scholarly journals Ten Fast Transfer Learning Models for Carotid Ultrasound Plaque Tissue Characterization in Augmentation Framework Embedded with Heatmaps for Stroke Risk Stratification

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2109
Author(s):  
Skandha S. Sanagala ◽  
Andrew Nicolaides ◽  
Suneet K. Gupta ◽  
Vijaya K. Koppula ◽  
Luca Saba ◽  
...  
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Tissue Characterization ◽  
Area Under The Curve ◽  
Learning Models ◽  
Non Invasive ◽  
Lower Accuracy ◽  
Improved Performance ◽  
Higher Order Spectra

Background and Purpose: Only 1–2% of the internal carotid artery asymptomatic plaques are unstable as a result of >80% stenosis. Thus, unnecessary efforts can be saved if these plaques can be characterized and classified into symptomatic and asymptomatic using non-invasive B-mode ultrasound. Earlier plaque tissue characterization (PTC) methods were machine learning (ML)-based, which used hand-crafted features that yielded lower accuracy and unreliability. The proposed study shows the role of transfer learning (TL)-based deep learning models for PTC. Methods: As pertained weights were used in the supercomputer framework, we hypothesize that transfer learning (TL) provides improved performance compared with deep learning. We applied 11 kinds of artificial intelligence (AI) models, 10 of them were augmented and optimized using TL approaches—a class of Atheromatic™ 2.0 TL (AtheroPoint™, Roseville, CA, USA) that consisted of (i–ii) Visual Geometric Group-16, 19 (VGG16, 19); (iii) Inception V3 (IV3); (iv–v) DenseNet121, 169; (vi) XceptionNet; (vii) ResNet50; (viii) MobileNet; (ix) AlexNet; (x) SqueezeNet; and one DL-based (xi) SuriNet-derived from UNet. We benchmark 11 AI models against our earlier deep convolutional neural network (DCNN) model. Results: The best performing TL was MobileNet, with accuracy and area-under-the-curve (AUC) pairs of 96.10 ± 3% and 0.961 (p < 0.0001), respectively. In DL, DCNN was comparable to SuriNet, with an accuracy of 95.66% and 92.7 ± 5.66%, and an AUC of 0.956 (p < 0.0001) and 0.927 (p < 0.0001), respectively. We validated the performance of the AI architectures with established biomarkers such as greyscale median (GSM), fractal dimension (FD), higher-order spectra (HOS), and visual heatmaps. We benchmarked against previously developed Atheromatic™ 1.0 ML and showed an improvement of 12.9%. Conclusions: TL is a powerful AI tool for PTC into symptomatic and asymptomatic plaques.

scholarly journals Vulnerability in Deep Transfer Learning Models to Adversarial Fast Gradient Sign Attack for COVID-19 Prediction from Chest Radiography Images

2021 ◽  
Vol 11 (9) ◽  
pp. 4233
Author(s):  
Biprodip Pal ◽  
Debashis Gupta ◽  
Md. Rashed-Al-Mahfuz ◽  
Salem A. Alyami ◽  
Mohammad Ali Moni
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Chest Radiography ◽  
High Sensitivity ◽  
Ct Images ◽  
Classification Performance ◽  
Learning Models ◽  
X Ray ◽  
Image Capturing ◽  
Fast Gradient

The COVID-19 pandemic requires the rapid isolation of infected patients. Thus, high-sensitivity radiology images could be a key technique to diagnose patients besides the polymerase chain reaction approach. Deep learning algorithms are proposed in several studies to detect COVID-19 symptoms due to the success in chest radiography image classification, cost efficiency, lack of expert radiologists, and the need for faster processing in the pandemic area. Most of the promising algorithms proposed in different studies are based on pre-trained deep learning models. Such open-source models and lack of variation in the radiology image-capturing environment make the diagnosis system vulnerable to adversarial attacks such as fast gradient sign method (FGSM) attack. This study therefore explored the potential vulnerability of pre-trained convolutional neural network algorithms to the FGSM attack in terms of two frequently used models, VGG16 and Inception-v3. Firstly, we developed two transfer learning models for X-ray and CT image-based COVID-19 classification and analyzed the performance extensively in terms of accuracy, precision, recall, and AUC. Secondly, our study illustrates that misclassification can occur with a very minor perturbation magnitude, such as 0.009 and 0.003 for the FGSM attack in these models for X-ray and CT images, respectively, without any effect on the visual perceptibility of the perturbation. In addition, we demonstrated that successful FGSM attack can decrease the classification performance to 16.67% and 55.56% for X-ray images, as well as 36% and 40% in the case of CT images for VGG16 and Inception-v3, respectively, without any human-recognizable perturbation effects in the adversarial images. Finally, we analyzed that correct class probability of any test image which is supposed to be 1, can drop for both considered models and with increased perturbation; it can drop to 0.24 and 0.17 for the VGG16 model in cases of X-ray and CT images, respectively. Thus, despite the need for data sharing and automated diagnosis, practical deployment of such program requires more robustness.

scholarly journals Study on Human Activity Recognition Using Semi-Supervised Active Transfer Learning

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2760
Author(s):  
Seungmin Oh ◽  
Akm Ashiquzzaman ◽  
Dongsu Lee ◽  
Yeonggwang Kim ◽  
Jinsul Kim
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Activity Recognition ◽  
Human Activity ◽  
Random Sampling ◽  
Data Gathering ◽  
Human Activity Recognition ◽  
Learning Models ◽  
Active Transfer ◽  
Existing Data

In recent years, various studies have begun to use deep learning models to conduct research in the field of human activity recognition (HAR). However, there has been a severe lag in the absolute development of such models since training deep learning models require a lot of labeled data. In fields such as HAR, it is difficult to collect data and there are high costs and efforts involved in manual labeling. The existing methods rely heavily on manual data collection and proper labeling of the data, which is done by human administrators. This often results in the data gathering process often being slow and prone to human-biased labeling. To address these problems, we proposed a new solution for the existing data gathering methods by reducing the labeling tasks conducted on new data based by using the data learned through the semi-supervised active transfer learning method. This method achieved 95.9% performance while also reducing labeling compared to the random sampling or active transfer learning methods.

Transfer Learning of The ResNet-18 and DenseNet-121 Model Used to Diagnose Intracranial Hemorrhage in CT Scanning

2021 ◽  
Vol 27 ◽  
Author(s):  
Qi Zhou ◽  
Wenjie Zhu ◽  
Fuchen Li ◽  
Mingqing Yuan ◽  
Linfeng Zheng ◽  
...  
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Intracranial Hemorrhage ◽  
Intraventricular Hemorrhage ◽  
Learning Model ◽  
Normal Group ◽  
Subdural Hemorrhage ◽  
Model Assessment ◽  
Learning Models ◽  
Deep Learning Model

Objective: To verify the ability of the deep learning model in identifying five subtypes and normal images in noncontrast enhancement CT of intracranial hemorrhage. Method: A total of 351 patients (39 patients in the normal group, 312 patients in the intracranial hemorrhage group) performed with intracranial hemorrhage noncontrast enhanced CT were selected, with 2768 images in total (514 images for the normal group, 398 images for the epidural hemorrhage group, 501 images for the subdural hemorrhage group, 497 images for the intraventricular hemorrhage group, 415 images for the cerebral parenchymal hemorrhage group, and 443 images for the subarachnoid hemorrhage group). Based on the diagnostic reports of two radiologists with more than 10 years of experience, the ResNet-18 and DenseNet-121 deep learning models were selected. Transfer learning was used. 80% of the data was used for training models, 10% was used for validating model performance against overfitting, and the last 10% was used for the final evaluation of the model. Assessment indicators included accuracy, sensitivity, specificity, and AUC values. Results: The overall accuracy of ResNet-18 and DenseNet-121 models were 89.64% and 82.5%, respectively. The sensitivity and specificity of identifying five subtypes and normal images were above 0.80. The sensitivity of DenseNet-121 model to recognize intraventricular hemorrhage and cerebral parenchymal hemorrhage was lower than 0.80, 0.73, and 0.76 respectively. The AUC values of the two deep learning models were above 0.9. Conclusion: The deep learning model can accurately identify the five subtypes of intracranial hemorrhage and normal images, and it can be used as a new tool for clinical diagnosis in the future.

scholarly journals Optimizing the Performance of Breast Cancer Classification by Employing the Same Domain Transfer Learning from Hybrid Deep Convolutional Neural Network Model

Electronics ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 445 ◽  
Author(s):  
Laith Alzubaidi ◽  
Omran Al-Shamma ◽  
Mohammed A. Fadhel ◽  
Laith Farhan ◽  
Jinglan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Transfer Learning ◽  
Cancer Diagnosis ◽  
Classification Accuracy ◽  
Cancer Classification ◽  
Learning Models ◽  
Proposed Model ◽  
Domain Transfer ◽  
Domain Transfer Learning

Breast cancer is a significant factor in female mortality. An early cancer diagnosis leads to a reduction in the breast cancer death rate. With the help of a computer-aided diagnosis system, the efficiency increased, and the cost was reduced for the cancer diagnosis. Traditional breast cancer classification techniques are based on handcrafted features techniques, and their performance relies upon the chosen features. They also are very sensitive to different sizes and complex shapes. However, histopathological breast cancer images are very complex in shape. Currently, deep learning models have become an alternative solution for diagnosis, and have overcome the drawbacks of classical classification techniques. Although deep learning has performed well in various tasks of computer vision and pattern recognition, it still has some challenges. One of the main challenges is the lack of training data. To address this challenge and optimize the performance, we have utilized a transfer learning technique which is where the deep learning models train on a task, and then fine-tune the models for another task. We have employed transfer learning in two ways: Training our proposed model first on the same domain dataset, then on the target dataset, and training our model on a different domain dataset, then on the target dataset. We have empirically proven that the same domain transfer learning optimized the performance. Our hybrid model of parallel convolutional layers and residual links is utilized to classify hematoxylin–eosin-stained breast biopsy images into four classes: invasive carcinoma, in-situ carcinoma, benign tumor and normal tissue. To reduce the effect of overfitting, we have augmented the images with different image processing techniques. The proposed model achieved state-of-the-art performance, and it outperformed the latest methods by achieving a patch-wise classification accuracy of 90.5%, and an image-wise classification accuracy of 97.4% on the validation set. Moreover, we have achieved an image-wise classification accuracy of 96.1% on the test set of the microscopy ICIAR-2018 dataset.

scholarly journals Deep Transfer Learning for Source Code Modeling

2020 ◽  
Vol 30 (05) ◽  
pp. 649-668
Author(s):  
Yasir Hussain ◽  
Zhiqiu Huang ◽  
Yu Zhou ◽  
Senzhang Wang
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Transfer Learning ◽  
Related Problem ◽  
State Of The Art ◽  
Source Code ◽  
Traditional Learning ◽  
Learning Models ◽  
Modeling And Analysis ◽  
F Measure

In recent years, deep learning models have shown great potential in source code modeling and analysis. Generally, deep learning-based approaches are problem-specific and data-hungry. A challenging issue of these approaches is that they require training from scratch for a different related problem. In this work, we propose a transfer learning-based approach that significantly improves the performance of deep learning-based source code models. In contrast to traditional learning paradigms, transfer learning can transfer the knowledge learned in solving one problem into another related problem. First, we present two recurrent neural network-based models RNN and GRU for the purpose of transfer learning in the domain of source code modeling. Next, via transfer learning, these pre-trained (RNN and GRU) models are used as feature extractors. Then, these extracted features are combined into attention learner for different downstream tasks. The attention learner leverages from the learned knowledge of pre-trained models and fine-tunes them for a specific downstream task. We evaluate the performance of the proposed approach with extensive experiments with the source code suggestion task. The results indicate that the proposed approach outperforms the state-of-the-art models in terms of accuracy, precision, recall and F-measure without training the models from scratch.

scholarly journals The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer

2020 ◽  
Vol 21 (24) ◽  
pp. 9472
Author(s):  
María Alarcón ◽  
Wilda Olivares ◽  
Miguel Córdova-Delgado ◽  
Matías Muñoz-Medel ◽  
Tomas de Mayo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Cancer Biology ◽  
Area Under The Curve ◽  
Soft Agar ◽  
Poor Overall Survival ◽  
Clinicopathologic Characteristics ◽  
Non Invasive

Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML expression was evaluated by immunohistochemistry in 90 patients with gastric cancer and associated with clinicopathologic characteristics and outcomes. The role of RPRML in cancer biology was investigated in vitro, through RPRML ectopic overexpression. Functional experiments included colony formation, soft agar, MTS, and Ki67 immunofluorescence assays. DNA methylation-mediated silencing was evaluated by the 5-azacytidine assay and direct bisulfite sequencing. Non-invasive detection of circulating methylated RPRML DNA was assessed in 25 gastric cancer cases and 25 age- and sex-balanced cancer-free controls by the MethyLight assay. Downregulation of RPRML protein expression was associated with poor overall survival in advanced gastric cancer. RPRML overexpression significantly inhibited clonogenic capacity, anchorage-independent growth, and proliferation in vitro. Circulating methylated RPRML DNA distinguished patients with gastric cancer from controls with an area under the curve of 0.726. The in vitro overexpression results and the poor patient survival associated with lower RPRML levels suggest that RPRML plays a tumor-suppressive role in the stomach. Circulating methylated RPRML DNA may serve as a biomarker for the non-invasive detection of gastric cancer.

scholarly journals Machine Learning Models for Abnormality Detection in Musculoskeletal Radiographs

Reports ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 26 ◽  
Author(s):  
Govind Chada
Keyword(s):  
Machine Learning ◽  
Primary Care ◽  
Deep Learning ◽  
Transfer Learning ◽  
Primary Care Physicians ◽  
Screening Tools ◽  
Learning Approaches ◽  
Limited Data ◽  
Learning Models ◽  
High Recognition Accuracy

Increasing radiologist workloads and increasing primary care radiology services make it relevant to explore the use of artificial intelligence (AI) and particularly deep learning to provide diagnostic assistance to radiologists and primary care physicians in improving the quality of patient care. This study investigates new model architectures and deep transfer learning to improve the performance in detecting abnormalities of upper extremities while training with limited data. DenseNet-169, DenseNet-201, and InceptionResNetV2 deep learning models were implemented and evaluated on the humerus and finger radiographs from MURA, a large public dataset of musculoskeletal radiographs. These architectures were selected because of their high recognition accuracy in a benchmark study. The DenseNet-201 and InceptionResNetV2 models, employing deep transfer learning to optimize training on limited data, detected abnormalities in the humerus radiographs with 95% CI accuracies of 83–92% and high sensitivities greater than 0.9, allowing for these models to serve as useful initial screening tools to prioritize studies for expedited review. The performance in the case of finger radiographs was not as promising, possibly due to the limitations of large inter-radiologist variation. It is suggested that the causes of this variation be further explored using machine learning approaches, which may lead to appropriate remediation.

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