scholarly journals Brain Anatomical Mediators of GRIN2B Gene Association with Attention/Hyperactivity Problems: An Integrated Genetic-Neuroimaging Study

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1193
Author(s):  
Maria Nobile ◽  
Eleonora Maggioni ◽  
Maddalena Mauri ◽  
Marco Garzitto ◽  
Sara Piccin ◽  
...  

This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic GRIN2B gene variants and inattention/hyperactivity with neuroanatomical measures as intermediates. Fifty-eight children and adolescents were evaluated for behavioral problems at three time points over approximately 7 years. The final assessment included blood drawing for genetic analyses and 3T magnetic resonance imaging. Attention/hyperactivity problems based on the Child Behavior Checklist/6-18, six GRIN2B polymorphisms and regional cortical thickness, and surface area and volume were estimated. Using general linear model (GLM) and mediation analyses, we tested whether GRIN2B exerted an influence on stable inattention/hyperactivity over development, and to what extent this effect was mediated by brain morphology. GLM results enlightened the relation between GRIN2B rs5796555-/A, volume in the left cingulate isthmus and inferior parietal cortices and inattention/hyperactivity. The mediation results showed that rs5796555-/A effect on inattention/hyperactivity was partially mediated by volume in the left isthmus of the cingulate cortex, suggesting a key role of this region in translating glutamatergic GRIN2B variations to attention/hyperactivity problems. This evidence can have important implications in the management of neurodevelopmental and psychiatric disorders.

2020 ◽  
pp. 088626052098390
Author(s):  
Jiahui Qu ◽  
Li Lei ◽  
Xingchao Wang ◽  
Xiaochun Xie ◽  
Pengcheng Wang

Previous studies have found some risk factors of cyberbullying. However, little is known about how mother phubbing may influence adolescent cyberbullying, and the mediating and moderating mechanisms underlying this relationship. “Phubbing,” which is a portmanteau of “phone” and “subbing,” refers to snubbing other people and focus on smartphones in social interactions. This study examined whether mother phubbing, which refers to being phubbed by one’s mother, would be positively related to adolescent cyberbullying, whether perceived mother acceptance would mediate the relationship between mother phubbing and adolescent cyberbullying, and whether emotional stability would moderate the pathways between mother phubbing and adolescent cyberbullying. The sample consisted of 4,213 Chinese senior high school students (mean age 16.41 years, SD = 0.77, 53% were female). Participants completed measurements regarding mother phubbing, cyberbullying, perceived mother acceptance, and emotional stability. The results indicated that mother phubbing was positively related to cyberbullying, which was mediated by perceived mother acceptance. Further, moderated mediation analyses showed that emotional stability moderated the direct path between mother phubbing and cyberbullying and the indirect path between mother phubbing and perceived mother acceptance. This study highlighted the harmful impact of mother phubbing on adolescents by showing a positive association between mother phubbing and adolescent cyberbullying, as well as the underlying mechanisms between mother phubbing and adolescent cyberbullying.


2021 ◽  
pp. 135910532110092
Author(s):  
Dylan G Serpas ◽  
Laura Zettel-Watson ◽  
Barbara J Cherry

This study investigated the mediating role of depressive symptoms among 147 middle-aged and older adults with FM in the relationship between pain intensity and 4 objective measures of physical performance: Fullerton Advanced Balance scale (FAB), 6-Minute Walk Test (6MWT), 30-Second Chair Stand (30SCS), and 8-Foot Up and Go Test (8FUPGT). Asymptotic mediation analyses revealed that depressive symptoms fully mediated the relationship between pain intensity and FAB (95% CI [−0.40, −0.10]) and 8FUPGT (CI [0.02, 0.11]) and partially mediated the relationship to 6MWT (CI [−9.15, −2.20]) and 30SCS (CI [−0.29, −0.06]). Findings support the evaluation of co-morbid depression in FM.


Author(s):  
Mitsuko Tanaka

AbstractVocabulary learning is often assigned as out-of-class learning, which learners need to autonomously initiate and be motivated to sustain. Under such learning modes, though independent learners may need less motivational scaffolding, learners who prefer a more interactive study environment may need to be provided with assistance to boost their motivation. Focusing on such personal determinants, this study examines the role of self-construal in vocabulary learning by employing self-determination theory. The participants were 155 engineering students from a Japanese technical college. Path and mediation analyses were performed based on vocabulary test scores and questionnaire responses. Results revealed that independent self-construal had a significant impact on more self-determined types of both motivation (i.e., intrinsic motivation and identified regulation) and amotivation, but interdependent self-construal was statistically irrelevant to them, in the context of vocabulary learning. Furthermore, perceived autonomy and competence mediated the relationship between independent self-construal and motivation. These findings indicate that vocabulary learning motivation is shaped and regulated by self-construal and may be enhanced through support of the mediators.


2014 ◽  
Vol 30 (11) ◽  
pp. 2309-2319 ◽  
Author(s):  
Luciane Albuquerque Sá de Souza ◽  
Ana Raquel Rosas Torres ◽  
Genário Alves Barbosa ◽  
Tiago Jessé Souza de Lima ◽  
Luana Elayne Cunha de Souza

The objective of this study is to investigate the role of self-efficacy beliefs as a mediator of the relationship between the subjective well-being and general health of military cadets (police and firefighters). For this study, 228 cadets participated, the majority being Military Police officer candidates (65%), male (79%), between 17 and 34 years of age (99%), and unmarried (74%). They responded to questionnaires on general health (GHQ-12), perceived general self-efficacy, to the multiple scales that cover subjective well-being, and demographic questions. Initial regression analyses indicate the predictive power of subject well-being regarding general health. Subsequently, the mediation analyses provide satisfactory evidence for the role of perceived self-efficacy as a mediator of the relationship between the subjective well-being variables and the overall health of military cadets. The implications of these results for the professional training of the cadets are discussed.


Climate ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 146
Author(s):  
Lindsay P. Galway ◽  
Thomas Beery ◽  
Chris Buse ◽  
Maya K. Gislason

Despite widespread calls to action from the scientific community and beyond, a concerning climate action gap exists. This paper aims to enhance our understanding of the role of connectedness to nature in promoting individual-level climate action in a unique setting where climate research and action are lacking: Canada’s Provincial North. To begin to understand possible pathways, we also examined whether climate worry and talking about climate change with family and friends mediate the relationship between connectedness to nature and climate action. We used data collected via postal surveys in two Provincial North communities, Thunder Bay (Ontario), and Prince George (British Columbia) (n = 628). Results show that connectedness to nature has a direct positive association with individual-level climate action, controlling for gender and education. Results of parallel mediation analyses further show that connectedness to nature is indirectly associated with individual-level climate action, mediated by both climate worry and talking about climate change with family and friends. Finally, results suggest that climate worry and talking about climate change with family and friends serially mediate the relationship between connectedness to nature and with individual-level climate action. These findings are relevant for climate change engagement and action, especially across Canada’s Provincial North, but also in similar settings characterized by marginalization, heightened vulnerability to climate change, urban islands within vast rural and remote landscapes, and economies and social identities tied to resource extraction. Drawing on these findings, we argue that cultivating stronger connections with nature in the places where people live, learn, work, and play is an important and currently underutilized leverage point for promoting individual-level climate action. This study therefore adds to the current and increasingly relevant calls for (re-)connecting with nature that have been made by others across a range of disciplinary and sectoral divides.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Justin F. McManus ◽  
Sergio W. Carvalho ◽  
Valerie Trifts

Purpose This study aims to explore the role of brand personality traits in explaining how different levels of brand favorability evoke affect from and forge connections to consumers. Design/methodology/approach The authors used a quantitative approach consisting of within-subjects (Study 1) and between-subjects (Study 2) experimental designs. Mediation analyses were tested using OLS regression with the MEMORE and PROCESS macros. Findings Findings suggest increases in brand excitement and sincerity to be related to differences in positive affect evoked by favorable and unfavorable brands; decreases in brand sincerity to be related to differences in negative affect between favorable and unfavorable brands (Study 1); brand competence and excitement to be related to the relationship between brand favorability and self-brand connection; and brand competence and excitement to best distinguish favorable brands from unfavorable brands (Study 2). Originality/value These results support the importance of brand personality traits that are considered to be universally positive and provide managers with an initial roadmap for which brand personality traits should be prioritized when communicating with consumers.


Author(s):  
Kiran Sakkar Sudha ◽  
M. Ghazi Shahnawaz

AbstractNarcissism is imbued with emotional dynamism and there is a strong need to assess the linkages with outcomes by analyzing their fusion. The present study examined the relationship between grandiose narcissism and performance through analyzing the mediating role of subjective wellbeing (positive affect, negative affect and life satisfaction). The wholesome assessment of performance was done by considering task performance, team-work and cognitive motivational effectiveness among 293 senior-level Indian employees of a big public sector organization. Data were analyzed by using SPSS 22 and Smart PLS 2.0. The correlation results showed that grandiose narcissism was negatively related to performance, life satisfaction and positively related to negative affect. The indirect pathways (through mediation analyses) revealed that negative affect and life satisfaction mediated the relationship between grandiose narcissism and performance. The study effectively contributes to the narcissism and performance literature by presenting clearer pathways of grandiose narcissism (through self-regulated emotions and subjective wellbeing). Practical implications were also highlighted beside the theoretical concerns.


Author(s):  
Khadija Alsarhi ◽  
Rahma ◽  
Mariëlle J. L. Prevoo ◽  
Lenneke R. A. Alink ◽  
Judi Mesman

The present study examined maternal religiosity as an underlying cultural factor in the effect of harsh physical parenting on child behavioral problems. Data was collected via a discipline observational task, religiosity-based vignettes, and a questionnaire in a group of 62 mothers and their children in slum areas in Yemen. Moderation and mediation models were tested, where the role of maternal religiosity as a predictor and a moderator in the association between harsh physical parenting and child behavioral problems was explored. Findings showed no direct association between harsh physical parenting, maternal religiosity, and child behavioral problems. However, maternal religiosity was found to significantly moderate the relationship between harsh physical parenting and child behavioral problems such that the positive association between harsh physical parenting and child behavior problems was stronger when parents were more religious. Implications of the moderating role of maternal religiosity on the association between harsh physical parenting and child behavioral problems are discussed.


Author(s):  
Martin Sanchez-Gomez ◽  
Edgar Breso

Previous research has highlighted the connection between emotional intelligence (EI) and work performance. However, the role of job burnout in this context remains relatively unexplored. This study aimed to examine the mediator role of burnout in the relationship between EI and work performance in a multioccupational sample of 1197 Spanish professionals (58.6% women). The participants completed the Wong and Law Emotional Intelligence Scale, the Maslach Burnout Inventory, and the Individual Work Performance Questionnaire. As expected, the results demonstrated a positive relationship between EI and performance, and a negative relationship with burnout, which has a mediator effect in the relationship between EI and work performance. Professionals with high levels of IE and low burnout reported the highest performance. Multiple mediation analyses showed that employees’ EI was indirectly connected to work performance via professional efficacy and exhaustion, even when controlling the effects of sociodemographic variables. The same pattern was found when multiple mediations were conducted for each EI dimension. These findings demonstrate the importance of burnout in understanding work performance and emphasize the role of EI as a protective variable which can prevent the development or chronic progression of workers’ burnout.


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