl-alanine (18F-DOPA) and O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) Positron Emission Tomography (PET)/Computed Tomography (CT) in patients with high grade glioma (HGG) and 2- describe the results of 18F-DOPA and 18F-FET PET/CT in a case series of patients with recurrent HGG. Methods: We searched for studies using the following databases: PubMed, Web of Science and Scopus. The search terms were: glioma OR brain neoplasm and DOPA OR DOPA PET OR DOPA PET/CT and FET OR FET PET OR FET PET/CT. From a mono-institutional database, we retrospectively analyzed the 18F-DOPA and 18F-FET PET/CT of 29 patients (age: 56 ± 12 years) with suspicious for recurrent HGG. All patients underwent 18F-DOPA or 18F-FET PET/CT for a multidisciplinary decision. The final definition of recurrence was made by magnetic resonance imaging (MRI) and/or multidisciplinary decision, mainly based on the clinical data. Results: Fifty-one articles were found, of which 49 were discarded, therefore 2 studies were finally selected. In both the studies, 18F-DOPA and 18F-FET as exchangeable in clinical practice particularly for HGG patients. From our institutional experience, in 29 patients, we found that sensitivity, specificity and accuracy of 18F-DOPA PET/CT in HGG were 100% (95% confidence interval- 95%CI - 81-100%), 63% (95%CI: 39-82%) and 62% (95%CI: 39-81%), respectively. 18F-FET PET/CT was true positive in 4 and true negative in 4 patients. Sensitivity, specificity and accuracy for 18F-FET PET/CT in HGG were 100%. Conclusion: 18F-DOPA and 18F-FET PET/CT have a similar diagnostic accuracy in patients with recurrent HGG. However, 18F-DOPA PET/CT could be affected by inflammation conditions (false positive) that can alter the final results. Large comparative trials are warranted in order to better understand the utility of 18F-DOPA or 18F-FET PET/CT in patients with HGG.

Democracy and Political Culture

2019 ◽  
Author(s):  
Ross McKibbin
Keyword(s):  
Political Culture ◽  
Case Studies ◽  
Social System ◽  
Political System ◽  
Democratic Politics ◽  
Social Structures ◽  
The Political ◽  
The Subject ◽  
The One ◽  
Definition Of

This book is an examination of Britain as a democratic society; what it means to describe it as such; and how we can attempt such an examination. The book does this via a number of ‘case-studies’ which approach the subject in different ways: J.M. Keynes and his analysis of British social structures; the political career of Harold Nicolson and his understanding of democratic politics; the novels of A.J. Cronin, especially The Citadel, and what they tell us about the definition of democracy in the interwar years. The book also investigates the evolution of the British party political system until the present day and attempts to suggest why it has become so apparently unstable. There are also two chapters on sport as representative of the British social system as a whole as well as the ways in which the British influenced the sporting systems of other countries. The book has a marked comparative theme, including one chapter which compares British and Australian political cultures and which shows British democracy in a somewhat different light from the one usually shone on it. The concluding chapter brings together the overall argument.

Historical Perspectives on Innovation in Indian Business

2018 ◽  
Author(s):  
Claude Markovits
Keyword(s):  
Case Studies ◽  
Technological Innovation ◽  
Historical Perspective ◽  
Specific Context ◽  
Colonial Era ◽  
Industrial Firm ◽  
Historical Perspectives ◽  
Entire World ◽  
Definition Of ◽  
Trading Network

This chapter deals with the question of innovation in Indian business from a historical perspective. After a brief survey of the literature, emphasizing how divided scholarly opinion was regarding the existence of forms of innovation in Indian business prior to the colonial era, the focus shifts to the British period. It is shown that Schumpeter’s definition of innovation equating it with technological innovation cannot be fruitfully applied to the Indian business scene. Two case studies are then proposed: Tata Iron & Steel, the largest Indian industrial firm, is shown to have been innovative in the specific context of India’s backward industrial scene, while the Sindwork merchants of Hyderabad are an instance of an Indian trading network which extended its range to the entire world. Concluding remarks interrogate post-Independence developments and stress the limits of the innovativeness of Indian business, prior to the recent liberal reforms.

Introduction

2018 ◽  
Author(s):  
Nicholas J. Wheeler
Keyword(s):  
Case Studies ◽  
Final Section ◽  
Definition Of ◽  
Calculative Trust

This Introduction to the book does three things. First, it introduces the concept of trust and develops a definition of trust as the ‘expectation of no harm in contexts where betrayal is always a possibility’. Next, it identities two conceptions of trust that guide the book, ‘calculative trust’ and ‘trust as suspension’, which provide very different explanations for how actors form expectations that another will be trustworthy. It then shows how trust as suspension opens up a new theory of accurate signal interpretation and demonstrates how this theory is superior to costly signalling-based theories of accurate signal interpretation. The final section of the Introduction sets out the rationale for the case studies and the key assumptions.

scholarly journals FROM THE DEFINITION OF USER EXPERIENCE TO A FRAMEWORK TO CLASSIFY ITS APPLICATIONS IN DESIGN

2021 ◽  
Vol 1 ◽  
pp. 1627-1636
Author(s):  
Aurora Berni ◽  
Yuri Borgianni
Keyword(s):  
Case Studies ◽  
User Experience ◽  
Previous Literature ◽  
Definition Of ◽  
System Context ◽  
Comprehensive Studies

AbstractThe concept of User Experience (UX) dates back to the 1990s, but a shared definition of UX is not available. As design integrates UX, different interpretations thereof can complicate the possibility to build upon previous literature and develop the field autonomously. Indeed, by analysing the literature, UX emerges as a cauldron of related and closely linked concepts. However, it is possible to find recurring attributes that emerge from those definitions, which are ascribable to two foci: the fundamental elements of the interaction (user, system, context) and typologies of experience (ergonomic, cognitive, and emotional). Those are used to build a framework. We have preliminarily investigated how UX is dealt with in design by mapping a sample of UX-related experimental articles published in design journals. We classified UX case studies based on the framework to individuate the UXs that emerge most frequently and the most studied ones in the design field. The two-focus framework allows the mapping of experiments involving UX in design, without highlighting specific favorable combinations. However, comprehensive studies dealing with all elements and UX typologies have not been found.

scholarly journals Remote Sensing Applications for Landslide Monitoring and Investigation in Western Canada

2021 ◽  
Vol 13 (3) ◽  
pp. 366
Author(s):  
Renato Macciotta ◽  
Michael T. Hendry
Keyword(s):  
Remote Sensing ◽  
Case Studies ◽  
Slope Failure ◽  
Landslide Monitoring ◽  
Western Canada ◽  
Extensive Literature ◽  
Sensing Applications ◽  
Remote Sensing Techniques ◽  
Definition Of ◽  
River Valleys

Transportation infrastructure in mountainous terrain and through river valleys is exposed to a variety of landslide phenomena. This is particularly the case for highway and railway corridors in Western Canada that connect towns and industries through prairie valleys and the Canadian cordillera. The fluidity of these corridors is important for the economy of the country and the safety of workers, and users of this infrastructure is paramount. Stabilization of all active slopes is financially challenging given the extensive area where landslides are a possibility, and monitoring and minimization of slope failure consequences becomes an attractive risk management strategy. In this regard, remote sensing techniques provide a means for enhancing the monitoring toolbox of the geotechnical engineer. This includes an improved identification of active landslides in large areas, robust complement to in-place instrumentation for enhanced landslide investigation, and an improved definition of landslide extents and deformation mechanisms. This paper builds upon the extensive literature on the application of remote sensing techniques and discusses practical insights gained from a suite of case studies from the authors’ experience in Western Canada. The review of the case studies presents a variety of landslide mechanisms and remote sensing technologies. The aim of the paper is to transfer some of the insights gained through these case studies to the reader.

scholarly journals Clinical, Laboratory and Histological Features of Dipeptidyl Peptidase-4 Inhibitor Related Noninflammatory Bullous Pemphigoid

2021 ◽  
Vol 10 (9) ◽  
pp. 1916
Author(s):  
Ágnes Kinyó ◽  
Anita Hanyecz ◽  
Zsuzsanna Lengyel ◽  
Dalma Várszegi ◽  
Péter Oláh ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Clinical Laboratory ◽  
Case Series ◽  
Dipeptidyl Peptidase ◽  
Area Index ◽  
Histological Features ◽  
Dipeptidyl Peptidase 4 ◽  
First Case ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
The Mean

Bullous pemphigoid (BP) is an autoimmune blistering disease of elderly patients that has shown increasing incidence in the last decades. Higher prevalence of BP may be due to more frequent use of provoking agents, such as antidiabetic dipeptidyl peptidase-4 inhibitor (DPP4i) drugs. Our aim was to assess DPP4i-induced bullous pemphigoid among our BP patients and characterize the clinical, laboratory and histological features of this drug-induced disease form. In our patient cohort, out of 127 BP patients (79 females (62.2%), 48 males (37.7%)), 14 (9 females and 5 males) were treated with DPP4i at the time of BP diagnosis. The Bullous Pemphigoid Disease Area Index (BPDAI) urticaria/erythema score was significantly lower, and the BPDAI damage score was significantly higher in DPP4i-BP patients compared to the nonDPP4i group. Both the mean absolute eosinophil number and the mean periblister eosinophil number was significantly lower in DPP4i-BP patients than in nonDPP4i cases (317.7 ± 0.204 vs. 894.0 ± 1.171 cells/μL, p < 0.0001; 6.75 ± 1.72 vs. 19.09 ± 3.1, p = 0.0012, respectively). Our results provide further evidence that DPP4i-associated BP differs significantly from classical BP, and presents with less distributed skin symptoms, mild erythema, normal or slightly elevated peripheral eosinophil count, and lower titers of BP180 autoantibodies. To our knowledge, this is the first case series of DPP4i-related BP with a non-inflammatory phenotype in European patients.

scholarly journals Recursion and the Definition of Universal Prosodic Categories

Languages ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 125
Author(s):  
Lisa Lai-Shen Cheng ◽  
Laura J. Downing
Keyword(s):  
Case Studies ◽  
High Ranking ◽  
Syntactic Theory ◽  
Current Controversy ◽  
Syntactic Representation ◽  
Definition Of ◽  
Prosodic Categories ◽  
Phonological Phrase

It is widely agreed that prosodic constituents should mirror syntactic constituents (unless high-ranking prosodic constraints interfere). Because recursion is a feature of syntactic representations, one expects recursion in prosodic representations as well. However, it is of current controversy what kinds of syntactic representation motivate prosodic recursion. In this paper, the use of Phonological Phrase recursion is reviewed in several case studies, chosen because prosodic recursion mostly does not reflect syntactic recursion as defined in current syntactic theory. We provide reanalyses that do not appeal to prosodic recursion (unless syntactically motivated), showing that Phonological Phrase recursion is not necessary to capture the relevant generalizations. The more restrictive use of prosodic recursion we argue for has the following conceptual advantages. It allows for more consistent cross-linguistic generalizations about the syntax–prosody mapping so that prosodic representations more closely reflect syntactic ones. It allows the fundamental syntactic distinctions between clause (and other phases) and phrase to be reflected in the prosodic representation, and it allows cross-linguistic generalizations to be made about the prosodic domain of intonational processes, such as downstep and continuation rise.

scholarly journals Failed Latarjet procedure: a systematic review of surgery revision options

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Matteo Buda ◽  
Riccardo D’Ambrosi ◽  
Enrico Bellato ◽  
Davide Blonna ◽  
Alessandro Cappellari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Series ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Latarjet Procedure ◽  
Shoulder Stabilization ◽  
Recurrent Instability ◽  
Level Of Evidence ◽  
Radiographic Outcomes

Abstract Background Revision surgery after the Latarjet procedure is a rare and challenging surgical problem, and various bony or capsular procedures have been proposed. This systematic review examines clinical and radiographic outcomes of different procedures for treating persistent pain or recurrent instability after a Latarjet procedure. Methods A systematic review of the literature was performed using the Medline, Cochrane, EMBASE, Google Scholar and Ovid databases with the combined keywords “failed”, “failure”, “revision”, “Latarjet”, “shoulder stabilization” and “shoulder instability” to identify articles published in English that deal with failed Latarjet procedures. Results A total of 11 studies (five retrospective and six case series investigations), all published between 2008 and 2020, fulfilled our inclusion criteria. For the study, 253 patients (254 shoulders, 79.8% male) with a mean age of 29.6 years (range: 16–54 years) were reviewed at an average follow-up of 51.5 months (range: 24–208 months). Conclusions Eden–Hybinette and arthroscopic capsuloplasty are the most popular and safe procedures to treat recurrent instability after a failed Latarjet procedure, and yield reasonable clinical outcomes. A bone graft procedure and capsuloplasty were proposed but there was no clear consensus on their efficacy and indication. Level of evidence Level IV Trial registration PROSPERO 2020 CRD42020185090—www.crd.york.ac.uk/prospero/

Sign in / Sign up

Export Citation Format

Share Document