scholarly journals SLC6A3 (DAT1) as a Novel Candidate Biomarker Gene for Suicidal Behavior

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 861
Author(s):  
Ekaterina Rafikova ◽  
Maria Shadrina ◽  
Peter Slominsky ◽  
Alla Guekht ◽  
Alexey Ryskov ◽  
...  
Keyword(s):  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Protective Role ◽  
Recessive Model ◽  
Depression And Anxiety ◽  
Allelic Variants ◽  
Vntr Locus ◽  
Symptoms Of Depression ◽  
Suicidal Attempts ◽  
Personal Anxiety

It has been previously shown that the serotonin and dopamine neurotransmitter systems might influence the predisposition to suicidal behavior. This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT, and BDNF to suicidal behavior and severity of symptoms of depression and anxiety in the Russian population. The study was performed on 100 patients with repeated suicide attempts and 154 controls. We first found an association between SLC6A3 (DAT1) 40 bp VNTR locus and suicidal behavior. This association was significant; when using the codominant (p = 0.006), dominant (p = 0.001), overdominant (p = 0.004), and log-additive (p = 0.004) models, LL genotype played a protective role (OR = 0.48, 0.29–0.82, p = 0.005). Difference in the distribution of COMT rs4680 genotypes was significant in the codominant (p = 0.04), dominant (p = 0.013), and log-additive (p = 0.02) models, and AA genotype might protect against suicide (OR = 0.49, 0.26–0.91, p = 0.025). SLC6A4 5-HTTLPR + rs25531 locus was significant in the recessive model (p = 0.024), and also affected the severity of symptoms of depression (p = 0.044) and personal anxiety (p = 0.029). Our results suggest that allelic variants of SLC6A3, COMT, and SLC6A4 genes might be considered as risk factors for suicidal attempts.

scholarly journals SLC6A3 (DAT1) as a novel candidate biomarker gene for suicidal behavior: a pilot study

2021 ◽  
Author(s):  
Ekaterina Rafikova ◽  
Maria I. Shadrina ◽  
Peter A. Slominsky ◽  
Alla B. Guekht ◽  
Aleksei P. Ryskov ◽  
...  
Keyword(s):  
Suicidal Behavior ◽  
Negative Binomial ◽  
Suicide Attempts ◽  
Negative Binomial Regression ◽  
Protective Role ◽  
Recessive Model ◽  
Vntr Locus ◽  
Symptoms Of Depression ◽  
Suicidal Attempts ◽  
Personal Anxiety

Abstract Objective This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT and BDNF to suicidal behavior and severity of symptoms of depression and anxiety in Russian population.Methods The study was performed on 100 patients with repeated suicide attempts and 154 controls. The SNP and VNTR genotyping was carried out using locus-specific PCR. Logistic regression approach was applied to establish associations between gene polymorphisms and risk of suicidal attempts. Negative binomial regression was used to analyze association between genotypes and count variables: severity of depressive symptoms, personal anxiety and situational anxiety. Results We have first found an association between SLC6A3 (DAT1) 40 bp VNTR locus and suicidal behavior. This association was significant in the co-dominant (P = 0.006), dominant (P = 0.001), over-dominant (P = 0.004) and log-additive (P = 0.004) models, LL genotype played a protective role (OR = 0.48, 0.29–0.82). Difference in the genotypes distribution of COMT rs4680 was significant in the co-dominant (P = 0.04), dominant (P = 0.013) and log-additive (P = 0.02) models, and AA genotype might protect against suicide (OR = 0.49, 0.26–0.91). SLC6A4 5-HTTLPR+rs25531 locus was significant only in the recessive model (P = 0.024) and also affected the severity of symptoms of depression (P = 0.044) and personal anxiety (P = 0.029). Conclusions Our results suggest that allelic variants of SLC6A3, COMT and SLC6A4 genes might be considered as risk factors for suicidal attempts.

Suicidal Behavior in German Adolescents

2015 ◽  
Vol 43 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Joana Straub ◽  
Ferdinand Keller ◽  
Nina Sproeber ◽  
Michael G. Koelch ◽  
Paul L. Plener
Keyword(s):  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Present Sample ◽  
Manic Symptoms ◽  
Symptoms Of Depression ◽  
Adolescent Sample ◽  
History Of ◽  
Sum Scores

Objective: Research in adults has identified an association between bipolar disorder and suicidal behavior. This relationship, however, has been insufficiently investigated in adolescents to date. Methods: 1,117 adolescents from 13 German schools (mean age = 14.83, SD = .63; 52.7% females) completed an extended German version of the Center for Epidemiological Studies Depression Scale (CES-D), which assesses depressive and manic symptoms during the last week, as well as the Self-Harm Behavior Questionnaire (SHBQ) for the assessment of lifetime suicidal behavior. Results: In the present sample 39.4% of the girls and 23.1% of the boys reported lifetime suicidal thoughts and 7.1% of the girls as well as 3.9% of the boys a lifetime history of suicide attempts. 18.7% of the adolescent sample revealed elevated symptoms of depression and 9% elevated levels of mania symptoms. Elevated sum scores of depression and mania were associated with a higher number of suicidal ideations and suicide attempts. A block-wise regression analysis revealed that sum scores of depression and mania predicted suicidal ideations best. Concerning suicide attempts, the best predictors were age as well as depression and mania sum scores. Conclusions: Suicidal behavior was reported more often when adolescents demonstrate symptoms of mania as well as symptoms of depression than when they demonstrate only depressive symptoms. The presence of bipolar symptoms in adolescents should alert clinicians to the heightened possibility of suicidal behavior.

scholarly journals The Psychological State of Family Members Who Have Experienced Various Forms of Suicide of a Loved One (Single Attempt, Chronic Suicide, Completed Suicide)

2018 ◽  
Vol 26 (1) ◽  
pp. 56-75 ◽  
Author(s):  
E.V. Borisonik ◽  
A.B. Kholmogorova
Keyword(s):  
Suicide Attempt ◽  
Coping Strategies ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Family System ◽  
Well Being ◽  
Psychological State ◽  
Symptoms Of Depression ◽  
Completed Suicide ◽  
The Family

The suicidal behavior of a member of a family influences the emotional well-being of his/her relatives. This paper presents the results of a pilot study of emotional well-being, coping strategies and characteristics of the family system among relatives of persons with suicidal behavior. The study involved 40 people, the total sample was divided into three subgroups: relatives of patients who survived the first suicide attempt (n = 16); relatives of patients after multiple suicide attempts (n = 10); relatives of persons who committed suicide (n = 14). In the first part of the study, the symptoms of emotional distress were analyzed for the entire sample. Relatives of people with different forms of suicidal behavior are at risk of depression: two-thirds of the combined sample showed increased symptoms of depression. The coping strategies of positive redefinition and personal growth are negatively correlated with symptoms of depression. In the second part of the study, we analyzed differences between subgroups. The severity of the symptoms of depression is significantly higher in the subgroup of relatives of people with completed suicide compared to relatives of those who survived a single suicide attempt, the indicators of hardiness and cohesion of the family system are lower in the families of people with multiple suicide attempts compared to other forms of suicidal behavior.

scholarly journals Formation and course of alcoholism, features of suicidal behavior in persons who have experienced alcoholic psychosis (gender aspect)

2018 ◽  
pp. 71-79
Author(s):  
P. S. Umanskaya ◽  
A. P. Agarkov ◽  
A. A. Agarkov
Keyword(s):  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Young Age ◽  
Alcoholic Beverages ◽  
Second Stage ◽  
Suicidal Attempts ◽  
Rapid Formation ◽  
The Relationship ◽  
Gender Aspect ◽  
Alcohol Dependent

Summary. Currently, a large number of both native and foreign literature are devoted to the issues of prevalence of alcoholism, alcoholic psychoses and peculiarities of suicidal activity of alcohol-dependent ones. Female alcoholism is formed in later than men’s, since later systematic consumption of alcoholic beverages begins. Recently, the problem of suicides among women suffering from alcoholism has become very relevant. It should be emphasized that the data on the relationship between alcoholism and suicide among women are usually underreported.The purpose of this study was to identify the features of the formation and progress of alcohol dependence and the specificity of suicidal activity among young women and men who had experienced alcoholic psychosis.Results. Men in the majority began to be alcoholized till 18 years, women — in 18-20 years. The beginning of systematic alcoholization was at a rather young age (18-20 years), among women — at a later age. The duration of the first stage of alcoholism was more often than in women, 3 years or not more than 8-9 years (p <0.05), and the duration of stage II — 5-10 years (p <0.01). The first stage of alcoholism lasted more than 4 years, but did not exceed 7 years. The duration of second stage was usually up to 3 years (p <0.01).Women more often than men have had suicide attempts. The most common ways of committing suicidal attempts among women are self-cutting, the use of drugs, falling from height. Among men, of all forms of suicidal behavior, designs prevailed, only they had suicidal intentions.Conclusions. Due to the rather rapid formation and flow of alcoholism in women, compared with men, it is necessary to conduct timely prevention of alcoholism among women of young age. Among patients with a narcological profile, autoagressive tendencies are often observed, which have certain gender differences.

Suicidal Behavior in Patients with Adjustment Disorders

Crisis ◽  
2001 ◽  
Vol 22 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Ludmila Kryzhanovskaya ◽  
Randolph Canterbury
Keyword(s):  
Personality Disorder ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Adjustment Disorder ◽  
Adjustment Disorders ◽  
Involuntary Hospitalization ◽  
Axis Ii ◽  
The Past ◽  
Substance Abuse Disorders ◽  
Axis I

Summary: This retrospective study characterizes the suicidal behavior in 119 patients with Axis I adjustment disorders as assessed by psychiatrists at the University of Virginia Hospital. Results indicated that 72 patients (60.5%) had documented suicide attempts in the past, 96% had been suicidal during their admission to the hospital, and 50% had attempted suicide before their hospitalization. The most commonly used method of suicide attempts was overdosing. Of the sample group with suicide attempts in the past, 67% had Axis II diagnoses of borderline personality disorder and antisocial personality disorder. Adjustment disorder diagnosis in patients with the suicide attempts was associated with a high level of suicidality at admission, involuntary hospitalization and substance-abuse disorders. Axis II diagnoses in patients with adjustment disorders constituted risk factors for further suicidal behavior. Additional future prospective studies with reliability checks on diagnosis of adjustment disorders and suicidal behavior are needed.

Interactive Effects of Acute Suicidal Affective Disturbance and Pain Persistence on Suicide Attempt Frequency and Lethality

Crisis ◽  
2019 ◽  
Vol 40 (6) ◽  
pp. 413-421 ◽  
Author(s):  
Megan L. Rogers ◽  
Thomas E. Joiner
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Pain Perception ◽  
Suicide Attempts ◽  
Pain Tolerance ◽  
Self Report ◽  
Interactive Effects ◽  
Physical Pain ◽  
Affective Disturbance ◽  
The Relationship

Abstract. Background: Acute suicidal affective disturbance (ASAD) has been proposed as a suicide-specific entity that confers risk for imminent suicidal behavior. Preliminary evidence suggests that ASAD is associated with suicidal behavior beyond a number of factors; however, no study to date has examined potential moderating variables.  Aims: The present study tested the hypotheses that physical pain persistence would moderate the relationship between ASAD and (1) lifetime suicide attempts and (2) attempt lethality. Method: Students ( N = 167) with a history of suicidality completed self-report measures assessing the lifetime worst-point ASAD episode and the presence of a lifetime suicide attempt, a clinical interview about attempt lethality, and a physical pain tolerance task. Results: Physical pain persistence was a significant moderator of the association between ASAD and lifetime suicide attempts ( B = 0.00001, SE = 0.000004, p = .032), such that the relationship between ASAD and suicide attempts strengthened at increasing levels of pain persistence. The interaction between ASAD and pain persistence in relation to attempt lethality was nonsignificant ( B = 0.000004, SE = 0.00001, p = .765). Limitations: This study included a cross-sectional/retrospective analysis of worst-point ASAD symptoms, current physical pain perception, and lifetime suicide attempts. Conclusion: ASAD may confer risk for suicidal behavior most strongly at higher levels of pain persistence, whereas ASAD and pain perception do not influence attempt lethality.

Symptoms of Depression and Anxiety in Adolescents and Young Adults With Allergies: A Comparison to Healthy Peers

2011 ◽  
Author(s):  
Elizabeth S. Molzon ◽  
Stephanie E. Hullmann ◽  
Angelica R. Eddington ◽  
Carmen A. Del Olmo Vazquez ◽  
Larry L. Mullins
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Depression And Anxiety ◽  
Symptoms Of Depression

A fully automated conversational agent with artificial intelligence capabilities (Youper) for treating depression and anxiety: A nonrandomized feasibility trial (Preprint)

2019 ◽  
Author(s):  
Jose Hamilton Vargas ◽  
Thiago Antonio Marafon ◽  
Diego Fernando Couto ◽  
Ricardo Giglio ◽  
Marvin Yan ◽  
...  
Keyword(s):  
Mental Health ◽  
Artificial Intelligence ◽  
Financial Incentives ◽  
Empirical Support ◽  
Digital Technologies ◽  
Feasibility Trial ◽  
Depression And Anxiety ◽  
Conversational Agents ◽  
Symptoms Of Depression ◽  
Viable Solution

BACKGROUND Mental health conditions, including depression and anxiety disorders, are significant global concerns. Many people with these conditions don't get the help they need because of the high costs of medical treatment and the stigma attached to seeking help. Digital technologies represent a viable solution to these challenges. However, these technologies are often characterized by relatively low adherence and their effectiveness largely remains empirical unverified. While digital technologies may represent a viable solution for this persisting problem, they often lack empirical support for their effectiveness and are characterized by relatively low adherence. Conversational agents using artificial intelligence capabilities have the potential to offer a cost-effective, low-stigma and engaging way of getting mental health care. OBJECTIVE The objective of this study was to evaluate the feasibility, acceptability, and effectiveness of Youper, a mobile application that utilizes a conversational interface and artificial intelligence capabilities to deliver cognitive behavioral therapy-based interventions to reduce symptoms of depression and anxiety in adults. METHODS 1,012 adults with symptoms of depression and anxiety participated in a real-world setting study, entirely remotely, unguided and with no financial incentives, over an 8-week period. Participants completed digital versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) at baseline, 2, 4, and 8 weeks. RESULTS After the eight-week study period, depression (PHQ-9) scores of participants decreased by 48% while anxiety (GAD-7) scores decreased by 43%. The RCI was outside 2 standard deviations for 93.0% of the individuals in the PHQ-9 assessment and 90.7% in the GAD-7 assessment. Participants were on average 24.79 years old (SD 7.61) and 77% female. On average, participants interacted with Youper 0.9 (SD 1.56) times per week. CONCLUSIONS Results suggest that Youper is a feasible, acceptable, and effective intervention for adults with depression and anxiety. CLINICALTRIAL Since this study involved a nonclinical population, it wasn't registered in a public trials registry.

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